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Table 3 Studies outlining the progress and understanding of umbilical cord lining-derived epithelial cells published since the year 2000

From: Short review on human umbilical cord lining epithelial cells and their potential clinical applications

Year

Author

Primary findings

2006

Lund et al. [46]

Human umbilical cord tissue in photoreceptor rescue

2008

Reutze et al. [18]

Comparison between CLECs and epidermal keratinocytes

2009

Sivalingam et al. [30]

Transgene integration in CLECs

2009

Branski et al. [16]

Stem cell therapy in cutaneous wound healing

2011

Zhou et al. [14]

Characterization and transplantation potential of CLECs

2011

Reza et al. [9]

Characterization of a novel cell line, CLEC-muc

2011

Huang et al. [12]

CLECs potential for epidermal reconstitution

2011

Reza et al. [10]

CLEC-muc in ocular regeneration

2012

Huang et al. [11]

Updated review on stem cell applications in burns and wounds

2012

Liras et al. [27]

Advanced therapies for hemophilia including transgene integration in CLECs

2013

Cheong et al. [38]

Derivation of hepatocyte-like cells from CLECs

2014

Lim et al. [5]

Review on CLSCs

2014

Cai et al. [47]

Characterization of the immunological properties of CLECs for allotransplantation

2014

Zhou et al. [40]

Hepatic-like cloned CLECs show potential in regeneration of hepatectomized liver

2015

Ang et al. [45]

CLEC-muc as novel feeder layer for human stem cells

2016

Sivalingam et al. [31]

Successful zinc finger nuclease-mediated integration and secretion of FVIII in CLECs for treatment of hemophilia A

  1. The studies relate to the characterization of the cord lining epithelial cell types, their various uses investigated in the past decade in terms of contribution to possible cure of chronic disorders, possible applicability in conjugation with gene therapy, and lastly their use as feeder layers for supporting other stem cell lines. Abbreviations: CLEC cord lining epithelial cell, CLSC cord lining stem cell, CLEC-muc Mucin1-expressing cord lining epithelial cells