Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6

Table 1 The top 10 transcripts of hMSCs, up-regulated in lung after OA delivery to LPS exposed mice

Gene name	Gene symbol	LPS + hMSCs vs LPS + hMSCs *in vitro* mix	LPS + hMSCs vs PBS + hMSCs	LPS + hMSCs vs LPS + PBS
Interferon-induced protein with tetratricopeptide repeats 3	IFIT3	29	29	31
Tumor necrosis factor, alpha-induced protein 6	*TNFAIP6*	25	3	24
Interleukin 8	IL8	19	10	23
Chemokine (C-X-C motif) ligand 6	CXCL6	18	18	17
Superoxide dismutase 2, mitochondrial	SOD2	16	12	19
Chemokine (C-X-C motif) ligand 5	CXCL5	11	9	8
Spermidine/spermine N1-acetyltransferase 1	SAT1	10	7	14
Integrin-binding sialoprotein	IBSP	7	6	6
Pregnancy-associated plasma protein A, pappalysin 1	PAPPA	6	8	6
ATP-binding cassette, sub-family A, member 1	ABCA1	6	3	5

Shown are fold changes in mRNA levels assayed by microarray (Supplemental Figure S1 in Additional file 1). LPS + hMSCs is RNA extracted from LPS-exposed lung 12 h after treatment with hMSCs; LPS + hMSCs in vitro mix is hMSCs added to lung tissue from LPS-exposed mouse immediately prior to RNA isolation; PBS + hMSCs is RNA extracted from PBS-exposed lung 12 h after treatment with hMSCs; LPS + PBS is RNA extracted from LPS-exposed lung 12 h after treatment with PBS. hMSCs, human multipotent stromal cells; LPS, lipopolysaccharide; OA, oropharyngeal aspiration; PBS, phosphate buffered saline.

ISSN: 1757-6512