Fig. 7

Monocyte phenotype and function depends on the initial viability of MSCs they efferocytose. Efferocytosis of viable MSC generated monocytes with increased expression of CD86, IDO activity, and immunosuppression toward T-cells. Efferocytosis of HI-MSC generated monocytes capable of decreasing total TNF-α production in simulated sepsis. This work highlights the importance of MSC quality, even for efferocytic mechanisms