Skip to main content
Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening

Figure 1

Potential applications of human induced pluripotent stem cell-derived cardiomyocytes towards cardiovascular medicine and therapy. Patient fibroblasts or blood cells are obtained and reprogrammed into human induced pluripotent stem cell (hiPSC) colonies by introduction of pluripotency factors - Oct4, Klf4, Sox2, and c-Myc. Subsequently, hiPSCs are differentiated directly into >95% cardiomyocytes using high efficiency protocols and non-cardiomyocyte depletion strategies. These purified hiPSC cardiomyocytes could then be utilized for autologous cell therapy, in vitro disease modeling, or high throughput drug screening studies. RBC, red blood cell.

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512