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  1. Previous studies have produced controversial results regarding whether mesenchymal stem cells (MSCs) promote or inhibit tumor development. Given the dual role of MSCs in inflammation and cancer, in this study ...

    Authors: Rui-jing Tang, Su-nan Shen, Xiao-yin Zhao, Yun-zhong Nie, Yu-jun Xu, Jing Ren, Ming-ming Lv, Ya-yi Hou and Ting-ting Wang
    Citation: Stem Cell Research & Therapy 2015 6:71
    Content type: Research Published on:

  2. Following injury such as stroke, adult mammalian subependymal neural precursor cells (NPCs) are induced to proliferate and migrate toward the lesion site where they differentiate into neural cells, albeit with...

    Authors: Robart Babona-Pilipos, Alex Pritchard-Oh, Milos R Popovic and Cindi M Morshead
    Citation: Stem Cell Research & Therapy 2015 6:67
    Content type: Research Published on:

  3. Diabetes is associated with reduced expression of heme oxygenase-1 (HO-1), a heme-degrading enzyme with cytoprotective and proangiogenic properties. In myoblasts and muscle satellite cells HO-1 improves surviv...

    Authors: Magdalena Kozakowska, Jerzy Kotlinowski, Anna Grochot-Przeczek, Maciej Ciesla, Bartosz Pilecki, Rafal Derlacz, Jozef Dulak and Alicja Jozkowicz
    Citation: Stem Cell Research & Therapy 2015 6:61
    Content type: Research Published on:

  4. This study tested the hypothesis that Major Histocompatibility Complex (MHC) incompatible equine mesenchymal stromal cells (MSCs) would induce cytotoxic antibodies to donor MHC antigens in recipient horses aft...

    Authors: Lynn M Pezzanite, Lisa A Fortier, Douglas F Antczak, Jennifer M Cassano, Margaret M Brosnahan, Donald Miller and Lauren V Schnabel
    Citation: Stem Cell Research & Therapy 2015 6:54
    Content type: Research Published on:

  5. The prevalence of impaired cutaneous wound healing is high and treatment is difficult and often ineffective, leading to negative social and economic impacts for our society. Innovative treatments to improve cu...

    Authors: Leen Bussche, Rebecca M Harman, Bethany A Syracuse, Eric L Plante, Yen-Chun Lu, Theresa M Curtis, Minglin Ma and Gerlinde R Van de Walle
    Citation: Stem Cell Research & Therapy 2015 6:66
    Content type: Research Published on:

  6. Mesenchymal stem cells (MSCs) have potential for re-epithelization and recovery in acute respiratory distress syndrome (ARDS). In a previous in vitro study, the results showed that the canonical Wnt/β-catenin pat...

    Authors: Shi-xia Cai, Ai-ran Liu, Song Chen, Hong-li He, Qi-hong Chen, Jing-yuan Xu, Chun Pan, Yi Yang, Feng-mei Guo, Ying-zi Huang, Ling Liu and Hai-bo Qiu
    Citation: Stem Cell Research & Therapy 2015 6:65
    Content type: Research Published on:

  7. The beta-amyloid (Aβ) peptide and the Aβ-oligomer receptor, prion protein (PrP), both influence neurogenesis. Using in vitro murine neural stem cells (NSCs), we investigated whether Aβ and PrP interact to modify ...

    Authors: Steven J Collins, Carolin Tumpach, Qiao-Xin Li, Victoria Lewis, Timothy M Ryan, Blaine Roberts, Simon C Drew, Victoria A Lawson and Cathryn L Haigh
    Citation: Stem Cell Research & Therapy 2015 6:60
    Content type: Short report Published on:

  8. Chemokine-directed migration is crucial for homing of regenerative cells to the infarcted heart and correlates with outcomes of cell therapy trials. Hence, transplantation of chemokine-responsive bone marrow c...

    Authors: Raimondo Ascione, Jonathan Rowlinson, Elisa Avolio, Rajesh Katare, Marco Meloni, Helen L Spencer, Giuseppe Mangialardi, Caroline Norris, Nicolle Kränkel, Gaia Spinetti, Costanza Emanueli and Paolo Madeddu
    Citation: Stem Cell Research & Therapy 2015 6:53
    Content type: Research Published on:

  9. The study of hematopoiesis has been a focus for developmental biologists for over 100 years. What started as a series of microscopic observations in different animal model systems has since evolved into studie...

    Authors: Haydn C-Y Liang and Juan Carlos Zúñiga-Pflücker
    Citation: Stem Cell Research & Therapy 2015 6:52
    Content type: Review Published on:

  10. ‘Patient-specific’ induced pluripotent stem cells (iPSCs) are attractive because they can generate abundant cells without the risk of immune rejection for cell therapy. Studies have shown that iPSC-derived mes...

    Authors: Guo-wen Hu, Qing Li, Xin Niu, Bin Hu, Juan Liu, Shu-min Zhou, Shang-chun Guo, Hai-li Lang, Chang-qing Zhang, Yang Wang and Zhi-feng Deng
    Citation: Stem Cell Research & Therapy 2015 6:10
    Content type: Research Published on:

  11. The therapeutic potential of acyclic retinoid (ACR), a synthetic retinoid, has been confirmed in experimental and clinical studies. Therapeutic targets include precancerous and cancer stem cells. As ACR is als...

    Authors: Hong-Bin Guan, Yun-Zhong Nie, Yun-Wen Zheng, Kazuya Takiguchi, Hong-Wei Yu, Ran-Ran Zhang, Bin Li, Tomonori Tsuchida and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2015 6:51
    Content type: Research Published on:

  12. Stem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in ...

    Authors: Saji Oommen, Satsuki Yamada, Susana Cantero Peral, Katherine A Campbell, Elizabeth S Bruinsma, Andre Terzic and Timothy J Nelson
    Citation: Stem Cell Research & Therapy 2015 6:50
    Content type: Research Published on:

  13. Chimeric mice with humanized livers were recently established by transplanting human hepatocytes. This mouse model that is repopulated with functional human hepatocytes could be a useful tool for investigating...

    Authors: Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Tomonori Tsuchida, Yasuharu Ueno, Yun-Zhong Nie and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2015 6:49
    Content type: Research Published on:

  14. Advances in the field of stem cells have led to novel avenues for generating induced pluripotent stem cells (iPSCs) from differentiated somatic cells. iPSCs are typically obtained by the introduction of four f...

    Authors: Christopher B Driscoll, Jason M Tonne, Moustafa El Khatib, Roberto Cattaneo, Yasuhiro Ikeda and Patricia Devaux
    Citation: Stem Cell Research & Therapy 2015 6:48
    Content type: Research Published on:

  15. The therapeutic potential of mesenchymal stem cells (MSCs) for traumatic brain injury (TBI) is attractive. Conducting systematic review and meta-analyses based on data from animal studies can be used to inform...

    Authors: Weijun Peng, Jing Sun, Chenxia Sheng, Zhe Wang, Yang Wang, Chunhu Zhang and Rong Fan
    Citation: Stem Cell Research & Therapy 2015 6:47
    Content type: Research Published on:

  16. Understanding the mechanism of stem cell mobilization into injured skeletal muscles is a prerequisite step for the development of muscle disease therapies. Many of the currently studied stem cell types present...

    Authors: Edyta Brzoska, Kamil Kowalski, Agnieszka Markowska-Zagrajek, Magdalena Kowalewska, Rafał Archacki, Izabela Plaskota, Władysława Stremińska, Katarzyna Jańczyk-Ilach and Maria A Ciemerych
    Citation: Stem Cell Research & Therapy 2015 6:46
    Content type: Research Published on:

  17. Bone marrow mesenchymal stem cells (BMSCs) have been studied extensively because of their potential use in clinical therapy, regenerative medicine, and tissue engineering. However, their application in tumor t...

    Authors: Lei Zhang, Xiao San Su, Jun Song Ye, Yi Yin Wang, Zheng Guan and Yan Feng Yin
    Citation: Stem Cell Research & Therapy 2015 6:45
    Content type: Research Published on:

  18. Mesenchymal stem cells (MSCs) have potent stabilising effects on vascular endothelium injury, inhibiting endothelial permeability in lung injury via paracrine hepatocyte growth factor (HGF). Recently, it has b...

    Authors: Qi-Hong Chen, Ai-Ran Liu, Hai-Bo Qiu and Yi Yang
    Citation: Stem Cell Research & Therapy 2015 6:44
    Content type: Research Published on:

  19. There is a practical need for the identification of robust cell-surface markers that can be used to enrich for living keratinocyte progenitor cells. Breast cancer resistance protein (ABCG2), a member of the AT...

    Authors: Dongrui Ma, Alvin Wen Choong Chua, Ennan Yang, Peiyun Teo, Yixin Ting, Colin Song, Ellen Birgitte Lane and Seng Teik Lee
    Citation: Stem Cell Research & Therapy 2015 6:43
    Content type: Research Published on:

  20. Mouse fibroblasts could be directly converted into induced neural stem cells (iNSCs), by introducing a set of known transcription factors (TFs). This process, known as direct reprogramming, is an alternative s...

    Authors: Moein Yaqubi, Abdulshakour Mohammadnia and Hossein Fallahi
    Citation: Stem Cell Research & Therapy 2015 6:42
    Content type: Research Published on:

  21. The loss of oligodendrocytes in a lesion of the central nervous system causes demyelination and therefore impairs axon function and survival. Transplantation of neural stem cell-derived oligodendrocyte precurs...

    Authors: Yongchao Li, Pei-Shan Wang, George Lucas, Rong Li and Li Yao
    Citation: Stem Cell Research & Therapy 2015 6:41
    Content type: Research Published on:

  22. Acute liver failure (ALF) is a highly lethal disease, for which effective therapeutic methods are limited. Although allogeneic liver transplantation is a viable treatment method for ALF, there is a serious sho...

    Authors: Guangfeng Chen, Yinpeng Jin, Xiujuan Shi, Yu Qiu, Yushan Zhang, Mingliang Cheng, Xiaojin Wang, Chengwei Chen, Yinxia Wu, Fuzhu Jiang, Li Li, Heng Zhou, Qingchun Fu and Xiaoqing Liu
    Citation: Stem Cell Research & Therapy 2015 6:40
    Content type: Research Published on:

  23. Type 1 long QT syndrome (LQT1) is a common type of cardiac channelopathy associated with loss-of-function mutations of KCNQ1. Currently there is a lack of drugs that target the defected slowly activating delayed ...

    Authors: Dongrui Ma, Heming Wei, Jun Lu, Dou Huang, Zhenfeng Liu, Li Jun Loh, Omedul Islam, Reginald Liew, Winston Shim and Stuart A Cook
    Citation: Stem Cell Research & Therapy 2015 6:39
    Content type: Research Published on:

  24. Successful stem cell therapy relies on large-scale generation of stem cells and their maintenance in a proliferative multipotent state. This study aimed to establish a three-dimension culture system for large-...

    Authors: Guifang Zhao, Feilin Liu, Shaowei Lan, Pengdong Li, Li Wang, Junna Kou, Xiaojuan Qi, Ruirui Fan, Deshun Hao, Chunling Wu, Tingting Bai, Yulin Li and Jin Yu Liu
    Citation: Stem Cell Research & Therapy 2015 6:38
    Content type: Research Published on:

  25. Unstable atherosclerotic plaques are prone to rupture, which leads to atherothrombosis. Endothelial progenitor cells (EPCs) are bone marrow-derived precursor cells that may repair vascular injury in atheroscle...

    Authors: Zhongwen Zhang, Jianjun Dong, Corrinne G Lobe, Peiyun Gong, Ju Liu and Lin Liao
    Citation: Stem Cell Research & Therapy 2015 6:36
    Content type: Research Published on:

  27. Local delivery of mesenchymal stem cells (MSCs) to the acutely injured or osteoarthritic joint retards cartilage destruction. However, in the absence of assistive materials the efficiency of engraftment of MSC...

    Authors: Sarah E Bulman, Cynthia M Coleman, J Mary Murphy, Nicholas Medcalf, Aideen E Ryan and Frank Barry
    Citation: Stem Cell Research & Therapy 2015 6:34
    Content type: Research Published on:

  28. Stem cells isolated from menstrual fluid (MenSCs) exhibit mesenchymal stem cell (MSCs)-like properties including multi-lineage differentiation capacity. Besides, menstrual fluid has important advantages over o...

    Authors: Francisca Alcayaga-Miranda, Jimena Cuenca, Patricia Luz-Crawford, Carolina Aguila-Díaz, Ainoa Fernandez, Fernando E Figueroa and Maroun Khoury
    Citation: Stem Cell Research & Therapy 2015 6:32
    Content type: Research Published on:

  29. Mesenchymal stromal/stem cells (MSCs) are multipotent cells that have the ability to express and secrete a wide range of immunomodulatory molecules, cytokines, growth factors and antiapoptotic proteins. MSCs m...

    Authors: Juliana Navarro Ueda Yaochite, Carolina Caliari-Oliveira, Lucas Eduardo Botelho de Souza, Lourenço Sbragia Neto, Patrícia Vianna Bonini Palma, Dimas Tadeu Covas, Kelen Cristina Ribeiro Malmegrim, Julio César Voltarelli and Eduardo Antônio Donadi
    Citation: Stem Cell Research & Therapy 2015 6:31
    Content type: Research Published on:

  30. Globoid cell leukodystrophy (GLD) is a severe disorder of the central and peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity. Cell-based therapies are highly promising stra...

    Authors: Xiao Ling Kuai, Run Zhou Ni, Guo Xiong Zhou, Zheng Biao Mao, Jian Feng Zhang, Nan Yi, Zhao Xiu Liu, Nan Shao, Wen Kai Ni and Zhi Wei Wang
    Citation: Stem Cell Research & Therapy 2015 6:30
    Content type: Research Published on:

  31. Retinitis pigmentosa (RP) is a severe neurodegenerative disease of the retina that can lead to blindness. Even without treatment, a clinical study with the use of stem cells is currently underway and the resul...

    Authors: Rubens C Siqueira, Andre Messias, Katharina Messias, Rafael S Arcieri, Milton A Ruiz, Neiglene F Souza, Lia C Martins and Rodrigo Jorge
    Citation: Stem Cell Research & Therapy 2015 6:29
    Content type: Research Published on:

  32. Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FB...

    Authors: José M Díez, Ewa Bauman, Rodrigo Gajardo and Juan I Jorquera
    Citation: Stem Cell Research & Therapy 2015 6:28
    Content type: Research Published on:

  33. Although there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best c...

    Authors: Leopoldo P Nucci, Helio R Silva, Viviana Giampaoli, Javier B Mamani, Mariana P Nucci and Lionel F Gamarra
    Citation: Stem Cell Research & Therapy 2015 6:27
    Content type: Research Published on:

  35. Bone marrow derived cellular therapies are an emerging approach to promoting therapeutic angiogenesis in ischemic cardiovascular disease. However, the percentage of regenerative cells in bone marrow mononuclea...

    Authors: Kelly J Ledford, Nikki Murphy, Frank Zeigler, Ronnda L Bartel and Ross Tubo
    Citation: Stem Cell Research & Therapy 2015 6:25
    Content type: Research Published on:

  36. Recent evidence has shown that bone marrow cells play critical roles during the inflammatory, proliferative and remodeling phases of cutaneous wound healing. Among the bone marrow cells delivered to wounds are...

    Authors: Luis Rodriguez-Menocal, Shahjahan Shareef, Marcela Salgado, Arsalan Shabbir and Evangelos Van Badiavas
    Citation: Stem Cell Research & Therapy 2015 6:24
    Content type: Research Published on:

  37. Depletion of limbal stem cells leads to a debilitating condition known as limbal stem cell deficiency, characterised by impaired corneal wound healing and poor vision. The aim of this study was to determine wh...

    Authors: Samantha Bobba, Sharron Chow, Stephanie Watson and Nick Di Girolamo
    Citation: Stem Cell Research & Therapy 2015 6:23
    Content type: Research Published on:

  38. The objective of the present study was to evaluate the capacity of a tissue-engineered complex of human osteoprotegerin (hOPG)-transfected periodontal ligament stem cells (PDLSCs) seeding on beta-tricalcium ph...

    Authors: Fang Su, Shi-Sen Liu, Jun-Li Ma, Dong-Sheng Wang, Ling-Ling E and Hong-Chen Liu
    Citation: Stem Cell Research & Therapy 2015 6:22
    Content type: Research Published on:

  39. Bone marrow-derived mesenchymal stem cells (BMSCs, also known as bone marrow-derived mesenchymal stromal cells) are known to be a component of the tumor microenvironment. BMSCs are multipotent stromal cells th...

    Authors: Chen Jiang, Jun Sun, Yafei Dai, Pengfei Cao, Liyang Zhang, Shuping Peng, Yanhong Zhou, Guiyuan Li, Jingqun Tang and Juanjuan Xiang
    Citation: Stem Cell Research & Therapy 2015 6:21
    Content type: Research Published on:

  40. Tumor necrosis factor-inducible gene 6 protein (TSG-6), one of the cytokines released by human mesenchymal stem/stromal cells (hMSC), has an anti-inflammatory effect and alleviates several pathological conditi...

    Authors: Sihyung Wang, Ji-Seon Lee, Jeongeun Hyun, Jieun Kim, Seung U Kim, Hyuk-Jin Cha and Youngmi Jung
    Citation: Stem Cell Research & Therapy 2015 6:20
    Content type: Research Published on:

  41. Mesenchymal stromal cells (MSC) have well defined immunomodulatory properties including the suppression of lymphocyte proliferation and inhibition of dendritic cell (DC) maturation involving both cell contact ...

    Authors: Emer F Cahill, Laura M Tobin, Fiona Carty, Bernard P Mahon and Karen English
    Citation: Stem Cell Research & Therapy 2015 6:19
    Content type: Research Published on:

  42. Microparticles (MPs) derived from kidney-derived mesenchymal stem cells (KMSCs) have recently been reported to ameliorate rarefaction of peritubular capillaries (PTC) in ischemic kidneys via delivery of proang...

    Authors: Hoon Young Choi, Hyun Gyu Lee, Beom Seok Kim, Sun Hee Ahn, Ara Jung, Mirae Lee, Jung Eun Lee, Hyung Jong Kim, Sung Kyu Ha and Hyeong Cheon Park
    Citation: Stem Cell Research & Therapy 2015 6:18
    Content type: Research Published on:

  43. Bone marrow mesenchymal stem cells (BMSCs), which have the ability to self-renew and to differentiate into multiple cell types, have recently become a novel strategy for cell-based therapies. The differentiati...

    Authors: Zhenzhen Li, Shichao Han, Xingqin Wang, Fu Han, Xiongxiang Zhu, Zhao Zheng, Hongtao Wang, Qin Zhou, Yunchuan Wang, Linlin Su, Jihong Shi, Chaowu Tang and Dahai Hu
    Citation: Stem Cell Research & Therapy 2015 6:17
    Content type: Research Published on:

  44. Developing cartilage constructs with injectability, appropriate matrix composition and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Bone marrow derived mesenchymal stem...

    Authors: Ruikai Ba, Jianhua Wei, Man Li, Xiaobing Cheng, Yimin Zhao and Wei Wu
    Citation: Stem Cell Research & Therapy 2015 6:16
    Content type: Research Published on:

  45. In recent years, mesenchymal stem cells (MSCs) have been demonstrated to play an important role in carcinogenesis. However, the effect of MSCs on tumor and metastasis development and the mechanisms underlying ...

    Authors: Aleksandra V Meleshina, Elena I Cherkasova, Marina V Shirmanova, Natalia V Klementieva, Ekaterina V Kiseleva, Ludmila Ð’ Snopova, Natalia N Prodanets and Elena V Zagaynova
    Citation: Stem Cell Research & Therapy 2015 6:15
    Content type: Research Published on:

  46. Human induced pluripotent stem cells (hiPSCs) have been derived from various somatic cell types. Granulosa cells, a group of cells which surround oocytes and are obtained from the (normally discarded) retrieve...

    Authors: Ching-Yu Chuang, Mei-Chi Huang, Hsin-Fu Chen, Li-Hui Tseng, Chun-Ying Yu, Lee Stone, Hsiang-Po Huang, Hong-Nerng Ho and Hung-Chih Kuo
    Citation: Stem Cell Research & Therapy 2015 6:14
    Content type: Research Published on:

  47. High-risk neuroblastoma (HR-NB) presenting with hematogenous metastasis is one of the most difficult cancers to cure. Patient survival is poor. Aggressive tumors contain populations of rapidly proliferating cl...

    Authors: Vijayabaskar Pandian, Satishkumar Ramraj, Faizan H Khan, Tasfia Azim and Natarajan Aravindan
    Citation: Stem Cell Research & Therapy 2015 6:400
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:32

  48. Follicular fluid is important for follicular development and oocyte maturation. Evidence suggests that follicular fluid is not only rich in proteins but cells. Besides oocytes, the follicular fluid contains gr...

    Authors: Dongmei Lai, Minhua Xu, Qiuwan Zhang, Yifei Chen, Ting Li, Qian Wang, Yimeng Gao and Chunsheng Wei
    Citation: Stem Cell Research & Therapy 2015 6:13
    Content type: Research Published on:

  49. Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum ...

    Authors: Julien Rossignol, Kyle D Fink, Andrew T Crane, Kendra K Davis, Matthew C Bombard, Steven Clerc, Angela M Bavar, Steven A Lowrance, Cheng Song, Steven Witte, Laurent Lescaudron and Gary L Dunbar
    Citation: Stem Cell Research & Therapy 2015 6:9
    Content type: Research Published on:

  50. An increasing number of private clinics in Australia are marketing and providing autologous stem cell therapies to patients. Although advocates point to the importance of medical innovation and the primacy of ...

    Authors: Alison K McLean, Cameron Stewart and Ian Kerridge
    Citation: Stem Cell Research & Therapy 2015 6:33
    Content type: Review Published on:
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ISSN: 1757-6512