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  1. Osteoporosis is a major public health concern for the elderly population and is characterized by fatigue load resulting in bone microdamage. The ability of bone mesenchymal stem cells (BMSCs) to repair bone mi...

    Authors: Jingqiong Xun, Chan Li, Meilu Liu, Yueming Mei, Qiongfei Zhou, Bo Wu, Fen Xie, Yuling Liu and Ruchun Dai
    Citation: Stem Cell Research & Therapy 2021 12:424
  2. Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell replacement therapy but often lack standardized cell production and live-cell shipment logistics as well as rigorous analys...

    Authors: Zengping Liu, Tanja Ilmarinen, Gavin S. W. Tan, Heidi Hongisto, Edmund Y. M. Wong, Andrew S. H. Tsai, Sami Al-Nawaiseh, Graham E. Holder, Xinyi Su, Veluchamy Amutha Barathi, Heli Skottman and Boris V. Stanzel
    Citation: Stem Cell Research & Therapy 2021 12:423
  3. Radiation-induced heart disease has been reported, but the underlying mechanisms remain unclear. Mesenchymal stem cells (MSCs), also residing in the heart, are highly susceptible to radiation. We examined the ...

    Authors: Lan Luo, Chen Yan, Naoki Fuchi, Yukinobu Kodama, Xu Zhang, Goto Shinji, Kiyonori Miura, Hitoshi Sasaki and Tao-Sheng Li
    Citation: Stem Cell Research & Therapy 2021 12:422
  4. Human dental pulp stem cells (hDPSCs) are the preferable choice of seed cells for craniomaxillofacial bone tissue regeneration. As a member of the miR-17-92 cluster, miR-20a-5p functions as an important regula...

    Authors: Xiao Cen, Xuefeng Pan, Bo Zhang, Wei Huang, Fang Pei, Tao Luo, Xinqi Huang, Jun Liu and Zhihe Zhao
    Citation: Stem Cell Research & Therapy 2021 12:421

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:173

  5. Unresponsive thin endometrium caused by Asherman syndrome (AS) is the major cause of uterine infertility. However, current therapies are ineffective. This study is to evaluate the effect of transplantation wit...

    Authors: Yanling Zhang, Libing Shi, Xiaona Lin, Feng Zhou, Liaobing Xin, Wenzhi Xu, Huaying Yu, Jing Li, Mei Pan, Yibin Pan, Yongdong Dai, Yinli Zhang, Jia Shen, Lijuan Zhao, Min Lu and Songying Zhang
    Citation: Stem Cell Research & Therapy 2021 12:420
  6. During aging, hematopoietic stem cells (HSC) lose progressively both their self-renewal and differentiation potential. The precise molecular mechanisms of this phenomenon are not well established. To uncover t...

    Authors: Christophe Desterke, Annelise Bennaceur-Griscelli and Ali G. Turhan
    Citation: Stem Cell Research & Therapy 2021 12:419
  7. Recently, tRNA-derived fragments (tRFs) have been shown to serve important biological functions. However, the role of tRFs in gastric cancer has not been fully elucidated. This study aimed to identify the tumo...

    Authors: Linwen Zhu, Zhe Li, Xiuchong Yu, Yao Ruan, Yijing Shen, Yongfu Shao, Xinjun Zhang, Guoliang Ye and Junming Guo
    Citation: Stem Cell Research & Therapy 2021 12:418
  8. MicroRNAs have been recognized as critical regulators for the osteoblastic lineage differentiation of human adipose-derived stem cells (hASCs). Previously, we have displayed that silencing of miR-137 enhances ...

    Authors: Cong Fan, Xiaohan Ma, Yuejun Wang, Longwei Lv, Yuan Zhu, Hao Liu and Yunsong Liu
    Citation: Stem Cell Research & Therapy 2021 12:417
  9. Human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes are recognized as novel cell-free therapeutic agents for inflammatory bowel disease (IBD), a condition caused by dysregulated intestinal muc...

    Authors: Xiu Cai, Zhi-yu Zhang, Jin-tao Yuan, Dickson Kofi Wiredu Ocansey, Qiang Tu, Xu Zhang, Hui Qian, Wen-rong Xu, Wei Qiu and Fei Mao
    Citation: Stem Cell Research & Therapy 2021 12:416
  10. Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined. The present study aimed to test the h...

    Authors: Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu and Xianyou Zheng
    Citation: Stem Cell Research & Therapy 2021 12:415
  11. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are promising candidates for tissue regeneration therapy. However, the therapeutic efficacy of MSC-EVs for meniscus regeneration is uncertain, ...

    Authors: Kazumasa Kawata, Hideyuki Koga, Kunikazu Tsuji, Kazumasa Miyatake, Yusuke Nakagawa, Takanori Yokota, Ichiro Sekiya and Hiroki Katagiri
    Citation: Stem Cell Research & Therapy 2021 12:414
  12. Intracerebral hemorrhage (ICH) is a major public health concern, and mesenchymal stem cells (MSCs) hold great potential for treating ICH. However, the quantity and quality of MSCs decline in the cerebral niche...

    Authors: Jianyang Liu, Jialin He, Lite Ge, Han Xiao, Yan Huang, Liuwang Zeng, Zheng Jiang, Ming Lu and Zhiping Hu
    Citation: Stem Cell Research & Therapy 2021 12:413
  13. Chondromalacia patellae (CMP), also known as runner’s knee, typically occurs in young patients, which is characterized by anterior knee pain (AKP) that is associated with visible changes in patellar cartilage....

    Authors: Weitao Zheng, Hanluo Li, Kanghong Hu, Liming Li and Mingjian Bei
    Citation: Stem Cell Research & Therapy 2021 12:412
  14. Our objective in this review was to determine (1) impactful research articles about CRISPR-edited stem cells, (2) factors that affected CRISPR method performance in stem cell, and (3) research design related t...

    Authors: Michael Anekson Widjaya, Shin-Da Lee and Yuh-Shan Ho
    Citation: Stem Cell Research & Therapy 2021 12:411
  15. Mesenchymal stem cells (MSCs) have received particular attention because of their ability to modulate the immune system and inhibit inflammation caused by cytokine storms due to SARS-CoV-2. New alternative the...

    Authors: Mahshid Saleh, Amir Abbas Vaezi, Rasoul Aliannejad, Amir Ali Sohrabpour, Seyedeh Zahra Fotook Kiaei, Mahdi Shadnoush, Vahid Siavashi, Leila Aghaghazvini, Batoul Khoundabi, Shahriyar Abdoli, Bahram Chahardouli, Iman Seyhoun, Neda Alijani and Javad Verdi
    Citation: Stem Cell Research & Therapy 2021 12:410
  16. Tubulointerstitial fibrosis (TIF) is one of the main pathological features of various progressive renal damages and chronic kidney diseases. Mesenchymal stromal cells (MSCs) have been verified with significant...

    Authors: Huajun Tang, Peiyue Zhang, Lianlin Zeng, Yu Zhao, Libo Xie and Bo Chen
    Citation: Stem Cell Research & Therapy 2021 12:409
  17. Accumulating evidence suggests that enhanced adipose tissue macrophages (ATMs) are associated with metabolic disorders in obesity and type 2 diabetes. However, therapeutic persistence and reduced homing stem c...

    Authors: Luochen Zhu, Ziqian Feng, Xin Shu, Qian Gao, Jiaqi Wu, Zuoqin Du, Rong Li, Liqun Wang, Ni Chen, Yi Li, Mao Luo and Jianbo Wu
    Citation: Stem Cell Research & Therapy 2021 12:408
  18. Atherosclerosis (AS) is a complex disease caused in part by dyslipidemia and chronic inflammation. AS is associated with serious cardiovascular disease and remains the leading cause of mortality worldwide. Mes...

    Authors: Yanhong Li, Guiying Shi, Yunlin Han, Haiquan Shang, Huiwu Li, Wei Liang, Wenjie Zhao, Lin Bai and Chuan Qin
    Citation: Stem Cell Research & Therapy 2021 12:407
  19. Current surgical therapies for pelvic organ prolapse (POP) do not repair weak vaginal tissue and just provide support; these therapies may trigger severe complications. Stem cell-based regenerative therapy, du...

    Authors: Ye Zhang, Yidi Ma, Juan Chen, Min Wang, Yuan Cao, Lei Li, Hua Yang, Xudong Liu, Yaqian Li and Lan Zhu
    Citation: Stem Cell Research & Therapy 2021 12:406
  20. Somatic stem cell transplantation has been performed for cartilage injury, but the reparative mechanisms are still conflicting. The chondrogenic potential of stem cells are thought as promising features for ca...

    Authors: Ryota Chijimatsu, Satoshi Miwa, Gensuke Okamura, Junya Miyahara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuji Maenohara, Shinsaku Tsuji, Shin Sameshima, Kentaro Takagi, Keiu Nakazato, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi…
    Citation: Stem Cell Research & Therapy 2021 12:405

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:479

  21. The recent COronaVIrus Disease (COVID)-19 pandemic has placed an unprecedented burden on the drug development opportunity to prevent the onset of multi-organ failure.

    Authors: Anahid Safari, Vicenzo Lionetti and Iman Razeghian-Jahromi
    Citation: Stem Cell Research & Therapy 2021 12:404
  22. Diabetic limb ischemia is a clinical syndrome and refractory to therapy. Our previous study demonstrated that adipose-derived stem cells (ADSCs) overexpressing glyoxalase-1 (GLO-1) promoted the regeneration of...

    Authors: Xing Zhang, Yihong Jiang, Qun Huang, Zhaoyu Wu, Hongji Pu, Zhijue Xu, Bo Li, Xinwu Lu, Xinrui Yang, Jinbao Qin and Zhiyou Peng
    Citation: Stem Cell Research & Therapy 2021 12:403
  23. Stem cell transplantation is a fascinating therapeutic approach for the treatment of many neurodegenerative disorders; however, clinical trials using stem cells have not been as effective as expected based on ...

    Authors: Jung Yeon Lim, Sang In Park, Soon A. Park, Jung Ho Jeon, Ho Yong Jung, Jung-Min Yon, Sin-Soo Jeun, Hyun Kook Lim and Sung Won Kim
    Citation: Stem Cell Research & Therapy 2021 12:402
  24. Perianal fistula is one of the most common complications in Crohn’s disease, and various medical and surgical treatments are being tried. The aim of this study was to compare the perianal fistula closure rates...

    Authors: Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang and Chang Sik Yu
    Citation: Stem Cell Research & Therapy 2021 12:401
  25. Multiple sclerosis (MS) is a central nervous system (CNS) chronic illness with autoimmune, inflammatory, and neurodegenerative effects characterized by neurological disorder and axonal loss signs due to myelin...

    Authors: Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi and Jafar Ai
    Citation: Stem Cell Research & Therapy 2021 12:400
  26. Umbilical cord blood (UCB) is a clinically relevant alternative source of hematopoietic stem/progenitor cells (HSPC). To overcome the low cell number per UCB unit, ex vivo expansion of UCB HSPC in co-culture w...

    Authors: Sara Bucar, André Dargen de Matos Branco, Márcia F. Mata, João Coutinho Milhano, Íris Caramalho, Joaquim M. S. Cabral, Ana Fernandes-Platzgummer and Cláudia L. da Silva
    Citation: Stem Cell Research & Therapy 2021 12:399
  27. A long-term of peritoneal dialysis (PD) using a hypertonic PD solution (PDS) leads to patient’s peritoneal membrane (PM) injury, resulting in ultrafiltration failure (UFF) and PD drop-out. Our previous study s...

    Authors: Yangchun Du, Ming Zong, Qiunong Guan, Zhongli Huang, Lan Zhou, Jing Cai, Gerald da Roza, Hao Wang, Hualin Qi, Yiping Lu and Caigan Du
    Citation: Stem Cell Research & Therapy 2021 12:398
  28. Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy is being investigated in clinical trials for the treatment...

    Authors: Zan Tang, Junxiao Gao, Jie Wu, Guifang Zeng, Yan Liao, Zhenkun Song, Xiao Liang, Junyuan Hu, Yong Hu, Muyun Liu and Nan Li
    Citation: Stem Cell Research & Therapy 2021 12:397
  29. Effective treatments for acute-on-chronic liver failure (ACLF) are lacking. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been applied in tissue regeneration and repair, acting through pa...

    Authors: Yulin He, Xingrong Guo, Tingyu Lan, Jianbo Xia, Jinsong Wang, Bei Li, Chunyan Peng, Yue Chen, Xiang Hu and Zhongji Meng
    Citation: Stem Cell Research & Therapy 2021 12:396

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:65

  30. Hepatic steatosis is a big hurdle to treat type 2 diabetes (T2D). Fasting-mimicking diet (FMD) has been shown to be an effective intervention in dyslipidemia of T2D. However, fasting may impair the normal gluc...

    Authors: Na Zhao, Ying-Feng Gao, Lei Bao, Jing Lei, Huan-Xiao An, Feng-Xing Pu, Rui-Ping Cheng, Ji Chen, Hua Ni, Bing-Dong Sui, Fan-Pu Ji and Cheng-Hu Hu
    Citation: Stem Cell Research & Therapy 2021 12:395
  31. The tumour microenvironment contributes to chemotherapy resistance in gliomas, and glioma-associated mesenchymal stromal/stem cells (gaMSCs) are important stromal cell components that play multiple roles in tu...

    Authors: Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu
    Citation: Stem Cell Research & Therapy 2021 12:394

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:493

  32. Mesenchymal stem cell treatments in dogs have been investigated as a potential innovative alternative to current conventional therapies for a variety of conditions. So far, the precise mode of action of the MS...

    Authors: Charlotte Beerts, Carlien Brondeel, Glenn Pauwelyn, Eva Depuydt, Liesa Tack, Luc Duchateau, Yangfeng Xu, Jimmy H. Saunders, Kathelijne Peremans and Jan H. Spaas
    Citation: Stem Cell Research & Therapy 2021 12:393
  33. Diabetic foot ulceration is a serious chronic complication of diabetes mellitus characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has been widely used for diabetic wound he...

    Authors: Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed M. Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed H. Khalil, Sami F. Abdalla, Mohamed El-Sherbiny…
    Citation: Stem Cell Research & Therapy 2021 12:392
  34. Mesenchymal stem cells (MSCs) have to be expanded in vitro to reach a sufficient cell dose for the treatment of various diseases. During the process of expansion, some obstacles remain to be overcome. The purp...

    Authors: Yong-Hong Wang, Ya-Chao Tao, Dong-Bo Wu, Meng-Lan Wang, Hong Tang and En-Qiang Chen
    Citation: Stem Cell Research & Therapy 2021 12:391
  35. Nontraumatic osteonecrosis of the femoral head (NONFH) is a common, progressive, and refractory orthopaedic disease. Decreased osteogenesis and angiogenesis are considered the main factors in the pathogenesis ...

    Authors: Wu Yang, Weiwen Zhu, Yunfei Yang, Minkang Guo, Husun Qian, Weiqian Jiang, Yu Chen, Chengjie Lian, Zijie Xu, Haobo Bai, Tingmei Chen and Jian Zhang
    Citation: Stem Cell Research & Therapy 2021 12:390
  36. Aberrations in exosomal circular RNA (circRNA) expression have been identified in various human diseases. In this study, we investigated whether exosomal circRNAs could act as competing endogenous RNAs (ceRNAs...

    Authors: Guping Mao, Yiyang Xu, Dianbo Long, Hong Sun, Hongyi Li, Ruobin Xin, Ziji Zhang, Zhiwen Li, Zhi Yang and Yan Kang
    Citation: Stem Cell Research & Therapy 2021 12:389
  37. Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features...

    Authors: Rishi Man Chugh, Hang-soo Park, Abdeljabar El Andaloussi, Amro Elsharoud, Sahar Esfandyari, Mara Ulin, Lale Bakir, Alshimaa Aboalsoud, Mohamed Ali, Dalia Ashour, Prosper Igboeli, Nahed Ismail, Jan McAllister and Ayman Al-Hendy
    Citation: Stem Cell Research & Therapy 2021 12:388
  38. Neointimal hyperplasia remains a major obstacle in vascular regeneration. Sca-1-positive progenitor cells residing within the vascular adventitia play a crucial role in the assemblage of vascular smooth muscle...

    Authors: Yan Wu, Yuan-jin Li, Liu-liu Shi, Yun Liu, Yan Wang, Xin Bao, Wei Xu, Lu-yuan Yao, Magdaleena Naemi Mbadhi, Long Chen, Shan Li, Xing-yuan Li, Zhi-feng Zhang, Sen Zhao, Ruo-nan Zhang, Shi-You Chen…
    Citation: Stem Cell Research & Therapy 2021 12:387
  39. Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as ...

    Authors: Ahmed Lotfy, Aya Elgamal, Anna Burdzinska, Ayman A. Swelum, Reham Soliman, Ayman A. Hassan and Gamal Shiha
    Citation: Stem Cell Research & Therapy 2021 12:386
  40. The therapeutic efficacy of mesenchymal stem cells (MSCs) of different tissue origins on metabolic disorders can be varied in many ways but remains poorly defined. Here we report a comprehensive comparison of ...

    Authors: Yinzhong Ma, Lisha Wang, Shilun Yang, Dongyu Liu, Yi Zeng, Lilong Lin, Linhui Qiu, Jiahao Lu, Junlei Chang and Zhihuan Li
    Citation: Stem Cell Research & Therapy 2021 12:385
  41. In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation ...

    Authors: Dehua Chang, Taibing Fan, Shuang Gao, Yongqiang Jin, Mingkui Zhang and Minoru Ono
    Citation: Stem Cell Research & Therapy 2021 12:384
  42. As a promising way to repair bone defect, bone tissue engineering has attracted a lot of attentions from researchers in recent years. Searching for new molecular target to modify the seed cells and enhance the...

    Authors: Xuenan Liu, Xiaomin Lian, Xuejiao Liu, Yangge Du, Yuan Zhu, Menglong Hu, Ping Zhang, Yunsong Liu and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2021 12:383
  43. Tissue-engineered bone grafts (TEBGs) that undergo vascularization and neurotization evolve into functioning bone tissue. Previously, we verified that implanting sensory nerve tracts into TEBGs promoted osteog...

    Authors: Xinxin Zhang, Xiaorui Jiang, Shan Jiang, Xiyu Cai, Shengji Yu and Guoxian Pei
    Citation: Stem Cell Research & Therapy 2021 12:382
  44. Radiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused on stem cell properties to obtain ideal therapeutic effects, and Sox9 ...

    Authors: Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang, Xiaocheng Wang, Maosheng Cheng, Jie Chen, Zhi Chen, Jianwen Chen, Caihua Zhang, Gan Xiong, Xiuyun Xu, Demeng Chen, Heping Li and Liang Peng
    Citation: Stem Cell Research & Therapy 2021 12:381
  45. Small blood stem cells (SB cells), isolated from human peripheral blood, demonstrated the ability to benefit bone regeneration and osseointegration. The primary goal of our study is to examine the safety and t...

    Authors: Sheng-Wei Feng, Yi-Han Su, Yen-Kuang Lin, Yu-Chih Wu, Yen-Hua Huang, Fu-Hung Yang, Hsi-Jen Chiang, Yun Yen and Peter Da-Yen Wang
    Citation: Stem Cell Research & Therapy 2021 12:380
  46. Embryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative of ES cells. Acute kidney injury (AKI) is a common acut...

    Authors: Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu, Zhongchao Han, Xiangmei Chen, Zongjin Li and Na Liu
    Citation: Stem Cell Research & Therapy 2021 12:379
  47. Idiopathic pneumonia syndrome (IPS) is a non-infectious fatal complication characterized by a massive infiltration of leukocytes in lungs and diffuse pulmonary injury after allogeneic hematopoietic stem cell t...

    Authors: Min Cao, Huihui Liu, Yujun Dong, Wei Liu, Zhengyu Yu, Qingya Wang, Qingyun Wang, Zeying Liang, Yuan Li and Hanyun Ren
    Citation: Stem Cell Research & Therapy 2021 12:378
  48. Direct reprogramming of human fibroblasts to hepatocyte-like cells was proposed to generate large-scale functional hepatocytes demanded by liver tissue engineering. However, the difficulty in obtaining large q...

    Authors: Jie Deng, Kai Luo, Pengchao Xu, Qingyuan Jiang, Yuan Wang, Yunqi Yao, Xiaolei Chen, Fuyi Cheng, Dan Xie and Hongxin Deng
    Citation: Stem Cell Research & Therapy 2021 12:375
  49. Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered ...

    Authors: Faroogh Marofi, Marwan Mahmood Saleh, Heshu Sulaiman Rahman, Wanich Suksatan, Moaed E. Al-Gazally, Walid Kamal Abdelbasset, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Ali Hassanzadeh, Mahboubeh Yazdanifar, Roza Motavalli, Yashwant Pathak, Adel Naimi, Behzad Baradaran, Marzieh Nikoo and Farhad Motavalli Khiavi
    Citation: Stem Cell Research & Therapy 2021 12:374

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