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  1. Coronary artery disease (CAD) is the leading cause of death worldwide. Chromosome locus 9p21 was the first to be associated with increased risk of CAD and coronary artery calcification (CAC). Vascular calcific...

    Authors: Anja Trillhaase, Beatrice Schmidt, Marlon Märtens, Undine Haferkamp, Jeanette Erdmann and Zouhair Aherrahrou
    Citation: Stem Cell Research & Therapy 2021 12:166
    Content type: Research Published on:

  2. Growing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors. Fibronectin (FN), fibroblas...

    Authors: Lingling Chen, Morgan Carlton, Xiaodan Chen, Navdeep Kaur, Hollie Ryan, Tony J Parker, Zhengmei Lin, Yin Xiao and Yinghong Zhou
    Citation: Stem Cell Research & Therapy 2021 12:165
    Content type: Research Published on:

  3. Mesenchymal stem cells (MSCs) are derived from multiple tissues, including amniotic fluid (AF-MSCs) and the umbilical cord (UC-MSCs). Although the therapeutic effect of MSCs on sepsis is already known, researc...

    Authors: Rui Chen, Yingjun Xie, Xuan Zhong, Fei Chen, Yu Gong, Na Wang and Ding Wang
    Citation: Stem Cell Research & Therapy 2021 12:164
    Content type: Research Published on:

  4. Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton’s jelly-derived mes...

    Authors: Yongjian Qi, Bin Li, Yinxian Wen, Xu Yang, Biao Chen, Zheng He, Zhe Zhao, Jacques Magdalou, Hui Wang and Liaobin Chen
    Citation: Stem Cell Research & Therapy 2021 12:163
    Content type: Research Published on:

  5. Recovery of muscle function after peripheral nerve injury is often poor, and this can be attributed to muscle fiber atrophy and cell death. In the current study, we have investigated the effects of stromal vas...

    Authors: R. El-Habta, G. Andersson, P. J. Kingham and L. J. Backman
    Citation: Stem Cell Research & Therapy 2021 12:162
    Content type: Research Published on:

  6. Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level...

    Authors: Yun-Xing Fu, Jing Ji, Fang Shan, Jialing Li and Rong Hu
    Citation: Stem Cell Research & Therapy 2021 12:161
    Content type: Review Published on:

  7. Autologous fat grafting is often a crucial aspect of reconstructive and aesthetic surgeries, yet poor graft retention is a major issue with this technique. Enriching fat grafts with adipose tissue-derived mese...

    Authors: Richard J. P. Smith, Alessandro Faroni, James R. Barrow, Jamie Soul and Adam J. Reid
    Citation: Stem Cell Research & Therapy 2021 12:160
    Content type: Research Published on:

  8. Dental pulp stem cells (DPSCs) are a promising cell source in endodontic regeneration and tissue engineering with limited self-renewal and pluripotency capacity. N6-methyladenosine (m6A) is the most prevalent, re...

    Authors: Haiyun Luo, Wenjing Liu, Yanli Zhang, Yeqing Yang, Xiao Jiang, Shiqing Wu and Longquan Shao
    Citation: Stem Cell Research & Therapy 2021 12:159
    Content type: Research Published on:

  9. The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety...

    Authors: Lingfei Zhao, Chenxia Hu, Fei Han, Dajin Chen, Jun Cheng, Jianyong Wu, Wenhan Peng and Jianghua Chen
    Citation: Stem Cell Research & Therapy 2021 12:158
    Content type: Research Published on:

  10. As one of the most common chronic diseases in the world, osteoporosis occurs especially in postmenopausal women. Circular RNAs (circRNAs) are emerging as major drivers in human disease. The aim of the present ...

    Authors: Feng Zhi, Yi Ding, Rong Wang, Yujiao Yang, Kaiming Luo and Fei Hua
    Citation: Stem Cell Research & Therapy 2021 12:157
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:381

  11. Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, ca...

    Authors: Yu-kun Yang, Ye Li, Yan-ying Wang, Guang-ping Ruan, Chuan Tian, Qiang Wang, Huan-yu He, Gao-hong Zhu, Dong Fang, Mao Wang, Xiang-qing Zhu and Xing-hua Pan
    Citation: Stem Cell Research & Therapy 2021 12:156
    Content type: Research Published on:

  12. A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multi...

    Authors: Rodrigo N. Riedel, Antonio Pérez-Pérez, Víctor Sánchez-Margalet, Cecilia L. Varone and Julieta L. Maymó
    Citation: Stem Cell Research & Therapy 2021 12:155
    Content type: Review Published on:

  13. Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG.

    Authors: Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li and De-Zhi Tang
    Citation: Stem Cell Research & Therapy 2021 12:154
    Content type: Research Published on:

  14. Mesenchymal stem cells (MSCs) have been utilized in treating acute graft-versus-host disease (aGvHD) as they show strong immunosuppressive capacity through the release of various mediators, including immunosup...

    Authors: Weijiang Liu, Na Zhou, Yuanlin Liu, Wei Zhang, Xue Li, Yang Wang, Rongxiu Zheng and Yi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:153
    Content type: Research Published on:

  15. Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed, immunomodulatory and anti-inflammatory properties, assoc...

    Authors: Miryam Mebarki, Camille Abadie, Jérôme Larghero and Audrey Cras
    Citation: Stem Cell Research & Therapy 2021 12:152
    Content type: Review Published on:

  16. Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepa...

    Authors: Tingcai Pan, Jiawang Tao, Yan Chen, Jiaye Zhang, Anteneh Getachew, Yuanqi Zhuang, Ning Wang, Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang, Xianhua Lin, Kai You, Yi Gao and Yin-xiong Li
    Citation: Stem Cell Research & Therapy 2021 12:151
    Content type: Research Published on:

  17. Little is known about the implications of circRNAs in the effects of melatonin (MEL) on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoporosis (OP) progression. The aim of our stu...

    Authors: Xudong Wang, Taiqiu Chen, Zhihuai Deng, Wenjie Gao, Tongzhou Liang, Xianjian Qiu, Bo Gao, Zizhao Wu, Jincheng Qiu, Yuanxin Zhu, Yanbo Chen, Zhancheng Liang, Hang Zhou, Caixia Xu, Anjing Liang, Peiqiang Su…
    Citation: Stem Cell Research & Therapy 2021 12:150
    Content type: Research Published on:

  18. Patients with coronary artery disease (CAD) are characterized by a decline in vascular regeneration, which is related to the dysfunction of endothelial progenitor cells (EPCs). G-protein-coupled receptor 4 (GP...

    Authors: Shun Ouyang, Yan Li, Xing Wu, Yan Wang, Fanmao Liu, Jianning Zhang, Yumin Qiu, Zhe Zhou, Zhichao Wang, Wenhao Xia and Xiufang Lin
    Citation: Stem Cell Research & Therapy 2021 12:149
    Content type: Research Published on:

  20. Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients...

    Authors: Linli Shi, Qian Han, Yimei Hong, Weifeng Li, Gencheng Gong, Jiangyu Cui, Mengmeng Mao, Xiaoting Liang, Bei Hu, Xin Li, Qun Luo and Yuelin Zhang
    Citation: Stem Cell Research & Therapy 2021 12:147
    Content type: Research Published on:

  21. Muscle is severely affected by ischemia/reperfusion injury (IRI). Quiescent satellite cells differentiating into myogenic progenitor cells (MPC) possess a remarkable regenerative potential. We herein establish...

    Authors: Franka Messner, Marco Thurner, Jule Müller, Michael Blumer, Julia Hofmann, Rainer Marksteiner, Sebastien Couillard-Despres, Jakob Troppmair, Dietmar Öfner, Stefan Schneeberger and Theresa Hautz
    Citation: Stem Cell Research & Therapy 2021 12:146
    Content type: Research Published on:

  22. Endothelial progenitor cells (EPCs) are promising candidates for the cellular therapy of peripheral arterial and cardiovascular diseases. However, hitherto there is no specific marker(s) defining precisely EPC...

    Authors: Mohamed Essameldin Abdelgawad, Christophe Desterke, Georges Uzan and Sina Naserian
    Citation: Stem Cell Research & Therapy 2021 12:145
    Content type: Research Published on:

  23. Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies hav...

    Authors: Sevil Korkmaz-Icöz, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamás Radovits, Alex Ali Sayour, Mihály Ruppert, Gábor Veres, Matthias Karck and Gábor Szabó
    Citation: Stem Cell Research & Therapy 2021 12:144
    Content type: Research Published on:

  24. Intervertebral fusion is the most common surgery to treat lumbar degenerative disease (LDD). And the graft material used in the operation is derived from the iliac crest to promote fusion. However, autografts ...

    Authors: Weigang Li, Chunwei Huang, Tian Ma, Jiachen Wang, Wenbin Liu, Jiyuan Yan, Gaohong Sheng, Ruizhuo Zhang, Hua Wu and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2021 12:143
    Content type: Research Published on:

  25. Dental pulp stem cells (DPSCs) are increasingly being advocated as viable cell sources for regenerative medicine-based therapies. However, significant heterogeneity in DPSC expansion and multi-potency capabili...

    Authors: Nadia Y. A. Alaidaroos, Amr Alraies, Rachel J. Waddington, Alastair J. Sloan and Ryan Moseley
    Citation: Stem Cell Research & Therapy 2021 12:142
    Content type: Research Published on:

  26. As a large capillary network, the human placenta plays an important role throughout pregnancy. Placental vascular development is complex and delicate and involves many types of placental cells, such as trophob...

    Authors: Haiying Ma, Shenglu Jiang, Lili Du, Jinfang Liu, Xiaoyan Xu, Xiaomei Lu, Ling Ma, Hua Zhu, Jun Wei and Yanqiu Yu
    Citation: Stem Cell Research & Therapy 2021 12:141
    Content type: Research Published on:

  27. Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-directional differentiation, and paracrine and immune regulation. As a result of these properties, the MSCs have great clinical...

    Authors: Wanhao Yan, Shu Diao and Zhipeng Fan
    Citation: Stem Cell Research & Therapy 2021 12:140
    Content type: Review Published on:

  28. Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for many hematological diseases; however, therapeutic applications are hampered by donor availability. In vivo, HSC exist in...

    Authors: Kyle Lewis, Momoko Yoshimoto and Takanori Takebe
    Citation: Stem Cell Research & Therapy 2021 12:139
    Content type: Review Published on:

  29. Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or modulate deleterious immune responses by various molecular mechanisms. These cells are the subject of major translational efforts as cellul...

    Authors: Yi Yu, Alejandra Vargas Valderrama, Zhongchao Han, Georges Uzan, Sina Naserian and Estelle Oberlin
    Citation: Stem Cell Research & Therapy 2021 12:138
    Content type: Research Published on:

  30. Burned human skin, which is routinely excised and discarded, contains viable mesenchymal stromal/stem cells (burn-derived mesenchymal stromal/stem cells; BD-MSCs). These cells show promising potential to enabl...

    Authors: Reinhard Dolp, Gertraud Eylert, Christopher Auger, Ayesha Aijaz, Yufei Andy Chen, Saeid Amini-Nik, Alexandra Parousis, Andrea-Kaye Datu and Marc G. Jeschke
    Citation: Stem Cell Research & Therapy 2021 12:137
    Content type: Research Published on:

  31. This arcticle has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-016-0438-5.

    Authors: Lihui Yu, Ying Lu, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang and Bo Song
    Citation: Stem Cell Research & Therapy 2021 12:136
    Content type: Retraction Note Published on:

    The original article was published in Stem Cell Research & Therapy 2016 7:180

  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren
    Citation: Stem Cell Research & Therapy 2021 12:134
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:21

  34. The purpose of this study was to investigate the therapeutic effects of genetically modified mesenchymal stem cells (MSCs) in the treatment of type 2 diabetes mellitus (T2DM) in order to identify a new method ...

    Authors: Binghua Xue, Xiuxiao Xiao, Tingting Yu, Xinhua Xiao, Jing Xie, Qiuhe Ji, Li Wang, Tao Na, Shufang Meng, Lingjia Qian and Haifeng Duan
    Citation: Stem Cell Research & Therapy 2021 12:133
    Content type: Research Published on:

  35. Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal ...

    Authors: Pengcheng Xiao, Zhenglin Zhu, Chengcheng Du, Yongsheng Zeng, Junyi Liao, Qiang Cheng, Hong Chen, Chen Zhao and Wei Huang
    Citation: Stem Cell Research & Therapy 2021 12:132
    Content type: Research Published on:

  36. Duchenne muscular dystrophy (DMD) is caused by mutations of the gene that encodes the protein dystrophin. A loss of dystrophin leads to severe and progressive muscle wasting in both skeletal and heart muscles....

    Authors: Wanling Xuan, Mahmood Khan and Muhammad Ashraf
    Citation: Stem Cell Research & Therapy 2021 12:131
    Content type: Research Published on:

  37. Thin endometrium adversely affects reproductive success rates with fertility treatment. Autologous transplantation of exogenously prepared endometrium can be a promising therapeutic option for thin endometrium...

    Authors: Ryo Yokomizo, Yukiko Fujiki, Harue Kishigami, Hiroshi Kishi, Tohru Kiyono, Sanae Nakayama, Haruhiko Sago, Aikou Okamoto and Akihiro Umezawa
    Citation: Stem Cell Research & Therapy 2021 12:130
    Content type: Research Published on:

  38. The repair of large-scale full-thickness skin defects represents a challenging obstacle in skin tissue engineering. To address the most important problem in skin defect repair, namely insufficient blood supply...

    Authors: Shuang Lin, Xiaoning He and Yuanjia He
    Citation: Stem Cell Research & Therapy 2021 12:129
    Content type: Research Published on:

  39. Recently, growing evidence has indicated an important role of the complement system, a crucial component of immunity, in mediating neuroinflammation and promoting neuronal apoptosis following closed head injur...

    Authors: Mou Gao, Qin Dong, Wenjia Wang, Zhijun Yang, Lili Guo, Yingzhou Lu, Boyun Ding, Lihua Chen, Jianning Zhang and Ruxiang Xu
    Citation: Stem Cell Research & Therapy 2021 12:128
    Content type: Research Published on:

  40. Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases. The large a...

    Authors: Jonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles and Jessie R. Lavoie
    Citation: Stem Cell Research & Therapy 2021 12:127
    Content type: Research Published on:

  41. Cancer is a leading cause of death in both developed and developing countries, and because of population growth and aging, it is a growing medical burden worldwide. With robust development in medicine, the use...

    Authors: Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali and Hassan Niknejad
    Citation: Stem Cell Research & Therapy 2021 12:126
    Content type: Review Published on:

  42. Stroke serves as a prevalent cerebrovascular disorder with severe cerebral ischemia/reperfusion (CIR) injury, in which neural stem cells (NSCs) play critical roles in the recovery of cerebral function. Circula...

    Authors: Bo Yang, Li’e Zang, Jingwen Cui and Linlin Wei
    Citation: Stem Cell Research & Therapy 2021 12:125
    Content type: Research Published on:

  43. Mesenchymal stromal cells (MSCs) constitute one of the cell types most frequently used in cell therapy. Although several studies have shown the efficacy of these cells to modulate inflammation in different ani...

    Authors: Rosario Hervás-Salcedo, María Fernández-García, Miriam Hernando-Rodríguez, Oscar Quintana-Bustamante, Jose-Carlos Segovia, Marcio Alvarez-Silva, Mariano García-Arranz, Pablo Minguez, Victoria del Pozo, Marta Rodríguez de Alba, Damián García-Olmo, Carmen Ayuso, María Luisa Lamana, Juan A. Bueren and Rosa María Yañez
    Citation: Stem Cell Research & Therapy 2021 12:124
    Content type: Research Published on:

  44. To repair bone defects, a variety of bone substitution materials have been used, such as ceramics, metals, natural and synthetic polymers, and combinations thereof. In recent decades, a wide range of synthetic...

    Authors: Siyi Wang, Rong Li, Dandan Xia, Xiao Zhao, Yuan Zhu, Ranli Gu, Jungmin Yoon and Yunsong Liu
    Citation: Stem Cell Research & Therapy 2021 12:123
    Content type: Review Published on:

  46. Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone regeneration. Our previous study confirmed th...

    Authors: Shuanglin Peng, Sirong Shi, Gang Tao, Yanjing Li, Dexuan Xiao, Lang Wang, Qing He, Xiaoxiao Cai and Jingang Xiao
    Citation: Stem Cell Research & Therapy 2021 12:120
    Content type: Research Published on:

  47. Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we ai...

    Authors: Xiong Shu, Kai-Yue Cao, Hui-Qi Liu, Long Yu, Li-Xin Sun, Zhi-Hua Yang, Cheng-Ai Wu and Yu-Liang Ran
    Citation: Stem Cell Research & Therapy 2021 12:119
    Content type: Research Published on:

  48. Oligovascular niche mediates interactions between cerebral endothelial cells and oligodendrocyte precursor cells (OPCs). Disruption of OPC-endothelium trophic coupling may aggravate the progress of cerebral wh...

    Authors: Ning Zhou, Lei Wang, Ping Fu, Zihao Cui, Yuhang Ge, Feiyu Jiang, Jing Liu, Chao Ren, Zuo Luan, Hongbin Fan and Ruiqin Yao
    Citation: Stem Cell Research & Therapy 2021 12:118
    Content type: Research Published on:

  49. Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action r...

    Authors: Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang and Limin Rong
    Citation: Stem Cell Research & Therapy 2021 12:117
    Content type: Research Published on:

  50. Combination of mesenchymal stem cells (MSCs) and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. T...

    Authors: Mohamed I. Elashry, Nadine Baulig, Alena-Svenja Wagner, Michele C. Klymiuk, Benjamin Kruppke, Thomas Hanke, Sabine Wenisch and Stefan Arnhold
    Citation: Stem Cell Research & Therapy 2021 12:116
    Content type: Research Published on:
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