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Table 1 The top 10 transcripts of hMSCs, up-regulated in lung after OA delivery to LPS exposed mice

From: Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6

Gene name Gene symbol LPS + hMSCs vs LPS + hMSCs in vitro mix LPS + hMSCs vs PBS + hMSCs LPS + hMSCs vs LPS + PBS
Interferon-induced protein with tetratricopeptide repeats 3 IFIT3 29 29 31
Tumor necrosis factor, alpha-induced protein 6 TNFAIP6 25 3 24
Interleukin 8 IL8 19 10 23
Chemokine (C-X-C motif) ligand 6 CXCL6 18 18 17
Superoxide dismutase 2, mitochondrial SOD2 16 12 19
Chemokine (C-X-C motif) ligand 5 CXCL5 11 9 8
Spermidine/spermine N1-acetyltransferase 1 SAT1 10 7 14
Integrin-binding sialoprotein IBSP 7 6 6
Pregnancy-associated plasma protein A, pappalysin 1 PAPPA 6 8 6
ATP-binding cassette, sub-family A, member 1 ABCA1 6 3 5
  1. Shown are fold changes in mRNA levels assayed by microarray (Supplemental Figure S1 in Additional file 1). LPS + hMSCs is RNA extracted from LPS-exposed lung 12 h after treatment with hMSCs; LPS + hMSCs in vitro mix is hMSCs added to lung tissue from LPS-exposed mouse immediately prior to RNA isolation; PBS + hMSCs is RNA extracted from PBS-exposed lung 12 h after treatment with hMSCs; LPS + PBS is RNA extracted from LPS-exposed lung 12 h after treatment with PBS. hMSCs, human multipotent stromal cells; LPS, lipopolysaccharide; OA, oropharyngeal aspiration; PBS, phosphate buffered saline.