Figure 4
From: Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling
Wharton's jelly-derived mesenchymal stem cell conditioned medium enhances wound healing in an in vivo mouse model. A murine wound healing model was used, and animals were wounded and treated as described previously. Images corresponded to histological sections of wounds and the satellite donut area (10×) from BALB-c mice, after 1 week of full-thickness excisional skin wounding and reconstruction with Wharton's jelly-derived mesenchymal stem cell conditioned medium (WJ-MSC-CM) and vehicle (Matrigel; BD Biosciences, San Jose, CA, USA) (B), or vehicle alone (A). Photomicrographs were taken after Masson’s Trichrome staining. BALB-c mice WJ-MSC-CM-treated wounds showed enhanced wound healing rates compared to the control mice (P ≤ 0.05) (C). *P ≤ 0.05. Error bars represent the 95% confidence interval.