Figure 1

Effect of exosomes on biochemical parameters and hepatocyte injury after CCl ₄ treatment in vivo . Serum (A) aspartate aminotransferase (AST) and (B) alanine aminotransferase (ALT) levels were measured after 24-hour dosing of CCl₄ with or without exosomes administration (n = 6 per group; *P < 0.05 versus of CCl₄ control for both AST and ALT). Standard hematoxylin and eosin (H&E) staining for liver tissue harvested after 24 hours of (C) CCl₄ administration and (D) CCl₄ with exosomes treatment. Obvious hepatic necrosis appeared in the section from a CCl₄-treated animal. Original magnification × 80; scale bar, 100 μm.