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  1. Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs. However, whether ...

    Authors: Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Bihl, Yanfang Chen, Bin Zhao and Xiaotang Ma
    Citation: Stem Cell Research & Therapy 2020 11:260
    Content type: Research Published on:

  2. After surgery, wound recovery in diabetic patients may be disrupted due to delayed inflammation, which can lead to undesired consequences, and there is currently a lack of effective measures to address this is...

    Authors: Wei Liu, Muyu Yu, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Fang Liu and Lili Yang
    Citation: Stem Cell Research & Therapy 2020 11:259
    Content type: Research Published on:

  3. Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in P...

    Authors: Lei Wang, Hao Zi, Yi Luo, Tongzu Liu, Hang Zheng, Conghua Xie, Xinghuan Wang and Xing Huang
    Citation: Stem Cell Research & Therapy 2020 11:258
    Content type: Research Published on:

  4. Schwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promi...

    Authors: Han-Seop Kim, Jae Yun Kim, Cho Lok Song, Ji Eun Jeong and Yee Sook Cho
    Citation: Stem Cell Research & Therapy 2020 11:257
    Content type: Research Published on:

  5. MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer protein TRAIL. Though cell-based therapies are typically designed wit...

    Authors: P. Stephen Patrick, Krishna K. Kolluri, May Zaw Thin, Adam Edwards, Elizabeth K. Sage, Tom Sanderson, Benjamin D. Weil, John C. Dickson, Mark F. Lythgoe, Mark Lowdell, Sam M. Janes and Tammy L. Kalber
    Citation: Stem Cell Research & Therapy 2020 11:256
    Content type: Research Published on:

  6. Clinical use of mesenchymal stem cells (MSCs) requires a uniform cell population, and their harvesting is invasive and produces a limited number of cells. Human embryonic stem cell-derived MSCs (hESC-MSCs) can...

    Authors: Sook Young Yoon, Jung Ah Yoon, Mira Park, Eun-Young Shin, Sookyung Jung, Jeoung Eun Lee, Jin Hee Eum, Haengseok Song, Dong Ryul Lee, Woo Sik Lee and Sang Woo Lyu
    Citation: Stem Cell Research & Therapy 2020 11:255
    Content type: Research Published on:

  7. Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this stu...

    Authors: Ji-Young Lim, Da-Bin Ryu, Tae Woo Kim, Sung-Eun Lee, Gyeongsin Park, Hyoung Kyu Yoon and Chang-Ki Min
    Citation: Stem Cell Research & Therapy 2020 11:254
    Content type: Research Published on:

  8. Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair of injured tissues. Though numerous studies have reported the effect of EVs on renal fibr...

    Authors: Zhengzhou Shi, Qi Wang, Youbo Zhang and Dapeng Jiang
    Citation: Stem Cell Research & Therapy 2020 11:253
    Content type: Research Published on:

  9. Recently, extensive researches about stem cell-based therapies for ischemic stroke have been published; our review evaluated the efficacy and safety of stem cell-based therapies for ischemic stroke. Our review...

    Authors: Zhonghao Li, Xiaoke Dong, Min Tian, Chongchong Liu, Kaiyue Wang, Lili Li, Zunjing Liu and Jinmin Liu
    Citation: Stem Cell Research & Therapy 2020 11:252
    Content type: Review Published on:

  10. GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. As functional paracrine units of therapeutic cells...

    Authors: Chunshu Hao, Zhengri Lu, Yuanyuan Zhao, Zhong Chen, Chengxing Shen, Genshan Ma and Lijuan Chen
    Citation: Stem Cell Research & Therapy 2020 11:251
    Content type: Research Published on:

  11. Consumption of non-nutritive sweeteners (NNS) has been consistently associated with obesity and cardiometabolic disease in epidemiologic studies. Herein, we investigated effects of sucralose, a widely used NNS...

    Authors: Nabanita Kundu, Cleyton C. Domingues, Jay Patel, Mohammed Aljishi, Neeki Ahmadi, Mona Fakhri, Allison C. Sylvetsky and Sabyasachi Sen
    Citation: Stem Cell Research & Therapy 2020 11:250
    Content type: Research Published on:

  12. The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectat...

    Authors: Dongwei Liu, Fei Cheng, Shaokang Pan and Zhangsuo Liu
    Citation: Stem Cell Research & Therapy 2020 11:249
    Content type: Review Published on:

  13. Melanoma is a type of aggressive skin cancer with a poor survival rate. The resistance to conventional therapy of this disease is, at least in part, attributed to its cancer stem cell population. However, the ...

    Authors: Wenlin Wu, Chenxi Xu, Xiaobo Zhang, An Yu and Le Shu
    Citation: Stem Cell Research & Therapy 2020 11:248
    Content type: Research Published on:

  14. Induced pluripotent stem cells (iPSCs) have enormous potential in developmental biology studies and in cellular therapies. Although extensively studied and characterized in human and murine models, iPSCs from ...

    Authors: Fabiana Fernandes Bressan, Vinícius Bassanezze, Laís Vicari de Figueiredo Pessôa, Chester Bittencourt Sacramento, Tathiane Maistro Malta, Simone Kashima, Paulo Fantinato Neto, Ricardo De Francisco Strefezzi, Naira Caroline Godoy Pieri, José Eduardo Krieger, Dimas Tadeu Covas and Flávio Vieira Meirelles
    Citation: Stem Cell Research & Therapy 2020 11:247
    Content type: Research Published on:

  15. Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury i...

    Authors: Haibin Sun, Xiaoqing Zhao, Qihang Tai, Guangxiao Xu, Yingnan Ju and Wei Gao
    Citation: Stem Cell Research & Therapy 2020 11:246
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:491

  16. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is considered a promising therapeutic approach for bone defect repair. However, during the transplantation procedure, the functions and viabilit...

    Authors: Yusi Guo, Xiaopei Chi, Yifan Wang, Boon Chin Heng, Yan Wei, Xuehui Zhang, Han Zhao, Ying Yin and Xuliang Deng
    Citation: Stem Cell Research & Therapy 2020 11:245
    Content type: Research Published on:

  17. Pathological skin scars, caused by cesarean section, affected younger mothers esthetically and psychosocially and to some extent frustrated obstetricians and dermatologists. Umbilical cord mesenchymal stem cel...

    Authors: Dazhi Fan, Meng Zeng, Qing Xia, Shuzhen Wu, Shaoxin Ye, Jiaming Rao, Dongxin Lin, Huishan Zhang, Huiting Ma, Zhongchao Han, Xiaoling Guo and Zhengping Liu
    Citation: Stem Cell Research & Therapy 2020 11:244
    Content type: Research Published on:

  18. In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we expl...

    Authors: Rui Ma, Zhili Ren, Bin Li, Shirley W. I. Siu, Guokai Chen and Hang Fai Kwok
    Citation: Stem Cell Research & Therapy 2020 11:243
    Content type: Research Published on:

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:242
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:147

  20. Mesenchymal stem cells (MSCs) have become a promising candidate for cell-based immune therapy for acute rejection (AR) after heart transplantation due to possessing immunomodulatory properties. In this study, ...

    Authors: Chao Gao, Xiaodong Wang, Jian Lu, Zhilin Li, Haowen Jia, Minghao Chen, Yuchen Chang, Yanhong Liu, Peiyuan Li, Baotong Zhang, Xuezhi Du and Feng Qi
    Citation: Stem Cell Research & Therapy 2020 11:241
    Content type: Research Published on:

  21. Many studies have shown that long noncoding RNAs (lncRNAs) are closely related to the stimulation of osteogenic differentiation of adipose-derived stem cells (ADSCs) and the prevention of osteoporosis. Current...

    Authors: Zheng-liang Shi, Hua Zhang, Zhi-yong Fan, Wei Ma, Yong-zhou Song, Ming Li, Tong-qiu Li, Shu-xing Cao and Guo-jun Feng
    Citation: Stem Cell Research & Therapy 2020 11:240
    Content type: Research Published on:

  22. The identification of endometrial stem/progenitor cells in a high turnover rate tissue suggests that a well-orchestrated underlying network controls the behaviour of these stem cells. The thickness of the endo...

    Authors: Shan Xu, Rachel W. S. Chan, Tianqi Li, Ernest H. Y. Ng and William S. B. Yeung
    Citation: Stem Cell Research & Therapy 2020 11:239
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:199

  23. Pluripotent stem cells present the ability to self-renew and undergo differentiation into any cell type building an organism. Importantly, a lot of evidence on embryonic stem cell (ESC) differentiation comes f...

    Authors: Anita Florkowska, Igor Meszka, Magdalena Zawada, Diana Legutko, Tomasz J. Proszynski, Katarzyna Janczyk-Ilach, Wladyslawa Streminska, Maria A. Ciemerych and Iwona Grabowska
    Citation: Stem Cell Research & Therapy 2020 11:238
    Content type: Research Published on:

  24. Although it has been preclinically suggested that adipose tissue-derived mesenchymal stem cell (ADSC)-based therapy could effectively treat chronic liver diseases, the hepatic engraftment of ADSCs is still ext...

    Authors: Naishun Liao, Yingjun Shi, Yingchao Wang, Fangyu Liao, Bixing Zhao, Youshi Zheng, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu
    Citation: Stem Cell Research & Therapy 2020 11:237
    Content type: Research Published on:

  25. Dental pulp stem cells (DPSCs) have high proliferation and multi-differentiation capabilities that maintain their functionality after cryopreservation. In our previous study, we demonstrated that cryopreserved...

    Authors: Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Eriko Makino, Saki Kanada, Tomokazu Saiki, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Shogo Ozawa, Ken Miyazawa…
    Citation: Stem Cell Research & Therapy 2020 11:236
    Content type: Research Published on:

  26. We would like to thank for the interest for the article and comments in the response. We believe that cell therapy may offer a treatment for severe voice problems in patients with vocal fold scarring and MSC t...

    Authors: Stellan Hertegård and Katarina LeBlanc
    Citation: Stem Cell Research & Therapy 2020 11:235
    Content type: Commentary Published on:

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:173

  27. Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies usi...

    Authors: Keerthana Shankar, Christian M. Capitini and Krishanu Saha
    Citation: Stem Cell Research & Therapy 2020 11:234
    Content type: Review Published on:

  28. Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal...

    Authors: Marco Thurner, Martin Deutsch, Katrin Janke, Franka Messner, Christina Kreutzer, Stanislav Beyl, Sébastien Couillard-Després, Steffen Hering, Jakob Troppmair and Rainer Marksteiner
    Citation: Stem Cell Research & Therapy 2020 11:233
    Content type: Research Published on:

  30. Preeclampsia (PE) is a frequently occurring pregnancy disorder in the placenta, which results in various maternal and fetal complications. The current study aims to evaluate the role of extracellular vesicles ...

    Authors: Jinhui Cui, Xinjuan Chen, Shuo Lin, Ling Li, Jianhui Fan, Hongying Hou and Ping Li
    Citation: Stem Cell Research & Therapy 2020 11:231
    Content type: Research Published on:

  31. Proliferation and transdifferentiation of lung stem cells (LSCs) could promote lung injury repair. The distal airways of the lung are innervated by the vagus nerve. Vagal-alpha7 nicotinic acetylcholine recepto...

    Authors: Xiaoyan Chen, Caiqi Zhao, Cuiping Zhang, Qingmei Li, Jie Chen, Lianping Cheng, Jian Zhou, Xiao Su and Yuanlin Song
    Citation: Stem Cell Research & Therapy 2020 11:230
    Content type: Research Published on:

  32. To investigate the therapeutic effect of human dental pulp stem cells (DPSCs) transfected with adenovirus expressing hepatocyte growth factor (HGF) in a mouse model of collagen-induced arthritis (CIA).

    Authors: Xiwen Dong, Fanxuan Kong, Chao Liu, Shiyun Dai, Yuning Zhang, Fengjun Xiao, Huan Zhang, Chu-Tse Wu and Hua Wang
    Citation: Stem Cell Research & Therapy 2020 11:229
    Content type: Research Published on:

  33. The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI). Irisin, a novel myokine which ...

    Authors: Jingyu Deng, Ning Zhang, Yong Wang, Chao Yang, Yabin Wang, Chao Xin, Jinming Zhao, Zhitao Jin, Feng Cao and Zheng Zhang
    Citation: Stem Cell Research & Therapy 2020 11:228
    Content type: Research Published on:

  34. Bone marrow mesenchymal stem cells (BMSCs) exhibit the capacity to self-renew and differentiate into multi-lineage cell types, including osteoblasts, which are crucial regulators of fracture healing. Thus, thi...

    Authors: Xueliang Zhang, Yongping Wang, Haiyan Zhao, Xingwen Han, Tong Zhao, Peng Qu, Guangjie Li and Wenji Wang
    Citation: Stem Cell Research & Therapy 2020 11:227
    Content type: Research Published on:

  35. Adipose-derived mesenchymal stem cells (ADMSCs) have attracted widespread interest as cell-based tissue repair systems. To obtain adequate quantities of ADMSCs for therapeutic applications, extensive in vitro ...

    Authors: Qiliang Yin, Na Xu, Dongsheng Xu, Mingxin Dong, Xiumin Shi, Yan Wang, Zhuo Hao, Shuangshuang Zhu, Donghai Zhao, Haofan Jin and Wensen Liu
    Citation: Stem Cell Research & Therapy 2020 11:226
    Content type: Research Published on:

  36. Acetaminophen (APAP) overdose is the common cause of acute liver failure (ALF) due to the oxidative damage of multiple cellular components. This study aimed to investigate whether plasma membrane vesicles (PMV...

    Authors: Mei-jia Lin, Shuang Li, Lu-jun Yang, Dan-yan Ye, Li-qun Xu, Xin Zhang, Ping-nan Sun and Chi-ju Wei
    Citation: Stem Cell Research & Therapy 2020 11:225
    Content type: Research Published on:

  37. Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiom...

    Authors: Hao Cheng, Shufu Chang, Rende Xu, Lu Chen, Xiaoyue Song, Jian Wu, Juying Qian, Yunzeng Zou and Jianying Ma
    Citation: Stem Cell Research & Therapy 2020 11:224
    Content type: Research Published on:

  38. Mesenchymal stem cell (MSC)-based therapy is currently considered to be an effective treatment strategy for diabetes and hepatic disorders, such as liver cirrhosis and non-alcoholic fatty liver disease. Exosom...

    Authors: Qin He, Lingshu Wang, Ruxing Zhao, Fei Yan, Sha Sha, Chen Cui, Jia Song, Huiqing Hu, Xinghong Guo, Mengmeng Yang, Yixin Cui, Yujing Sun, Zheng Sun, Fuqiang Liu, Ming Dong, Xinguo Hou…
    Citation: Stem Cell Research & Therapy 2020 11:223
    Content type: Research Published on:

  39. Machado-Joseph disease is the most common autosomal dominant hereditary ataxia worldwide without effective treatment. Mesenchymal stem cells (MSCs) could slow the disease progression, but side effects limited ...

    Authors: Hua-Jing You, Shu-Bin Fang, Teng-Teng Wu, Hongyu Zhang, Yu-Kun Feng, Xue-Jiao Li, Hui-Hua Yang, Ge Li, Xun-Hua Li, Chao Wu, Qing-Ling Fu and Zhong Pei
    Citation: Stem Cell Research & Therapy 2020 11:222
    Content type: Research Published on:

  40. Mesenchymal stem cells (MSCs) can improve limb perfusion and increase vessel density in a murine model of hindlimb ischemia. But low engraftment rate of those cells limited their therapeutic effect. Endothelia...

    Authors: Ziping Yao, Huihui Liu, Min Yang, Yun Bai, Bihui Zhang, Chengen Wang, Ziguang Yan, Guochen Niu, Yinghua Zou and Yuan Li
    Citation: Stem Cell Research & Therapy 2020 11:221
    Content type: Research Published on:

  41. Restenosis is a serious problem in patients who have undergone percutaneous transluminal angioplasty. Endothelial injury resulting from surgery can lead to endothelial dysfunction and neointimal formation by i...

    Authors: Zhihui Liu, Chao Wu, Xinliang Zou, Weiming Shen, Jiacai Yang, Xiaorong Zhang, Xiaohong Hu, Haidong Wang, Yi Liao and Tao Jing
    Citation: Stem Cell Research & Therapy 2020 11:220
    Content type: Research Published on:

  42. This study tested the optimal time point for left intra-carotid arterial (LICA) administration of circulatory-derived autologous endothelial progenitor cells (EPCs) for improving the outcome in rat after acute...

    Authors: Kun-Chen Lin, Han-Tan Chai, Kuan-Hung Chen, Pei-Hsun Sung, John Y. Chiang, Pei-Lin Shao, Chi-Ruei Huang, Yi-Chen Li, Sheung-Fat Ko and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2020 11:219
    Content type: Research Published on:

  43. Donation after circulatory death (DCD) liver grafts have a poor prognosis after transplantation. We investigated whether the outcome of DCD donor organs can be improved by heme oxygenase 1 (HO-1)-modified bone...

    Authors: Huan Cao, Liu Yang, Bin Hou, Dong Sun, Ling Lin, Hong-Li Song and Zhong-Yang Shen
    Citation: Stem Cell Research & Therapy 2020 11:218
    Content type: Research Published on:

  44. A marked egg-induced CD4+ T cell programmed inflammation and subsequent hepatic fibrosis characterize the pathogenesis of schistosomiasis. Mesenchymal stem cell (MSC) has been extensively studied for the treatmen...

    Authors: Chao Liu, Yi-shu Zhang, Fang Chen, Xiao-ying Wu, Bei-bei Zhang, Zhong-dao Wu and Jun-xia Lei
    Citation: Stem Cell Research & Therapy 2020 11:217
    Content type: Research Published on:

  46. In periodontal tissue engineering, periodontal ligament stem cells derived from patients with periodontitis (P-PDLSCs) are among the most promising and accessible stem cells for repairing disrupted alveolar bo...

    Authors: Han Li, Yuejia Deng, Minmin Tan, Ge Feng, Yunchun Kuang, Jie Li and Jinlin Song
    Citation: Stem Cell Research & Therapy 2020 11:215
    Content type: Research Published on:

  47. Idiopathic pulmonary fibrosis is a chronic, progressive, and severe disease with a limited response to currently available therapies. Epithelial cell injury and failure of appropriate healing or regeneration a...

    Authors: Belén Alvarez-Palomo, Luis Ignacio Sanchez-Lopez, Yuben Moodley, Michael J. Edel and Anna Serrano-Mollar
    Citation: Stem Cell Research & Therapy 2020 11:213
    Content type: Research Published on:

  48. The therapeutic effects of adipose-derived mesenchymal stem cell (ADSC) transplantation have been demonstrated in several models of central nervous system (CNS) injury and are thought to involve the modulation...

    Authors: Zhilai Zhou, Xiaobo Tian, Biling Mo, Huali Xu, Li Zhang, Lishan Huang, Shun Yao, Zixiang Huang, Yeyang Wang, Huan Xie, Liwei Xu and Hui Zhang
    Citation: Stem Cell Research & Therapy 2020 11:212
    Content type: Research Published on:

  50. The differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts (OBs) is a prerequisite for bone formation. However, little is known about the definitive surface markers for OBs during osteogenesis.

    Authors: Hyun Min Lee, Se-Ri Seo, Jeeseung Kim, Min Kyu Kim, Hyosun Seo, Kyoung Soo Kim, Young-Joo Jang and Chun Jeih Ryu
    Citation: Stem Cell Research & Therapy 2020 11:210
    Content type: Research Published on:
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