Table 2 Changes in the gene expression levels of ADSCs and pSCCs in co-culture compared to mono-culture
Gene | Fold ADSC mono-/co-culture | Up-/down-regulation | Main impact of gene or gene product |
|---|---|---|---|
Part 1. Changes in the gene expression of ADSCs | |||
E-Cadherin | n.d. | n.a. | EMT, i, m, ms |
N-Cadherin | 0.9 (0.0) | → | EMT |
CCL5 | 16 (0.1) | ↑ | a, i, ms, p |
CCL20 | 32 (0.4) | ↑ | im |
CCL28 | 27 (7.6) | ↑ | a, i, ms, p |
CSF-2 | 13 (4,3) | ↑ | a, i, m |
CSF-3 | 63 (0.2) | ↑ | im |
CXCL1 | 16 (0.0) | ↑ | a, i, m, ms, p |
CXCL2 | 4.0 (0.0) | ↑ | a, i, m |
CXCL3 | 16 (0.1) | ↑ | a, i, m |
CXCL5 | 8.1 (0.0) | ↑ | a, i, m |
CXCL6 | 64 (0.2) | ↑ | a, i, m, ms, p |
CXCL14 | 5.4 (1.9) | ↑ | a |
IL-1α | 13 (3.7) | ↑ | a, ms |
IL-1β | 16 (0.1) | ↑ | a, ms |
IL-6 | 65 (0.8) | ↑ | p |
IL-8 | 32 (0.7) | ↑ | a |
ITGA2B | 5.4 (1.9) | ↑ | m, i, ms |
KISS1R | 5.6 (2.0) | ↑ | ms |
MMP-3 | 13 (3.8) | ↑ | m, i, ms |
PTGS2 | 22 (7.8) | ↑ | a, i, im, m, ms, p |
SERPINE1 | 5.4 (2.0) | ↑ | i, a, m |
TLR-2 | 21 (7.6) | ↑ | a, ms |
VEGFA | 6.7 (1.9) | ↑ | a |
WISP-1 | 20 (12) | ↑ | m, im |
Gene | Fold primary SCC mono-/co-culture | Up-/down-regulation | Main impact of gene or gene product |
Part 2. Changes in the gene expression of primary SCCs | |||
E-Cadherin | 1.5 (0.1) | → | EMT, i, m, ms |
N-Cadherin | 3.0 (0.0) | ↓ | EMT |
CCND2 | 4.7 (3.9) | ↑ | i |