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  1. The side effects of busulfan on male reproduction are serious, so fertility preservation in children undergoing busulfan treatment is a major worldwide concern. Human placental mesenchymal stem cells (hPMSCs) ...

    Authors: Jiafeng Lu, Zhenxing Liu, Mingkai Shu, Liya Zhang, Wenjuan Xia, Liuna Tang, Jincheng Li, Boxian Huang and Hong Li
    Citation: Stem Cell Research & Therapy 2021 12:199
    Content type: Research Published on:

  2. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable nonbacterial inflammatory disease. Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs, iMSCs) h...

    Authors: Xufeng Peng, Hailin Guo, Ji Yuan, Yu Chen, Yuguo Xia, Lin Wang, Ying Wang, Yichen Huang, Hua Xie, Yang Wang and Fang Chen
    Citation: Stem Cell Research & Therapy 2021 12:198
    Content type: Research Published on:

  4. The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation of extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP),...

    Authors: Xiangnan Zhao, Yue Liu, Pingping Jia, Hui Cheng, Chen Wang, Shang Chen, Haoyan Huang, Zhibo Han, Zhong-Chao Han, Krzysztof Marycz, Xiaoniao Chen and Zongjin Li
    Citation: Stem Cell Research & Therapy 2021 12:196
    Content type: Research Published on:

  5. Propofol can have adverse effects on developing neurons, leading to cognitive disorders, but the mechanism of such an effect remains elusive. Here, we aimed to investigate the effect of propofol on neuronal de...

    Authors: Xiaoqing Fan, Haoran Yang, Lizhu Hu, Delong Wang, Ruiting Wang, Aijun Hao and Xueran Chen
    Citation: Stem Cell Research & Therapy 2021 12:195
    Content type: Research Published on:

  6. While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells...

    Authors: Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank…
    Citation: Stem Cell Research & Therapy 2021 12:194
    Content type: Research Published on:

  7. Life-long peritoneal dialysis (PD) as a renal replacement therapy is limited by peritoneal fibrosis. Previous studies showed immunomodulatory and antifibrotic effects of adipose-derived mesenchymal stem cells ...

    Authors: Chih-Yu Yang, Pu-Yuan Chang, Jun-Yi Chen, Bo-Sheng Wu, An-Hang Yang and Oscar Kuang-Sheng Lee
    Citation: Stem Cell Research & Therapy 2021 12:193
    Content type: Research Published on:

  8. Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical applications have received much attention from the global scientific community in an increasing manner. Firstly, MSCs wer...

    Authors: Alexander Markov, Lakshmi Thangavelu, Surendar Aravindhan, Angelina Olegovna Zekiy, Mostafa Jarahian, Max Stanley Chartrand, Yashwant Pathak, Faroogh Marofi, Somayeh Shamlou and Ali Hassanzadeh
    Citation: Stem Cell Research & Therapy 2021 12:192
    Content type: Review Published on:

  9. The objective was to explore the therapeutic effect of autologous adipose-derived stem cells (ADSCs) combined with ShakeGelâ„¢3D transplantation to activate the BMP7-Smad5 signaling pathway to treat intrauterine...

    Authors: Yun-xia Zhao, Shao-rong Chen, Qiao-yi Huang, Wei-can Chen, Tian Xia, Yan-chuan Shi, Hong-zhi Gao, Qi-yang Shi and Shu Lin
    Citation: Stem Cell Research & Therapy 2021 12:191
    Content type: Research Published on:

  10. Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could ...

    Authors: Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak and Heikki Ruskoaho
    Citation: Stem Cell Research & Therapy 2021 12:190
    Content type: Research Published on:

  11. The potential of regenerative medicine to improve human health has led to the rapid expansion of stem cell clinics throughout the world with varying levels of regulation and oversight. This has led to a market...

    Authors: Javier Chavez, Neal A. Shah, Severin Ruoss, Raphael E. Cuomo, Samuel R. Ward and Tim K. Mackey
    Citation: Stem Cell Research & Therapy 2021 12:189
    Content type: Research Published on:

  12. Neural stem cell (NSC) therapy remains one of the most potential approaches for the treatment of neurological disorders. The discovery of human induced pluripotent stem cells (hiPSCs) and the establishment of ...

    Authors: Shuai Li, Huifang Zhao, Xiaobo Han, Bin Ni, Lang He, Omar Mukama, Jean de Dieu Habimana, Zuoxian Lin, Rongqi Huang, Hualin Huang, Chao Tian, Feng Tang and Zhiyuan Li
    Citation: Stem Cell Research & Therapy 2021 12:188
    Content type: Research Published on:

  13. Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regenerati...

    Authors: Ashley A. Krull, Deborah O. Setter, Tania F. Gendron, Sybil C. L. Hrstka, Michael J. Polzin, Joseph Hart, Amel Dudakovic, Nicolas N. Madigan, Allan B. Dietz, Anthony J. Windebank, Andre J. van Wijnen and Nathan P. Staff
    Citation: Stem Cell Research & Therapy 2021 12:187
    Content type: Research Published on:

  14. Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-renewal capacity, would account not only for the tumor growth, the peritoneal metastasis, and the relapse, but also for the acquisition ...

    Authors: Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang and Xingsheng Yang
    Citation: Stem Cell Research & Therapy 2021 12:186
    Content type: Research Published on:

  15. This study aims to investigate whether apoptosis repressor with caspase recruitment domain (ARC) could promote survival and enhance osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMS...

    Authors: Longwei Hu, Yang Wang, Hongya Pan, Kathreena Kadir, Jin Wen, Siyi Li and Chenping Zhang
    Citation: Stem Cell Research & Therapy 2021 12:185
    Content type: Research Published on:

  16. Acute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular inflammation and permeability and is a major cause of mortality in many criti...

    Authors: Maria Florian, Jia-Pey Wang, Yupu Deng, Luciana Souza-Moreira, Duncan J. Stewart and Shirley H. J. Mei
    Citation: Stem Cell Research & Therapy 2021 12:184
    Content type: Research Published on:

  17. Peripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the most advanced stage of PAD, can cause nonhealing ulcers and strong chron...

    Authors: Yuan-chi Teng, Alfredo Leonardo Porfírio-Sousa, Giulia Magri Ribeiro, Marcela Corso Arend, Lindolfo da Silva Meirelles, Elizabeth Suchi Chen, Daniela Santoro Rosa and Sang Won Han
    Citation: Stem Cell Research & Therapy 2021 12:183
    Content type: Research Published on:

  18. Sjögren’s syndrome (SS) is a chronic autoimmune disease primarily characterized by inflammation in the salivary and lacrimal glands. Activated T cells contribute to disease pathogenesis by producing proinflamm...

    Authors: Mayu Matsumura-Kawashima, Kenichi Ogata, Masafumi Moriyama, Yuka Murakami, Tatsuya Kawado and Seiji Nakamura
    Citation: Stem Cell Research & Therapy 2021 12:182
    Content type: Research Published on:

  19. The bone marrow mesenchymal stem cell (BMSCs)-derived extracellular vesicles (EVs) open up a new avenue for ulcerative colitis (UC) treatment recently, but they are not selectively enriched in targeted tissues...

    Authors: Ting Yu, Si Chu, Xingxing Liu, Junyi Li, Qianyun Chen, Meng Xu, Hui Wu, Mingyue Li, Yalan Dong, Feng Zhu, Haifeng Zhou, Desheng Hu and Heng Fan
    Citation: Stem Cell Research & Therapy 2021 12:181
    Content type: Research Published on:

  20. Severe peripheral nerve injury significantly affects patients’ quality of life and induces neuropathic pain. Neural crest stem cells (NCSCs) exhibit several attractive characteristics for cell-based therapies ...

    Authors: Yang Zhang, Xiang Xu, Yuxin Tong, Xijie Zhou, Jian Du, In Young Choi, Shouwei Yue, Gabsang Lee, Blake N. Johnson and Xiaofeng Jia
    Citation: Stem Cell Research & Therapy 2021 12:180
    Content type: Research Published on:

  21. Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical...

    Authors: Zhuoqun Fang, Penghong Chen, Shijie Tang, Aizhen Chen, Chaoyu Zhang, Guohao Peng, Ming Li and Xiaosong Chen
    Citation: Stem Cell Research & Therapy 2021 12:179
    Content type: Review Published on:

  22. Premature ovarian insufficiency (POI) is one of the major causes of infertility. We previously demonstrated that transplantation of menstrual blood-derived stromal cells (MenSCs) effectively improved ovarian f...

    Authors: Siwen Zhang, Boxian Huang, Peng Su, Qiyuan Chang, Pingping Li, Aixin Song, Xinyang Zhao, Zhengwei Yuan and Jichun Tan
    Citation: Stem Cell Research & Therapy 2021 12:178
    Content type: Research Published on:

  23. Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs) inadequately recapitulate complete development and result in PSC-derived cardiomyocytes (PSC-CMs) with an immature or fe...

    Authors: Jessica C. Garbern and Richard T. Lee
    Citation: Stem Cell Research & Therapy 2021 12:177
    Content type: Review Published on:

  24. Obesity has received increasing attention because of its widespread worldwide occurrence and many threats to health. Human adipose-derived mesenchymal stem cells (hADSCs) are a critical source of adipocytes. L...

    Authors: Haoying Xu, Yanlei Yang, Linyuan Fan, Luchan Deng, Junfen Fan, Di Li, Hongling Li and Robert Chunhua Zhao
    Citation: Stem Cell Research & Therapy 2021 12:176
    Content type: Research Published on:

  25. Cellular therapy based on mesenchymal stem cells (MSCs) is a promising novel therapeutic strategy for the osteonecrosis of the femoral head (ONFH), which is gradually becoming popular, particularly for early-s...

    Authors: Meiling Zhou, Jiaoya Xi, Yaofeng Cheng, Denglong Sun, Peng Shu, Shuiqing Chi, Shuo Tian and Shunan Ye
    Citation: Stem Cell Research & Therapy 2021 12:175
    Content type: Research Published on:

  26. Spinal cord injury (SCI) is a debilitating medical condition that can result in the irreversible loss of sensorimotor function. Current therapies fail to provide an effective recovery being crucial to develop ...

    Authors: Wenshu Zhou, Marta Silva, Chun Feng, Shumei Zhao, Linlin Liu, Shuai Li, Jingmei Zhong and Wenhua Zheng
    Citation: Stem Cell Research & Therapy 2021 12:174
    Content type: Research Published on:

  27. Osteoporosis (OP) is a metabolic bone disease due to the imbalance of osteogenesis and bone resorption, in which, bone marrow mesenchymal stem cells (BMSCs) have a significant effect as the seed cells. Recent ...

    Authors: Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen and Liaobin Chen
    Citation: Stem Cell Research & Therapy 2021 12:173
    Content type: Research Published on:

  28. Spinal cord injury (SCI) is a common disease that results in motor and sensory disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic stem cells (ESCs), induced pluripotent...

    Authors: Desheng Kong, Baofeng Feng, Asiamah Ernest Amponsah, Jingjing He, Ruiyun Guo, Boxin Liu, Xiaofeng Du, Xin Liu, Shuhan Zhang, Fei Lv, Jun Ma and Huixian Cui
    Citation: Stem Cell Research & Therapy 2021 12:172
    Content type: Research Published on:

  29. Renal interstitial fibrosis, an important pathological feature of kidney aging and chronic renal failure, is regulated by mesenchymal stem cells (MSCs). We have previously demonstrated low expression of miR-13...

    Authors: Dan Cao, Yuan Wang, Yingjie Zhang, Yinping Zhang, Qi Huang, Zhong Yin, Guangyan Cai, Xiangmei Chen and Xuefeng Sun
    Citation: Stem Cell Research & Therapy 2021 12:171
    Content type: Research Published on:

  30. Skin wounds in diabetic patients hardly recover. Accumulating evidence has shown that mammalian target of rapamycin (mTOR) pathway and myeloid-derived suppressor cells (MDSCs) are involved in inflammatory-rela...

    Authors: Yi Li, Yujun Xu, Xinghan Liu, Xin Yan, Yue Lin, Qian Tan and Yayi Hou
    Citation: Stem Cell Research & Therapy 2021 12:170
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:494

  31. New mechanistic insights into the self-renewal ability and multipotent properties of neural stem cells (NSCs) are currently under active investigation for potential use in the treatment of neurological disease...

    Authors: Jiaoying Jia, Yan Cui, Zhigang Tan, Min Liu and Yugang Jiang
    Citation: Stem Cell Research & Therapy 2021 12:169
    Content type: Research Published on:

  32. Retina diseases may lead to blindness as they often afflict both eyes. Stem cell transplantation into the affected eye(s) is a promising therapeutic strategy for certain retinal diseases. Human peripheral bloo...

    Authors: Jianfa Huang, Bikun Xian, Yuting Peng, Baozhu Zeng, Weihua Li, Zhiquan Li, Yaojue Xie, Minglei Zhao, Hening Zhang, Minyi Zhou, Huan Yu, Peixin Wu, Xing Liu and Bing Huang
    Citation: Stem Cell Research & Therapy 2021 12:168
    Content type: Research Published on:

  33. Brown adipocytes (BAs) are major components of brown adipose tissue (BAT), which is involved in blood pressure regulation. BAs are derived from multiple progenitors, including PDGFRα+ adipose-derived stem cells (...

    Authors: Wenda Xi, Wendong Chen, Weihong Sun, Xiangxiao Li, Zhimin Suo, Gonghao Jiang, Pingjin Gao and Qun Li
    Citation: Stem Cell Research & Therapy 2021 12:167
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:351

  34. Coronary artery disease (CAD) is the leading cause of death worldwide. Chromosome locus 9p21 was the first to be associated with increased risk of CAD and coronary artery calcification (CAC). Vascular calcific...

    Authors: Anja Trillhaase, Beatrice Schmidt, Marlon Märtens, Undine Haferkamp, Jeanette Erdmann and Zouhair Aherrahrou
    Citation: Stem Cell Research & Therapy 2021 12:166
    Content type: Research Published on:

  35. Growing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors. Fibronectin (FN), fibroblas...

    Authors: Lingling Chen, Morgan Carlton, Xiaodan Chen, Navdeep Kaur, Hollie Ryan, Tony J Parker, Zhengmei Lin, Yin Xiao and Yinghong Zhou
    Citation: Stem Cell Research & Therapy 2021 12:165
    Content type: Research Published on:

  36. Mesenchymal stem cells (MSCs) are derived from multiple tissues, including amniotic fluid (AF-MSCs) and the umbilical cord (UC-MSCs). Although the therapeutic effect of MSCs on sepsis is already known, researc...

    Authors: Rui Chen, Yingjun Xie, Xuan Zhong, Fei Chen, Yu Gong, Na Wang and Ding Wang
    Citation: Stem Cell Research & Therapy 2021 12:164
    Content type: Research Published on:

  37. Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton’s jelly-derived mes...

    Authors: Yongjian Qi, Bin Li, Yinxian Wen, Xu Yang, Biao Chen, Zheng He, Zhe Zhao, Jacques Magdalou, Hui Wang and Liaobin Chen
    Citation: Stem Cell Research & Therapy 2021 12:163
    Content type: Research Published on:

  38. Recovery of muscle function after peripheral nerve injury is often poor, and this can be attributed to muscle fiber atrophy and cell death. In the current study, we have investigated the effects of stromal vas...

    Authors: R. El-Habta, G. Andersson, P. J. Kingham and L. J. Backman
    Citation: Stem Cell Research & Therapy 2021 12:162
    Content type: Research Published on:

  39. Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level...

    Authors: Yun-Xing Fu, Jing Ji, Fang Shan, Jialing Li and Rong Hu
    Citation: Stem Cell Research & Therapy 2021 12:161
    Content type: Review Published on:

  40. Autologous fat grafting is often a crucial aspect of reconstructive and aesthetic surgeries, yet poor graft retention is a major issue with this technique. Enriching fat grafts with adipose tissue-derived mese...

    Authors: Richard J. P. Smith, Alessandro Faroni, James R. Barrow, Jamie Soul and Adam J. Reid
    Citation: Stem Cell Research & Therapy 2021 12:160
    Content type: Research Published on:

  41. Dental pulp stem cells (DPSCs) are a promising cell source in endodontic regeneration and tissue engineering with limited self-renewal and pluripotency capacity. N6-methyladenosine (m6A) is the most prevalent, re...

    Authors: Haiyun Luo, Wenjing Liu, Yanli Zhang, Yeqing Yang, Xiao Jiang, Shiqing Wu and Longquan Shao
    Citation: Stem Cell Research & Therapy 2021 12:159
    Content type: Research Published on:

  42. The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety...

    Authors: Lingfei Zhao, Chenxia Hu, Fei Han, Dajin Chen, Jun Cheng, Jianyong Wu, Wenhan Peng and Jianghua Chen
    Citation: Stem Cell Research & Therapy 2021 12:158
    Content type: Research Published on:

  43. As one of the most common chronic diseases in the world, osteoporosis occurs especially in postmenopausal women. Circular RNAs (circRNAs) are emerging as major drivers in human disease. The aim of the present ...

    Authors: Feng Zhi, Yi Ding, Rong Wang, Yujiao Yang, Kaiming Luo and Fei Hua
    Citation: Stem Cell Research & Therapy 2021 12:157
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:381

  44. Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, ca...

    Authors: Yu-kun Yang, Ye Li, Yan-ying Wang, Guang-ping Ruan, Chuan Tian, Qiang Wang, Huan-yu He, Gao-hong Zhu, Dong Fang, Mao Wang, Xiang-qing Zhu and Xing-hua Pan
    Citation: Stem Cell Research & Therapy 2021 12:156
    Content type: Research Published on:

  45. A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multi...

    Authors: Rodrigo N. Riedel, Antonio Pérez-Pérez, Víctor Sánchez-Margalet, Cecilia L. Varone and Julieta L. Maymó
    Citation: Stem Cell Research & Therapy 2021 12:155
    Content type: Review Published on:

  46. Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG.

    Authors: Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li and De-Zhi Tang
    Citation: Stem Cell Research & Therapy 2021 12:154
    Content type: Research Published on:

  47. Mesenchymal stem cells (MSCs) have been utilized in treating acute graft-versus-host disease (aGvHD) as they show strong immunosuppressive capacity through the release of various mediators, including immunosup...

    Authors: Weijiang Liu, Na Zhou, Yuanlin Liu, Wei Zhang, Xue Li, Yang Wang, Rongxiu Zheng and Yi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:153
    Content type: Research Published on:

  48. Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed, immunomodulatory and anti-inflammatory properties, assoc...

    Authors: Miryam Mebarki, Camille Abadie, Jérôme Larghero and Audrey Cras
    Citation: Stem Cell Research & Therapy 2021 12:152
    Content type: Review Published on:

  50. Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients...

    Authors: Linli Shi, Qian Han, Yimei Hong, Weifeng Li, Gencheng Gong, Jiangyu Cui, Mengmeng Mao, Xiaoting Liang, Bei Hu, Xin Li, Qun Luo and Yuelin Zhang
    Citation: Stem Cell Research & Therapy 2021 12:147
    Content type: Research Published on:
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