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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Highly efficient differentiation of neural precursors from human embryonic stem cells and benefits of transplantation after ischemic stroke in mice

Figure 6

Transplantation of hES cell-derived neural precursors increases BrdU co-localization with NeuN. (A) Representative images of staining for NeuN (green), BrdU (red), and Col IV (blue) in the penumbra region of a medium control and a cell transplant animal. White arrows indicate co-localization of NeuN and BrdU. Scale bars = 40 μm. (B) A significantly higher percentage of BrdU-positive cells in the transplant animals co-localized with NeuN as compared with control animals, potentially indicating a higher degree of neurogenesis. ***P <0.001, n = 6 (control) and 8 (transplant). (C) No significant difference was observed in the percentage of BrdU-positive cells co-localized with Col IV, indicating no difference in angiogenesis. n = 6 (control) and 7 (transplant).

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Stem Cell Research & Therapy

ISSN: 1757-6512