Li J, Xu S-Q, Zhao Y-M, Yu S, Ge L-H, Bao-Hua X. Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord. Mol Med Rep. 2018;18(6):4969–77.
CAS
PubMed
PubMed Central
Google Scholar
Guan Y-T, Xie Y, Li D-S, Zhu Y-Y, Zhang X-L, Feng Y-L, Chen Y-P, Xu L-J, Liao P-F, Wang G. Comparison of biological characteristics of mesenchymal stem cells derived from the human umbilical cord and decidua parietalis. Mol Med Rep. 2019;20(1):633–9.
CAS
PubMed
PubMed Central
Google Scholar
Han Z-X, Shi Q, Wang D-K, Dong L, Lyu M. Basic biological characteristics of mesenchymal stem cells derived from bone marrow and human umbilical cord. J Exp Hematol. 2013;21(5):1248–55.
CAS
Google Scholar
Bharti D, Shivakumar SB, Park J-K, Ullah I, Subbarao RB, Park J-S, Lee S-L, Park B-W, Rho G-J. Comparative analysis of human Wharton’s jelly mesenchymal stem cells derived from different parts of the same umbilical cord. Cell Tissue Res. 2018;372(1):51–65.
Article
CAS
PubMed
Google Scholar
Filip A, Dabrowski AB, Kulesza A, Sladowska A, Zolocinska A, Gala K, Paczek L, Wielgos M. Comparison of the paracrine activity of mesenchymal stem cells derived from human umbilical cord, amniotic membrane and adipose tissue. J Obstet Gynaecol Res. 2017;43(11):1758–68.
Article
CAS
Google Scholar
Cheng Z, Lu Z, Kong W, Liang J, Xu X, Wu H, Feng X, Hua B, Wang H, Sun L. Umbilical cord-derived mesenchymal stem cells inhibit cadherin-11 expression by fibroblast-like synoviocytes in rheumatoid arthritis. J Immunol Res. 2015;2015:Article ID 137695 10 pages.
Google Scholar
Bi Z-M, Zhou Q-F, Geng Y, Zhang H-M. Human umbilical cord mesenchymal stem cells ameliorate experimental cirrhosis through activation of keratinocyte growth factor by suppressing microRNA-199. Eur Rev Med Pharmacol Sci. 2016;20(23):4905–12.
PubMed
Google Scholar
Sun X, Hao H, Han Q, Song X, Liu J, Liang D, Han W, Yiming M. Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats. Stem Cell Res Ther. 2017;8(1):241–55.
Article
PubMed
PubMed Central
CAS
Google Scholar
Yao J, Zheng J, Cai J, Zeng K, Zhou C, JiebinZhang SL, Li H, Liang C, He L, Chen H, Hongyuan F, Zhang Q, Chen G, Yang Y, Zhang Y. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate rat hepatic ischemia-reperfusion injury by suppressing oxidative stress and neutrophil inflammatory response. FASEB J. 2019;33(2):1695–710.
Article
CAS
PubMed
Google Scholar
Yao J, Zheng J, Cai J, Zeng K, Zhou C, JiebinZhang SL, Li H, Liang C, He L, Chen H, Hongyuan F, Zhang Q, Chen G, Yang Y, Zhang Y. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate rat hepatic ischemia-reperfusion injury by suppressing oxidative stress and neutrophil inflammatory response. FASEB J. 2019;33(2):1695–710.
Article
CAS
PubMed
Google Scholar
Bao Z, Zhang L, Liang C, Liu B, Pan X, Wang Y, Zhang Y, Yu Z, Xie W, Yan B, Liu F, Yip H-K, Yu X-Y, Li Y. Stem cell-derived exosomes prevent aging-induced cardiac dysfunction through a novel exosome/lncRNA MALAT1/NF-κ B/TNF-α signaling pathway. Oxidative Med Cell Longev. 2019;2019:Article ID 9739258 14 pages.
Google Scholar
Ruan Z-B, Chen G-C, Zhang R, Zhu L. Circular RNA expression profiles during the differentiation of human umbilical cord–derived mesenchymal stem cells into cardiomyocyte-like cells. J Cell Physiol. 2019;234(9):16412–23.
Article
CAS
Google Scholar
Kwak SH, Park KS. Recent progress in genetic and epigenetic research on type 2 diabetes. Exp Mol Med. 2016;48:e220.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yin Y, Hao H, Yu C, Gao J, Liu J, Xie Z, Zhang Q, Zang L, Han W, Yiming M. The homing of human umbilical cord-derived mesenchymal stem cells and the subsequent modulation of macrophage polarization in type 2 diabetic mice. Int Immunopharmacol. 2018;60:235–45.
Article
CAS
PubMed
Google Scholar
Cai J, Wu Z, Xu X, Liao L, Chen J, Huang L, Wu W, Luo F, Wu C, Pugliese A, Pileggi A, Ricordi C, Tan J. Umbilical cord mesenchymal stromal cell with autologous bone marrow cell transplantation in established type 1 diabetes: a pilot randomized controlled open-label clinical study to assess safety and impact on insulin secretion. Diabetes Care. 2016;39(1):149–57.
Article
CAS
PubMed
Google Scholar
Kong D, Zhuang X, Wang D, et al. Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus. Clin Lab. 2014;60(12):1969–76.
CAS
PubMed
Google Scholar
Wang Y, Dan Q-Q, Wang Q-P, Zhou N, Jin X-F, Hou Z-L, Peng B-K, Wang T-H. Human umbilic mesenchymal stromal cells repairs diabetic foot in rats associated with VEGF expressional change. J Sichuan Univ. 2014;45(1):29–33.
Google Scholar
Zhou N, Wang Q-P, Jin X-F, Hou Z-L, Peng B-K, Dan Q-Q, Wang T-H. Effect of human umbilici mesenchymal stromal cells implantation on the BDNF expression in diabetic foot rats. J Sichuan Univ. 2013;44(6):931–4.
Google Scholar
Zhao Q-S, Xia N, Zhao N, Li M, Bi C-L, Zhu Q, Qiao G-F, Cheng Z-F. Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. Int J Biol Sci. 2014;10(1/2):80–9.
Article
CAS
Google Scholar
Treiman DM. Clinical evaluation of human umbilical cord mesenchymal stem cell transplantation after angioplasty for diabetic foot. Exp Clin Endocrinol Diabetes. 2016;124(08):497–503.
Article
CAS
Google Scholar
Xiang E, Han B, Zhang Q, Rao W, Wang Z, Chang C, Zhang Y, Tu C, Li C, Wu D. Human umbilical cord-derivedmesenchymal stem cells prevent the progression of early diabetic nephropathythrough inhibiting inflammation and fibrosis. Stem Cell Res Ther. 2020;11(1):336–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xian Y, Lin Y, Cao C, Li L, Wang J, Niu J, YunleiGuo YS, Wang Y, Wang W. Protective effect of umbilical cord mesenchymal stem cells combined with resveratrol against renal podocyte damage in NOD mice. Diabetes Res Clin Pract. 2019;156:107755–64.
Article
CAS
PubMed
Google Scholar
Hashemi S-S, Mohammadi AA, Kabiri H, Hashempoor MR, Mahmoodi M, Amini M, Mehrabani D. The healing effect of Wharton’s jelly stem cells seeded on biological scaffold in chronic skin ulcers: a randomized clinical trial. J Cosmet Dermatol. 2019;18(6):1961–7.
Article
PubMed
Google Scholar
Zhang S, Chen L, Zhang G, Zhang B. Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages. BioMed Central. 2020;11(1):39–54.
Google Scholar
Yue C, Guo Z, Luo Y, Yuan J, Wan X, Mo Z. c-Jun overexpression accelerates wound healing in diabetic rats by human umbilical cord-derived mesenchymal stem cells. Stem Cells Int. 2020;2020:Article ID 7430968 10 pages.
Google Scholar
Wei Z, Wang Y, Kong J, Dong M, Hongtao D, Song C. Therapeutic efficacy of neural stem cells originating from umbilical cord-derived mesenchymal stem cells in diabetic retinopathy. Sci Rep. 2017;7(1):408–16.
Article
CAS
Google Scholar
Yu C, Yang K, Meng X, Cao B, Wang F. Downregulation of long noncoding RNA MIAT in the retina of diabetic rats with tail-vein injection of human umbilical-cord mesenchymal stem cells. Int J Med Sci. 2020;17(5):591–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krenkel O, Hundertmark J, Ritz TP, Weiskirchen R, Tacke F. Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis. Cells. 2019;8(5):503.
Article
CAS
PubMed Central
Google Scholar
Zhang L-T, Peng X-B, Fang X-Q, Li J-F, Chen H, Mao X-R. Human umbilical cord mesenchymal stem cells inhibit proliferation of hepatic stellate cells in vitro. Int J Mol Med. 2018;41(5):2545–52.
CAS
PubMed
PubMed Central
Google Scholar
Zhang G-Z, Sun H-C, Zheng L-B, Guo J-B, Zhang X-L. In vivo hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells: therapeutic effect on liver fibrosis/cirrhosis. World J Gastroenterol. 2017;23(46):8152–68.
Article
CAS
PubMed
PubMed Central
Google Scholar
An SY, Jang YJ, Lim H-J, Han J, Lee J, Lee G, Park JY, Park S-Y, Kim JH, Do B-R, Han C, Park H-K, Kim O-H, Song MJ, Kim S-J, Kim J-H. Milk fat globule-EGF factor 8, secreted by mesenchymal stem cells, protects against liver fibrosis in mice. Gastroenterology. 2017;152(5):1174–86.
Article
CAS
PubMed
Google Scholar
Jiang L, Zhang S, Hu H, Yang J, Wang X, Ma Y, Jiang J, Wang J, Lin Z, Chen M, Wang H, Yu H, Zhu RR, Zhang Q. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages. Biochem Biophys Res Commun. 2019;508(3):735–41.
Article
CAS
PubMed
Google Scholar
Yun J-W, Ahn JH, Kwon E, Kim S-H, Kim H, Jang J-J, Kim WH, Kim JH, Han S-y, Kim JT, Kim J-H, Kim W, Seung-Yup K, Do B-R, Kang B-C. Human umbilical cord-derived mesenchymal stem cells in acute liver injury: hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution. Regul Toxicol Pharmacol. 2016;81:437–47.
Article
CAS
PubMed
Google Scholar
Dandan W, Lingying N, Xuebing F, Xinran Y, Shengnan Z, Huayong Z, Jun L, Cheng Z, Hong W, Bingzhu H, Lingyun S. Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study. Clin Exp Med. 2017;17(3):333–40.
Article
CAS
Google Scholar
Gu F, Wang D, Zhang H, Feng X, Gilkeson GS, Shi S, Sun L. Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy. Clin Rheumatol. 2014;33(11):1611–9.
Article
PubMed
Google Scholar
Wang D, Zhang H, Liang J, Wang H, Hua B, Feng X, Gilkeson GS, Farge D, Shi S, Sun L. A long-term follow-up study of allogeneic mesenchymal stem/ stromal cell transplantation in patients with drug-resistant systemic lupus erythematosus. Stem Cell Rep. 2018;10(3):933–41.
Article
CAS
Google Scholar
Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L. The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus. Cell Mol Immunol. 2017;14(5):423–31.
Article
CAS
PubMed
Google Scholar
Mai S, Lin Z, Tian X, Liao X, Luan Y, XingHan YW, Wu Y, Kuang S, Yang Y, Ma J, Chen Q, Yang J. Double-edged effect of hydroxychloroquine on human umbilical cord-derived mesenchymal stem cells treating lupus nephritis in MRL/lpr mice. Mol Pharm. 2018;15(5):1800–13.
Article
CAS
PubMed
Google Scholar
Li D, Li X, Duan M, Dou Y, Feng Y, Nan N, Zhang W. MiR-153-3p induces immune dysregulation by inhibiting PELI1 expression in umbilical cord-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Autoimmunity. 2020;53(4):201–9.
Article
CAS
PubMed
Google Scholar
Zheng B, Zhang P, Yuan L, Chhetri RK, Guo Y, Deng D. Effects of human umbilical cord mesenchymal stem cells on inflammatory factors and miR-181a in T lymphocytes from patients with systemic lupus erythematosus. Lupus. 2020;29(2):126–35.
Article
CAS
PubMed
Google Scholar
Dao TT-T, Nguyen CT-H, Ngoc Bich V, Le HT-N, Nguyen PD-N, Van Pham P. Evaluation of proliferation and osteogenic differentiation of human umbilical cord-derived mesenchymal stem cells in porous scaffolds. Adv Exp Med Biol. 2019;1084:207–20.
Article
CAS
PubMed
Google Scholar
Zhang B-Y, Wang B-Y, Li S-C, Luo D-Z, Zhan X, Chen S-F, Chen Z-S, Liu C-Y, Ji H-Q, Bai Y-S, Li D-S, Yang H. Evaluation of the curative effect of umbilical cord mesenchymal stem cell therapy for knee arthritis in dogs using imaging technology. Stem Cells Int. 2018;2018:Article ID 1983025 12 pages.
Google Scholar
Sun Y, Kong W, Huang S, Shi B, Zhang H, Chen W, Zhang H, Cheng Z, Tang X, Yao G, Feng X, Sun L. Comparable therapeutic potential of umbilical cord mesenchymal stem cells in collagen-induced arthritis to TNF inhibitor or anti-CD20 treatment. Clin Exp Rheumatol. 2017;35(2):288–95.
PubMed
Google Scholar
Ma D, Xu K, Zhang G, Yang L, Gao J, Tian M, Wei C, Li J, Zhang L. Immunomodulatory effect of human umbilical cord mesenchymal stem cells on T lymphocytes in rheumatoid arthritis. Int Immunopharmacol. 2019;74:105687.
Article
CAS
PubMed
Google Scholar
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y. Efficacy and safety of umbilical cord mesenchymal stem cell therapy for rheumatoid arthritis patients: a prospective phase I/II study. Drug Des Devel Ther. 2019;13:4331–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Y, Jin W, Liu H, Cui Y, Mao Q, Fei Z, Xiang C. Curative effect of human umbilical cord mesenchymal stem cells by intra-articular injection for degenerative knee osteoarthritis. Chinese J Reparative Reconstr Surg. 2016;30(12):1472–7.
Google Scholar
Wang H, Xu Y, Jiang Y, Zheng W, Li Y, Shao Q. The human umbilical cord stem cells improve the viability of OA degenerated chondrocytes. Mol Med Rep. 2018;17(3):4474–82.
CAS
PubMed
PubMed Central
Google Scholar
Sadlik B, Jaroslawski G, Gladysz D, Puszkarz M, Markowska M, Pawelec K, Boruczkowski D, Oldak T. Knee cartilage regeneration with umbilical cord mesenchymal stem cells embedded in collagen scaffold using dry arthroscopy technique. Adv Exp Med Biol. 2017;1020:113–22.
Article
CAS
PubMed
Google Scholar
Matas J, Orrego M, Amenabar D, Infante C, Tapia-Limonchi R, Cadiz MI, Alcayaga-Miranda F, González PL, Muse E, Khoury M, Figueroa FE, Espinoza F. Umbilical cord-derived mesenchymal stromal cells (MSCs) for knee osteoarthritis: repeated MSC dosing is superior to a single MSC dose and to hyaluronic acid in a controlled randomized phase I/II trial. Stem Cells Transl Med. 2019;8(3):215–24.
Article
CAS
PubMed
Google Scholar
Wang S, Cheng H, Dai G, Wang X, RongrongHua XL, Wang P, Chen G, Wu Y, An Y. Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury. Brain Res. 2013;1532:76–84.
Article
CAS
PubMed
Google Scholar
Dong H-J, Shang C-Z, Li G, Niu Q, Luo Y-C, Yang Y, Meng H-P, Yin H-J, Zhang H-X, Zhao M-L, Lin L. The distribution of transplanted umbilical cord mesenchymal stem cells in large blood vessel of experimental design with traumatic brain injury. J Craniofac Surg. 2017;28(6):1615–9.
Article
PubMed
Google Scholar
Qi L, Xue X, Sun J, Wu Q, Wang H, Guo Y, Sun B. The promising effects of transplanted umbilical cord mesenchymal stem cells on the treatment in traumatic brain injury. J Craniofac Surg. 2018;29(7):1689–92.
Article
PubMed
PubMed Central
Google Scholar
Lin W, Hsuan YC-Y, Lin M-T, et al. Human umbilical cord mesenchymal stem cells preserve adult newborn neurons and reduce neurological injury after cerebral ischemia by reducing the number of hypertrophic microglia/macrophages. Cell Transplant. 2017;26(11):1798–810.
Article
PubMed
Google Scholar
Thomi G, Joerger-Messerli M, Haesler V, Muri L, Surbek D, Schoeberlein A. Intranasally administered exosomes from umbilical cord stem cells have preventive neuroprotective effects and contribute to functional recovery after perinatal brain injury. Cells. 2019;8(8):855.
Article
CAS
PubMed Central
Google Scholar
Oppliger B, Joerger-Messerli M, Mueller M, Reinhart U, Schneider P, Surbek DV, Schoeberlein A. Intranasal delivery of umbilical cord-derived mesenchymal stem cells preserves myelination in perinatal brain damage. Stem Cells Dev. 2016;25(16):1234–42.
Article
CAS
PubMed
Google Scholar
Shiue S-J, Rau R-H, Shiue H-S, Hung Y-W, Li Z-X, Yang KD, Cheng J-K. Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury-induced pain in rats. Pain. 2019;60(1):210–23.
Article
CAS
Google Scholar
Jiang Y, Zhu W, Zhu J, et al. Feasibility of delivering mesenchymal stem cells via catheter to the proximal end of the lesion artery in patients with stroke in the territory of the middle cerebral artery. Cell Transplant. 2013;22(12):2291–8.
Article
PubMed
Google Scholar
Tanaka E, Ogawa Y, Mukai T, Sato Y, Hamazaki T, Nagamura-Inoue T, Harada-Shiba M, Shintaku H, Tsuji M. Dose-dependent effect of intravenous administration of human umbilical cord-derived mesenchymal stem cells in neonatal stroke mice. Front Neurol. 2018;9:133–45.
Article
PubMed
PubMed Central
Google Scholar
Zhang Q, Shang X, Hao M, Zheng M, Li Y, Liang Z, Cui Y, Liu Z. Effects of human umbilical cord mesenchymal stem cell transplantation combined with minimally invasive hematoma aspiration on intracerebral hemorrhage in rats. Am J Transl Res. 2015;7(11):2176–86.
CAS
PubMed
PubMed Central
Google Scholar
Wang G-H, Yang L, Wu X-B, Lu Y, Liu J, Qin Y-R, Li T, Duan H-F. Neuroprotective effects of human umbilical cord–derived mesenchymal stromal cells combined with nimodipine against radiation-induced brain injury through inhibition of apoptosis. Cytotherapy. 2016;18(1):53–64.
Article
PubMed
CAS
Google Scholar
Meikuang L, Wang W, Lu L, Zhi-Bo H, Zongjin L, Jie G, Meng Z, Honghong J, Jie F, Zhe W, Baoquan S, Jiemin Z, Jun L, Tianwen L, Wang F, Ting L, Jianming L, Yihu F, Gao J, Zhongchao H. Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction. Stem Cell Res Ther. 2018;9(1):129.
Article
CAS
Google Scholar
Bartolucci J, Verdugo FJ, González PL, Larrea RE, Abarzua E, Goset C, Rojo P, Palma I, Lamich R, Pedreros PA, Valdivia G, Lopez VM, Nazzal C, Alcayaga-Miranda F, Cuenca J, Brobeck MJ, Patel AN, Figueroa FE, Khoury M. Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: a phase 1/2 randomized controlled trial (RIMECARD trial [randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on cardiopathy]). Circ Res. 2017;121(10):1192–204.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fang Z, Yin X, Wang J, Tian N, Ao Q, Yongquan G, Liu Y. Functional characterization of human umbilical cord-derived mesenchymal stem cells for treatment of systolic heart failure. Exp Ther Med. 2016;12(5):3328–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ni J, Liu X, Yin Y, Zhang P, Xu Y-W, Zheng L. Exosomes derived from TIMP2-modified human umbilical cord mesenchymal stem cells enhance the repair effect in rat model with myocardial infarction possibly by the Akt/Sfrp2 pathway. Oxidative Med Cell Longev. 2019;2019:Article ID 1958941 19 pages.
Google Scholar
Ruan Z, Zhu L, Yin Y, Chen G. Overexpressing NKx2.5 increases the differentiation of human umbilical cord derived mesenchymal stem cells into cardiomyocyte-like cells. Biomed Pharmacother. 2016;78:110–5.
Article
CAS
PubMed
Google Scholar
Yang L, Zhu S, Li Y, Zhuang J, Chen J, HuanleiHuang YC, Wen Y, Wen Y, Guo H, Fan X, WuzhouYuan ZJ, Wang Y, Wu X, Zhu P. Overexpression of Pygo2 increases differentiation of human umbilical cord derived mesenchymal stem cells into cardiomyocyte-like cells. Curr Mol Med. 2020;20(4):318–24.
Article
CAS
PubMed
Google Scholar
Ruan Z-B, Zhu L, Yin Y-G, Chen G-C. Inhibitor of p53-p21 pathway induces the differentiation of human umbilical cord derived mesenchymal stem cells into cardiomyogenic cells. Cytotechnology. 2016;68(4):1257–65.
Article
CAS
PubMed
Google Scholar
Zhang C, Zhou G, Chen Y, Liu S, Chen F, Xie L, Wang W, Zhang Y, Wang T, Lai X, Ma L. Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF-α and TGF-β1/ERK1/2 signaling pathways. Mol Med Rep. 2018;17(1):71–8.
CAS
PubMed
Google Scholar
Xiao Z, Tang F, Zhao Y, et al. Significant improvement of acute complete spinal cord injury patients diagnosed by a combined criteria implanted with neuro regen scaffolds and mesenchymal stem cells. Cell Transplant. 2018;27(6):907–15.
Article
PubMed
PubMed Central
Google Scholar
Deng W-S, Ma K, Liang B, Liu X-Y, Xu H-Y, Zhang J, Shi H-Y, Sun H-T, Chen X-Y, Zhang S. Collagen scaffold combined with human umbilical cord-mesenchymal stem cells transplantation for acute complete spinal cord injury. Neural Regen Res. 2020;15(09):1686–700.
Article
PubMed
PubMed Central
Google Scholar
Sun L, Wang F, Chen H, et al. Co-transplantation of human umbilical cord mesenchymal stem cells and human neural stem cells improves the outcome in rats with spinal cord injury. Cell Transplant. 2019;28(7):893–906.
Article
PubMed
PubMed Central
Google Scholar
Yang CH, Yu BQ, You QH, Feng JJ. Human umbilical cord mesenchymal stem cell transplantation for the treatment of two noncontinuous segments spinal cord compression injury in rabbits. Natl Med J China. 2017;97(30):2366–71.
CAS
Google Scholar
Jiao G, Lou G, Mo Y, Pan Y, Zhang Z, Guo R, Li Z. A combination of GDNF and hUCMSC transplantation loaded on SF/AGs composite scaffolds for spinal cord injury repair. Mater Sci Eng C. 2017;74:230–7.
Article
CAS
Google Scholar
Tian D-Z, Deng D, Qiang J-L, Zhu Q, Li Q-C, Yi Z-G. Repair of spinal cord injury in rats by umbilical cord mesenchymal stem cells through P38MAPK signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23(3 Suppl):47–53.
PubMed
Google Scholar
Sun G, Li G, Li D, Huang W, Zhang R, Zhang H, Duan Y, Wang B. hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation. Mater Sci Eng C. 2018;89:194–204.
Article
CAS
Google Scholar
Wu L-L, Xiao-Ming P, Hao-Hao C, Xiao-Yan F, Jinzhan J, Ming-Xing D. Repairing and analgesic effects of umbilical cord mesenchymal stem cell transplantation in mice with spinal cord injury. Biomed Res Int. 2020;2020:Article ID 7650354 10 pages.
Google Scholar
Liu W-w, Yu W, Chen J-y, Ye G-x, Liu Y-m, Chen L-z, Chen Y-x, Cheng Z, Zhong X-y. Effects of human umbilical cord mesenchymal stem cells in the treatment of paraquat-induced lung injury. Chinese J Ind Hyg Occup Dis. 2012;30(11):811–5.
Google Scholar
Liu D, Kong F, Yuan Y, Seth P, Xu W, Wang H, Xiao F, Wang L, Zhang Q, Yang Y, Wang H. Decorin-modified umbilical cord mesenchymal stem cells (MSCs) attenuate radiation-induced lung injuries via regulating inflammation, fibrotic factors, and immune responses. Int J Radiat Oncol Biol Phys. 2018;101(4):945–56.
Article
PubMed
Google Scholar
Huang ZW, Liu N, Dong L, Zhang HY, Wang Y, Liu Y, Zhang LL, Xiu LJ. Angiopoietin-1 modified human umbilical cord mesenchymal stem cell therapy for endotoxin-induced acute lung injury in rats. Yonsei Med J. 2017;58(1):206–16.
Article
CAS
PubMed
Google Scholar
Hao Y, Ran Y, Lu B, Li J, Zhang J, Feng C, Fang J, Ma R, Qiao Z, Dai X, Xiong W, Liu J, Zhou Q, Hao J, Li R, Dai J. Therapeutic effects of human umbilical cord–derived mesenchymal stem cells on canine radiation-induced lung injury. Int J Radiat Oncol Biol Phys. 2018;102(2):407–16.
Article
PubMed
Google Scholar
Zhu H, Xiong Y, Xia Y, Zhang R, Tian D, Wang T, Dai J, Wang L, Yao H, Jiang H, Yang K, Liu E, Shi Y, Zhou F, Gao L, Lin Z. Therapeutic effects of human umbilical cord-derived mesenchymal stem cells in acute lung injury mice. Sci Rep. 2017;7:39889–900.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mathias LJ, Khong SML, Spyroglou L, Payne NL, Siatskas C, Thorburn AN, Boyd RL, Heng TSP. Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells. J Immunol. 2013;191(12):5914–24.
Article
CAS
PubMed
Google Scholar
Dong L, Yanan P, Zhang L, Qi Q, Xu L, Li W, Wei C, Wang X, Zhou S, Zhu J, Wang X, Liu F, Chen X, Su C. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410. Cell Death Dis. 2018;9(2):218.
Article
PubMed
PubMed Central
CAS
Google Scholar
Liu J-S, Juan D, Cheng X, Zhang X-Z, Li Y, Chen X-L. Exosomal miR-451 from human human umbilical cord mesenchymal stem cells attenuates burn-induced acute lung injury. J Chin Med Assoc. 2019;82(12):895–901.
Article
PubMed
Google Scholar
Yang L, Xu S, Yang L, Mou Y, Li Y, Dang R, Li C. Hypoxia promotes the skewed differentiation of umbilical cord mesenchymal stem cells toward type II alveolar epithelial cells by regulating microRNA-145. Gene. 2017;630:68–75.
Article
PubMed
CAS
Google Scholar
Atluri S, Manchikanti L, Hirsch JA. Expanded umbilical cord mesenchymal stem cells (UC-MSCs) as a therapeutic strategy in managing critically ill COVID-19 patients: the case for compassionate use. Pain Physician. 2020;23(2):E71–83.
PubMed
Google Scholar
Loy H, Kuok DIT, Hui KPY, Choi MHL, Yuen W, Nicholls JM, Peiris JSM, Chan MCW. Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A(H5N1) virus-associated acute lung injury. J Infect Dis. 2019;219(2):186–96.
Article
CAS
PubMed
Google Scholar
Zheng Z, Junliang F, Xu X, Wang S, Xu R, MinZhao WN, Wang X, Zhang J, Li T, Su L, Wang F-S. Safety and immunological responses to human mesenchymal stem cell therapy in difficult-to-treat HIV-1-infected patients. AIDS. 2013;27(8):1283–93.
Article
CAS
Google Scholar
Chen P, Zhang K-H, Na T, Lin W, Yin W-D, Yuan B-Z, Wang J-Z. The hUC-MSCs cell line CCRC-1 represents a novel, safe and high-yielding HDCs for the production of human viral vaccines. Sci Rep. 2017;7(1):12484.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gao L, Zhang Y, Hu B, Liu J, Kong P, Lou S, Yi S, Yang T, Li H, Liu Y, Cheng Z, Gao L, LidanZhu QW, Wang P, Chen X, Zhong J, Zhang X. Phase II multicenter, randomized, double-blind controlled study of efficacy and safety of umbilical cord-derived mesenchymal stromal cells in the prophylaxis of chronic graft-versus-host disease after HLA-haploidentical stem-cell transplantation. J Clin Oncol. 2016;34(24):2843–50.
Article
CAS
PubMed
Google Scholar
Li Q, Chen C-F, Wang D-Y, Lü Y-T, Huan Y, Fang S-X, Han Y, Ge R-C, Chen X-W. Changes in growth factor levels in the cerebrospinal fluid of autism patients after transplantation of human umbilical cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells. Genet Mol Res. 2016;15(2).
Chen C, Zhiguo Q, Yin X, Shang C, Ao Q, Yongquan G, Liu Y. Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: a three-year follow-up study. Mol Med Rep. 2016;14(5):4209–15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ding L, Yan G, Bin Wang LX, Yan G, Tong R, Cui X, LeiLei JL, Sheng X, Wang B, Zhang C, Yang Y, Jiang R, Zhou J, Kong N, Lu F, Zhou H, Zhao Y, Chen B, Hu Y, Dai J, Sun H. Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility. Sci China Life Sci. 2018;61(12):1554–65.
Article
CAS
PubMed
Google Scholar
Mao F, Wu Y, Tang X, Kang J, Zhang B, Yan Y, Qian H, Zhang X, Xu W. Exosomes derived from human umbilical cord mesenchymal stem cells relieve inflammatory bowel disease in mice. Biomed Res Int. 2017;2017:Article ID 5356760 12 pages.
Google Scholar
Mao D, Yang S, Wang P, Xie Z, Xu S, Zhu ZY, Wang Y, Lyu Y, Wang D, Xu L, Bi JZ, Yang H. Exosomes isolated from human umbilical cord mesenchymal stem cells alleviate neuroinflammation and reduce amyloid-beta deposition by modulating microglial activation in Alzheimer’s disease. Neurochem Res. 2018;43(11):2165–77.
Article
CAS
Google Scholar
Riordan Neil H, Isabela M, Giselle F, Nicole A, Fearnot Neal E, Leckrone Michael E, Jones MD, Darla M, Dorita A, Patel Amit N, Santosh K, Jorge PR. Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. J Transl Med. 2018;16(1):57.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gan X. China’s first universal requirements for stem cells have been released [N]. Chinese Sci News. 2017;11-23(1).
Cooper K, Viswanathan C. Establishment of a mesenchymal stem cell bank. Stem Cells Int. 2011;2011:905621.
Article
PubMed
PubMed Central
Google Scholar
Chen G, Yue A, Ruan Z, Yin Y, Wang RZ, Ren Y, Zhu L. Human umbilical cord-derived mesenchymal stem cells do not undergo malignant transformation during long-term culturing in serum-free medium. PLoS One. 2014;9(6):e98565.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wang Y, Fan H, Zhou B, Zhenyu J, Yu L, Guo L, Han J, Shixin L. Fusion of human umbilical cord mesenchymal stem cells with esophageal carcinoma cells inhibits the tumorigenicity of esophageal carcinoma cells. Int J Oncol. 2012;40(2):370–7.
CAS
PubMed
Google Scholar
Melzer C, von der Ohe J, Hass R. MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells. Cell Commun Signal. 2018;16(1):67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xue J, Zhu Y, Sun Z, et al. Tumorigenic hybrids between mesenchymal stem cells and gastric cancer cells enhanced cancer proliferation, migration and stemness. BMC Cancer. 2015;15:793.
Article
PubMed
PubMed Central
CAS
Google Scholar
Li Q, Pang Y, Liu T, Tang Y, Xie J, Zhang B, Hu C. Effects of human umbilical cord-derived mesenchymal stem cells on hematologic malignancies. Oncol Lett. 2018;15(5):6982–90.
PubMed
PubMed Central
Google Scholar
Lian J, Lv S, Liu C, Yang L, Wang S, Guo X, Nan F, Yu H, He X, Sun G, Ma X. Effects of serial passage on the characteristics and cardiac and neural differentiation of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells. Stem Cells Int. 2016;2016:9291013.
Article
PubMed
CAS
Google Scholar
Shi Z, Liang Z, Qiu G, He R, Detamore MS. The effect of extended passaging on the phenotype and osteogenic potential of human umbilical cord mesenchymal stem cells. Mol Cell Biochem. 2015;401(1–2):155–64.
Article
CAS
PubMed
Google Scholar
Tang Y-M, Bao W-M, Yang J-H, Ma L-K, Yang J, Xu Y, Yang L-H, Sha F, Xu Z-Y, Wu H-M, Zhou W, Li Y, Li Y-H. Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells. Mol Med Rep. 2016;14(3):2717–24.
Article
CAS
PubMed
Google Scholar
Zhang Y, Li Y, Li W, Cai J, Yue M, Jiang L, Xu R, Zhang L, Li J, Zhu C. Therapeutic effect of human umbilical cord mesenchymal stem cells at various passages on acute liver failure in rats. Stem Cells Int. 2018;2018:7159465.
PubMed
PubMed Central
Google Scholar