Figure 4

Immunomodulatory excitation of orbital fat-derived stem cells by activated macrophages. Upon noncontact culture, the lipopolysaccharide (LPS)-activated macrophages (MØ) did not alter transforming growth factor beta (TGFβ) expression (A), but significantly upregulated interleukin (IL)-10 (B), indoleamine 2,3-dioxygenase (IDO) (C), soluble tumor necrosis factor receptor type II (sTNFRII) (D) and IL-1 receptor antagonist (IL-1RA) (E) expression in orbital fat-derived stem cells (OFSCs). t test, *P < 0.05, n = 3.