Aldehyde dehydrogenase and ATP binding cassette transporter G2 (ABCG2) functional assays isolate different populations of prostate stem cells where ABCG2 function selects for cells with increased stem cell activity

Table 5 Incidence of ductal growth in ALDH ^Hi , ALDH ^Low , side population and non-side population recombinants

Prostate Ductal Growth^(#Analyzed)[weeks grafted]
			1^stgeneration				2^ndgeneration
Specimen	# of Cells	ALDH^Hi	ALDH^Low	SP	NSP	ALDH^Hi	ALDH^Low	SP	NSP
5NT	50	0⁽³⁾ [12]	0⁽³⁾ [12]	2⁽³⁾ [12]	2⁽³⁾ [12]			1⁽²⁾ [15]	2⁽²⁾ [15]
5NT	250	1⁽²⁾ [12]	1⁽²⁾ [12]			1⁽¹⁾ [12]	1⁽¹⁾ [12]
6 T	125			0⁽²⁾ [8]	1⁽³⁾ [8]				0⁽¹⁾ [6]
6 T	250	1⁽²⁾ [8]	0⁽³⁾ [8]	0⁽²⁾ [8]	0⁽³⁾ [8]	0⁽¹⁾ [6]
6 T	500	2⁽²⁾ [8]	0⁽³⁾ [8]
Total		4 ⁽⁹⁾	1 ⁽¹¹⁾	2 ⁽⁷⁾	3 ⁽⁹⁾	1 ⁽²⁾	1 ⁽¹⁾	1 ⁽²⁾	2 ⁽³⁾

NT, Histologically non-tumor areas; T, Histologically tumor areas from radical prostatectomies; SP, Side Population; NSP, Non-Side Population.

ISSN: 1757-6512