Fig. 4

Wnt signaling pathway regulations in tri-lineage differentiation. The Wnt signaling pathway regulate the tri-lineage differentiation of C3H10T1/2 through canonical or non-canonical signaling pathway. Specific miRNAs have been confirmed to regulate the activation or inhibition of Wnt signaling pathway, which further acts on the downstream signal molecules, and then guide the commitments of osteogenic, adipogenic and chondrogenic differentiation of C3H10T1/2. “ → ”represents the upstream signal promoting the downstream signal, and “⊥”represents the downstream signal inhibiting the downstream signal. The red arrows refer to the promoting effects, while the green arrows and lines refer to suppressing effects