Figure 3

Human central nervous system stem cells (HuCNS-SC) preferentially differentiate to specific lineages depending upon their site of migration. Transplanted HuCNS-SC or their progeny were detected by staining using human-specific antibodies. Cell lineage was determined by morphology or co-staining for lineage markers. (A) Human astrocytes (STEM123, hGFAP, red) are observed juxtaposed to mouse blood vessels (beta-dystroglycan, green). (B) Human oligodendrocytes (Olig 2; green; STEM121 red) were confined to white matter areas such as the corpus collosum. (C) Within the olfactory system, human cells differentiate to granular neurons with long axons (STEM 121, red).