Table 2 Preclinical advances in scaffold-based stem cell therapy in the last 5 years
From: Meniscus repair: up-to-date advances in stem cell-based therapy
Injury model | Animal | Cell source | Cell density | Scaffold | Stimuli | Duration | Year/References |
|---|---|---|---|---|---|---|---|
Punch defect in the lateral meniscus with early osteoarthritis | Rabbit | BMSCs and meniscal cells | 1.0 × 106 | Collagen–hyaluronan | – | 12 weeks | 2017/[99] |
Full-thickness defect | Rat | BMSCs | 5.0 × 105 | Decellularized meniscus extracellular matrix | – | 2 months | 2020/[100] |
Full-thickness meniscus defect | Rat | BMSCs | 7.5 × 105 | Decellularized meniscus extracellular matrix | – | 4 weeks | 2018/[101] |
Meniscectomy | Rabbit | BMSCs | 5.0 × 106 | 3D-printed Poly(e-caprolactone) (PCL) | – | 24 weeks | 2017/[104] |
Punch defects | Rabbit | BMSCs | 4.0 × 106 | Thermosensitive, injectable, in situ crosslinked hydrogel | TGF-β1 | 8 weeks | 2020/[105] |
Punch defects | Rabbit | BMSCs | 1.0 × 106 | Kartogenin-platelet-rich plasma gel | Kartogenin and platelet | 3 months | 2019/[106] |
Radial defects (5 mm width) | Rabbit | SMSCs | 1.6 × 106 | Aligned electrospun nanofibrous | – | 12 weeks | 2018/[108] |
Punch defects | Rabbit | ADSCs | 4.0 × 105 | Polycaprolactone/silk/fibroin/gelatin/ascorbic acid composite | – | 2 months | 2021/[110] |
Full-thickness radial tear spanning 90% of the medial meniscal width | Goat | ADSCs | 2.0 × 106 | Methacrylated gelatin hydrogel | TGF-β3 | 6 months | 2019/[112] |
Unilateral total medial meniscectomy | Rabbit | ADSCs and chondrocytes | 2 × 104 | Polyvinyl alcohol/Chitosan | – | 7 months | 2017/[113] |
Full-thickness cylindrical defects (diameter = 1.5 mm) | Rabbit | Tonsil-derived mesenchymal stem cells | 1.5 × 105 | Riboflavin-induced photocrosslinked collagen–hyaluronic acid hydrogel | TGF-β1 | 10 weeks | 2017/[117] |
Meniscectomy | Rat | Tendon-derived stem cells and SMSCs | – | Decellularized semitendinosus tendon | – | 24 weeks | 2017/[118] |
Avascular meniscal tear | Sheep | BMSCs | 3.0 × 105 | Collagen | – | 13 weeks | 2017/[119] |