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  1. Research

    Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton’s jelly mesenchymal stromal cells

    Mesenchymal stromal cells (MSCs) from various tissues have shown moderate therapeutic efficacy in reversing liver fibrosis in preclinical models. Here, we compared the relative therapeutic potential of pooled,...

    Mathiyazhagan Rengasamy, Gurbind Singh, Noor Atiqah Fakharuzi, Siddikuzzaman, Sudha Balasubramanian, Priyanka Swamynathan, Charan Thej, Gopinath Sasidharan, Pawan Kumar Gupta, Anjan Kumar Das, Ahmad Zuhairi Abd Rahman, Kamal Shaik Fakiruddin, Lim Moon Nian, Zubaidah Zakaria and Anish S. Majumdar

    Stem Cell Research & Therapy 2017 8:143

    Published on: 13 June 2017

  2. Research

    Complete human serum maintains viability and chondrogenic potential of human synovial stem cells: suitable conditions for transplantation

    In our clinical practice, we perform transplantations of autologous synovial mesenchymal stem cells (MSCs) for cartilage and meniscus regenerative medicine. One of the most important issues to ensuring clinica...

    Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta and Ichiro Sekiya

    Stem Cell Research & Therapy 2017 8:144

    Published on: 13 June 2017

  3. Short report

    Evaluation of bone marrow mononuclear cells as an adjunct therapy to minced muscle graft for the treatment of volumetric muscle loss injuries

    The delivery of alternative myogenic cell sources to enhance the efficacy of minced muscle grafts (MG) for the treatment of volumetric muscle loss (VML) injuries is a promising strategy to overcome the demand ...

    Stephen M. Goldman, Beth E. P. Henderson and Benjamin T. Corona

    Stem Cell Research & Therapy 2017 8:142

    Published on: 9 June 2017

  4. Research

    Generation of tooth–periodontium complex structures using high-odontogenic potential dental epithelium derived from mouse embryonic stem cells

    A number of studies have shown that tooth-like structures can be regenerated using induced pluripotent stem cells and mouse embryonic stem (mES) cells. However, few studies have reported the regeneration of to...

    Yancong Zhang, Yongliang Li, Ruirui Shi, Siqi Zhang, Hao Liu, Yunfei Zheng, Yan Li, Jinglei Cai, Duanqing Pei and Shicheng Wei

    Stem Cell Research & Therapy 2017 8:141

    Published on: 8 June 2017

  5. Research

    Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells

    Mechanical stimuli play important roles in the proliferation and differentiation of adult stem cells. However, few studies on their effects on induced pluripotent stem cells (iPSCs) have been published.

    Young Mi Kim, Yun Gyeong Kang, So Hee Park, Myung-Kwan Han, Jae Ho Kim, Ji Won Shin and Jung-Woog Shin

    Stem Cell Research & Therapy 2017 8:139

    Published on: 8 June 2017

  6. Research

    Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease

    Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in cl...

    Samantha F. H. de Witte, Ana M. Merino, Marcella Franquesa, Tanja Strini, Johanna A. A. van Zoggel, Sander S. Korevaar, Franka Luk, Madhu Gargesha, Lisa O’Flynn, Debashish Roy, Steve J. Elliman, Philip N. Newsome, Carla C. Baan and Martin J. Hoogduijn

    Stem Cell Research & Therapy 2017 8:140

    Published on: 8 June 2017

  7. Research

    Exosome miR-371b-5p promotes proliferation of lung alveolar progenitor type II cells by using PTEN to orchestrate the PI3K/Akt signaling

    Pathways directing endogenous stem/progenitor cells to restore normal architecture and function of damaged/diseased lungs remain underexplored. Published data have revealed that alveolar progenitor type II cel...

    Yuan Quan, Zhaohua Wang, Ling Gong, Xinmiao Peng, Melissa A. Richard, Junlan Zhang, Myriam Fornage, Joseph L. Alcorn and Dachun Wang

    Stem Cell Research & Therapy 2017 8:138

    Published on: 8 June 2017

  8. Review

    Bringing the age-related macular degeneration high-risk allele age-related maculopathy susceptibility 2 into focus with stem cell technology

    Age-related macular degeneration (AMD) is a major cause of blindness in older adults in developed countries. It is a multifactorial disease triggered by both environmental and genetic factors. High-temperature...

    Shuo Sun, ZhiQing Li, Patrick Glencer, BinCui Cai, XiaoMin Zhang, Jin Yang and XiaoRong Li

    Stem Cell Research & Therapy 2017 8:135

    Published on: 6 June 2017

  9. Review

    Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohn’s disease

    Stem cell therapy (SCT) for the treatment of Crohn’s disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed a meta-analysis to evaluate the efficacy...

    Yun Qiu, Man-ying Li, Ting Feng, Rui Feng, Ren Mao, Bai-li Chen, Yao He, Zhi-rong Zeng, Sheng-hong Zhang and Min-hu Chen

    Stem Cell Research & Therapy 2017 8:136

    Published on: 6 June 2017

  10. Review

    Mesenchymal stem cells for treating autoimmune dacryoadenitis

    Autoimmune dacryoadenitis, such as Sjögren syndrome, comprises multifactorial and complex diseases. Inflammation of the lacrimal gland plays a key role in the pathogenesis of diseases. Unfortunately, current t...

    Xiaoxiao Lu, Xilian Wang, Hong Nian, Dan Yang and Ruihua Wei

    Stem Cell Research & Therapy 2017 8:126

    Published on: 5 June 2017

  11. Method

    Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming

    Non-integrating episomal vectors have become an important tool for induced pluripotent stem cell reprogramming. The episomal vectors carrying the “Yamanaka reprogramming factors” (Oct4, Klf, Sox2, and L-Myc + ...

    Christopher E. Schmitt, Blanca M. Morales, Ellen M. H. Schmitz, John S. Hawkins, Carlos O. Lizama, Joan P. Zape, Edward C. Hsiao and Ann C. Zovein

    Stem Cell Research & Therapy 2017 8:132

    Published on: 5 June 2017

  12. Research

    Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation

    Progressive liver fibrosis leads to cirrhosis and end-stage liver disease. This disease is a consequence of strong interactions between matrix-producing hepatic stellate cells (HSCs) and resident and infiltrat...

    Mustapha Najimi, Silvia Berardis, Hoda El-Kehdy, Valérie Rosseels, Jonathan Evraerts, Catherine Lombard, Adil El Taghdouini, Patrick Henriet, Leo van Grunsven and Etienne Marc Sokal

    Stem Cell Research & Therapy 2017 8:131

    Published on: 5 June 2017

  13. Research

    miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop

    MicroRNAs (miRNAs) have emerged as crucial factors that regulate proliferation and apoptosis of cardiac c-kit+ cells. Although much is known about their role in maintaining cardiac c-kit+ cell pluripotency, the m...

    Jingjin Liu, Yongshun Wang, Jinjin Cui, Meng Sun, Zhongyue Pu, Chao Wang, Wenjuan Du, Xinxin Liu, Jian Wu, Jingbo Hou, Shuo Zhang and Bo Yu

    Stem Cell Research & Therapy 2017 8:127

    Published on: 5 June 2017

  14. Research

    Engineering biomimetic periosteum with β-TCP scaffolds to promote bone formation in calvarial defects of rats

    There is a critical need for the management of large bone defects. The purpose of this study was to engineer a biomimetic periosteum and to combine this with a macroporous β-tricalcium phosphate (β-TCP) scaffo...

    Dan Zhang, Peng Gao, Qin Li, Jinda Li, Xiaojuan Li, Xiaoning Liu, Yunqing Kang and Liling Ren

    Stem Cell Research & Therapy 2017 8:134

    Published on: 5 June 2017

  15. Research

    Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: a controlled experimental trial

    Adipose tissue is a promising source of mesenchymal stromal cells (MSCs) for the treatment of tendon disease. The goal of this study was to assess the effect of a single intralesional implantation of adipose t...

    Florian Geburek, Florian Roggel, Hans T. M. van Schie, Andreas Beineke, Roberto Estrada, Kathrin Weber, Maren Hellige, Karl Rohn, Michael Jagodzinski, Bastian Welke, Christof Hurschler, Sabine Conrad, Thomas Skutella, Chris van de Lest, René van Weeren and Peter M. Stadler

    Stem Cell Research & Therapy 2017 8:129

    Published on: 5 June 2017

  16. Research

    High quality clinical grade human embryonic stem cell lines derived from fresh discarded embryos

    Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems...

    Jinpei Ye, Nicola Bates, Despina Soteriou, Lisa Grady, Clare Edmond, Alex Ross, Alan Kerby, Philip A. Lewis, Tope Adeniyi, Ronnie Wright, Kay V. Poulton, Marcus Lowe, Susan J. Kimber and Daniel R. Brison

    Stem Cell Research & Therapy 2017 8:128

    Published on: 5 June 2017

  17. Review

    Direct reprogramming of fibroblasts into cardiomyocytes

    Cardiovascular diseases are the leading causes of death in the world. The limited regenerative capacity of adult cardiomyocytes is the major barrier for heart regeneration. After myocardial infarction, myofibr...

    Yueqiu Chen, Ziying Yang, Zhen-Ao Zhao and Zhenya Shen

    Stem Cell Research & Therapy 2017 8:118

    Published on: 25 May 2017

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