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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells

Figure 5

Hypertrophic differentiation in chondrogenically induced cultures of human bone marrow-derived mesenchymal stem cells transduced with rAAV-hIGF-I. Human bone marrow-derived mesenchymal stem cell aggregates were transduced with rAAV-hIGF-I or rAAV-lacZ as described in Figure 2 and histologically processed after 21 days to examine the expression of type I collagen (A) and type X collagen (B) by immunohistochemistry/histomorphometry and by analysis of the type I collagen (A) and type X collagen (B) contents, and to evaluate matrix mineralization (alizarin red staining with histomorphometry) (C) (all at magnification × 4). *Statistically significant compared with rAAV-lacZ. hIGF-I, human insulin-like growth factor I; rAAV, recombinant adeno-associated virus.

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Stem Cell Research & Therapy

ISSN: 1757-6512