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  1. Recent advances in the identification and application of different stem cell types have offered alternative therapeutic approaches for clinicians. The lack of successful engraftment, migration into the injured...

    Authors: Aysa Rezabakhsh, Emel Sokullu and Reza Rahbarghazi
    Citation: Stem Cell Research & Therapy 2021 12:521
    Content type: Viewpoint Published on:

  2. Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI re...

    Authors: Hongjuan Ning, Haixu Chen, Jingyu Deng, Chun Xiao, Moyan Xu, Lina Shan, Chao Yang and Zheng Zhang
    Citation: Stem Cell Research & Therapy 2021 12:519
    Content type: Research Published on:

  3. To investigate the effect of the combination of Wharton's jelly derived mesenchymal stem cells (WJ-MSC) and high frequency repetitive electromagnetic stimulation (rEMS) in the therapy of toxic optic neuropathi...

    Authors: Emin Özmert and Umut Arslan
    Citation: Stem Cell Research & Therapy 2021 12:518
    Content type: Research Published on:

  4. Very small embryonic-like stem cells (VSELs) are a rare population within the ovarian epithelial surface. They contribute to postnatal oogenesis as they have the ability to generate immature oocytes and resist...

    Authors: Nesrine Ebrahim, Hajir A. Al Saihati, Amani Shaman, Arigue A. Dessouky, Ayman Samir Farid, Noha I. Hussien, Ola Mostafa, Yasmin Seleem, Dina Sabry, Ahmed S. Saad, Hanan Tawfeek Emam, Amira Hassouna, Omnia A. M. Badr, Bayan A. Saffaf, Nicholas R. Forsyth and Rabab F. Salim
    Citation: Stem Cell Research & Therapy 2021 12:517
    Content type: Research Published on:

  5. Adipose stromal/stem cells (ASCs) are promising candidates for future clinical applications. ASCs have regenerative capacity, low immunogenicity, and immunomodulatory ability. The success of future cell-based ...

    Authors: Miia Juntunen, Sini Heinonen, Heini Huhtala, Aila Rissanen, Jaakko Kaprio, Kirsi Kuismanen, Kirsi H. Pietiläinen, Susanna Miettinen and Mimmi Patrikoski
    Citation: Stem Cell Research & Therapy 2021 12:516
    Content type: Research Published on:

  6. Peptic ulcer is one of the most common gastrointestinal tract disorders worldwide, associated with challenges such as refractory morbidity, bleeding, interference with use of anticoagulants, and potential side...

    Authors: Mahshid Saleh, Amir Ali Sohrabpour, Mohammad Reza Mehrabi, Iman Seyhoun and Amir Abbas Vaezi
    Citation: Stem Cell Research & Therapy 2021 12:515
    Content type: Review Published on:

  7. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) seriously affects patient health. Despite the elusiveness of innate therapeutic effects, mesenchymal stromal cells (MSCs) hold great promise for infla...

    Authors: Hanchao Liu, Xinning Zhu, Xiaohui Cao, Ani Chi, Jian Dai, Zhenqing Wang, Chunhua Deng and Min Zhang
    Citation: Stem Cell Research & Therapy 2021 12:514
    Content type: Research Published on:

  8. Bones have a remarkable capacity to heal upon fracture. Yet, in large defects or compromised conditions healing processes become impaired, resulting in delayed or non-union. Current therapeutic approaches ofte...

    Authors: Wai Long Tam, Luís Freitas Mendes, Xike Chen, Raphaëlle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, Noriyuki Tsumaki, Liesbet Geris, Scott J. Roberts and Frank P. Luyten
    Citation: Stem Cell Research & Therapy 2021 12:513
    Content type: Research Published on:

  9. Considerable experimental and clinical evidences have proved that human umbilical cord mesenchymal stem cells (UC-MSCs) transplantation was powerful in systemic lupus erythematosus (SLE) treatment. MSCs could ...

    Authors: Wang Chun, Jilai Tian and Ying Zhang
    Citation: Stem Cell Research & Therapy 2021 12:512
    Content type: Research Published on:

  11. Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the cellular reprogramming including generation of in...

    Authors: Yoichi Sekita, Yuki Sugiura, Akari Matsumoto, Yuki Kawasaki, Kazuya Akasaka, Ryo Konno, Momoka Shimizu, Toshiaki Ito, Eiji Sugiyama, Terushi Yamazaki, Eriko Kanai, Toshinobu Nakamura, Makoto Suematsu, Fumitoshi Ishino, Yoshio Kodera, Takashi Kohda…
    Citation: Stem Cell Research & Therapy 2021 12:510
    Content type: Research Published on:

  12. Authors: Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet
    Citation: Stem Cell Research & Therapy 2021 12:509
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2015 6:211

  13. The c.G6055A (p.G2019S) mutation in leucine-rich repeat kinase 2 (LRRK2) is the most prevalent genetic cause of Parkinson’s disease (PD). CRISPR/Cas9-mediated genome editing by homology-directed repair (HDR) has ...

    Authors: Kuo-Hsuan Chang, Cheng-Yen Huang, Chih-Hsin Ou-Yang, Chang-Han Ho, Han-Yi Lin, Chia-Lang Hsu, You-Tzung Chen, Yu-Chi Chou, Yi-Jing Chen, Ying Chen, Jia-Li Lin, Ji-Kuan Wang, Pei-Wen Lin, Ying-Ru Lin, Miao-Hsia Lin, Chi-Kang Tseng…
    Citation: Stem Cell Research & Therapy 2021 12:508
    Content type: Research Published on:

  14. Our previous study proved that Salvia miltiorrhiza could enhance fat graft survival by promoting adipogenesis. However, the effect of salvianolic acid B (Sal-B), the most abundant and bioactive water-soluble comp...

    Authors: Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Chio-Hou Chong, Dan-Ning Zheng, Yi-Fan Zhang and Li Yu
    Citation: Stem Cell Research & Therapy 2021 12:507
    Content type: Research Published on:

  15. Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in th...

    Authors: Shun Takao, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Shinya Takahashi, Ayumu Nakashima and Noboru Hattori
    Citation: Stem Cell Research & Therapy 2021 12:506
    Content type: Research Published on:

  16. Sympathetic activity plays an important role in the proliferation and differentiation of stem cells, and it changes over time, thereby exerting differential effects on various stem cell types. Aging causes sym...

    Authors: Shiguo Yuan, Sheng Zheng, Kai Zheng, Yanping Gao, Meixiong Chen, Yikai Li and Xiaochun Bai
    Citation: Stem Cell Research & Therapy 2021 12:505
    Content type: Research Published on:

  17. Mesenchymal stem cells (MSCs), known from their key role in the regeneration process of tissues, and their abilities to release bioactive factors like extracellular vesicles (EVs) could be considered as a pote...

    Authors: Magdalena M. Kraińska, Natalia Pietrzkowska, Eliza Turlej, Li Zongjin and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2021 12:504
    Content type: Review Published on:

  18. Approximately one third of patients undergoing core decompression (CD) for early-stage osteonecrosis of the femoral head (ONFH) experience progression of the disease, and subsequently require total hip arthrop...

    Authors: Roberto Alfonso Guzman, Masahiro Maruyama, Seyedsina Moeinzadeh, Elaine Lui, Ning Zhang, Hunter W. Storaci, Kaysie Tam, Elijah Ejun Huang, Takeshi Utsunomiya, Claire Rhee, Qi Gao, Zhenyu Yao, Yunzhi Peter Yang and Stuart B. Goodman
    Citation: Stem Cell Research & Therapy 2021 12:503
    Content type: Research Published on:

  19. Although the immunomodulatory properties of mesenchymal stem cells (MSCs) have been highlighted as a new therapy for autoimmune diseases, including rheumatoid arthritis (RA), the disease-specific characteristi...

    Authors: Hyeon-Jeong Lee, Won-Jae Lee, Sun-Chul Hwang, Yongho Choe, Saetbyul Kim, Eunyeong Bok, Sangyeob Lee, Seung-Joon Kim, Hyun-Ok Kim, Sun-A Ock, Hae-Sook Noh, Gyu-Jin Rho, Sang-Il Lee and Sung-Lim Lee
    Citation: Stem Cell Research & Therapy 2021 12:502
    Content type: Research Published on:

  20. Hyperpigmentation of skin is caused by an imbalance between the melanosome/melanin synthesis in melanocytes and the melanosome/melanin degradation in keratinocytes. Although studies showed that stem cells play...

    Authors: Xiao-Yu Wang, Xiao-Hui Guan, Zhen-Ping Yu, Jie Wu, Qi-Ming Huang, Ke-Yu Deng and Hong-Bo Xin
    Citation: Stem Cell Research & Therapy 2021 12:501
    Content type: Research Published on:

  21. The advent of next-generation genome engineering tools like CRISPR-Cas9 has transformed the field of gene therapy, rendering targeted treatment for several incurable diseases. Hematopoietic stem and progenitor...

    Authors: Manoj Kumar K. Azhagiri, Prathibha Babu, Vigneshwaran Venkatesan and Saravanabhavan Thangavel
    Citation: Stem Cell Research & Therapy 2021 12:500
    Content type: Review Published on:

  22. Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). MS affects millions of people and causes a great economic and societal burden. There is no cure for MS. We use...

    Authors: Christina Brown, Christina McKee, Sophia Halassy, Suleiman Kojan, Doug L. Feinstein and G. Rasul Chaudhry
    Citation: Stem Cell Research & Therapy 2021 12:499
    Content type: Research Published on:

  23. Cross talk between cancer cells and the immune system is determinant for cancer progression. Emerging evidence demonstrates that GC characteristics such as metastasis, treatment resistance, and disease recurre...

    Authors: Jared Becerril-Rico, Eduardo Alvarado-Ortiz, Mariel E. Toledo-Guzmán, Rosana Pelayo and Elizabeth Ortiz-Sánchez
    Citation: Stem Cell Research & Therapy 2021 12:498
    Content type: Review Published on:

  24. Adipose-derived mesenchymal stem cells (ADSC)-based therapy is an outstanding treatment strategy for ischaemic disease. However, the therapeutic efficacy of this strategy is not ideal due to the poor paracrine...

    Authors: Yanan Tang, Jiayan Li, Weiyi Wang, Bingyi Chen, Jinxing Chen, Zekun Shen, Jiaxuan Hou, Yifan Mei, Shuang Liu, Liwei Zhang, Zongjin Li and Shaoying Lu
    Citation: Stem Cell Research & Therapy 2021 12:497
    Content type: Research Published on:

  25. Fulminant hepatitis is a severe life-threatening clinical condition with rapid progressive loss of liver function. It is characterized by massive activation and infiltration of immune cells into the liver and ...

    Authors: Lijie Pan, Chang Liu, Qiuli Liu, Yanli Li, Cong Du, Xinmei Kang, Shuai Dong, Zhuowei Zhou, Huaxin Chen, Xiaoqi Liang, Jiajie Chu, Yan Xu and Qi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:496
    Content type: Research Published on:

  26. Feline adipose-derived mesenchymal stem cells (ASCs) engage with a variety of immune cells and have been used in several clinical trials for the treatment of inflammatory and immune-dysregulated diseases in ca...

    Authors: Nopmanee Taechangam, Naomi J. Walker and Dori L. Borjesson
    Citation: Stem Cell Research & Therapy 2021 12:495
    Content type: Research Published on:

  28. Authors: Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu
    Citation: Stem Cell Research & Therapy 2021 12:493
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:394

  29. It is postulated as a general concept of cancer stem cells (CSCs) that they can produce cancer cells overtly and repopulate cancer progenitor cells indefinitely. The CSC niche is part of a specialized cancer m...

    Authors: Kenly Wuputra, Chia-Chen Ku, Kohsuke Kato, Deng-Chyang Wu, Shigeo Saito and Kazunari K. Yokoyama
    Citation: Stem Cell Research & Therapy 2021 12:492
    Content type: Review Published on:

  31. Authors: Yan Li, Jian Zhang, Jihong Shi, Kaituo Liu, Xujie Wang, Yanhui Jia, Ting He, Kuo Shen, Yunchuan Wang, Jiaqi Liu, Wei Zhang, Hongtao Wang, Zhao Zheng and Dahai Hu
    Citation: Stem Cell Research & Therapy 2021 12:490
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:221

  32. Adipose-derived stem cells are frequently used for bone regeneration both in vitro and in vivo. N6-methyladenosine (m6A) is the most abundant post-transcriptional modification on eukaryotic RNAs and plays multifa...

    Authors: Wentian Sun, Yidan Song, Kai Xia, Liyuan Yu, Xinqi Huang, Zhihe Zhao and Jun Liu
    Citation: Stem Cell Research & Therapy 2021 12:489
    Content type: Research Published on:

  33. Human mesenchymal stem cells from dental pulp (hMSC-DP), including dental pulp stem cells from permanent teeth and exfoliated deciduous teeth, possess unique MSC characteristics such as expression of specific ...

    Authors: Lan Ma, Zhiqing Huang, Di Wu, Xiaoxing Kou, Xueli Mao and Songtao Shi
    Citation: Stem Cell Research & Therapy 2021 12:488
    Content type: Research Published on:

  34. Acute lung injury (ALI) is a common lung disorder that affects millions of people every year. The infiltration of inflammatory cells into the lungs and death of the alveolar epithelial cells are key factors to...

    Authors: Junwen Han, Gu Li, Minmin Hou, Julie Ng, Min-Young Kwon, Kevin Xiong, Xiaoliang Liang, Elizabeth Taglauer, Yuanyuan Shi, S. Alex Mitsialis, Stella Kourembanas, Souheil El-Chemaly, James A. Lederer, Ivan O. Rosas, Mark A. Perrella and Xiaoli Liu
    Citation: Stem Cell Research & Therapy 2021 12:487
    Content type: Research Published on:

  35. Alopecia refers to a condition developed by gradual reduction of hair loss by various abnormal causes such as endocrine system, genetic factors, and stress. Stromal vascular fraction (SVF) isolated from the fa...

    Authors: Sun Jong Kim, Myung Jin Kim, Young Jun Lee, Joo Chan Lee, Ji Hyang Kim, Do Ha Kim, Young Hoo Do, Jun Woo Choi, Sung Ill Chung and Byung-Rok Do
    Citation: Stem Cell Research & Therapy 2021 12:486
    Content type: Short report Published on:

  36. Achondroplasia (ACH) is the most common genetic form of dwarfism and belongs to dominant monogenic disorder caused by a gain-of-function point mutation in the transmembrane region of FGFR3. There are no effective...

    Authors: Huan Zou, Mingfeng Guan, Yundong Li, Fang Luo, Wenyuan Wang and Yiren Qin
    Citation: Stem Cell Research & Therapy 2021 12:485
    Content type: Research Published on:

  37. Senile osteoporosis can cause bone fragility and increased risk for fractures and has been one of the most prevalent and severe diseases affecting the elderly population worldwidely. The underlying mechanisms ...

    Authors: Chao Ma, Juan Gao, Jun Liang, Weixiang Dai, Zhenfei Wang, Mengjiao Xia, Tao Chen, Sen Huang, Jian Na, Long Xu, Shiming Feng, Kerong Dai and Guangwang Liu
    Citation: Stem Cell Research & Therapy 2021 12:484
    Content type: Research Published on:

  38. The administration of mesenchymal stem cells (MSCs) remains the most promising approach for cardiac repair after myocardial infarct (MI). However, their poor survival and potential in the ischemic environment ...

    Authors: Zhou Ji, Songsheng Chen, Jin Cui, Weiguang Huang, Rui Zhang, Jianrui Wei and Shaoheng Zhang
    Citation: Stem Cell Research & Therapy 2021 12:483
    Content type: Research Published on:

  39. Human mesenchymal stem cells (hMSCs) therapy has recently been considered a promising treatment for atopic dermatitis (AD) due to their immunomodulation and tissue regeneration ability. In our previous studies...

    Authors: Nari Shin, Namhee Jung, Seung-Eun Lee, Dasom Kong, Nam Gyo Kim, Myung Geun Kook, Hwanhee Park, Soon Won Choi, Seunghee Lee and Kyung-Sun Kang
    Citation: Stem Cell Research & Therapy 2021 12:482
    Content type: Research Published on:

  40. Adipose tissue (AT) has become a source of mesenchymal stromal/stem cells (MSC) for regenerative medicine applications, in particular skeletal disorders. Several enzymatic or mechanical procedures have been pr...

    Authors: Giulia Casari, Elisa Resca, Andrea Giorgini, Olivia Candini, Tiziana Petrachi, Maria Serena Piccinno, Elisabetta Manuela Foppiani, Lucrezia Pacchioni, Marta Starnoni, Massimo Pinelli, Giorgio De Santis, Filippo Selleri, Fabio Catani, Massimo Dominici and Elena Veronesi
    Citation: Stem Cell Research & Therapy 2021 12:481
    Content type: Research Published on:

  41. In human subcutaneous adipose tissue, the superficial fascia distinguishes superficial and deep microenvironments showing extensions called retinacula cutis. The superficial subcutaneous adipose tissue has bee...

    Authors: Leandra Santos Baptista, Isis Côrtes, Bianca Montenegro, Cesar Claudio-da-Silva, Marielle Bouschbacher, Lara Jobeili, Celine Auxenfans and Dominique Sigaudo-Roussel
    Citation: Stem Cell Research & Therapy 2021 12:480
    Content type: Research Published on:

  42. Authors: Ryota Chijimatsu, Satoshi Miwa, Gensuke Okamura, Junya Miyahara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuji Maenohara, Shinsaku Tsuji, Shin Sameshima, Kentaro Takagi, Keiu Nakazato, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi…
    Citation: Stem Cell Research & Therapy 2021 12:479
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:405

  43. Sjögren's syndrome (SS) is a chronic, systemic autoimmune disorder characterized by sicca syndrome and/or systemic manifestations. The disease severely affects the health and life of patients, and the treatmen...

    Authors: Boya Li, Yixiao Xing, Yehua Gan, Jing He and Hong Hua
    Citation: Stem Cell Research & Therapy 2021 12:478
    Content type: Research Published on:

  44. Osteoarthritis (OA) is the most common joint degenerative disorder, with little effective therapy to date. Nanofat is a cocktail of cells obtained from fat tissue, which possesses regenerative capacity and has...

    Authors: Zuxiang Chen, Yanzhi Ge, Li Zhou, Ting Li, Bo Yan, Junjie Chen, Jiefeng Huang, Wenxi Du, Shuaijie Lv, Peijian Tong and Letian Shan
    Citation: Stem Cell Research & Therapy 2021 12:477
    Content type: Research Published on:

  45. An extra copy of chromosome 21 in humans can alter cellular phenotypes as well as immune and metabolic systems. Down syndrome is associated with many health-related problems and age-related disorders including...

    Authors: Akiko Tanuma-Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Ryo Takagi, Ayumi Yamaguchi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Aikou Okamoto and Akihiro Umezawa
    Citation: Stem Cell Research & Therapy 2021 12:476
    Content type: Research Published on:

  46. Uterine tissue engineering can provide the opportunity for curing female infertility. Natural scaffold is a good choice to recapitulate the architecture and functionality of the native tissue. In this study, w...

    Authors: Nouri Arezoo, Hajian Mohammad and Monsefi Malihezaman
    Citation: Stem Cell Research & Therapy 2021 12:475
    Content type: Research Published on:

  47. Endometrial stem/progenitor cells have been proved to exist in periodically regenerated female endometrium and can be divided into three categories: endometrial epithelial stem/progenitor cells, CD140b+CD146+ or ...

    Authors: Yue Kong, Yang Shao, Chunxia Ren and Gong Yang
    Citation: Stem Cell Research & Therapy 2021 12:474
    Content type: Review Published on:

  48. Adipose tissue-derived stem cells (ADSCs) autologous transplantation has been a promising strategy for aging-related disorders. However, the relationship between ADSCs senescence and organismal aging has not b...

    Authors: Keya Li, Guiying Shi, Xuepei Lei, Yiying Huang, Xinyue Li, Lin Bai and Chuan Qin
    Citation: Stem Cell Research & Therapy 2021 12:473
    Content type: Research Published on:

  49. Mesenchymal stem cells (MSCs) repair injured tissue in a paracrine manner. To enhance their therapeutic properties, preconditioning with various factors has been researched. We have previously showed that MSCs...

    Authors: Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ryo Kanai, Satoshi Maeda, Shinya Takahashi, Masataka Nagao and Takao Masaki
    Citation: Stem Cell Research & Therapy 2021 12:472
    Content type: Research Published on:

  50. Aldehyde dehydrogenase (ALDH) is highly expressed in stem/progenitor cells in various tissues, and cell populations with high ALDH activity (ALDHbr) are associated with tissue repair. However, little is known abo...

    Authors: Hiroshi Takahashi, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada and Noboru Hattori
    Citation: Stem Cell Research & Therapy 2021 12:471
    Content type: Research Published on:
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