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  1. Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepa...

    Authors: Tingcai Pan, Jiawang Tao, Yan Chen, Jiaye Zhang, Anteneh Getachew, Yuanqi Zhuang, Ning Wang, Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang, Xianhua Lin, Kai You, Yi Gao and Yin-xiong Li
    Citation: Stem Cell Research & Therapy 2021 12:151
    Content type: Research Published on:

  2. Little is known about the implications of circRNAs in the effects of melatonin (MEL) on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoporosis (OP) progression. The aim of our stu...

    Authors: Xudong Wang, Taiqiu Chen, Zhihuai Deng, Wenjie Gao, Tongzhou Liang, Xianjian Qiu, Bo Gao, Zizhao Wu, Jincheng Qiu, Yuanxin Zhu, Yanbo Chen, Zhancheng Liang, Hang Zhou, Caixia Xu, Anjing Liang, Peiqiang Su…
    Citation: Stem Cell Research & Therapy 2021 12:150
    Content type: Research Published on:

  3. Patients with coronary artery disease (CAD) are characterized by a decline in vascular regeneration, which is related to the dysfunction of endothelial progenitor cells (EPCs). G-protein-coupled receptor 4 (GP...

    Authors: Shun Ouyang, Yan Li, Xing Wu, Yan Wang, Fanmao Liu, Jianning Zhang, Yumin Qiu, Zhe Zhou, Zhichao Wang, Wenhao Xia and Xiufang Lin
    Citation: Stem Cell Research & Therapy 2021 12:149
    Content type: Research Published on:

  4. Muscle is severely affected by ischemia/reperfusion injury (IRI). Quiescent satellite cells differentiating into myogenic progenitor cells (MPC) possess a remarkable regenerative potential. We herein establish...

    Authors: Franka Messner, Marco Thurner, Jule Müller, Michael Blumer, Julia Hofmann, Rainer Marksteiner, Sebastien Couillard-Despres, Jakob Troppmair, Dietmar Öfner, Stefan Schneeberger and Theresa Hautz
    Citation: Stem Cell Research & Therapy 2021 12:146
    Content type: Research Published on:

  5. Endothelial progenitor cells (EPCs) are promising candidates for the cellular therapy of peripheral arterial and cardiovascular diseases. However, hitherto there is no specific marker(s) defining precisely EPC...

    Authors: Mohamed Essameldin Abdelgawad, Christophe Desterke, Georges Uzan and Sina Naserian
    Citation: Stem Cell Research & Therapy 2021 12:145
    Content type: Research Published on:

  6. Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies hav...

    Authors: Sevil Korkmaz-Icöz, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamás Radovits, Alex Ali Sayour, Mihály Ruppert, Gábor Veres, Matthias Karck and Gábor Szabó
    Citation: Stem Cell Research & Therapy 2021 12:144
    Content type: Research Published on:

  7. Intervertebral fusion is the most common surgery to treat lumbar degenerative disease (LDD). And the graft material used in the operation is derived from the iliac crest to promote fusion. However, autografts ...

    Authors: Weigang Li, Chunwei Huang, Tian Ma, Jiachen Wang, Wenbin Liu, Jiyuan Yan, Gaohong Sheng, Ruizhuo Zhang, Hua Wu and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2021 12:143
    Content type: Research Published on:

  8. Dental pulp stem cells (DPSCs) are increasingly being advocated as viable cell sources for regenerative medicine-based therapies. However, significant heterogeneity in DPSC expansion and multi-potency capabili...

    Authors: Nadia Y. A. Alaidaroos, Amr Alraies, Rachel J. Waddington, Alastair J. Sloan and Ryan Moseley
    Citation: Stem Cell Research & Therapy 2021 12:142
    Content type: Research Published on:

  9. As a large capillary network, the human placenta plays an important role throughout pregnancy. Placental vascular development is complex and delicate and involves many types of placental cells, such as trophob...

    Authors: Haiying Ma, Shenglu Jiang, Lili Du, Jinfang Liu, Xiaoyan Xu, Xiaomei Lu, Ling Ma, Hua Zhu, Jun Wei and Yanqiu Yu
    Citation: Stem Cell Research & Therapy 2021 12:141
    Content type: Research Published on:

  10. Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-directional differentiation, and paracrine and immune regulation. As a result of these properties, the MSCs have great clinical...

    Authors: Wanhao Yan, Shu Diao and Zhipeng Fan
    Citation: Stem Cell Research & Therapy 2021 12:140
    Content type: Review Published on:

  11. Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for many hematological diseases; however, therapeutic applications are hampered by donor availability. In vivo, HSC exist in...

    Authors: Kyle Lewis, Momoko Yoshimoto and Takanori Takebe
    Citation: Stem Cell Research & Therapy 2021 12:139
    Content type: Review Published on:

  12. Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or modulate deleterious immune responses by various molecular mechanisms. These cells are the subject of major translational efforts as cellul...

    Authors: Yi Yu, Alejandra Vargas Valderrama, Zhongchao Han, Georges Uzan, Sina Naserian and Estelle Oberlin
    Citation: Stem Cell Research & Therapy 2021 12:138
    Content type: Research Published on:

  13. Burned human skin, which is routinely excised and discarded, contains viable mesenchymal stromal/stem cells (burn-derived mesenchymal stromal/stem cells; BD-MSCs). These cells show promising potential to enabl...

    Authors: Reinhard Dolp, Gertraud Eylert, Christopher Auger, Ayesha Aijaz, Yufei Andy Chen, Saeid Amini-Nik, Alexandra Parousis, Andrea-Kaye Datu and Marc G. Jeschke
    Citation: Stem Cell Research & Therapy 2021 12:137
    Content type: Research Published on:

  14. This arcticle has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-016-0438-5.

    Authors: Lihui Yu, Ying Lu, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang and Bo Song
    Citation: Stem Cell Research & Therapy 2021 12:136
    Content type: Retraction Note Published on:

    The original article was published in Stem Cell Research & Therapy 2016 7:180

  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren
    Citation: Stem Cell Research & Therapy 2021 12:134
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:21

  17. The purpose of this study was to investigate the therapeutic effects of genetically modified mesenchymal stem cells (MSCs) in the treatment of type 2 diabetes mellitus (T2DM) in order to identify a new method ...

    Authors: Binghua Xue, Xiuxiao Xiao, Tingting Yu, Xinhua Xiao, Jing Xie, Qiuhe Ji, Li Wang, Tao Na, Shufang Meng, Lingjia Qian and Haifeng Duan
    Citation: Stem Cell Research & Therapy 2021 12:133
    Content type: Research Published on:

  18. Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal ...

    Authors: Pengcheng Xiao, Zhenglin Zhu, Chengcheng Du, Yongsheng Zeng, Junyi Liao, Qiang Cheng, Hong Chen, Chen Zhao and Wei Huang
    Citation: Stem Cell Research & Therapy 2021 12:132
    Content type: Research Published on:

  19. Duchenne muscular dystrophy (DMD) is caused by mutations of the gene that encodes the protein dystrophin. A loss of dystrophin leads to severe and progressive muscle wasting in both skeletal and heart muscles....

    Authors: Wanling Xuan, Mahmood Khan and Muhammad Ashraf
    Citation: Stem Cell Research & Therapy 2021 12:131
    Content type: Research Published on:

  20. Thin endometrium adversely affects reproductive success rates with fertility treatment. Autologous transplantation of exogenously prepared endometrium can be a promising therapeutic option for thin endometrium...

    Authors: Ryo Yokomizo, Yukiko Fujiki, Harue Kishigami, Hiroshi Kishi, Tohru Kiyono, Sanae Nakayama, Haruhiko Sago, Aikou Okamoto and Akihiro Umezawa
    Citation: Stem Cell Research & Therapy 2021 12:130
    Content type: Research Published on:

  21. The repair of large-scale full-thickness skin defects represents a challenging obstacle in skin tissue engineering. To address the most important problem in skin defect repair, namely insufficient blood supply...

    Authors: Shuang Lin, Xiaoning He and Yuanjia He
    Citation: Stem Cell Research & Therapy 2021 12:129
    Content type: Research Published on:

  22. Recently, growing evidence has indicated an important role of the complement system, a crucial component of immunity, in mediating neuroinflammation and promoting neuronal apoptosis following closed head injur...

    Authors: Mou Gao, Qin Dong, Wenjia Wang, Zhijun Yang, Lili Guo, Yingzhou Lu, Boyun Ding, Lihua Chen, Jianning Zhang and Ruxiang Xu
    Citation: Stem Cell Research & Therapy 2021 12:128
    Content type: Research Published on:

  23. Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases. The large a...

    Authors: Jonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles and Jessie R. Lavoie
    Citation: Stem Cell Research & Therapy 2021 12:127
    Content type: Research Published on:

  24. Cancer is a leading cause of death in both developed and developing countries, and because of population growth and aging, it is a growing medical burden worldwide. With robust development in medicine, the use...

    Authors: Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali and Hassan Niknejad
    Citation: Stem Cell Research & Therapy 2021 12:126
    Content type: Review Published on:

  25. Stroke serves as a prevalent cerebrovascular disorder with severe cerebral ischemia/reperfusion (CIR) injury, in which neural stem cells (NSCs) play critical roles in the recovery of cerebral function. Circula...

    Authors: Bo Yang, Li’e Zang, Jingwen Cui and Linlin Wei
    Citation: Stem Cell Research & Therapy 2021 12:125
    Content type: Research Published on:

  26. Mesenchymal stromal cells (MSCs) constitute one of the cell types most frequently used in cell therapy. Although several studies have shown the efficacy of these cells to modulate inflammation in different ani...

    Authors: Rosario Hervás-Salcedo, María Fernández-García, Miriam Hernando-Rodríguez, Oscar Quintana-Bustamante, Jose-Carlos Segovia, Marcio Alvarez-Silva, Mariano García-Arranz, Pablo Minguez, Victoria del Pozo, Marta Rodríguez de Alba, Damián García-Olmo, Carmen Ayuso, María Luisa Lamana, Juan A. Bueren and Rosa María Yañez
    Citation: Stem Cell Research & Therapy 2021 12:124
    Content type: Research Published on:

  27. To repair bone defects, a variety of bone substitution materials have been used, such as ceramics, metals, natural and synthetic polymers, and combinations thereof. In recent decades, a wide range of synthetic...

    Authors: Siyi Wang, Rong Li, Dandan Xia, Xiao Zhao, Yuan Zhu, Ranli Gu, Jungmin Yoon and Yunsong Liu
    Citation: Stem Cell Research & Therapy 2021 12:123
    Content type: Review Published on:

  28. This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1+/− heterozygote mouse using blastocyst complementation. Additionally, this approach corrected n...

    Authors: Aleta R. Steevens, Matthew W. Griesbach, Yun You, James R. Dutton, Walter C. Low and Peter A. Santi
    Citation: Stem Cell Research & Therapy 2021 12:122
    Content type: Short report Published on:

  30. Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone regeneration. Our previous study confirmed th...

    Authors: Shuanglin Peng, Sirong Shi, Gang Tao, Yanjing Li, Dexuan Xiao, Lang Wang, Qing He, Xiaoxiao Cai and Jingang Xiao
    Citation: Stem Cell Research & Therapy 2021 12:120
    Content type: Research Published on:

  31. Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we ai...

    Authors: Xiong Shu, Kai-Yue Cao, Hui-Qi Liu, Long Yu, Li-Xin Sun, Zhi-Hua Yang, Cheng-Ai Wu and Yu-Liang Ran
    Citation: Stem Cell Research & Therapy 2021 12:119
    Content type: Research Published on:

  32. Oligovascular niche mediates interactions between cerebral endothelial cells and oligodendrocyte precursor cells (OPCs). Disruption of OPC-endothelium trophic coupling may aggravate the progress of cerebral wh...

    Authors: Ning Zhou, Lei Wang, Ping Fu, Zihao Cui, Yuhang Ge, Feiyu Jiang, Jing Liu, Chao Ren, Zuo Luan, Hongbin Fan and Ruiqin Yao
    Citation: Stem Cell Research & Therapy 2021 12:118
    Content type: Research Published on:

  33. Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action r...

    Authors: Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang and Limin Rong
    Citation: Stem Cell Research & Therapy 2021 12:117
    Content type: Research Published on:

  34. Combination of mesenchymal stem cells (MSCs) and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. T...

    Authors: Mohamed I. Elashry, Nadine Baulig, Alena-Svenja Wagner, Michele C. Klymiuk, Benjamin Kruppke, Thomas Hanke, Sabine Wenisch and Stefan Arnhold
    Citation: Stem Cell Research & Therapy 2021 12:116
    Content type: Research Published on:

  35. Mesenchymal stem cells (MSCs) are favourable treatments for ischaemic diseases; however, MSCs from diabetic patients are not useful for this purpose. Recent studies have...

    Authors: Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu and Zhuoqi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:115
    Content type: Research Published on:

  36. Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are asso...

    Authors: Jun Sung Kim, Young Hyun Jung, Hyun Jik Lee, Chang Woo Chae, Gee Euhn Choi, Jae Ryong Lim, Seo Yihl Kim, Joo Eun Lee and Ho Jae Han
    Citation: Stem Cell Research & Therapy 2021 12:114
    Content type: Research Published on:

  37. Despite recent rapid progress in method development and biological understanding of induced pluripotent stem (iPS) cells, there has been a relative shortage of tools that monitor the early reprogramming proces...

    Authors: Sandhya Sriram, Nam-Young Kang, Subha Subramanian, Tannistha Nandi, Samydurai Sudhagar, Qiaorui Xing, Gerine Jin-Ling Tong, Allen Kuan-Liang Chen, Thekkeparambil Chandrabose Srijaya, Patrick Tan, Yuin-Han Loh, Young-Tae Chang and Shigeki Sugii
    Citation: Stem Cell Research & Therapy 2021 12:113
    Content type: Method Published on:

  38. Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD+)-dependent sirtuins (SIRTs). SIRTs regulate functi...

    Authors: Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima and Julia Skokowa
    Citation: Stem Cell Research & Therapy 2021 12:112
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:299

  39. Cerebral ischemia-reperfusion (I/R) injury, the most common form of stroke, has high mortality and often brings persistent and serious brain dysfunction among survivors. Administration of adipose-derived mesen...

    Authors: Yamei Zhang, Junying Liu, Mi Su, Xin Wang and Chenchen Xie
    Citation: Stem Cell Research & Therapy 2021 12:111
    Content type: Research Published on:

  40. Novel therapeutic strategies for the healing of nonunion, which has serious effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of local transplantation of human stromal...

    Authors: Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura…
    Citation: Stem Cell Research & Therapy 2021 12:110
    Content type: Research Published on:

  41. Effective stem cell therapy is dependent on the stem cell quality that is determined by their differentiation potential, impairment of which leads to poor engraftment and survival into the target cells. Howeve...

    Authors: Smarajit Chakraborty, Wee Kiat Ong, Winifred W. Y. Yau, Zhihong Zhou, K. N. Bhanu Prakash, Sue-Anne Toh, Weiping Han, Paul M. Yen and Shigeki Sugii
    Citation: Stem Cell Research & Therapy 2021 12:109
    Content type: Research Published on:

  42. Bone fracture repair has gained a lot of attention due to the high incidence of delayed union or even nonunion especially in osteoporotic patients, resulting in a dreadful impact on the quality of life. Howeve...

    Authors: Liang Chen, Ri-Yan Zhang, Jun Xie, Jia-Yi Yang, Kang-Hao Fang, Chen-Xuan Hong, Rong-Bo Yang, Najeeb Bsoul and Lei Yang
    Citation: Stem Cell Research & Therapy 2021 12:108
    Content type: Research Published on:

  43. A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There ar...

    Authors: Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang and Xueran Chen
    Citation: Stem Cell Research & Therapy 2021 12:107
    Content type: Research Published on:

  44. Mesenchymal stromal cells (MSCs) are an emerging prophylaxis option for graft-versus-host disease (GVHD) in haplo-identical hematopoietic stem cell transplantation (haplo-HSCT) recipients with severe aplastic ...

    Authors: Ruonan Li, Jingke Tu, Jingyu Zhao, Hong Pan, Liwei Fang and Jun Shi
    Citation: Stem Cell Research & Therapy 2021 12:106
    Content type: Research Published on:

  45. Multipotent mesenchymal stromal cells (MSCs) are potentially therapeutic for muscle disease because they can accumulate at the sites of injury and act as immunosuppressants. MSCs are attractive candidates for ...

    Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Yuki Oda, Hiromi Hayashita-Kinoh, Shin’ichi Takeda and Takashi Okada
    Citation: Stem Cell Research & Therapy 2021 12:105
    Content type: Research Published on:

  46. This study aimed to explore the effect of KAT6A on the decreased stemness of aging bone marrow-derived mesenchymal stem cells (BMSCs) and its potential mechanism.

    Authors: Dongdong Fei, Yazheng Wang, Qiming Zhai, Xige Zhang, Yang Zhang, Yang Wang, Bei Li and Qintao Wang
    Citation: Stem Cell Research & Therapy 2021 12:104
    Content type: Research Published on:

  47. The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still...

    Authors: Chao Yang, Mingjun Wu, Min You, Yu Chen, Maowen Luo and Qiang Chen
    Citation: Stem Cell Research & Therapy 2021 12:103
    Content type: Review Published on:

  48. Secretome profiles of mesenchymal stem cells (MSCs) are reflective of their local microenvironments. These biologically active factors exert an impact on the surrounding cells, eliciting regenerative responses...

    Authors: Nurul Dinah Kadir, Zheng Yang, Afizah Hassan, Vinitha Denslin and Eng Hin Lee
    Citation: Stem Cell Research & Therapy 2021 12:100
    Content type: Research Published on:

  49. Reendothelialisation is the natural pathway that inhibits neointimal hyperplasia and in-stent restenosis. Circulating endothelial progenitor cells (EPCs) derived from bone marrow (BM) might contribute to endot...

    Authors: Wei Wang, Yingqian Zhang, Hui Hui, Wei Tong, Zechen Wei, Zhongxuan Li, Suhui Zhang, Xin Yang, Jie Tian and Yundai Chen
    Citation: Stem Cell Research & Therapy 2021 12:99
    Content type: Research Published on:

  50. Previous reports have identified that human bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) with their cargo microRNAs (miRNAs) are a promising therapeutic approach for the treatmen...

    Authors: Jing Zhou, Yang Lin, Xiuhua Kang, Zhicheng Liu, Wei Zhang and Fei Xu
    Citation: Stem Cell Research & Therapy 2021 12:96
    Content type: Research Published on:
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