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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: 17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway

Figure 6

SP600125 and SB203580 inhibited odonto/osteogenic differentiation of E2-treated SCAP. (A) ALP activity at day 5 in different groups (control group, E2 group, E2 + SP600125 group and E2 + SB203580 group). (B) Odonto/osteogenic protein expression (DMP1, DSP, RUNX2, OSX and OCN) in different groups at day 3. (C) Quantitative analysis of odonto/osteogenic proteins (DMP1, DSP, RUNX2, OSX and OCN) in different groups at day 3. (D) Western blot analysis for odonto/osteogenic proteins (DMP1, DSP, RUNX2, OSX and OCN) in different groups at day 7. (E) Quantitative analysis of odonto/osteogenic proteins (DMP1, DSP, RUNX2, OSX and OCN) in different groups at day 7. Values are the mean ± SD, n = 3. *P <0.05, **P <0.01. ALP, alkaline phosphatase; E2, 17beta-estradiol; SCAP, stem cells from apical papilla; SD, standard deviation.

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Stem Cell Research & Therapy

ISSN: 1757-6512