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  1. Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy...

    Authors: Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, Wan Wai Tse, Bimal Gurung, Suet Yee Mak, Deborah K. Lieu, Kevin D. Costa, Camie W. Chan, Alain Martelli, Joseph F. Nabhan and Ronald A. Li
    Citation: Stem Cell Research & Therapy 2019 10:203
    Content type: Research Published on:

  2. By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma cells (ECCs) are...

    Authors: Ildercílio Mota de Souza Lima, Josiane Lilian dos Santos Schiavinato, Sarah Blima Paulino Leite, Danuta Sastre, Hudson Lenormando de Oliveira Bezerra, Bruno Sangiorgi, Amanda Cristina Corveloni, Carolina Hassibe Thomé, Vitor Marcel Faça, Dimas Tadeu Covas, Marco Antônio Zago, Mauro Giacca, Miguel Mano and Rodrigo Alexandre Panepucci
    Citation: Stem Cell Research & Therapy 2019 10:202
    Content type: Research Published on:

  3. Follicle depletion is one of the causes of premature ovarian failure (POF) and primary ovarian insufficiency (POI). Hence, maintenance of a certain number of female germline stem cells (FGSCs) is optimal to pr...

    Authors: Yu Jiang, Dantian Zhu, Wenfeng Liu, Qiushi Qin, Zhi Fang and Zezheng Pan
    Citation: Stem Cell Research & Therapy 2019 10:198
    Content type: Research Published on:

  5. Adipose-derived stem cells (ASCs) are promising therapeutic cells for ischemic heart diseases, due to the ease and efficiency of acquisition, the potential of myocardial lineage differentiation, and the paracr...

    Authors: Xiaoting Li, Teng Ma, Jiacheng Sun, Mingjing Shen, Xiang Xue, Yongbing Chen and Zhiwei Zhang
    Citation: Stem Cell Research & Therapy 2019 10:196
    Content type: Review Published on:

  6. Recent progress in the induced generation of dopaminergic (DA) neurons from different types of stem cells or reprogrammed somatic cells holds tremendous potential for the treatment of Parkinson’s disease (PD)....

    Authors: Hao Yang, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An and Jingjing Zhao
    Citation: Stem Cell Research & Therapy 2019 10:195
    Content type: Research Published on:

  7. Exosomes are bilayer membrane vesicles with cargos that contain a variety of surface proteins, markers, lipids, nucleic acids, and noncoding RNAs. Exosomes from different cardiac cells participate in the proce...

    Authors: Ming-yue Xu, Zhi-shuai Ye, Xian-tao Song and Rong-chong Huang
    Citation: Stem Cell Research & Therapy 2019 10:194
    Content type: Review Published on:

  8. Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. In addition, transplantation studies using pi...

    Authors: Junjun Xu, Leqian Yu, Jianxiong Guo, Jinzhu Xiang, Zheng Zheng, Dengfeng Gao, Bingbo Shi, Haiyang Hao, Deling Jiao, Liang Zhong, Yu Wang, Jun Wu, Hongjiang Wei and Jianyong Han
    Citation: Stem Cell Research & Therapy 2019 10:193
    Content type: Research Published on:

  9. The use of mesenchymal stem cells (MSCs) is being extensively studied in clinical trials in the setting of various diseases including diabetes, stroke, and progressive multiple sclerosis. The unique immunomodu...

    Authors: Caroline Laroye, Amir Boufenzer, Lucie Jolly, Lisiane Cunat, Corentine Alauzet, Jean-Louis Merlin, Clémence Yguel, Danièle Bensoussan, Loïc Reppel and Sébastien Gibot
    Citation: Stem Cell Research & Therapy 2019 10:192
    Content type: Research Published on:

  10. WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. ...

    Authors: Maryam Kay, Bahram Mohammad Soltani, Fahimeh Hosseini Aghdaei, Hassan Ansari and Hossein Baharvand
    Citation: Stem Cell Research & Therapy 2019 10:191
    Content type: Research Published on:

  11. There is an urgent need for targeted biological therapies for prostate cancer with greater efficacy and less toxicity, particularly for metastatic disease, where current therapies are not curative. Therapeutic...

    Authors: Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Ling Ma, Ruth A. Gjerset and Yinghui Huang
    Citation: Stem Cell Research & Therapy 2019 10:190
    Content type: Research Published on:

  12. Management of fracture healing with a large bone defect remains a tricky subject in orthopedic trauma. Enhancing osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the useful t...

    Authors: Kai Hang, Chenyi Ye, Jianxiang Xu, Erman Chen, Cong Wang, Wei Zhang, Lic Ni, Zhih Kuang, Li Ying, Deting Xue and Zhijun Pan
    Citation: Stem Cell Research & Therapy 2019 10:189
    Content type: Research Published on:

  13. Feline adipose-derived mesenchymal stem cells (ASCs) have been successfully used in clinical trials for the treatment of immune-mediated diseases with T cell dysregulation. However, the immunomodulatory pathwa...

    Authors: Nopmanee Taechangam, Smita S. Iyer, Naomi J. Walker, Boaz Arzi and Dori L. Borjesson
    Citation: Stem Cell Research & Therapy 2019 10:188
    Content type: Research Published on:

  14. Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissues. However, in order to evaluate the therapeutic activity of MSC, cell tracking techniques are r...

    Authors: Anna Andrzejewska, Anna Jablonska, Martyna Seta, Sylwia Dabrowska, Piotr Walczak, Miroslaw Janowski and Barbara Lukomska
    Citation: Stem Cell Research & Therapy 2019 10:187
    Content type: Research Published on:

  15. Mesenchymal stem/stromal cells (MSCs) derived from human embryonic stem cells (hESCs) are attractive for their hematopoietic-supporting or potential therapeutic effects. However, procedures for high-effective ...

    Authors: Yimeng Wei, Huixing Hou, Leisheng Zhang, Nianhuan Zhao, Chengwen Li, Jiali Huo, Ying Liu, Wenxia Zhang, Zongjin Li, Dengke Liu, Zhibo Han, Lei Zhang, Baoquan Song, Ying Chi and Zhongchao Han
    Citation: Stem Cell Research & Therapy 2019 10:186
    Content type: Research Published on:

  16. Disease modeling with patient-derived induced pluripotent stem cells (iPSCs) is a powerful tool for elucidating the mechanisms underlying disease pathogenesis and developing safe and effective treatments. Pati...

    Authors: Takashi Okumura, Yumi Horie, Chen-Yi Lai, Huan-Ting Lin, Hirofumi Shoda, Bunki Natsumoto, Keishi Fujio, Eri Kumaki, Tsubasa Okano, Shintaro Ono, Kay Tanita, Tomohiro Morio, Hirokazu Kanegane, Hisanori Hasegawa, Fumitaka Mizoguchi, Kimito Kawahata…
    Citation: Stem Cell Research & Therapy 2019 10:185
    Content type: Research Published on:

  17. Our group has developed a novel method for spontaneous spheroid formation using a specific low-adherence culture plate with around 90° water contact angle. In this study, this method was applied for oral mucos...

    Authors: Ni Li, Xianqi Li, Kai Chen, Hongwei Dong and Hideaki Kagami
    Citation: Stem Cell Research & Therapy 2019 10:184
    Content type: Research Published on:

  18. Evidence has suggested that human adipose-derived stem cells (hADSCs) and low-level laser has neuroprotective effects on spinal cord injury (SCI). Therefore, the combined effect of the hADSCs and laser on neur...

    Authors: Arash Sarveazad, Atousa Janzadeh, Gholamreza Taheripak, Sima Dameni, Mahmoud Yousefifard and Farinaz Nasirinezhad
    Citation: Stem Cell Research & Therapy 2019 10:183
    Content type: Research Published on:

  19. The use and effectiveness of hematopoietic stem cell transplantation (HSCT) are limited by lethal complications, i.e., acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively), in which immu...

    Authors: Lu Zhao, Shanquan Chen, Panxin Yang, Hongcui Cao and Lanjuan Li
    Citation: Stem Cell Research & Therapy 2019 10:182
    Content type: Review Published on:

  21. Radiation exposure negatively affects the regenerative ability and makes reconstruction of bone defects after tumor section difficult. miR-34a is involved in radiation biology and bone metabolism. The aim of t...

    Authors: Huan Liu, Yan Dong, Xiaoke Feng, Liya Li, Yang Jiao, Shizhu Bai, Zhihong Feng, Hao Yu, Xuejian Li and Yimin Zhao
    Citation: Stem Cell Research & Therapy 2019 10:180
    Content type: Research Published on:

  22. Disruptions of angiogenesis can have a significant effect on the healing of uterine scars. Human endometrial perivascular cells (CD146+PDGFRβ+) function as stem cells in the endometrium. Cysteine-rich angiogen...

    Authors: Zhongxun Li, Guijun Yan, Qiang Diao, Fei Yu, Xin’an Li, Xiaoqiang Sheng, Yong Liu, Yimin Dai, Huaijun Zhou, Xin Zhen, Yali Hu, Bruno Péault, Lijun Ding, Haixiang Sun and Hairong Li
    Citation: Stem Cell Research & Therapy 2019 10:179
    Content type: Research Published on:

  23. Equine metabolic syndrome (EMS) refers to a cluster of associated abnormalities and metabolic disorders, including insulin resistance and adiposity. The numerous biological properties of mesenchymal stem cells...

    Authors: Lynda Bourebaba, Fatiha Bedjou, Michael Röcken and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2019 10:178
    Content type: Research Published on:

  24. Human decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal–fetal tolerance. Precursors of DSCs (p...

    Authors: Raquel Muñoz-Fernández, Claudia De La Mata, Francisco Requena, Francisco Martín, Pablo Fernandez-Rubio, Tatiana Llorca, Maria José Ruiz-Magaña, Carmen Ruiz-Ruiz and Enrique G. Olivares
    Citation: Stem Cell Research & Therapy 2019 10:177
    Content type: Research Published on:

  25. Molecular mechanisms underlying the regenerative process induced by stem cells in tissue-engineered urinary bladder are poorly explained. The study was performed to explore the pathways associated with regener...

    Authors: Marta Pokrywczynska, Marta Rasmus, Arkadiusz Jundzill, Daria Balcerczyk, Jan Adamowicz, Karolina Warda, Lukasz Buchholz and Tomasz Drewa
    Citation: Stem Cell Research & Therapy 2019 10:176
    Content type: Research Published on:

  26. Cancer stem cells (CSCs) play a critical role in tumor development and progression and are involved in cancer metastasis. The role of reactive oxygen species (ROS) in CSCs and cancer metastasis remains controv...

    Authors: Caihua Wang, Liming Shao, Chi Pan, Jun Ye, Zonghui Ding, Jia Wu, Qin Du, Yuezhong Ren and Chunpeng Zhu
    Citation: Stem Cell Research & Therapy 2019 10:175
    Content type: Research Published on:

  27. Our previous study proved that nanofat could enhance fat graft survival by promoting neovascularization. Fat extract (FE), a cell-free component derived from nanofat, also possesses proangiogenic activity.

    Authors: Hongjie Zheng, Ziyou Yu, Mingwu Deng, Yizuo Cai, Xiangsheng Wang, Yuda Xu, Lu Zhang, Wenjie Zhang and Wei Li
    Citation: Stem Cell Research & Therapy 2019 10:174
    Content type: Research Published on:

  28. Hematopoietic stem cell (HSC) transplantation has been widely applied to the treatment of malignant blood diseases. However, limited number of functional HSCs hinders successful transplantation. The purpose of...

    Authors: Yu Zhang, Bin Shen, Xin Guan, Meng Qin, Zhihua Ren, Yupo Ma, Wei Dai, Xinxin Ding and Yongping Jiang
    Citation: Stem Cell Research & Therapy 2019 10:173
    Content type: Research Published on:

  29. Clinically, for stem cell-based therapy (SCBT), autologous stem cells are considered better than allogenic stem cells because of little immune rejection and no risk of communicable disease infection. However, ...

    Authors: Anyuan Shi, Aerali Heinayati, Dongyu Bao, Huifen Liu, Xiaochen Ding, Xin Tong, Liudi Wang, Bin Wang and Haiyan Qin
    Citation: Stem Cell Research & Therapy 2019 10:172
    Content type: Research Published on:

  30. Administration of the iron chelator deferasirox (DFX) in transfusion-dependent patients occasionally results in haematopoiesis recovery by a mechanism remaining elusive. This study aimed to investigate at a mo...

    Authors: Tiziana Tataranni, Carmela Mazzoccoli, Francesca Agriesti, Luciana De Luca, Ilaria Laurenzana, Vittorio Simeon, Vitalba Ruggieri, Consiglia Pacelli, Gerardo Della Sala, Pellegrino Musto, Nazzareno Capitanio and Claudia Piccoli
    Citation: Stem Cell Research & Therapy 2019 10:171
    Content type: Research Published on:

  31. Exosomes derived from dental pulp stem cells (DPSCs) can be used as biomimetic tools to induce odontogenic differentiation of stem cells, but the regulatory mechanisms and functions of exosome-encapsulated mic...

    Authors: Xiaoli Hu, Yingqun Zhong, Yuanyuan Kong, Yanan Chen, Junming Feng and Jianmao Zheng
    Citation: Stem Cell Research & Therapy 2019 10:170
    Content type: Research Published on:

  32. Due to its complex pathogenesis and low clinical cure rate, bisphosphonate-related osteonecrosis of the jaw (BRONJ) poses a substantial challenge for oral and maxillofacial surgeons. Therefore, the treatment o...

    Authors: Xiaolong Zang, Linhai He, Lu Zhao, Yang He, E. Xiao and Yi Zhang
    Citation: Stem Cell Research & Therapy 2019 10:169
    Content type: Research Published on:

  33. Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit can...

    Authors: Yan Wang, Yijing Chu, Xianfeng Ren, Hongfei Xiang, Yongming Xi, Xuexiao Ma, Kai Zhu, Zhu Guo, Chuanli Zhou, Guoqing Zhang and Bohua Chen
    Citation: Stem Cell Research & Therapy 2019 10:168
    Content type: Research Published on:

  34. Ischemic heart diseases are still a threat to human health. Human pluripotent stem cell-based transplantation exhibits great promise in cardiovascular disease therapy, including heart ischemia. The purpose of ...

    Authors: You Yu, Nianci Qin, Xing-Ai Lu, Jingjing Li, Xinglong Han, Xuan Ni, Lingqun Ye, Zhenya Shen, Weiqian Chen, Zhen-Ao Zhao, Wei Lei and Shijun Hu
    Citation: Stem Cell Research & Therapy 2019 10:167
    Content type: Research Published on:

  35. Cell reprogramming is a promising avenue for cell-based therapies as it allows for the generation of multipotent, unipotent, or mature somatic cells without going through a pluripotent state. While the use of ...

    Authors: Jan-Eric Ahlfors, Ashkan Azimi, Rouwayda El-Ayoubi, Alexander Velumian, Ilan Vonderwalde, Cecile Boscher, Oana Mihai, Sarathi Mani, Marina Samoilova, Mohamad Khazaei, Michael G. Fehlings and Cindi M Morshead
    Citation: Stem Cell Research & Therapy 2019 10:166
    Content type: Research Published on:

  36. Mounting evidence has shown that a novel subset of mesenchymal stem cells (MSCs) derived from human gingiva referred to as gingival mesenchymal stem cells (GMSCs) displays a greater immunotherapeutic potential...

    Authors: Jun Zhao, Julie Wang, Junlong Dang, Wangyu Zhu, Yaqiong Chen, Ximei Zhang, Junliang Xie, Bo Hu, Feng Huang, Baoqing Sun, Joseph A. Bellanti and Song Guo Zheng
    Citation: Stem Cell Research & Therapy 2019 10:165
    Content type: Research Published on:

  37. Contrary to the minimal criteria proposed by the International Society for Cell and Gene Therapy for defining multipotent mesenchymal stromal cells (MSC), human leukocyte antigen (HLA)-DR expression is largely...

    Authors: Marta Grau-Vorster, Anita Laitinen, Johanna Nystedt and Joaquim Vives
    Citation: Stem Cell Research & Therapy 2019 10:164
    Content type: Research Published on:

  38. Pulmonary emphysema is a major component of chronic obstructive pulmonary disease (COPD). Emphysema progression attributed not only to alveolar structure loss and pulmonary regeneration impairment, but also to...

    Authors: Ying-Wei Lan, Jing-Chan Yang, Chih-Ching Yen, Tsung-Teng Huang, Ying-Cheng Chen, Hsiao-Ling Chen, Kowit-Yu Chong and Chuan-Mu Chen
    Citation: Stem Cell Research & Therapy 2019 10:163
    Content type: Research Published on:

  39. The authors have retracted this article [1] because there is erroneous data in Figure 1C. Flow cytometry results of EPC cell markers CD31 and CD45 could not be replicated. Due to incorrect cell markers, the ce...

    Authors: Jiacheng Sun, Zhiwei Zhang, Teng Ma, Ziying Yang, Jinlong Zhang, Xuan Liu, Da Lu, Zhenya Shen, Junjie Yang and Qingyou Meng
    Citation: Stem Cell Research & Therapy 2019 10:162
    Content type: Retraction Note Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:223

  40. Idiopathic pulmonary fibrosis is characterized by loss of lung epithelial cells and inexorable progression of fibrosis with no effective and approved treatments. The distal airway stem/progenitor cells (DASCs)...

    Authors: Yun Shi, Mingqing Dong, Yueqing Zhou, Wangping Li, Yongheng Gao, Luyao Han, Min Chen, Hongwei Lin, Wei Zuo and Faguang Jin
    Citation: Stem Cell Research & Therapy 2019 10:161
    Content type: Research Published on:

  41. To investigate the effect of ectopic high expression of OCT4 on the stemness characteristics of bone marrow-derived mesenchymal stromal cells (BM-MSCs).

    Authors: Xiaoping Guo, Yongmin Tang, Ping Zhang, Sisi Li, Yuanyuan Chen, Baiqin Qian, Hongqiang Shen and Ning Zhao
    Citation: Stem Cell Research & Therapy 2019 10:160
    Content type: Research Published on:

  42. To investigate the potential effect of IP7 on the autophagy and apoptosis of bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia.

    Authors: Jingyu Deng, Chao Yang, Yong Wang, Ming Yang, Haixu Chen, Hongjuan Ning, Chengzhu Wang, Yanjun Liu, Zheng Zhang and Taohong Hu
    Citation: Stem Cell Research & Therapy 2019 10:159
    Content type: Research Published on:

  43. Ischemic diseases, which are caused by a reduction of blood supply that results in reduced oxygen transfer and nutrient uptake, are becoming the leading cause of disabilities and deaths. Therapeutic angiogenes...

    Authors: Xiaowei Bian, Kui Ma, Cuiping Zhang and Xiaobing Fu
    Citation: Stem Cell Research & Therapy 2019 10:158
    Content type: Review Published on:

  44. Small nucleolar RNA host gene 3 (Snhg3) is a long non-coding RNA (lncRNA) that was shown to participate in the tumorigenesis of certain cancers. However, little is known about its role in embryonic stem cells ...

    Authors: Weisi Lu, Jianping Yu, Fengtao Shi, Jianing Zhang, Rui Huang, Shanshan Yin, Zhou Songyang and Junjiu Huang
    Citation: Stem Cell Research & Therapy 2019 10:157
    Content type: Research Published on:

  45. Premature ovarian insufficiency (POI) is a common disease in reproductive women. The pathogenesis of POI is not clear, although it is known that it involves the disorder of oocyte differentiation and developme...

    Authors: Sheng Yang, Shufang Ding, Shiwei He, Lixia He, Kefei Gao, Shuping Peng and Cijun Shuai
    Citation: Stem Cell Research & Therapy 2019 10:156
    Content type: Research Published on:

  46. Induced pluripotent stem cells (iPSCs) can generate epithelial stem cells (EpSCs) as seed cells for skin substitutes to repair skin defects. Here, we investigated the effects of a human acellular amniotic memb...

    Authors: Huateng Zhou, Lixiang Wang, Cui Zhang, Jintao Hu, Jianlin Chen, Weibin Du, Fei Liu, Weifan Ren, Jinfu Wang and Renfu Quan
    Citation: Stem Cell Research & Therapy 2019 10:155
    Content type: Research Published on:

  47. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interactions and communication and stereotypical patterns of behaviors, interests, or activities. Even wit...

    Authors: Ruiyu Zhang, Yulong Cai, Rui Xiao, Hongyu Zhong, Xin Li, Lihe Guo, Haiwei Xu and Xiaotang Fan
    Citation: Stem Cell Research & Therapy 2019 10:153
    Content type: Research Published on:

  48. Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provide an effective ancillary therapy to improve cardiac function in reperfused myocardial infarction. We set out to perform a...

    Authors: Veronica Crisostomo, Claudia Baez, José Luis Abad, Belén Sanchez, Virginia Alvarez, Rosalba Rosado, Guadalupe Gómez-Mauricio, Olivier Gheysens, Virginia Blanco-Blazquez, Rebeca Blazquez, José Luis Torán, Javier G. Casado, Susana Aguilar, Stefan Janssens, Francisco M. Sánchez-Margallo, Luis Rodriguez-Borlado…
    Citation: Stem Cell Research & Therapy 2019 10:152
    Content type: Research Published on:

  49. Epigenetic alteration is an important indicator of crosstalk between cancer cells and surrounding microenvironment components including mesenchymal stem cells (MSC). Human menstrual blood-derived stem cells (M...

    Authors: Yichen Wu, Xin Chen, Yongjia Zhao, Yanling Wang, Yifei Li and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2019 10:151
    Content type: Research Published on:

  50. Heart failure (HF) is the end stage of most heart disease. Mesenchymal stem cells (MSCs), with their specific biological effects, have been applied in several clinical trials to evaluate the efficacy in HF the...

    Authors: Mengkang Fan, Yin Huang, Zhangwei Chen, Yan Xia, Ao Chen, Danbo Lu, Yuan Wu, Ning Zhang and Juying Qian
    Citation: Stem Cell Research & Therapy 2019 10:150
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:206

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