Skip to main content

Table 2 Changes in the gene expression levels of ADSCs and pSCCs in co-culture compared to mono-culture

From: Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications

Gene Fold ADSC mono-/co-culture Up-/down-regulation Main impact of gene or gene product
Part 1. Changes in the gene expression of ADSCs
E-Cadherin n.d. n.a. EMT, i, m, ms
N-Cadherin 0.9 (0.0) EMT
CCL5 16 (0.1) a, i, ms, p
CCL20 32 (0.4) im
CCL28 27 (7.6) a, i, ms, p
CSF-2 13 (4,3) a, i, m
CSF-3 63 (0.2) im
CXCL1 16 (0.0) a, i, m, ms, p
CXCL2 4.0 (0.0) a, i, m
CXCL3 16 (0.1) a, i, m
CXCL5 8.1 (0.0) a, i, m
CXCL6 64 (0.2) a, i, m, ms, p
CXCL14 5.4 (1.9) a
IL-1α 13 (3.7) a, ms
IL-1β 16 (0.1) a, ms
IL-6 65 (0.8) p
IL-8 32 (0.7) a
ITGA2B 5.4 (1.9) m, i, ms
KISS1R 5.6 (2.0) ms
MMP-3 13 (3.8) m, i, ms
PTGS2 22 (7.8) a, i, im, m, ms, p
SERPINE1 5.4 (2.0) i, a, m
TLR-2 21 (7.6) a, ms
VEGFA 6.7 (1.9) a
WISP-1 20 (12) m, im
Gene Fold primary SCC mono-/co-culture Up-/down-regulation Main impact of gene or gene product
Part 2. Changes in the gene expression of primary SCCs
E-Cadherin 1.5 (0.1) EMT, i, m, ms
N-Cadherin 3.0 (0.0) EMT
CCND2 4.7 (3.9) i
  1. GUSB was used as the referring housekeeping-gene. Except for E- and N-Cadherin only changes of 2.5-fold or higher are displayed. Part 1 displays the changes in the gene expression levels of ADSCs. Part 2 shows the changes in the gene expression levels of pSCCs. Arrows mark an up- (↑) or down-regulation (↓) of the gene expression compared to the referring mono-culture. Abbreviations of main impact: a, angiogenesis; i, invasion; im, impaired anti-tumor response; m, migration; ms, metastasis; p, proliferation.