Limb-clasping of R6/2 mice following umbilical cord mesenchymal stem cell (UC MSC) transplantation. Untreated R6/2 mice had significantly more limb-clasping responses than did WT mice, starting at eight-weeks of age, with this impairment continuing for the duration of the study. Mice receiving either low- or high-passaged UC MSCs were similar to untreated R6/2 mice. (Note: *significant from WT; #significant from R6/2; †significant from high-passage BM MSCs). Line graph represents mean value; error bars represents SEM. BM, bone marrow; SEM, standard error of the mean; WT, wild type.