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  1. The mesenchymal stem cells (MSCs) were used to repair tissue injury. However, the treatment effect was not satisfactory. We investigated whether lncRNA MIR155HG could promote survival and migration of MSCs und...

    Authors: Xiao Bai, Zaiwen Qi, Mingzhen Zhu, Zhuangzhuang Lu, Xin Zhao, Lining Zhang and Guangmin Song
    Citation: Stem Cell Research & Therapy 2022 13:512
    Content type: Research Published on:

  5. Mesenchymal stem cells (MSCs) have shown immense therapeutic potential for various brain diseases. Intrathecal administration of MSCs may enhance their recruitment to lesions in the central nervous system, but...

    Authors: Ye Ran, Yankai Dong, Yuejiao Li, Jundong Xie, Shubin Zeng, Chuanlei Liang, Wei Dai, Wenjing Tang, Yaojiong Wu and Shengyuan Yu
    Citation: Stem Cell Research & Therapy 2022 13:507
    Content type: Research Published on:

  7. Authors: Qin He, Lingshu Wang, Ruxing Zhao, Fei Yan, Sha Sha, Chen Cui, Jia Song, Huiqing Hu, Xinghong Guo, Mengmeng Yang, Yixin Cui, Yujing Sun, Zheng Sun, Fuqiang Liu, Ming Dong, Xinguo Hou…
    Citation: Stem Cell Research & Therapy 2022 13:505
    Content type: Retraction Note Published on:

  9. Cell-based therapy using adipose-derived mesenchymal stem cells (ADSCs) is a promising treatment strategy for neurogenic bladder (NB) associated with spinal cord injury (SCI). However, therapeutic efficacy is ...

    Authors: Jiasheng Chen, Lin Wang, Meng Liu, Guo Gao, Weixin Zhao, Qiang Fu and Ying Wang
    Citation: Stem Cell Research & Therapy 2022 13:503
    Content type: Research Published on:

  10. Allogeneic therapeutic cells may be rejected if they express HLA alleles not found in the recipient. As finding cell donors with a full HLA match to a recipient requires vast donor pools, the use of HLA homozy...

    Authors: Jonna Clancy, Kati Hyvärinen, Jarmo Ritari, Tiina Wahlfors, Jukka Partanen and Satu Koskela
    Citation: Stem Cell Research & Therapy 2022 13:502
    Content type: Research Published on:

  11. Human dermal fibroblasts (HDFs) have the potential to differentiate into vascular endothelial cells (VECs), but their differentiation rate is low and the mechanism involved is not clear. The small molecule pat...

    Authors: XiaoLing Cui, XiaoTan Wang, Jie Wen, Xiao Li, Nan Li, XuXiao Hao, BaoXiang Zhao, Xunwei Wu and JunYing Miao
    Citation: Stem Cell Research & Therapy 2022 13:501
    Content type: Research Published on:

  12. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important curative therapy for adult acute lymphoblastic leukemia (ALL). For patients who lack a human leukocyte antigen (HLA)-matched sibli...

    Authors: Guangyu Sun, Baolin Tang, Kaidi Song, Yue Wu, Meijuan Tu, Xiang Wan, Wen Yao, Liangquan Geng, Ping Qiang and Xiaoyu Zhu
    Citation: Stem Cell Research & Therapy 2022 13:500
    Content type: Research Published on:

  13. Localized scleroderma causes cosmetic disfigurement, joint contractures, and other functional impairment, but no currently available medications can reverse the resulting skin lesions. Fat grafting is benefici...

    Authors: Jing Wang, Junrong Cai, Qian Zhang, Jiaqing Wen, Yunjun Liao and Feng Lu
    Citation: Stem Cell Research & Therapy 2022 13:499
    Content type: Research Published on:

  14. In enteric neural stem cell (ENSC) therapy for enteric neuropathy, the gut is ostensibly accessible via laparotomy, laparoscopy or endoscopy, whereas its elongated configuration and multilayered structures sub...

    Authors: Jeng-Chang Chen
    Citation: Stem Cell Research & Therapy 2022 13:498
    Content type: Short report Published on:

  16. Microvesicles (MVs) derived from human bone marrow mesenchymal stem cell (MSC) were demonstrated to restore lung protein permeability and attenuate acute lung injury. In our previous study, we found that MSC M...

    Authors: Lifang Ye, Jieqiong Song, Yijun Zheng, Ming Zhong, Jun Liu, Duming Zhu and Shuling Hu
    Citation: Stem Cell Research & Therapy 2022 13:496
    Content type: Research Published on:

  17. The repair of cranio-maxillofacial bone defects remains a formidable clinical challenge. The Ets variant 2 (ETV2) transcription factor, which belongs to the E26 transformation-specific (ETS) family, has been r...

    Authors: Jing Li, Haoran Du, Xin Ji, Yihan Chen, Yishuai Li, Boon Chin Heng and Jianguang Xu
    Citation: Stem Cell Research & Therapy 2022 13:495
    Content type: Research Published on:

  18. Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to liver cirrhosis. Accumulating evidence suggests that adipose-derived stromal cells (ADSCs)-bas...

    Authors: Baitong Wu, Jiuxing Feng, Jingyi Guo, Jian Wang, Guanghui Xiu, Jiaqi Xu, Ke Ning, Bin Ling, Qingchun Fu and Jun Xu
    Citation: Stem Cell Research & Therapy 2022 13:494
    Content type: Research Published on:

  19. Postmastectomy radiotherapy is considered to be a necessary treatment in the therapy of breast cancer, while it will cause soft tissue damage and complications, which are closely related to the success rate an...

    Authors: Haojing Tang, Yufei He, Zhuokai Liang, Jian Li, Ziqing Dong and Yunjun Liao
    Citation: Stem Cell Research & Therapy 2022 13:493
    Content type: Review Published on:

  20. Pulmonary fibrosis (PF) is a chronic and relentlessly progressive interstitial lung disease in which the accumulation of fibroblasts and extracellular matrix (ECM) induces the destruction of normal alveolar st...

    Authors: Wenzhao Cheng, Yiming Zeng and Dachun Wang
    Citation: Stem Cell Research & Therapy 2022 13:492
    Content type: Review Published on:

  21. Mesenchymal stem/stromal cells (MSCs) acquire immunosuppressive capacity only in an inflammatory microenvironment. This can be recapitulated in vitro by treating MSCs with inflammatory cytokines TNFα and IFNγ, wh...

    Authors: Chenchang Xu, Chao Feng, Peiqing Huang, Yinghong Li, Rui Liu, Chunxiao Liu, Yuyi Han, Lei Chen, Yayun Ding, Changshun Shao and Yufang Shi
    Citation: Stem Cell Research & Therapy 2022 13:491
    Content type: Research Published on:

  22. Human amniotic mesenchymal stem cells (hAMSCs) are splendid cell sources for clinical application in the administration of numerous refractory and relapse diseases. Despite the preferable prospect of serum-fre...

    Authors: Yunyan Sun, Ti-er Wang, Qianwen Hu, Wenxia Zhang, Yun Zeng, Xun Lai, Leisheng Zhang and Mingxia Shi
    Citation: Stem Cell Research & Therapy 2022 13:490
    Content type: Research Published on:

  25. Acute spinal cord injury (SCI) is a devastating result of neurological trauma with subsequent microenvironment dyshomeostasis that induces neurotoxic phenotype acquisition by astrocytes, exacerbating neurologi...

    Authors: Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu and Limin Rong
    Citation: Stem Cell Research & Therapy 2022 13:487
    Content type: Research Published on:

  26. Dental follicles are necessary for tooth eruption, surround the enamel organ and dental papilla, and regulate both the formation and resorption of alveolar bone. Dental follicle progenitor cells (DFPCs), which...

    Authors: Li Zeng, Hong He, Mingjie Sun, Xinyi Gong, Mengqi Zhou, Yaya Hong, Yongjia Wu, Xuepeng Chen and Qianming Chen
    Citation: Stem Cell Research & Therapy 2022 13:486
    Content type: Review Published on:

  27. Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is widely used as a curative treatment strategy for most types of hematological diseases. However, strategies for enhancing the graft versus ...

    Authors: Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu and Hongtao Wang
    Citation: Stem Cell Research & Therapy 2022 13:485
    Content type: Research Published on:

  28. Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-infla...

    Authors: Mingchao Zhang, Takerra K. Johnson-Stephenson, Weiran Wang, Yang Wang, Jing Li, Limin Li, Ke Zen, Xi Chen and Dihan Zhu
    Citation: Stem Cell Research & Therapy 2022 13:484
    Content type: Research Published on:

  29. Mesenchymal stem cells (MSCs) may be one of candidates for disease-modifying therapy in Parkinsonian diseases. As knowledge regarding the therapeutic properties of MSCs accumulates, some obstacles still remain...

    Authors: Jin Young Shin, Dong-Yeol Kim, Jieun Lee, Yu Jin Shin, Yi Seul Kim and Phil Hyu Lee
    Citation: Stem Cell Research & Therapy 2022 13:483
    Content type: Research Published on:

  30. Advancements in adoptive cell therapy over the last four decades have revealed various new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated immune cells that are engineere...

    Authors: Ali Keshavarz, Ali Salehi, Setareh Khosravi, Yasaman Shariati, Navid Nasrabadi, Mohammad Saeed Kahrizi, Sairan Maghsoodi, Amirhossein Mardi, Ramyar Azizi, Samira Jamali and Farnoush Fotovat
    Citation: Stem Cell Research & Therapy 2022 13:482
    Content type: Review Published on:

  32. The most serious condition of male infertility is complete Sertoli cell-only syndrome (SCOS), which refers to the lack of all spermatogenic cells in the testes. The genetic cause of SCOS remains to be explored...

    Authors: Xiaotong Wang, Zili Li, Mengyuan Qu, Chengliang Xiong and Honggang Li
    Citation: Stem Cell Research & Therapy 2022 13:480
    Content type: Research Published on:

  33. Mesenchymal stromal/stem cells (MSCs) have been intensively investigated in both pre-clinical and clinical studies. However, the therapeutic efficacy varies resulting from the heterogenicity of MSCs. Therefore...

    Authors: Lingyun Li, Lei Yang, Xian Chen, Xiangjuan Chen, Lianghui Diao, Yong Zeng and Jianyong Xu
    Citation: Stem Cell Research & Therapy 2022 13:479
    Content type: Research Published on:

  34. Human-induced pluripotent stem cell-derived retinal organoids are a valuable tool for disease modelling and therapeutic development. Many efforts have been made over the last decade to optimise protocols for t...

    Authors: Carla Sanjurjo-Soriano, Nejla Erkilic, Krishna Damodar, Hassan Boukhaddaoui, Michalitsa Diakatou, Marcela Garita-Hernandez, Daria Mamaeva, Gregor Dubois, Zhour Jazouli, Carla Jimenez-Medina, Olivier Goureau, Isabelle Meunier and Vasiliki Kalatzis
    Citation: Stem Cell Research & Therapy 2022 13:478
    Content type: Research Published on:

  35. Mesenchymal stem cells (MSCs) secrete paracrine factors and extracellular matrix proteins that contribute to their ability to support tissue healing and regeneration. Both the transcriptome and the secretome o...

    Authors: Drew W. Koch, Lauren V. Schnabel, Ilene M. Ellis, Rowan E. Bates and Alix K. Berglund
    Citation: Stem Cell Research & Therapy 2022 13:477
    Content type: Research Published on:

  36. Insulin producing cells generated by liver cell transdifferentiation, could serve as an attractive source for regenerative medicine. The present study assesses the relationship between DNA methylation pTFs ind...

    Authors: Adi Har-Zahav, Daniela Lixandru, David Cheishvili, Ioan Valentin Matei, Ioana Raluca Florea, Veronica Madalina Aspritoiu, Inna Blus-Kadosh, Irit Meivar-Levy, Andreea Madalina Serban, Irinel Popescu, Moshe Szyf, Sarah Ferber and Simona Olimpia Dima
    Citation: Stem Cell Research & Therapy 2022 13:476
    Content type: Research Published on:

  37. Crohn's disease (CD) is a chronic non-specific inflammatory bowel disease. Current CD therapeutics cannot fundamentally change the natural course of CD. Therefore, it is of great significance to find new treat...

    Authors: Fan Yang, Beibei Ni, Qiuli Liu, Fangping He, Li Li, Xuemei Zhong, Xiaofan Zheng, Jianxi Lu, Xiaoyan Chen, Huizhu Lin, Ruixuan Xu, Yizhan He, Qi Zhang, Xiaoguang Zou and Wenjie Chen
    Citation: Stem Cell Research & Therapy 2022 13:475
    Content type: Research Published on:

  38. The massive loss of follicles in the early stage of ovarian tissue transplantation is considered a significant restriction to the efficacy of ovarian tissue cryopreservation (OTC) and transplantation (OT). The...

    Authors: Jiaojiao Cheng, Xiangyan Ruan, Yanglu Li, Juan Du, Fengyu Jin, Muqing Gu, Qi Zhou, Xin Xu, Yu Yang, Husheng Wang and Alfred Otto Mueck
    Citation: Stem Cell Research & Therapy 2022 13:474
    Content type: Research Published on:

  39. More than 40% patients with diffuse large B cell lymphoma (DLBCL) experienced relapse or refractory (R/R) lymphoma after the standard first R-CHOP therapy. IL-6 was reportedly associated with chemotherapy resi...

    Authors: Jiayi Zhang, Minglu Zhong, Weijie Zhong, Yanfei Lan, Zhaohu Yuan, Yuyou Duan and Yaming Wei
    Citation: Stem Cell Research & Therapy 2022 13:473
    Content type: Research Published on:

  40. Cell therapy is the frontier technology of biotechnology innovation and the most promising method for the treatment of refractory diseases such as tumours. However, cell therapy has disadvantages, such as toxi...

    Authors: Caifeng Li, Zhao Cui, Shiwen Deng, Peng Chen, Xianyu Li and Hongjun Yang
    Citation: Stem Cell Research & Therapy 2022 13:472
    Content type: Review Published on:

  42. We previously established a human mesenchymal stem cell (MSC) line that was modified to express trophic factors. Transplanting a cell sheet produced from this line in an amyotrophic lateral sclerosis mouse mod...

    Authors: Naoto Honda, Yasuhiro Watanabe, Yuta Tokuoka and Ritsuko Hanajima
    Citation: Stem Cell Research & Therapy 2022 13:470
    Content type: Research Published on:

  43. Regularly discarded lip tissue obtained from corrective surgeries to close the cleft lip represents an easily accessible and rich source for the isolation of primary fibroblasts. Primary fibroblasts have been ...

    Authors: Ludovica Parisi, Silvia Rihs, Giorgio C. La Scala, Isabelle Schnyder, Christos Katsaros and Martin Degen
    Citation: Stem Cell Research & Therapy 2022 13:469
    Content type: Research Published on:

  44. Human-induced pluripotent stem cell (hiPSC)-derived functional hepatic endoderm (HE) is supposed to be an alternative option for replacement therapy for end-stage liver disease. However, the high heterogeneity...

    Authors: Fang Bai, Jinliang Duan, Daopeng Yang, Xingqiang Lai, Xiaofeng Zhu, Xiaoshun He and Anbin Hu
    Citation: Stem Cell Research & Therapy 2022 13:468
    Content type: Research Published on:

  45. Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) are two key transcription co-activators of the Hippo pathway. Both were originally characteriz...

    Authors: Nattaya Damkham, Chanchao Lorthongpanich, Phatchanat Klaihmon, Usaneeporn Lueangamornnara, Pakpoom Kheolamai, Kongtana Trakarnsanga and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2022 13:467
    Content type: Research Published on:

  46. Dental follicle stem cells (DFSCs) show mesenchymal stem cell properties with the potential for alveolar bone regeneration. Stem cell properties can be impaired by reactive oxygen species (ROS), prompting us t...

    Authors: Zhaosong Meng, Jiacheng Liu, Zhipeng Feng, Shuling Guo, Mingzhe Wang, Zheng Wang, Zhe Li, Hongjie Li and Lei Sui
    Citation: Stem Cell Research & Therapy 2022 13:466
    Content type: Research Published on:

  47. Inflammatory bowel diseases (IBD) are chronic relapsing–remitting inflammatory diseases of the gastrointestinal tract that are typically categorized into two subtypes: Crohn's disease (CD) and ulcerative colit...

    Authors: Yixin Ye, Xiaomei Zhang, Dongsheng Su, Yushuang Ren, Fuyi Cheng, Yunqi Yao, Gang Shi, Yanhong Ji, Shuang Chen, Pengyi Shi, Lei Dai, Xiaolan Su and Hongxin Deng
    Citation: Stem Cell Research & Therapy 2022 13:465
    Content type: Research Published on:

  48. Small airway infections caused by respiratory viruses are some of the most prevalent causes of illness and death. With the recent worldwide pandemic due to the severe acute respiratory syndrome coronavirus 2 (...

    Authors: Taylor Do, Lilly Synan, Gibran Ali and Heather Gappa-Fahlenkamp
    Citation: Stem Cell Research & Therapy 2022 13:464
    Content type: Review Published on:

  49. Urethral stricture and reconstruction are one of the thorny difficult problems in the field of urology. The continuous development of tissue engineering and biomaterials has given new therapeutic thinking to t...

    Authors: Zhenpeng Zhu, Jiayu Yang, Xing Ji, Zicheng Wang, Chengxiang Dai, Suke Li, Xuesong Li, Yajie Xie, Yudong Zheng, Jian Lin and Liqun Zhou
    Citation: Stem Cell Research & Therapy 2022 13:463
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:53

  50. Hematopoietic stem cell transplantation (HSCT) is the main treatment for acute radiation sickness, especially after fatal radiation. The determination of HSCT for radiation patients is mainly based on radiatio...

    Authors: Shixiang Zhou, Yaqiong Li, Lexin He, Min Chen, Weihong Li, Ting Xiao, Jian Guan, Zhenhua Qi, Qi Wang, Siyuan Li, Pingkun Zhou and Zhidong Wang
    Citation: Stem Cell Research & Therapy 2022 13:461
    Content type: Research Published on:
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