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Figure 10 | Stem Cell Research & Therapy

Figure 10

From: Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Figure 10

Immunosuppression of UCX® and UCX®-ATMP. (A) Suppression of T cell activation was assayed by incubating CD3, CD28 and IL2 activated peripheral blood mononucleated cells (PBMCs) from two different donors with irradiated UCX® and UCX®- advanced therapy medicinal product (ATMP) and measuring lymphocyte proliferation (B) Treg conversion was measured in the same cells by culturing irradiated cells with CD3+CD4+CD25- T-cells and comparing the percentage of converted CD3+CD4+CD25+Foxp3+ regulatory T-cells with unstimulated cells (negative control) or induced conversion with TGFβ. Results are represented as mean ± SEM.

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