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  1. Research

    Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury

    Mesenchymal stromal cells (MSCs) represent an option for the treatment of acute kidney injury (AKI). It is known that young stem cells are better than are aged stem cells at reducing the incidence of the senes...

    Camila Eleuterio Rodrigues, José Manuel Condor Capcha, Ana Carolina de Bragança, Talita Rojas Sanches, Priscila Queiroz Gouveia, Patrícia Aparecida Ferreira de Oliveira, Denise Maria Avancini Costa Malheiros, Rildo Aparecido Volpini, Mirela Aparecida Rodrigues Santinho, Bárbara Amélia Aparecida Santana, Rodrigo do Tocantins Calado, Irene de Lourdes Noronha and Lúcia Andrade

    Stem Cell Research & Therapy 2017 8:19

    Published on: 28 January 2017

  2. Research

    Generation of mesenchymal stromal cells from cord blood: evaluation of in vitro quality parameters prior to clinical use

    Increasing evidence suggests the safety and efficacy of mesenchymal stromal cells (MSC) as advanced therapy medicinal products because of their immunomodulatory properties and supportive role in hematopoiesis....

    Eliana Amati, Sabrina Sella, Omar Perbellini, Alberta Alghisi, Martina Bernardi, Katia Chieregato, Chiara Lievore, Denise Peserico, Manuela Rigno, Anna Zilio, Marco Ruggeri, Francesco Rodeghiero and Giuseppe Astori

    Stem Cell Research & Therapy 2017 8:14

    Published on: 24 January 2017

  3. Research

    TGF-β1-induced differentiation of SHED into functional smooth muscle cells

    Adequate vascularization is crucial for supplying nutrition and discharging metabolic waste in freshly transplanted tissue-engineered constructs. Obtaining the appropriate building blocks for vascular tissue e...

    Jian Guang Xu, Shao Yue Zhu, Boon Chin Heng, Waruna Lakmal Dissanayaka and Cheng Fei Zhang

    Stem Cell Research & Therapy 2017 8:10

    Published on: 23 January 2017

  4. Research

    Integrated analysis of hematopoietic differentiation outcomes and molecular characterization reveals unbiased differentiation capacity and minor transcriptional memory in HPC/HSC-iPSCs

    Transcription factor-mediated reprogramming can reset the epigenetics of somatic cells into a pluripotency compatible state. Recent studies show that induced pluripotent stem cells (iPSCs) always inherit start...

    Shuai Gao, Xinfeng Hou, Yonghua Jiang, Zijian Xu, Tao Cai, Jiajie Chen and Gang Chang

    Stem Cell Research & Therapy 2017 8:13

    Published on: 23 January 2017

  5. Research

    Synergistic antibacterial effect of co-administering adipose-derived mesenchymal stromal cells and Ophiophagus hannah l-amino acid oxidase in a mouse model of methicillin-resistant Staphylococcus aureus-infected wounds

    Mesenchymal stromal cells (MSCs) and Ophiophagus hannah l-amino acid oxidase (Oh-LAAO) have been reported to exhibit antimicrobial activity against methicillin-resistant Staphylococcus...

    Yee Yik Mot, Iekhsan Othman and Syed Hassan Sharifah

    Stem Cell Research & Therapy 2017 8:5

    Published on: 23 January 2017

  6. Research

    Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis

    The hematopoietic system is especially sensitive to total body irradiation (TBI), and myelosuppression is one of the major effects of TBI. Astaxanthin (ATX) is a powerful natural anti-oxidant with low toxicity...

    Xiao-Lei Xue, Xiao-Dan Han, Yuan Li, Xiao-Fei Chu, Wei-Min Miao, Jun-Ling Zhang and Sai-Jun Fan

    Stem Cell Research & Therapy 2017 8:7

    Published on: 23 January 2017

  7. Research

    Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells

    Generation of large quantities of endothelial cells is highly desirable for vascular research, for the treatment of ischemia diseases, and for tissue regeneration. To achieve this goal, we developed a simple, ...

    Fengzhi Zhang, Lin Wang, Yaqian Li, Wei Liu, Fuyu Duan, Rujin Huang, Xi Chen, Sophia Chia-Ning Chang, Yanan Du and Jie Na

    Stem Cell Research & Therapy 2017 8:6

    Published on: 23 January 2017

  8. Research

    Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro

    Mesenchymal stem cells (MSCs) have limited potential of cardiogenic differentiation. In this study, we investigated the influence of long noncoding RNA Braveheart (lncRNA-Bvht) on cardiogenic differentiation o...

    Jingying Hou, Huibao Long, Changqing Zhou, Shaoxin Zheng, Hao Wu, Tianzhu Guo, Quanhua Wu, Tingting Zhong and Tong Wang

    Stem Cell Research & Therapy 2017 8:4

    Published on: 17 January 2017

  9. Research

    The lncRNAs involved in mouse airway allergic inflammation following induced pluripotent stem cell-mesenchymal stem cell treatment

    We have previously reported that induced pluripotent stem cell (iPSC)-mesenchymal stem cells (MSCs) alleviated asthma inflammation in mice. Long noncoding RNAs (lncRNAs) were recently reported as being involve...

    Shu-Yue Wang, Xing-Liang Fan, Qiu-Ning Yu, Meng-Xia Deng, Yue-Qi Sun, Wen-Xiang Gao, Cheng-Lin Li, Jian-Bo Shi and Qing-Ling Fu

    Stem Cell Research & Therapy 2017 8:2

    Published on: 6 January 2017

  10. Research

    Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency

    Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinat...

    James Koudy Williams, Ashley Dean, Shannon Lankford, Tracy Criswell, Gopal Badlani and Karl-Erik Andersson

    Stem Cell Research & Therapy 2017 8:1

    Published on: 6 January 2017

  11. Research

    Oxidative status predicts quality in human mesenchymal stem cells

    Human bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations ...

    Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel and Jivko Stoyanov

    Stem Cell Research & Therapy 2017 8:3

    Published on: 6 January 2017

  12. Research

    Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

    Human embryonic stem cells (hESCs) partially recapitulate early embryonic three germ layer development, allowing testing of potential teratogenic hazards. Because use of hESCs is ethically debated, we investig...

    Vaibhav Shinde, Sureshkumar Perumal Srinivasan, Margit Henry, Tamara Rotshteyn, Jürgen Hescheler, Jörg Rahnenführer, Marianna Grinberg, Johannes Meisig, Nils Blüthgen, Tanja Waldmann, Marcel Leist, Jan Georg Hengstler and Agapios Sachinidis

    Stem Cell Research & Therapy 2016 7:190

    Published on: 30 December 2016

  13. Review

    Nanostructured scaffold as a determinant of stem cell fate

    The functionality of stem cells is tightly regulated by cues from the niche, comprising both intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals are important compone...

    Lekshmi Krishna, Kamesh Dhamodaran, Chaitra Jayadev, Kaushik Chatterjee, Rohit Shetty, S. S. Khora and Debashish Das

    Stem Cell Research & Therapy 2016 7:188

    Published on: 30 December 2016

  14. Research

    Grafted c-kit+/SSEA1 eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses

    Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacem...

    Xi Chen, Zehua Chen, Zhengya Li, Chen Zhao, Yuxiao Zeng, Ting Zou, Caiyun Fu, Xiaoli Liu, Haiwei Xu and Zheng Qin Yin

    Stem Cell Research & Therapy 2016 7:191

    Published on: 30 December 2016

  15. Research

    LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells

    Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing MSC migratory capacity as well as potentializing immune response suppre...

    Martha Oliveira-Bravo, Bruno Braga Sangiorgi, Josiane Lilian dos Santos Schiavinato, Juliana Lott Carvalho, Dimas Tadeu Covas, Rodrigo Alexandre Panepucci, Francisco de Assis Rocha Neves, Octávio Luiz Franco, Rinaldo Wellerson Pereira and Felipe Saldanha-Araujo

    Stem Cell Research & Therapy 2016 7:189

    Published on: 30 December 2016

  16. Research

    High glucose suppresses embryonic stem cell differentiation into cardiomyocytes

    Babies born to mothers with pregestational diabetes have a high risk for congenital heart defects (CHD). Embryonic stem cells (ESCs) are excellent in vitro models for studying the effect of high glucose on car...

    Penghua Yang, Xi Chen, Sunjay Kaushal, E. Albert Reece and Peixin Yang

    Stem Cell Research & Therapy 2016 7:187

    Published on: 9 December 2016

  17. Research

    Extracellular matrix components and culture regimen selectively regulate cartilage formation by self-assembling human mesenchymal stem cells in vitro and in vivo

    Cartilage formation from self-assembling mesenchymal stem cells (MSCs) in vitro recapitulate important cellular events during mesenchymal condensation that precedes native cartilage development. The goal of th...

    Johnathan Ng, Yiyong Wei, Bin Zhou, Aonnicha Burapachaisri, Edward Guo and Gordana Vunjak-Novakovic

    Stem Cell Research & Therapy 2016 7:183

    Published on: 9 December 2016

  18. Research

    A systematic review of randomised controlled trials examining the therapeutic effects of adult bone marrow-derived stem cells for non-ischaemic dilated cardiomyopathy

    Certain early-phase clinical trials have suggested that bone marrow-derived stem cell transplantation might improve left ventricular function in patients with non-ischaemic dilated cardiomyopathy (NIDCM), wher...

    Yi Lu, Yiqin Wang, Menglu Lin, Jiale Zhou, Zi Wang, Meng Jiang and Ben He

    Stem Cell Research & Therapy 2016 7:186

    Published on: 9 December 2016

  19. Research

    Centrifugal gravity-induced BMP4 induces chondrogenic differentiation of adipose-derived stem cells via SOX9 upregulation

    Cartilage does not have the capability to regenerate itself. Therefore, stem cell transplantation is a promising therapeutic approach for impaired cartilage. For stem cell transplantation, in vitro enrichment ...

    Yeonsue Jang, Hyerin Jung, Yoojun Nam, Yeri Alice Rim, Juryun Kim, Sang Hoon Jeong and Ji Hyeon Ju

    Stem Cell Research & Therapy 2016 7:184

    Published on: 8 December 2016

  20. Research

    Molecular control of nitric oxide synthesis through eNOS and caveolin-1 interaction regulates osteogenic differentiation of adipose-derived stem cells by modulation of Wnt/β-catenin signaling

    Nitric oxide (NO) plays a role in a number of physiological processes including stem cell differentiation and osteogenesis. Endothelial nitric oxide synthase (eNOS), one of three NO-producing enzymes, is locat...

    Nadeeka Bandara, Saliya Gurusinghe, Shiang Yong Lim, Haying Chen, Shuangfeng Chen, Dawei Wang, Bryan Hilbert, Le-Xin Wang and Padraig Strappe

    Stem Cell Research & Therapy 2016 7:182

    Published on: 7 December 2016

  21. Research

    Mitochondrial co-chaperone protein Tid1 is required for energy homeostasis during skeletal myogenesis

    Tid1 is a mitochondrial co-chaperone protein and its transcript is abundantly expressed in skeletal muscle tissues. However, the physiological function of Tid1 during skeletal myogenesis remains unclear.

    Li-Hao Cheng, Kai-Feng Hung, Te-Chang Lee, Chih-Yang Huang, Wen-Ting Chiu, Jeng-Fan Lo and Tung-Fu Huang

    Stem Cell Research & Therapy 2016 7:185

    Published on: 7 December 2016

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