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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Low-dose insulin-like growth factor binding proteins 1 and 2 and angiopoietin-like protein 3 coordinately stimulate ex vivo expansion of human umbilical cord blood hematopoietic stem cells as assayed in NOD/SCID gamma null mice

Figure 4

Human cell engraftment and multi-lineage reconstitution profile. (A) Amount of human chimerism in the bone marrow of NOD/SCID-IL2Rγ−/−mice that received a transplant of 5 × 105 and 1 × 106 unexpanded human mononuclear cord blood cells and 1 × 106 and 2 × 106 expanded progeny cells. Each symbol represents the engraftment of a single mouse that underwent transplantation assayed at 4 months post transplantation. (B) Summary of multi-lineage reconstitution from mice bone marrow transplanted 5 × 105 unexpanded cells in lane 1 and transplanted 2 × 106 expanded cells with the cytokine combination ‘S + F + T + ABD’ in lane 10 of (A). S, stem cell factor; F, FLT3 ligand; T, thrombopoietin. A, IGFBP1; B, IGFBP2; C, IGF2; D, ANGPTL3. ANGPTL, angiopoietin-like protein; IGF, insulin-like growth factor; IGFBP, insulin-like growth factor binding protein.

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