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Table 1 Ixmyelocel-T secretes minimal amounts of proinflammatory cytokines after lipid loading

From: Potential beneficial effects of ixmyelocel-T in the treatment of atherosclerotic diseases

  THP-1 (-LPS) THP-1 (+LPS) IXT (-LPS) IXT (+LPS)
IL-1β 25.7 ± 6 13,213 ± 269a 2.2 ± 0.8b 10 ± 1.9a
TNF-α 135 ± 30 67,063 ± 8,539a 86 ± 54 151 ± 80a
IL-6 97 ± 19 15,733 ± 1,874a 769 ± 353c 2,376 ± 551ad
MCP-1 940 ± 120 29,611 ± 2,713a 5,575 ± 1,912c 8,480 ± 2,491a
  1. Cytokines were quantified in supernatants from lipid-loaded ixmyelocel-T and THP-1 macrophages treated with and without LPS (n ≥ 6). The amount of cytokine expressed was normalized to the cell number of each sample. Values are presented as mean ± SEM relative to control. aP < 0.001 versus THP-1 - LPS; bP < 0.01 versus THP-1 - LPS. cP < 0.05, LPS, lipopolysaccharide; SEM, standard error of the mean; IXT, ixmyelocel-T. dP < 0.05 versus IXT -LPS.