Aldehyde dehydrogenase and ATP binding cassette transporter G2 (ABCG2) functional assays isolate different populations of prostate stem cells where ABCG2 function selects for cells with increased stem cell activity

Table 2 Incidence of ductal growth in ALDH ^Hi and ALDH ^Low recombinants

Prostate Ductal Growth^(#Analyzed)[Weeks Grafted]
		ALDH^HiGeneration		ALDH^LowGeneration
Specimen	# of Cells	1^st	2^nd	3^rd	1^st	2^nd	3^rd
1NT	250	0⁽³⁾[7]			1⁽³⁾[7]	1⁽¹⁾[10]
1NT	1,000	1⁽³⁾[7]	1⁽¹⁾[10]	1⁽¹⁾[9]	1⁽³⁾[7]	1⁽³⁾[10]
1T	250	1⁽³⁾[7]	1⁽¹⁾[10]	1⁽¹⁾[9]	0⁽³⁾[7]
1T	1,000	2⁽³⁾[7]	2⁽²⁾[10]		0⁽¹⁾[7]
2NT	2,000	2⁽³⁾[7]	2⁽²⁾[10]	1⁽¹⁾[9]	1⁽²⁾[7]	1⁽¹⁾[10]
3NT	500	1⁽³⁾[10]	1⁽¹⁾[9]		2⁽³⁾[10]	1⁽²⁾[9]
3NT	2,000	1⁽³⁾[10]	0⁽¹⁾[9]		1⁽³⁾[10]	1⁽¹⁾[9]
4M	250	0⁽³⁾[10]			2⁽³⁾[7]	0⁽²⁾[8]
4M	1,000	2⁽³⁾[7]	0⁽²⁾[8]		0⁽³⁾[7]
4T	50	0⁽³⁾[7]			1⁽³⁾[7]
4T	250	0⁽³⁾[7]			0⁽³⁾[7]
5NT	50	0⁽³⁾[12]			0⁽³⁾[12]
5NT	250	1⁽²⁾[12]	1⁽¹⁾[12]		1⁽²⁾[12]	1⁽¹⁾[12]
6T	250	1⁽²⁾[8]	0⁽¹⁾[6]		0⁽³⁾[8]
6T	500	2⁽²⁾[8]			0⁽³⁾[8]
Total		14 ⁽⁴²⁾	8 ⁽¹²⁾	3 ⁽³⁾	10 ⁽⁴¹⁾	6 ⁽¹¹⁾

NT: Histologically non-tumor areas; T: Histologically tumor areas; M: Mixed prostate specimen from radical prostatectomies.

ISSN: 1757-6512