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  1. Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues. This behavior of MSCs has been exploited as a tumor-targeting strategy for cell-based cancer therapy. However, the effects of MSCs on tumor ...

    Authors: Ting Zhang, Yuk Wai Lee, Yun Feng Rui, Tin Yan Cheng, Xiao Hua Jiang and Gang Li

    Citation: Stem Cell Research & Therapy 2013 4:70

    Content type: Research

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  2. The use of immortalized neural stem cells either as models of neural development in vitro or as cellular therapies in central nervous system (CNS) disorders has been controversial. This controversy has centered o...

    Authors: Graham Cocks, Nataliya Romanyuk, Takashi Amemori, Pavla Jendelova, Oksana Forostyak, Aaron R Jeffries, Leo Perfect, Sandrine Thuret, Govindan Dayanithi, Eva Sykova and Jack Price

    Citation: Stem Cell Research & Therapy 2013 4:69

    Content type: Research

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  3. A growing number of studies have highlighted the potential of stem cell and more-differentiated neural cell transplantation as intriguing therapeutic approaches for neural repair after spinal cord injury (SCI).

    Authors: Takashi Amemori, Nataliya Romanyuk, Pavla Jendelova, Vit Herynek, Karolina Turnovcova, Pavel Prochazka, Miroslava Kapcalova, Graham Cocks, Jack Price and Eva Sykova

    Citation: Stem Cell Research & Therapy 2013 4:68

    Content type: Research

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  4. Platelet-rich plasma (PRP) is nowadays widely applied in different clinical scenarios, such as orthopedics, ophthalmology and healing therapies, as a growth factor pool for improving tissue regeneration. Studi...

    Authors: Paola Romina Amable, Rosana Bizon Vieira Carias, Marcus Vinicius Telles Teixeira, Ítalo da Cruz Pacheco, Ronaldo José Farias Corrêa do Amaral, José Mauro Granjeiro and Radovan Borojevic

    Citation: Stem Cell Research & Therapy 2013 4:67

    Content type: Research

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  5. Because of their multi/pluripotency and immunosuppressive properties, mesenchymal stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue repair. The increasing use of MSCs, ...

    Authors: Luc Sensebé, Mélanie Gadelorge and Sandrine Fleury-Cappellesso

    Citation: Stem Cell Research & Therapy 2013 4:66

    Content type: Review

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  6. Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes,...

    Authors: Patricia Luz-Crawford, Monica Kurte, Javiera Bravo-Alegría, Rafael Contreras, Estefania Nova-Lamperti, Gautier Tejedor, Danièle Noël, Christian Jorgensen, Fernando Figueroa, Farida Djouad and Flavio Carrión

    Citation: Stem Cell Research & Therapy 2013 4:65

    Content type: Research

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  7. Based on some well-documented reports, we attempted to clarify the antifibrotic mechanisms of human Wharton’s-jelly-derived mesenchymal stromal cells (WJ-MSCs) from the perspective of induction of hepatocyte g...

    Authors: Tao Du, Xiangyu Zou, Jun Cheng, Shuai Wu, Liang Zhong, Guanqun Ju, Jiang Zhu, Guohua Liu, Yingjian Zhu and Shujie Xia

    Citation: Stem Cell Research & Therapy 2013 4:59

    Content type: Research

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  8. Accumulating evidence indicates that the protective effect of mesenchymal stem cells in models of tissue injury is related to the endocrine/pcrine release of factors. The delivery of growth factors, cytokines,...

    Authors: Stefania Bruno and Benedetta Bussolati

    Citation: Stem Cell Research & Therapy 2013 4:55

    Content type: Commentary

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  9. This study tested the hypothesis that cyclosporine (CsA)-supported syngeneic adipose-derived mesenchymal stem cell (ADMSC) therapy offered superior attenuation of acute ischemia–reperfusion (IR) kidney injury ...

    Authors: Yen-Ta Chen, Chih-Chau Yang, Yen-Yi Zhen, Christopher Glenn Wallace, Jenq-Lin Yang, Cheuk-Kwan Sun, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Sarah Chua, Chia-Lo Chang, Chung-Lung Cho, Steve Leu and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2013 4:62

    Content type: Research

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  10. Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide trophic support to improve surviva...

    Authors: Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci and Martin Marsala

    Citation: Stem Cell Research & Therapy 2013 4:57

    Content type: Research

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  11. Human hematopoietic stem cells (HSCs) have been clinically used for transplantation and gene and cellular therapy for more than 4 decades. However, this use is limited because of the challenges in the ex vivo cul...

    Authors: Kiranpreet Kaur, Mohammad Reza Mirlashari, Gunnar Kvalheim and Jens Kjeldsen-Kragh

    Citation: Stem Cell Research & Therapy 2013 4:60

    Content type: Research

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  12. Mesenchymal stem cells (MSCs) have the potential for treatment of diabetic cardiomyopathy; however, the repair capability of MSCs declines with age and disease. MSCs from diabetic animals exhibit impaired surv...

    Authors: Mohsin Khan, Fatima Ali, Sadia Mohsin, Shoaib Akhtar, Azra Mehmood, Mahmood S Choudhery, Shaheen N Khan and Sheikh Riazuddin

    Citation: Stem Cell Research & Therapy 2013 4:58

    Content type: Research

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  13. Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome th...

    Authors: Eun Mi Lee, Sunghoon Hurh, Bumrae Cho, Kook-Hwan Oh, Seung U Kim, Charles D Surh, Jonathan Sprent, Jaeseok Yang, Jae Young Kim and Curie Ahn

    Citation: Stem Cell Research & Therapy 2013 4:56

    Content type: Research

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  14. The main aim of this study is to evaluate potential human stem cells, such as dental pulp stem cells and amniotic fluid stem cells, combined with collagen scaffold to reconstruct critical-size cranial bone def...

    Authors: Tullia Maraldi, Massimo Riccio, Alessandra Pisciotta, Manuela Zavatti, Gianluca Carnevale, Francesca Beretti, Giovanni B La Sala, Antonella Motta and Anto De Pol

    Citation: Stem Cell Research & Therapy 2013 4:53

    Content type: Research

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  15. A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic gene-...

    Authors: Torbjorn O Pedersen, Anna L Blois, Zhe Xing, Ying Xue, Yang Sun, Anna Finne-Wistrand, Lars A Akslen, James B Lorens, Knut N Leknes, Inge Fristad and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2013 4:52

    Content type: Research

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  16. Neurons have the intrinsic capacity to produce insulin, similar to pancreatic cells. Adult neural stem cells (NSCs), which give rise to functional neurons, can be established and cultured not only by intracere...

    Authors: Ryo Hidaka, Masanao Machida, Shin Fujimaki, Kazuyuki Terashima, Makoto Asashima and Tomoko Kuwabara

    Citation: Stem Cell Research & Therapy 2013 4:51

    Content type: Research

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  17. Sufficient uterine blood supply is essential for the fetus to develop normally in the uterus. Several mechanisms are involved in the process of vessel development in deciduas and villus. We focus on whether fi...

    Authors: Qiushi Wang, Licong Shen, Wei Huang, Yong Song, Li Xiao, Wenming Xu and Ying Liu

    Citation: Stem Cell Research & Therapy 2013 4:50

    Content type: Research

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  18. SALL4 and BMI-1 are important factors in hematopoiesis. Placental tissue (PT) and umbilical cord blood (CB) are rich in hematopoietic stem/progenitor cells (HSCs/HPCs), but their SALL4 and BMI-1 expression levels...

    Authors: Shaohua Chen, Sichu Liu, Ling Xu, Lijian Yang, Zhenyi Jin, Yu Ma, Bo Li, Xiuli Wu, Jianchang Yang, Yupo Ma and Yangqiu Li

    Citation: Stem Cell Research & Therapy 2013 4:49

    Content type: Research

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  19. Administration of mesenchymal stem cells (MSCs) has been shown to improve renal function in rodent models of chronic kidney disease (CKD), in part by reducing intrarenal inflammation and suppressing fibrosis. ...

    Authors: Jessica M Quimby, Tracy L Webb, Lauren M Habenicht and Steven W Dow

    Citation: Stem Cell Research & Therapy 2013 4:48

    Content type: Research

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  20. Mesenchymal stem cells (MSCs) have attracted increasing interest in the field of oncology because of their inherent capacity to migrate and home tumor tissues. The remarkable tropism of MSCs for tumor microenv...

    Authors: Célia Maria Freitas Gomes

    Citation: Stem Cell Research & Therapy 2013 4:42

    Content type: Commentary

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  21. Understanding the multiple biological functions played by human mesenchymal stem cells (hMSCs) as well as their development as therapeutics in regenerative medicine or in cancer treatment are major fields of r...

    Authors: Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard, Jean-Luc Coll and Claire Rome

    Citation: Stem Cell Research & Therapy 2013 4:41

    Content type: Research

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  22. Administration of bone marrow mesenchymal stem cells (MSCs) or secreted microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles and mechanisms are not well understood. In t...

    Authors: Ying Zhou, Huitao Xu, Wenrong Xu, Bingying Wang, Huiyi Wu, Yang Tao, Bin Zhang, Mei Wang, Fei Mao, Yongmin Yan, Shuo Gao, Hongbing Gu, Wei Zhu and Hui Qian

    Citation: Stem Cell Research & Therapy 2013 4:34

    Content type: Research

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  23. Differentiation of vascular endothelial cells (ECs) in clinically relevant numbers for injection into ischaemic areas could offer therapeutic potential in the treatment of cardiovascular conditions, including ...

    Authors: Lynsey Howard, Ruth M Mackenzie, Nikolay A Pchelintsev, Tony McBryan, John D McClure, Martin W McBride, Nicole M Kane, Peter D Adams, Graeme Milligan and Andrew H Baker

    Citation: Stem Cell Research & Therapy 2013 4:36

    Content type: Research

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  24. No comparative study of adipose-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) by using superparamagnetic iron oxide nanoparticles (SPIOs)-labeling and magnetic resonance imaging (MR...

    Authors: Jingjing Fan, Yanbin Tan, Liyong Jie, Xinying Wu, Risheng Yu and Minming Zhang

    Citation: Stem Cell Research & Therapy 2013 4:44

    Content type: Research

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  25. Administration of bone marrow-derived mesenchymal stem cells (MSCs) after myocardial infarction (MI) results in modest functional improvements. However; the effect of microenvironment changes after MI, such as...

    Authors: Archana V Boopathy, Karl D Pendergrass, Pao Lin Che, Young-Sup Yoon and Michael E Davis

    Citation: Stem Cell Research & Therapy 2013 4:43

    Content type: Research

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  26. In the event of chronic diabetes or burn wounds, accomplishing skin regeneration is a major concern. Autologous skin grafting is the most effective remedy, but the tissue harvest may create more nonhealing wou...

    Authors: Renjith P Nair and Lissy K Krishnan

    Citation: Stem Cell Research & Therapy 2013 4:38

    Content type: Research

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  27. Invariant left-right (LR) patterning or chirality is critical for embryonic development. The loss or reversal of LR asymmetry is often associated with malformations and disease. Although several theories have ...

    Authors: Leo Q Wan, Kacey Ronaldson, Mark Guirguis and Gordana Vunjak-Novakovic

    Citation: Stem Cell Research & Therapy 2013 4:24

    Content type: Review

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  28. Recently, cell-based therapy has gained significant attention for the treatment of central nervous system diseases. Although bone marrow stromal cells (BMSCs) are considered to have good engraftment potential,...

    Authors: Takafumi Mitsuhara, Masaaki Takeda, Satoshi Yamaguchi, Tomotaka Manabe, Masaya Matsumoto, Yumi Kawahara, Louis Yuge and Kaoru Kurisu

    Citation: Stem Cell Research & Therapy 2013 4:35

    Content type: Research

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  29. The field of regenerative medicine is approaching translation to clinical practice, and significant safety concerns and knowledge gaps have become clear as clinical practitioners are considering the potential ...

    Authors: John Harding, R Michael Roberts and Oleg Mirochnitchenko

    Citation: Stem Cell Research & Therapy 2013 4:23

    Content type: Review

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  30. Loss of adult stem cell function during aging contributes to impaired tissue regeneration. Here, we tested the aging-related decline in regeneration potential of adult stem cells residing in the skeletal muscle.

    Authors: Minjung Song, Mitra Lavasani, Seth D Thompson, Aiping Lu, Bahar Ahani and Johnny Huard

    Citation: Stem Cell Research & Therapy 2013 4:33

    Content type: Research

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  31. Cell therapy using adipose-derived stem cells has been reported to improve chronic wounds via differentiation and paracrine effects. One such strategy is to deliver stem cells in hydrogels, which are studied i...

    Authors: Waqar Hassan, Yixiao Dong and Wenxin Wang

    Citation: Stem Cell Research & Therapy 2013 4:32

    Content type: Research

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  32. We hypothesized that dipeptidyl peptidase-IV (DPP4) may impair angiogenesis, endothelial function, and the circulating number of endothelial progenitor cells (EPC) in a model of critical limb ischemia (CLI) th...

    Authors: Cheuk-Kwan Sun, Steve Leu, Jiunn-Jye Sheu, Tzu-Hsien Tsai, Hsin-Chin Sung, Yung-Lung Chen, Sheng-Ying Chung, Sheung-Fat Ko, Hsueh-Wen Chang and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2013 4:31

    Content type: Research

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  33. Prior in vivo murine studies suggest circadian oscillations for hematopoietic stem cell release, which are maintained following administration of granulocyte colony-stimulating factor (G-CSF) or plerixafor. Furth...

    Authors: Patricia A Shi, Luis M Isola, Janice L Gabrilove, Erin L Moshier, James H Godbold, Lorraine K Miller and Paul S Frenette

    Citation: Stem Cell Research & Therapy 2013 4:30

    Content type: Research

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  34. Heme oxygenase (HO), a major cytoprotective enzyme, attenuates oxidative stress and obesity. The canonical Wnt signaling cascade plays a pivotal role in the regulation of adipogenesis. The present study examin...

    Authors: Luca Vanella, Komal Sodhi, Dong Hyun Kim, Nitin Puri, Mani Maheshwari, Terry D Hinds Jr, Lars Bellner, Dov Goldstein, Stephen J Peterson, Joseph I Shapiro and Nader G Abraham

    Citation: Stem Cell Research & Therapy 2013 4:28

    Content type: Research

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  35. Adipose tissue is an attractive and abundant source of multipotent stem cells. Human adipose stem cells (ASCs) have shown to have therapeutic relevancy in diverse clinical applications. Nevertheless, expansion...

    Authors: Mimmi Patrikoski, Miia Juntunen, Shayne Boucher, Andrew Campbell, Mohan C Vemuri, Bettina Mannerström and Susanna Miettinen

    Citation: Stem Cell Research & Therapy 2013 4:27

    Content type: Research

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  36. The acute respiratory distress syndrome (ARDS), affects up to 150,000 patients per year in the United States. We and other groups have demonstrated that bone marrow derived mesenchymal stromal stem cells preve...

    Authors: Mauricio Rojas, Richard E Parker, Natalie Thorn, Claudia Corredor, Smita S Iyer, Marta Bueno, Lyle Mroz, Nayra Cardenes, Ana L Mora, Arlene A Stecenko and Kenneth L Brigham

    Citation: Stem Cell Research & Therapy 2013 4:26

    Content type: Research

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