Table 1 Repair of injured spinal cord using biomaterial scaffolds
From: Repair of injured spinal cord using biomaterial scaffolds and stem cells
Injury | Animal model | SCI stagea | Scaffold | Outcome | Reference |
|---|---|---|---|---|---|
Complete transection (mid thoracic) | Rat | Acute | Collagen single channel tube | Significant axonal regeneration in tube and reduced scar invasion | [27] |
Complete transection (T9) | Rat | Acute | Fibrin beads | Increased axonal fiber density along injury site | [29] |
Hemisection (T7-T9) | Rat | Acute | Fibronectin mat | Considerable axonal growth along implant site | [30] |
Hemisection (T7-T9) | Rat | Acute | Fibrin/fibronectin gel | Axonal growth observed | [31] |
Complete transection (C4) | Rat | Acute | Agarose multichannel tube | Axonal regeneration along lesion site | [32] |
Complete transection (T3) | Rat | Acute | Agarose multichannel honeycomb structure | Linear axonal regeneration along injury site | [33] |
Hemisection (C3) | Rat | Acute | Agarose multichannel tube | Linear axonal regeneration and significant linear axonal growth | [34] |
Compression (T9) | Rat | Acute | Hyaluronic acid hydrogel | Axon proliferation and motor function improvement | [35] |
Hemisection (T8-T9) | Rat | Acute | Hyaluronic acid hydrogel | Increased axonal regeneration and inhibition of scar formation | [36] |
Compression (T12-L1) | Guinea pig | Acute | Chitosan injectable solution | Partial restoration of somatosensory- evoked potential | [37] |
Complete transection (T9) | Rat | Acute | Chitosan single channel tube | Axonal regeneration and partial locomotor functional recovery of hind limbs | [38] |
Complete transection (C6-C7) | Rat | Acute | Self-assembled peptide nanofiber | Axonal regeneration | [18] |
Compression (T2) | Rat | Acute | Hyaluronan and methyl cellulose hydrogel blend | Host axon survival and functional improvement | [39] |
Hemisection (C3-C4) | Rat | Acute | Poly-β-hydroxybutyrate single channel tube | Axonal regeneration along conduit | [40] |
Complete transection (T8) | Rat | Acute | PHEMA-co-MMA hydrogel | Axonal regeneration | [41] |
Complete transection (T9-T10) | Rat | Acute | PLA macroporous sponge | Myelinated axon regeneration and gradual functional recovery in hind limb motion | [42] |