Cohen J, Torres C. Astrocyte senescence: evidence and significance. Aging Cell. 2019;18:e12937.
Article
PubMed
PubMed Central
CAS
Google Scholar
Popov A, Brazhe A, Denisov P, Sutyagina O, Li L, Lazareva N, et al. Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity. Aging Cell. 2021;20:e13334.
Article
CAS
PubMed
PubMed Central
Google Scholar
Verkhratsky A, Augusto-Oliveira M, Pivoriūnas A, Popov A, Brazhe A, Semyanov A. Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain. Pflugers Arch. 2021;473:753–74.
Article
CAS
PubMed
Google Scholar
Rodríguez-Arellano JJ, Parpura V, Zorec R, Verkhratsky A. Astrocytes in physiological aging and Alzheimer’s disease. Neuroscience. 2016;323:170–82.
Article
PubMed
CAS
Google Scholar
Tarantini S, Tran CHT, Gordon GR, Ungvari Z, Csiszar A. Impaired neurovascular coupling in aging and Alzheimer’s disease: contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Exp Gerontol. 2017;94:52–8.
Article
CAS
PubMed
Google Scholar
Boisvert MM, Erikson GA, Shokhirev MN, Allen NJ. The aging astrocyte transcriptome from multiple regions of the mouse brain. Cell Rep. 2018;22:269–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gage FH. Mammalian neural stem cells. Science. 2000;287:1433–8.
Article
CAS
PubMed
Google Scholar
Goldman SA. Progenitor cell-based treatment of glial disease. Prog Brain Res. 2017;231:165–89.
Article
PubMed
PubMed Central
Google Scholar
Zhang K, Chen X. Sensory response in host and engrafted astrocytes of adult brain in vivo. Glia. 2017;65:1867–84.
Article
PubMed
Google Scholar
Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, et al. Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell. 2013;12:252–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lepore AC, Rauck B, Dejea C, Pardo AC, Rao MS, Rothstein JD, et al. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci. 2008;11:1294–301.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jiang P, Chen C, Wang R, Chechneva OV, Chung SH, Rao MS, et al. hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. Nat Commun. 2013;4:2196.
Article
PubMed
CAS
Google Scholar
Esposito G, Sarnelli G, Capoccia E, Cirillo C, Pesce M, Lu J, et al. Autologous transplantation of intestine-isolated glia cells improves neuropathology and restores cognitive deficits in β amyloid-induced neurodegeneration. Sci Rep. 2016;6:22605.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goldman SA, Nedergaard M, Windrem MS. Glial progenitor cell-based treatment and modeling of neurological disease. Science. 2012;338:491–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Osorio MJ, Goldman SA. Glial progenitor cell-based treatment of the childhood leukodystrophies. Exp Neurol. 2016;283:476–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang K, Chen C, Yang Z, He W, Liao X, Ma Q, et al. Sensory response of transplanted astrocytes in adult mammalian cortex in vivo. Cereb Cortex. 2016;26:3690–704.
Article
PubMed
PubMed Central
Google Scholar
Lim D, Semyanov A, Genazzani A, Verkhratsky A. Calcium signaling in neuroglia. Int Rev Cell Mol Biol. 2021;362:1–53.
Article
CAS
PubMed
Google Scholar
Haydon PG, Nedergaard M. How do astrocytes participate in neural plasticity? Cold Spring Harb Perspect Biol. 2014;7:a020438.
Article
PubMed
Google Scholar
Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermel M, et al. Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse. Neuron. 2014;83:1058–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hu NY, Chen YT, Wang Q, Jie W, Liu YS, You QL, et al. Expression patterns of inducible Cre recombinase driven by differential astrocyte-specific promoters in transgenic mouse lines. Neurosci Bull. 2020;36:530–44.
Article
PubMed
Google Scholar
Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, et al. New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in situ and in vivo. Neuron. 2016;92:1181–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Salter MW, Hicks JL. ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord. J Neurosci. 1995;15:2961–71.
Article
CAS
PubMed
PubMed Central
Google Scholar
Scemes E, Giaume C. Astrocyte calcium waves: what they are and what they do. Glia. 2006;54:716–25.
Article
PubMed
PubMed Central
Google Scholar
Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, et al. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell. 2013;12:342–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Windrem MS, Schanz SJ, Morrow C, Munir J, Chandler-Militello D, Wang S, et al. A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia. J Neurosci. 2014;34:16153–61.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kunzelmann P, Schröder W, Traub O, Steinhäuser C, Dermietzel R, Willecke K. Late onset and increasing expression of the gap junction protein connexin30 in adult murine brain and long-term cultured astrocytes. Glia. 1999;25:111–9.
Article
CAS
PubMed
Google Scholar
Schell MJ, Molliver ME, Snyder SH. D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci USA. 1995;92:3948–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Duncombe J, Lennen RJ, Jansen MA, Marshall I, Wardlaw JM, Horsburgh K. Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis. Neuropathol Appl Neurobiol. 2017;43:477–91.
Article
CAS
PubMed
Google Scholar
Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D, et al. Impairment of paravascular clearance pathways in the aging brain. Ann Neurol. 2014;76:845–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li G, He X, Li H, Wu Y, Guan Y, Liu S, et al. Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain. Int J Mol Med. 2018;42:1935–44.
CAS
PubMed
PubMed Central
Google Scholar
Calì C, Wawrzyniak M, Becker C, Maco B, Cantoni M, Jorstad A, et al. The effects of aging on neuropil structure in mouse somatosensory cortex-A 3D electron microscopy analysis of layer 1. PLoS ONE. 2018;13:e0198131.
Article
PubMed
PubMed Central
CAS
Google Scholar
David-Jürgens M, Churs L, Berkefeld T, Zepka RF, Dinse HR. Differential effects of aging on fore- and hindpaw maps of rat somatosensory cortex. PLoS ONE. 2008;3: e3399.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kalisch T, Ragert P, Schwenkreis P, Dinse HR, Tegenthoff M. Impaired tactile acuity in old age is accompanied by enlarged hand representations in somatosensory cortex. Cereb Cortex. 2009;19:1530–8.
Article
PubMed
Google Scholar
Coq JO, Xerri C. Sensorimotor experience modulates age-dependent alterations of the forepaw representation in the rat primary somatosensory cortex. Neuroscience. 2001;104:705–15.
Article
CAS
PubMed
Google Scholar
Liguz-Lecznar M, Lehner M, Kaliszewska A, Zakrzewska R, Sobolewska A, Kossut M. Altered glutamate/GABA equilibrium in aged mice cortex influences cortical plasticity. Brain Struct Funct. 2015;220:1681–93.
Article
CAS
PubMed
Google Scholar
Huttunen J, Wikström H, Korvenoja A, Seppäläinen AM, Aronen H, Ilmoniemi RJ. Significance of the second somatosensory cortex in sensorimotor integration: enhancement of sensory responses during finger movements. NeuroReport. 1996;7:1009–12.
Article
CAS
PubMed
Google Scholar
Xerri C, Merzenich MM, Peterson BE, Jenkins W. Plasticity of primary somatosensory cortex paralleling sensorimotor skill recovery from stroke in adult monkeys. J Neurophysiol. 1998;79:2119–48.
Article
CAS
PubMed
Google Scholar
Halley AC, Baldwin MKL, Cooke DF, Englund M, Krubitzer L. Distributed motor control of limb movements in rat motor and somatosensory cortex: the sensorimotor amalgam revisited. Cereb Cortex. 2020;30:6296–312.
Article
PubMed
PubMed Central
Google Scholar
Matias I, Morgado J, Gomes FCA. Astrocyte heterogeneity: impact to brain aging and disease. Front Aging Neurosci. 2019;11:59.
Article
CAS
PubMed
PubMed Central
Google Scholar
Palmer AL, Ousman SS. Astrocytes and aging. Front Aging Neurosci. 2018;10:337.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tang Y, Wang J, Lin X, Wang L, Shao B, Jin K, et al. Neural stem cell protects aged rat brain from ischemia-reperfusion injury through neurogenesis and angiogenesis. J Cereb Blood Flow Metab. 2014;34:1138–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Windrem MS, Schanz SJ, Zou L, Chandler-Militello D, Kuypers NJ, Nedergaard M, et al. Human glial progenitor cells effectively remyelinate the demyelinated adult brain. Cell Rep. 2020;31:107658.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen H, Qian K, Chen W, Hu B, Blackbourn LW, Du Z, et al. Human-derived neural progenitors functionally replace astrocytes in adult mice. J Clin Investig. 2015;125:1033–42.
Article
PubMed
PubMed Central
Google Scholar
Madhavan L, Ourednik V, Ourednik J. Increased, “vigilance” of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress. Stem Cells. 2006;24:2110–9.
Article
CAS
PubMed
Google Scholar
Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, et al. Human glia can both induce and rescue aspects of disease phenotype in Huntington disease. Nat Commun. 2016;7:11758.
Article
PubMed
PubMed Central
Google Scholar
L’Episcopo F, Tirolo C, Peruzzotti-Jametti L, Serapide MF, Testa N, Caniglia S, et al. Neural stem cell grafts promote astroglia-driven neurorestoration in the aged Parkinsonian brain via Wnt/β-catenin signaling. Stem Cells. 2018;36:1179–97.
Article
CAS
PubMed
Google Scholar
Piao J, Major T, Auyeung G, Policarpio E, Menon J, Droms L, et al. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation. Cell Stem Cell. 2015;16:198–210.
Article
CAS
PubMed
PubMed Central
Google Scholar
Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Chang CD, et al. Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats. Exp Neurol. 2016;280:41–9.
Article
PubMed
Google Scholar