Fig. 6

Monocytes experience differential secretome shift after simulated sepsis stimulation dependent on MSC efferocytosis condition. a Schematic of isolated human monocyte efferocytic-licensing without and with viable- or HI-MSCs followed by simulated sepsis stimulation with IL-2, IFN-γ, and LPS. See Fig. 5a for monocyte isolation process. Quantification of b IL-10, c kynurenine, and d TNF-α production detected after 2-day sepsis stimulation without or with efferocytic-licensing with viable- or HI-MSCs (mean ± SEM, n = 3 independent experiments, *p < 0.05 calculated after 1-way ANOVA with Tukey post hoc test)