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  1. Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC) derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to have great potential in treating ischemic diseas...

    Authors: Yuguo Xia, Xiaozheng Ling, Guowen Hu, Qingwei Zhu, Juntao Zhang, Qing Li, Bizeng Zhao, Yang Wang and Zhifeng Deng
    Citation: Stem Cell Research & Therapy 2020 11:313
    Content type: Research Published on:

  2. Organoids play an important role in basic research, drug screening, and regenerative medicine. Here, we aimed to develop a novel kind of three-dimensional (3D) organoids generated from urine-derived stem cells...

    Authors: Guoliang Sun, Beichen Ding, Meimei Wan, Liang Chen, John Jackson and Anthony Atala
    Citation: Stem Cell Research & Therapy 2020 11:309
    Content type: Research Published on:

  3. Canine inflammatory brain disease (IBD) is a severe inflammatory disorder characterized by infiltration of activated immune cell subsets into the brain and spinal cord. Multipotent mesenchymal stromal cells (M...

    Authors: Rogério Martins Amorim, Kaitlin C. Clark, Naomi J. Walker, Priyadarsini Kumar, Kyle Herout, Dori L. Borjesson and Aijun Wang
    Citation: Stem Cell Research & Therapy 2020 11:304
    Content type: Research Published on:

  4. Intracavernous injection of mesenchymal stem cells (MSCs) is a promising method for diabetic mellitus-induced erectile dysfunction (DMED), but short survival time of MSCs in cavernous is a fatal defect for the...

    Authors: Haoran Wang, Keqin Zhang, Zheng Ruan, Dingqi Sun, Hui Zhang, Guiting Lin, Liangliang Hu, Shengtian Zhao and Qiang Fu
    Citation: Stem Cell Research & Therapy 2020 11:302
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:47

  5. Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cult...

    Authors: Joao Victor Cabral, Catherine Joan Jackson, Tor Paaske Utheim and Katerina Jirsova
    Citation: Stem Cell Research & Therapy 2020 11:301
    Content type: Review Published on:

  6. Despite recent advances in neonatal care, sepsis remains a leading cause of mortality in neonates. Mesenchymal stem cells derived from various tissues, such as bone marrow, umbilical cord, and adipose tissue, ...

    Authors: Yu Sato, Daigo Ochiai, Yushi Abe, Hirotaka Masuda, Marie Fukutake, Satoru Ikenoue, Yoshifumi Kasuga, Masayuki Shimoda, Yae Kanai and Mamoru Tanaka
    Citation: Stem Cell Research & Therapy 2020 11:300
    Content type: Research Published on:

  7. Stem cell therapies have been widely investigated for their healing effects. However, the translation of these therapies has been hampered by the requirement to deliver live allogeneic or autologous cells dire...

    Authors: Parinaz Ahangar, Stuart J. Mills, Louise E. Smith, Xanthe L. Strudwick, Anthony E. Ting, Bart Vaes and Allison J. Cowin
    Citation: Stem Cell Research & Therapy 2020 11:299
    Content type: Research Published on:

  8. Diabetic patients suffer from impaired wound healing. Mesenchymal stem cell (MSC) therapy represents a promising approach toward improving skin wound healing through the release of soluble growth factors and c...

    Authors: Yongfa Sun, Lili Song, Yong Zhang, Hongjun Wang and Xiao Dong
    Citation: Stem Cell Research & Therapy 2020 11:298
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:82

  9. Cellular replacement strategies using human induced pluripotent stem cells (iPSCs) and their cardiac derivatives are emerging as novel treatments for post-myocardial infarction (MI) heart failure (HF); however...

    Authors: Xin Jiang, Ziyi Yang and Ming Dong
    Citation: Stem Cell Research & Therapy 2020 11:297
    Content type: Research Published on:

  10. Systemic transplantation of stem cells from human exfoliated deciduous teeth (SHED) recovers bone loss in animal models of osteoporosis; however, the mechanisms underlying this remain unclear. Here, we hypothe...

    Authors: Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita and Takayoshi Yamaza
    Citation: Stem Cell Research & Therapy 2020 11:296
    Content type: Research Published on:

  11. The oral cavity is a complex environment in which periodontal tissue is constantly stimulated by external microorganisms and mechanical forces. Proper mechanical force helps maintain periodontal tissue homeost...

    Authors: Pei-ying Lv, Peng-fei Gao, Guang-jie Tian, Yan-yan Yang, Fei-fei Mo, Zi-hui Wang, Lu Sun, Ming-jie Kuang and Yong-lan Wang
    Citation: Stem Cell Research & Therapy 2020 11:295
    Content type: Research Published on:

  12. This study was designed to determine the effect of human umbilical cord multipotent mesenchymal stromal cells (hUC-MSC) on acute ischemia/reperfusion (I/R) injury of spermatogenic cells.

    Authors: Liang Zhong, Mengbo Yang, Xiangyu Zou, Tao Du, Huiming Xu and Jie Sun
    Citation: Stem Cell Research & Therapy 2020 11:294
    Content type: Research Published on:

  13. There have been limited advances in the treatment of bone and joint infections, which currently involves a combination of surgery and antibiotic administration. There is a timely need in orthopedics to develop...

    Authors: Haruyo Yagi, Antonia F. Chen, David Hirsch, Adam C. Rothenberg, Jian Tan, Peter G. Alexander and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2020 11:293
    Content type: Research Published on:

  15. Acute respiratory distress syndrome virus-2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) infection, which causes global public health emergencies, has sped widely for more than 5 months and...

    Authors: Hongbing Peng, Tiefeng Gong, Xiaoying Huang, Xun Sun, Hong Luo, Weizhong Wang, Junbiao Luo, Baowei Luo, Yanhui Chen, Xingxing Wang, Haifeng Long, Hua Mei, Chuang Li, Yanni Dai and Honghui Li
    Citation: Stem Cell Research & Therapy 2020 11:291
    Content type: Short report Published on:

  16. Before starting gonadotoxic therapies, cryopreservation of mature sperm has been proposed worldwide as a method for male fertility preservation and for enabling the conception of a healthy baby with assisted r...

    Authors: Chunfeng Qian, Qingxia Meng, Jiafeng Lu, Liya Zhang, Hong Li and Boxian Huang
    Citation: Stem Cell Research & Therapy 2020 11:290
    Content type: Research Published on:

  17. Regeneration of articular cartilage poses a tremendous challenge due to its limited self-repair capability and inflammation at the damaged site. To generate the desired structures that mimic the structure of n...

    Authors: Negin Asgari, Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad, Mohammad Hossein Ghanian, Forogh Azam Sayahpour and Amir Mohammad Ghafari
    Citation: Stem Cell Research & Therapy 2020 11:289
    Content type: Research Published on:

  18. β-Thalassaemia is a clinically common cause of hereditary haemolytic anaemia stemming from mutations in important functional regions of the β-globin gene. The rapid development of gene editing technology and i...

    Authors: Yexing Xian, Yingjun Xie, Bing Song, Zhanhui Ou, Shuming Ouyang, Yuhuan Xie, Yi Yang, Zeyu Xiong, Haoxian Li and Xiaofang Sun
    Citation: Stem Cell Research & Therapy 2020 11:288
    Content type: Research Published on:

  19. Avascular necrosis of the femoral head (ANFH) is a severely disabling disease of the hip. Several clinical trials have shown promising outcomes on the use of mesenchymal stem cells for the treatment of ANFH, b...

    Authors: Mengyuan Li, Yuanchen Ma, Guangtao Fu, Ruiying Zhang, Qingtian Li, Zhantao Deng, Minghao Zheng and Qiujian Zheng
    Citation: Stem Cell Research & Therapy 2020 11:287
    Content type: Research Published on:

  20. Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term...

    Authors: Hanke Zhang, Jiayu Huang, Jiaying Liu, Yanhui Li and Ying Gao
    Citation: Stem Cell Research & Therapy 2020 11:286
    Content type: Research Published on:

  22. Biological pacemakers derived from pluripotent stem cell (PSC) have been considered as a potential therapeutic surrogate for sick sinus syndrome. So it is essential to develop highly efficient strategies for e...

    Authors: Feng Liu, Yibing Fang, Xiaojie Hou, Ying Yan, Haiying Xiao, Dongchuan Zuo, Jing Wen, Linli Wang, Zhichao Zhou, Xitong Dang, Rui Zhou and Bin Liao
    Citation: Stem Cell Research & Therapy 2020 11:284
    Content type: Research Published on:

  23. Mesenchymal stem cells (MSCs) have the capacity to differentiate into multiple lineages including osteogenic and adipogenic lineages. An increasing number of studies have indicated that lineage commitment by M...

    Authors: Asmat Ullah Khan, Rongmei Qu, Tingyu Fan, Jun Ouyang and Jingxing Dai
    Citation: Stem Cell Research & Therapy 2020 11:283
    Content type: Review Published on:

  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Younghee Ju, Jun Sung Park, Daejeong Kim, Bumsoo Kim, Jeong Ho Lee, Yoonkey Nam, Han-Wook Yoo, Beom Hee Lee and Yong-Mahn Han
    Citation: Stem Cell Research & Therapy 2020 11:282
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:209

  25. In addition to their multilineage potential, mesenchymal stem cells (MSCs) have a broad range of functions from tissue regeneration to immunomodulation. MSCs have the ability to modulate the immune response an...

    Authors: Ghada Beldi, Maryam Khosravi, Mohamed Essameldin Abdelgawad, Benoît L. Salomon, Georges Uzan, Houda Haouas and Sina Naserian
    Citation: Stem Cell Research & Therapy 2020 11:281
    Content type: Research Published on:

  26. Human dental pulp stem cells (DPSCs) are a readily accessible and promising cell source for regenerative medicine. We recently reported that a xenogeneic serum-free culture medium (XFM) is preferable to fetal ...

    Authors: Mai Mochizuki, Hiroshi Sagara and Taka Nakahara
    Citation: Stem Cell Research & Therapy 2020 11:267
    Content type: Research Published on:

  27. Human umbilical cord mesenchymal stem cell (hUC-MSC) therapy is considered as a promising approach in the treatment of intrauterine adhesions (IUAs). Considerable researches have already detected hUC-MSCs by d...

    Authors: Jia-Hua Zheng, Jing-Kun Zhang, De-Sheng Kong, Yan-Biao Song, Shuang-Dan Zhao, Wen-Bo Qi, Ya-Nan Li, Ming-le Zhang and Xiang-Hua Huang
    Citation: Stem Cell Research & Therapy 2020 11:280
    Content type: Research Published on:

  28. Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been ch...

    Authors: Hailong Liu, Biao Huang, Shaolong Xue, Kin Pong U, Lai Ling Tsang, Xiaohu Zhang, Gang Li and Xiaohua Jiang
    Citation: Stem Cell Research & Therapy 2020 11:279
    Content type: Research Published on:

  29. Diabetic cystopathy (DCP) is a chronic complication of diabetes mainly within the submucosal and muscular layers of the bladder due to the hyperglycemia-induced ischemia. As no effective therapies are currentl...

    Authors: Yi Huang, Jie Gao, Yiduo Zhou, Shuo Wu, Yunpeng Shao, Haoliang Xue, Baixin Shen, Liucheng Ding and Zhongqing Wei
    Citation: Stem Cell Research & Therapy 2020 11:278
    Content type: Research Published on:

  30. Umbilical cord mesenchymal stem cells (UCMSCs) have been demonstrated to have good therapeutic effects in the treatment of HBV-related liver diseases. However, the therapeutic effect of UCMSCs on HBV-related l...

    Authors: Yifan Jia, Xin Shu, Xiaoan Yang, Haixia Sun, Huijuan Cao, Hong Cao, Ka Zhang, Qihuan Xu, Gang Li and Yang Yang
    Citation: Stem Cell Research & Therapy 2020 11:277
    Content type: Research Published on:

  31. This study aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro and in vivo models of osteoarthritis (OA).

    Authors: Lei He, Tianwei He, Jianghao Xing, Qing Zhou, Lei Fan, Can Liu, Yuyong Chen, Depeng Wu, Zhenming Tian, Bin Liu and Limin Rong
    Citation: Stem Cell Research & Therapy 2020 11:276
    Content type: Research Published on:

  33. Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular v...

    Authors: Yan Wang, Yi Fang Guo, Guang Ping Fu, Chang Guan, Xin Zhang, Dong Gang Yang and Yun Cong Shi
    Citation: Stem Cell Research & Therapy 2020 11:274
    Content type: Research Published on:

  34. Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study i...

    Authors: Ning Zhang, Jinyun Zhu, Qunchao Ma, Yun Zhao, Yingchao Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, Zhongchao Han and Hong Yu
    Citation: Stem Cell Research & Therapy 2020 11:273
    Content type: Research Published on:

  35. Adult clinical trials have reported safety and the therapeutic potential of stem cells for cardiac disease. These observations have now translated to the pediatric arena. We conducted a meta-analysis to assess...

    Authors: John Martinez, Sarah Zoretic, Axel Moreira and Alvaro Moreira
    Citation: Stem Cell Research & Therapy 2020 11:272
    Content type: Review Published on:

  36. Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the p...

    Authors: Haoqing Yang, Yangyang Cao, Jianpeng Zhang, Yuncun Liang, Xiaomin Su, Chen Zhang, Huina Liu, Xiao Han, Lihua Ge and Zhipeng Fan
    Citation: Stem Cell Research & Therapy 2020 11:271
    Content type: Research Published on:

  37. Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak bone mass in adult offspring. Here we evaluated whether and how PDE...

    Authors: Jianwen Su, Yu Chai, Zhiguo Ji, Yongheng Xie, Bin Yu and Xianrong Zhang
    Citation: Stem Cell Research & Therapy 2020 11:270
    Content type: Research Published on:

  38. Bone mass loss in aging is linked with imbalanced lineage differentiation of bone marrow mesenchymal stem cells (BMMSCs). Recent studies have proved that histone deacetylases (HDACs) are regarded as key regula...

    Authors: Liqiang Zhang, Meng Qi, Ji Chen, Jiangdong Zhao, Liya Li, Jiachen Hu, Yan Jin and Wenjia Liu
    Citation: Stem Cell Research & Therapy 2020 11:269
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:360

  39. Previous studies of primary ovarian insufficiency (POI) have focused on granulosa cells (GCs) and ignored the role of theca-interstitial cells (TICs). This study aims to explore the mechanism of the protective...

    Authors: Xueyan Lu, Hongchu Bao, Linlu Cui, Wenqian Zhu, Lianshuang Zhang, Zheng Xu, Xuejing Man, Yongli Chu, Qiang Fu and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2020 11:268
    Content type: Research Published on:

  40. Mesenchymal stem cells (MSCs) can provide therapeutic benefits for myocardial infarction (MI) recovery; however, the molecular mechanism by which MSCs improve the heart function is unclear.

    Authors: Baoping Deng, Xianlan Zhang, Yi Liang, Haiming Jiang, Weizhao Huang, Yinmeng Wu and Weiping Deng
    Citation: Stem Cell Research & Therapy 2020 11:266
    Content type: Research Published on:

  41. Hemophagocytic lymphohistiocytosis (HLH) is a severe or even fatal inflammatory state. Epstein–Barr virus (EBV) infection-associated HLH (EBV-HLH) is one of the most common secondary HLH and suffers a very poo...

    Authors: Yue Song, Jingshi Wang, Yini Wang and Zhao Wang
    Citation: Stem Cell Research & Therapy 2020 11:265
    Content type: Research Published on:

  42. Large numbers of adipose-derived stem cells (ADSCs) are easily obtained and have been demonstrated to protect against ultraviolet B (UVB)-induced skin photoaging. Extracellular vesicles (EVs) exhibit some of t...

    Authors: Peng Xu, Yu Xin, Zheng Zhang, Xiangyu Zou, Ke Xue, Huizhong Zhang, Wenjie Zhang and Kai Liu
    Citation: Stem Cell Research & Therapy 2020 11:264
    Content type: Research Published on:

  43. Lamina-associated polypeptide 2α (LAP2α) is a nucleoplasmic protein that has been involved in the regulation of the cell cycle, gene transcription, and adult stem cell function. LAP2α down-regulation is linked...

    Authors: Yiman Tang, Xiao Zhang, Wenshu Ge and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2020 11:263
    Content type: Research Published on:

  44. Mesenchymal stem/stromal cells (MSC) are commonly used in regenerative medicine. Among different tissues, iliac crest bone marrow (BM) represents the most exploited source, but its disadvantages are a painful ...

    Authors: Katarzyna Drela, Luiza Stanaszek, Konrad Snioch, Zuzanna Kuczynska, Mikolaj Wrobel, Sylwia Sarzynska, Pawel Legosz, Pawel Maldyk and Barbara Lukomska
    Citation: Stem Cell Research & Therapy 2020 11:262
    Content type: Research Published on:

  45. Wound healing is a complex biological process comprised of a series of sequential events aiming to repair injured tissue. Adult mesenchymal stem cells (MSCs) have been used in cellular therapy in preclinical a...

    Authors: Nathaly Enciso, Luis Avedillo, María Luisa Fermín, Cristina Fragío and Concepción Tejero
    Citation: Stem Cell Research & Therapy 2020 11:261
    Content type: Research Published on:

  46. Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs. However, whether ...

    Authors: Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Bihl, Yanfang Chen, Bin Zhao and Xiaotang Ma
    Citation: Stem Cell Research & Therapy 2020 11:260
    Content type: Research Published on:

  47. After surgery, wound recovery in diabetic patients may be disrupted due to delayed inflammation, which can lead to undesired consequences, and there is currently a lack of effective measures to address this is...

    Authors: Wei Liu, Muyu Yu, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Fang Liu and Lili Yang
    Citation: Stem Cell Research & Therapy 2020 11:259
    Content type: Research Published on:

  48. Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in P...

    Authors: Lei Wang, Hao Zi, Yi Luo, Tongzu Liu, Hang Zheng, Conghua Xie, Xinghuan Wang and Xing Huang
    Citation: Stem Cell Research & Therapy 2020 11:258
    Content type: Research Published on:

  49. GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. As functional paracrine units of therapeutic cells...

    Authors: Chunshu Hao, Zhengri Lu, Yuanyuan Zhao, Zhong Chen, Chengxing Shen, Genshan Ma and Lijuan Chen
    Citation: Stem Cell Research & Therapy 2020 11:251
    Content type: Research Published on:

  50. Consumption of non-nutritive sweeteners (NNS) has been consistently associated with obesity and cardiometabolic disease in epidemiologic studies. Herein, we investigated effects of sucralose, a widely used NNS...

    Authors: Nabanita Kundu, Cleyton C. Domingues, Jay Patel, Mohammed Aljishi, Neeki Ahmadi, Mona Fakhri, Allison C. Sylvetsky and Sabyasachi Sen
    Citation: Stem Cell Research & Therapy 2020 11:250
    Content type: Research Published on:
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