Fig. 5
From: CD146/MCAM defines functionality of human bone marrow stromal stem cell populations
Functional assessment of migrational ability of CD146 sorted human mesenchymal stem cell (hMSC) populations. a Analysis of in vitro transwell (Boyden chamber) migration assay. Data demonstrate statistically significant migration of hMSC-CD146+ in 10 % fetal bovine serum (FBS) as compared with hMSC-CD146− under the same conditions. gray box, 0.2 % FBS hMSC-CD146+/−; white box, 10 % FBS hMSC-CD146+; black box, 10 % FBS hMSC-CD146, n = 2 independent experiments. *P < 0.05. b IVIS® in vivo imaging of hMSC-CD146+ and hMSC-CD146− cells at days 0, 3, and 6 after intravenous tail vein injection. As can be observed in the images and from the radiance plots, hMSC-CD146+ cells (n = 4 mice) demonstrate migration away from the lung area at days 3 and 6, and hMSC-CD146− cells (n = 5 mice) display less migration in comparison with hMSC-CD146+