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Table 1 Ixmyelocel-T secretes minimal amounts of proinflammatory cytokines after lipid loading

From: Potential beneficial effects of ixmyelocel-T in the treatment of atherosclerotic diseases

 

THP-1 (-LPS)

THP-1 (+LPS)

IXT (-LPS)

IXT (+LPS)

IL-1β

25.7 ± 6

13,213 ± 269a

2.2 ± 0.8b

10 ± 1.9a

TNF-α

135 ± 30

67,063 ± 8,539a

86 ± 54

151 ± 80a

IL-6

97 ± 19

15,733 ± 1,874a

769 ± 353c

2,376 ± 551ad

MCP-1

940 ± 120

29,611 ± 2,713a

5,575 ± 1,912c

8,480 ± 2,491a

  1. Cytokines were quantified in supernatants from lipid-loaded ixmyelocel-T and THP-1 macrophages treated with and without LPS (n ≥ 6). The amount of cytokine expressed was normalized to the cell number of each sample. Values are presented as mean ± SEM relative to control. aP < 0.001 versus THP-1 - LPS; bP < 0.01 versus THP-1 - LPS. cP < 0.05, LPS, lipopolysaccharide; SEM, standard error of the mean; IXT, ixmyelocel-T. dP < 0.05 versus IXT -LPS.
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Stem Cell Research & Therapy

ISSN: 1757-6512