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Table 1 Gene expression in cells cultured with HS or hPL as substitutes of FBS

From: Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Gene name

Symbol

>two-fold change

>two-fold change

  

HS-FBS

hPL-FBS

chemokine (C-C motif) ligand 5

CCL5

 

fibroblast growth factor 2 (basic)

FGF2

 

fibroblast growth factor 7

FGF7

hepatocyte growth factor (hepapoietin A; scatter factor)

HGF

insulin-like growth factor binding protein 5

IGFBP5

 

interleukin 1, beta

IL1B

interleukin 6 (interferon, beta 2)

IL6

keratinocyte growth factor-like protein 2

KGFLP2

 

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

KIT

 

prostaglandin E synthase

PTGES

 

fibroblast growth factor 5

FGF5

 

latent transforming growth factor beta binding protein 2

LTBP2

 

5′-nucleotidase, ecto (CD73)

NT5E

 

platelet derived growth factor D

PDGFD

 

platelet-derived growth factor receptor, alpha polypeptide

PDGFRA

 

prostaglandin E receptor 4 (subtype EP4)

PTGER4

 

transforming growth factor, beta receptor II (70/80 kDa)

TGFBR2

 

  1. FBS, fetal bovine serum; hPL, human Platelet Lysate; HS, human serum.
  2. 163 Affymetrix-clustered genes described to be involved in immune regulation, antigen presentation, growth control, and MSC markers were analyzed.