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  1. Research

    Effects of mesenchymal stem cells from human induced pluripotent stem cells on differentiation, maturation, and function of dendritic cells

    Mesenchymal stem cells (MSCs) have potent immunomodulatory effects on multiple immune cells and have great potential in treating immune disorders. Induced pluripotent stem cells (iPSCs) serve as an unlimited a...

    Wen-Xiang Gao, Yue-Qi Sun, Jianbo Shi, Cheng-Lin Li, Shu-Bin Fang, Dan Wang, Xue-Quan Deng, Weiping Wen and Qing-Ling Fu

    Stem Cell Research & Therapy 2017 8:48

    Published on: 2 March 2017

  2. Research

    Exploiting decellularized cochleae as scaffolds for inner ear tissue engineering

    Use of decellularized tissues has become popular in tissue engineering applications as the natural extracellular matrix can provide necessary physical cues that help induce the restoration and development of f...

    Adam J. Mellott, Heather E. Shinogle, Jennifer G. Nelson-Brantley, Michael S. Detamore and Hinrich Staecker

    Stem Cell Research & Therapy 2017 8:41

    Published on: 28 February 2017

  3. Review

    p53 switches off pluripotency on differentiation

    The role of p53 as “a guardian of the genome” has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understand...

    Tongxiang Lin and Yi Lin

    Stem Cell Research & Therapy 2017 8:44

    Published on: 28 February 2017

  4. Research

    Development of a surrogate potency assay to determine the angiogenic activity of Stempeucel®, a pooled, ex-vivo expanded, allogeneic human bone marrow mesenchymal stromal cell product

    Mesenchymal stromal cells (MSCs) have emerged as a more beneficial alternative to conventional therapy and may offer a potential cure for unmet medical needs. MSCs are known to possess strong immunomodulatory ...

    Charan Thej, Balamurugan Ramadasse, Ankita Walvekar, Anish S. Majumdar and Sudha Balasubramanian

    Stem Cell Research & Therapy 2017 8:47

    Published on: 28 February 2017

  5. Research

    Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model

    Intra-articular injection of mesenchymal stem cells (MSCs) is efficacious in osteoarthritis therapy. A direct comparison of the response of the synovial joint to intra-articular injection of autologous versus ...

    Amanda-Jo Joswig, Alexis Mitchell, Kevin J. Cummings, Gwendolyn J. Levine, Carl A. Gregory, Roger Smith and Ashlee E. Watts

    Stem Cell Research & Therapy 2017 8:42

    Published on: 28 February 2017

  6. Research

    Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury

    Human amnion epithelial cells (hAECs) are clonogenic and have been proposed to reduce inflammatory-induced tissue injury. Perturbation of the immune response is implicated in the pathogenesis of perinatal brai...

    Bryan Leaw, Dandan Zhu, Jean Tan, Ruth Muljadi, Mohamed I. Saad, Joanne C. Mockler, Euan M. Wallace, Rebecca Lim and Mary Tolcos

    Stem Cell Research & Therapy 2017 8:46

    Published on: 28 February 2017

  7. Research

    Netrin-1 acts as a non-canonical angiogenic factor produced by human Wharton’s jelly mesenchymal stem cells (WJ-MSC)

    Angiogenesis, the process in which new blood vessels are formed from preexisting ones, is highly dependent on the presence of classical angiogenic factors. Recent evidence suggests that axonal guidance protein...

    Catalina P. Prieto, María Carolina Ortiz, Andrea Villanueva, Cynthia Villarroel, Sandra S. Edwards, Matías Elliott, José Lattus, Sócrates Aedo, Daniel Meza, Pablo Lois and Verónica Palma

    Stem Cell Research & Therapy 2017 8:43

    Published on: 28 February 2017

  8. Research

    A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial

    Anal sphincter defects are a major cause of fecal incontinence causing negative effects on daily life, social interactions, and mental health. Because human adipose-derived stromal/stem cells (hADSCs) are easi...

    Arash Sarveazad, Graham L. Newstead, Rezvan Mirzaei, Mohammad Taghi Joghataei, Mehrdad Bakhtiari, Asrin Babahajian and Bahar Mahjoubi

    Stem Cell Research & Therapy 2017 8:40

    Published on: 21 February 2017

  9. Research

    Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells

    Magnesium is essential for numerous physiological functions. Magnesium exists mostly in bone and the amount is dynamically regulated by skeletal remodeling. Accelerating bone mass loss occurs when magnesium in...

    Yu-Tzu Tsao, Ya-Yi Shih, Yu-An Liu, Yi-Shiuan Liu and Oscar K. Lee

    Stem Cell Research & Therapy 2017 8:39

    Published on: 21 February 2017

  10. Research

    Mesenchymal stem cells alleviate Japanese encephalitis virus-induced neuroinflammation and mortality

    Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia. Japanese encephalitis (JE) caused by JEV is characterized by extensive inflammatory cytokine secretion, microglia activatio...

    Peiyu Bian, Chuantao Ye, Xuyang Zheng, Jing Yang, Wei Ye, Yuan Wang, Yun Zhou, Hongwei Ma, Peijun Han, Hai Zhang, Ying Zhang, Fanglin Zhang, Yingfeng Lei and Zhansheng Jia

    Stem Cell Research & Therapy 2017 8:38

    Published on: 16 February 2017

  11. Research

    In vitro generation of Sertoli-like and haploid spermatid-like cells from human umbilical cord perivascular cells

    First trimester (FTM) and term human umbilical cord-derived perivascular cells (HUCPVCs), which are rich sources of mesenchymal stem cells (MSCs), can give rise to Sertoli cell (SC)-like as well as haploid ger...

    Ekaterina Shlush, Leila Maghen, Sonja Swanson, Shlomit Kenigsberg, Sergey Moskovtsev, Tanya Barretto, Andrée Gauthier-Fisher and Clifford L. Librach

    Stem Cell Research & Therapy 2017 8:37

    Published on: 15 February 2017

  12. Research

    Cardiosphere-derived cells do not improve cardiac function in rats with cardiac failure

    Heart failure represents an important public health issue due to its high costs and growing incidence worldwide. Evidence showing the regenerative potential of postmitotic heart tissue has suggested the existe...

    Taís Hanae Kasai-Brunswick, Andréa Rodrigues da Costa, Raiana Andrade Quintanilha Barbosa, Bruna Farjun, Fernanda Cristina Paccola Mesquita, Danúbia Silva dos Santos, Isalira Peroba Ramos, Grazielle Suhett, Guilherme Visconde Brasil, Sandro Torrentes da Cunha, José Oscar R. Brito, Juliana do Amaral Passipieri, Adriana Bastos Carvalho and Antonio Carlos Campos de Carvalho

    Stem Cell Research & Therapy 2017 8:36

    Published on: 15 February 2017

  13. Research

    Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling

    Cell-based gene therapy has become a subject of interest for the treatment of pulmonary arterial hypertension (PAH), a devastating disease characterized by pulmonary artery smooth muscle cell (PASMC) hyperplas...

    Gesheng Cheng, Xingye Wang, Yongxin Li and Lu He

    Stem Cell Research & Therapy 2017 8:34

    Published on: 10 February 2017

  14. Research

    GMP-conformant on-site manufacturing of a CD133+ stem cell product for cardiovascular regeneration

    CD133+ stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. Several clinical trials have shown remarkable beneficial effects following their intramyoc...

    Anna Skorska, Paula Müller, Ralf Gaebel, Jana Große, Heiko Lemcke, Cornelia A. Lux, Manuela Bastian, Frauke Hausburg, Nicole Zarniko, Sandra Bubritzki, Ulrike Ruch, Gudrun Tiedemann, Robert David and Gustav Steinhoff

    Stem Cell Research & Therapy 2017 8:33

    Published on: 10 February 2017

  15. Research

    Differential long noncoding RNA/mRNA expression profiling and functional network analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells

    Mesenchymal stem cells (MSCs) are the most promising cell types for bone regeneration and repair due to their osteogenic potential. MSC differentiation is precisely regulated and orchestrated by the mechanical...

    Wenyuan Zhang, Rui Dong, Shu Diao, Juan Du, Zhipeng Fan and Fu Wang

    Stem Cell Research & Therapy 2017 8:30

    Published on: 7 February 2017

  16. Research

    Endothelial differentiation of bone marrow mesenchyme stem cells applicable to hypoxia and increased migration through Akt and NFκB signals

    Bone marrow mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are used to repair hypoxic or ischemic tissue. However, the underlining mechanism of resistance in the hypoxic microenvironment...

    Cheng Liu, An-Ly Tsai, Ping-Chia Li, Chia-Wei Huang and Chia-Ching Wu

    Stem Cell Research & Therapy 2017 8:29

    Published on: 7 February 2017

  17. Research

    Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis

    The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine p...

    Anwar Abdalmula, Laura M. Dooley, Claire Kaufman, Elizabeth A. Washington, Jacqueline V. House, Barbara A. Blacklaws, Peter Ghosh, Silviu Itescu, Simon R. Bailey and Wayne G. Kimpton

    Stem Cell Research & Therapy 2017 8:22

    Published on: 7 February 2017

  18. Research

    Characteristics of human adipose derived stem cells in scleroderma in comparison to sex and age matched normal controls: implications for regenerative medicine

    Adipose-derived stem cells (ADSCs) are emerging as an alternative stem cell source for cell-based therapies. Recent data suggest that autologous ADSC-enriched micrografting improves the effects of facial invol...

    Michelle Griffin, Caroline M. Ryan, Omar Pathan, David Abraham, Christopher P. Denton and Peter E. M. Butler

    Stem Cell Research & Therapy 2017 8:23

    Published on: 7 February 2017

  19. Research

    Phenotype and multipotency of rabbit (Oryctolagus cuniculus) amniotic stem cells

    Stem cells are capable of unlimited self-renewal and are able to remain undifferentiated for extended periods of time prior to their differentiation into specific cell lineages. Because of the issues (ethical ...

    Jéssica Borghesi, Lara Carolina Mario, Ana Claudia Oliveira Carreira, Maria Angélica Miglino and Phelipe Oliveira Favaron

    Stem Cell Research & Therapy 2017 8:27

    Published on: 7 February 2017

  20. Research

    CCL11 promotes migration and proliferation of mouse neural progenitor cells

    Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenito...

    Feifei Wang, Nobuyasu Baba, Yuan Shen, Tatsuyuki Yamashita, Emi Tsuru, Masayuki Tsuda, Nagamasa Maeda and Yusuke Sagara

    Stem Cell Research & Therapy 2017 8:26

    Published on: 7 February 2017

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