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Figure 3 | Stem Cell Research & Therapy

Figure 3

From: Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages

Figure 3

MSCs increase infiltration of M2-polarised macrophages in rhabdomyolysis kidney and promote tubular cell regeneration. (a) Representative confocal microscopy images of macrophages (F4/80) and M2-polarised macrophage (CD206) infiltration in kidneys after saline or MSC infusion. (b) PCNA–positive nuclei within the tubuli of glycerol-treated mice treated with saline or MSCs at various time intervals (24, 48 and 72 hours). (c) Representative western blotting analysis showing time-dependent increases in mannose receptor (CD206) expression induced by MSC treatment. *P <0.05 versus RM + NS, n = 3. MSC, mesenchymal stem cell; NS, normal saline; PCNA, proliferating cell nuclear antigen; RM, rhabdomyolysis.

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Stem Cell Research & Therapy

ISSN: 1757-6512