Figure 4

Transplantation of lithium chloride-primed SVZ-derived adult neural progenitor cells accelerated the onset of sensorimotor-function recovery after QA striatal lesioning compared with rats that received nonprimed transplants. Unilateral lesioning of the striatum results in lateralized deficits to the rats' sensorimotor behavior that was quantitatively assessed in (a) the spontaneous exploratory forelimb-use test, and (b) sensorimotor-neglect corridor task to monitor the development of functional impairments after QA injection and functional improvement after adult SVZ-derived neural progenitor-cell transplantation. Significance designated by repeated-measure two-way analysis of variance (ANOVA) with Bonferroni post hoc analysis relative to sham transplant. *P < 0.05; **P < 0.01.