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Table 1 Gene expression in cells cultured with HS or hPL as substitutes of FBS

From: Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Gene name Symbol >two-fold change >two-fold change
   HS-FBS hPL-FBS
chemokine (C-C motif) ligand 5 CCL5  
fibroblast growth factor 2 (basic) FGF2  
fibroblast growth factor 7 FGF7
hepatocyte growth factor (hepapoietin A; scatter factor) HGF
insulin-like growth factor binding protein 5 IGFBP5  
interleukin 1, beta IL1B
interleukin 6 (interferon, beta 2) IL6
keratinocyte growth factor-like protein 2 KGFLP2  
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KIT  
prostaglandin E synthase PTGES  
fibroblast growth factor 5 FGF5  
latent transforming growth factor beta binding protein 2 LTBP2  
5′-nucleotidase, ecto (CD73) NT5E  
platelet derived growth factor D PDGFD  
platelet-derived growth factor receptor, alpha polypeptide PDGFRA  
prostaglandin E receptor 4 (subtype EP4) PTGER4  
transforming growth factor, beta receptor II (70/80 kDa) TGFBR2  
  1. FBS, fetal bovine serum; hPL, human Platelet Lysate; HS, human serum.
  2. 163 Affymetrix-clustered genes described to be involved in immune regulation, antigen presentation, growth control, and MSC markers were analyzed.