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  1. Mesenchymal stem cells (MSCs) have been widely used in cytotherapy and tissue engineering due to their immunosuppressive ability and regenerative potential. Recently, the immunomodulatory influence of MSCs has...

    Authors: Yuan Yin, Rui-Xin Wu, Xiao-Tao He, Xin-Yue Xu, Jia Wang and Fa-Ming Chen
    Citation: Stem Cell Research & Therapy 2017 8:153
    Content type: Research Published on:

  2. Asthma is a chronic inflammatory disease that can be difficult to treat due to its complex pathophysiology. Most current drugs focus on controlling the inflammatory process, but are unable to revert the change...

    Authors: Ligia Lins de Castro, Debora Gonçalves Xisto, Jamil Zola Kitoko, Fernanda Ferreira Cruz, Priscilla Christina Olsen, Patricia Albuquerque Garcia Redondo, Tatiana Paula Teixeira Ferreira, Daniel Jay Weiss, Marco Aurélio Martins, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco
    Citation: Stem Cell Research & Therapy 2017 8:151
    Content type: Research Published on:

  3. Disorders of the oxidative phosphorylation (OXPHOS) system represent a large group among the inborn errors of metabolism. The most frequently observed biochemical defect is isolated deficiency of mitochondrial...

    Authors: Marlen Melcher, Katharina Danhauser, Annette Seibt, Özer Degistirici, Fabian Baertling, Arun Kumar Kondadi, Andreas S. Reichert, Werner J. H. Koopman, Peter H. G. M. Willems, Richard J. Rodenburg, Ertan Mayatepek, Roland Meisel and Felix Distelmaier
    Citation: Stem Cell Research & Therapy 2017 8:150
    Content type: Research Published on:

  4. Due to the multilineage differentiation ability and paracrine role of adipose-derived stem cells (ASCs) for bladder defect repair, various scaffolds have been applied in combination with ASCs to promote bladde...

    Authors: Qiong Wang, Dong-dong Xiao, Hao Yan, Yang Zhao, Shi Fu, Juan Zhou, Zhong Wang, Zhe Zhou, Ming Zhang and Mu-Jun Lu
    Citation: Stem Cell Research & Therapy 2017 8:149
    Content type: Research Published on:

  5. Recent studies have indicated that microRNA-223 (miR-223) plays a role in the tissue-protective effect of mesenchymal stem cells (MSCs). NLR family-pyrin domain containing 3 (NLRP3) was reported to affect a re...

    Authors: Xiaopeng Yuan, Xiaoping Wang, Chuanbao Chen, Jian Zhou and Ming Han
    Citation: Stem Cell Research & Therapy 2017 8:146
    Content type: Research Published on:

  7. In our clinical practice, we perform transplantations of autologous synovial mesenchymal stem cells (MSCs) for cartilage and meniscus regenerative medicine. One of the most important issues to ensuring clinica...

    Authors: Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2017 8:144
    Content type: Research Published on:

  8. Mesenchymal stromal cells (MSCs) from various tissues have shown moderate therapeutic efficacy in reversing liver fibrosis in preclinical models. Here, we compared the relative therapeutic potential of pooled,...

    Authors: Mathiyazhagan Rengasamy, Gurbind Singh, Noor Atiqah Fakharuzi, Siddikuzzaman, Sudha Balasubramanian, Priyanka Swamynathan, Charan Thej, Gopinath Sasidharan, Pawan Kumar Gupta, Anjan Kumar Das, Ahmad Zuhairi Abd Rahman, Kamal Shaik Fakiruddin, Lim Moon Nian, Zubaidah Zakaria and Anish S. Majumdar
    Citation: Stem Cell Research & Therapy 2017 8:143
    Content type: Research Published on:

  9. The delivery of alternative myogenic cell sources to enhance the efficacy of minced muscle grafts (MG) for the treatment of volumetric muscle loss (VML) injuries is a promising strategy to overcome the demand ...

    Authors: Stephen M. Goldman, Beth E. P. Henderson and Benjamin T. Corona
    Citation: Stem Cell Research & Therapy 2017 8:142
    Content type: Short report Published on:

  10. A number of studies have shown that tooth-like structures can be regenerated using induced pluripotent stem cells and mouse embryonic stem (mES) cells. However, few studies have reported the regeneration of to...

    Authors: Yancong Zhang, Yongliang Li, Ruirui Shi, Siqi Zhang, Hao Liu, Yunfei Zheng, Yan Li, Jinglei Cai, Duanqing Pei and Shicheng Wei
    Citation: Stem Cell Research & Therapy 2017 8:141
    Content type: Research Published on:

  11. Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in cl...

    Authors: Samantha F. H. de Witte, Ana M. Merino, Marcella Franquesa, Tanja Strini, Johanna A. A. van Zoggel, Sander S. Korevaar, Franka Luk, Madhu Gargesha, Lisa O’Flynn, Debashish Roy, Steve J. Elliman, Philip N. Newsome, Carla C. Baan and Martin J. Hoogduijn
    Citation: Stem Cell Research & Therapy 2017 8:140
    Content type: Research Published on:

  12. Mechanical stimuli play important roles in the proliferation and differentiation of adult stem cells. However, few studies on their effects on induced pluripotent stem cells (iPSCs) have been published.

    Authors: Young Mi Kim, Yun Gyeong Kang, So Hee Park, Myung-Kwan Han, Jae Ho Kim, Ji Won Shin and Jung-Woog Shin
    Citation: Stem Cell Research & Therapy 2017 8:139
    Content type: Research Published on:

  13. Pathways directing endogenous stem/progenitor cells to restore normal architecture and function of damaged/diseased lungs remain underexplored. Published data have revealed that alveolar progenitor type II cel...

    Authors: Yuan Quan, Zhaohua Wang, Ling Gong, Xinmiao Peng, Melissa A. Richard, Junlan Zhang, Myriam Fornage, Joseph L. Alcorn and Dachun Wang
    Citation: Stem Cell Research & Therapy 2017 8:138
    Content type: Research Published on:

  14. Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that ...

    Authors: Jie Wang, Panpan Cen, Jiajia Chen, Linxiao Fan, Jun Li, Hongcui Cao and Lanjuan Li
    Citation: Stem Cell Research & Therapy 2017 8:137
    Content type: Review Published on:

  15. Stem cell therapy (SCT) for the treatment of Crohn’s disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed a meta-analysis to evaluate the efficacy...

    Authors: Yun Qiu, Man-ying Li, Ting Feng, Rui Feng, Ren Mao, Bai-li Chen, Yao He, Zhi-rong Zeng, Sheng-hong Zhang and Min-hu Chen
    Citation: Stem Cell Research & Therapy 2017 8:136
    Content type: Review Published on:

  16. Age-related macular degeneration (AMD) is a major cause of blindness in older adults in developed countries. It is a multifactorial disease triggered by both environmental and genetic factors. High-temperature...

    Authors: Shuo Sun, ZhiQing Li, Patrick Glencer, BinCui Cai, XiaoMin Zhang, Jin Yang and XiaoRong Li
    Citation: Stem Cell Research & Therapy 2017 8:135
    Content type: Review Published on:

  17. There is a critical need for the management of large bone defects. The purpose of this study was to engineer a biomimetic periosteum and to combine this with a macroporous β-tricalcium phosphate (β-TCP) scaffo...

    Authors: Dan Zhang, Peng Gao, Qin Li, Jinda Li, Xiaojuan Li, Xiaoning Liu, Yunqing Kang and Liling Ren
    Citation: Stem Cell Research & Therapy 2017 8:134
    Content type: Research Published on:

  18. Biological scaffolds composed of tissue-derived extracellular matrix (ECM) can promote homologous (i.e., tissue-specific) cell differentiation through preservation of biophysical and biochemical motifs found i...

    Authors: Benjamin B. Rothrauff, Guang Yang and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2017 8:133
    Content type: Research Published on:

  19. Non-integrating episomal vectors have become an important tool for induced pluripotent stem cell reprogramming. The episomal vectors carrying the “Yamanaka reprogramming factors” (Oct4, Klf, Sox2, and L-Myc + ...

    Authors: Christopher E. Schmitt, Blanca M. Morales, Ellen M. H. Schmitz, John S. Hawkins, Carlos O. Lizama, Joan P. Zape, Edward C. Hsiao and Ann C. Zovein
    Citation: Stem Cell Research & Therapy 2017 8:132
    Content type: Method Published on:

  20. Progressive liver fibrosis leads to cirrhosis and end-stage liver disease. This disease is a consequence of strong interactions between matrix-producing hepatic stellate cells (HSCs) and resident and infiltrat...

    Authors: Mustapha Najimi, Silvia Berardis, Hoda El-Kehdy, Valérie Rosseels, Jonathan Evraerts, Catherine Lombard, Adil El Taghdouini, Patrick Henriet, Leo van Grunsven and Etienne Marc Sokal
    Citation: Stem Cell Research & Therapy 2017 8:131
    Content type: Research Published on:

  22. Adipose tissue is a promising source of mesenchymal stromal cells (MSCs) for the treatment of tendon disease. The goal of this study was to assess the effect of a single intralesional implantation of adipose t...

    Authors: Florian Geburek, Florian Roggel, Hans T. M. van Schie, Andreas Beineke, Roberto Estrada, Kathrin Weber, Maren Hellige, Karl Rohn, Michael Jagodzinski, Bastian Welke, Christof Hurschler, Sabine Conrad, Thomas Skutella, Chris van de Lest, René van Weeren and Peter M. Stadler
    Citation: Stem Cell Research & Therapy 2017 8:129
    Content type: Research Published on:

  23. Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide cost-effective treatments affordable by public health systems...

    Authors: Jinpei Ye, Nicola Bates, Despina Soteriou, Lisa Grady, Clare Edmond, Alex Ross, Alan Kerby, Philip A. Lewis, Tope Adeniyi, Ronnie Wright, Kay V. Poulton, Marcus Lowe, Susan J. Kimber and Daniel R. Brison
    Citation: Stem Cell Research & Therapy 2017 8:128
    Content type: Research Published on:

  24. MicroRNAs (miRNAs) have emerged as crucial factors that regulate proliferation and apoptosis of cardiac c-kit+ cells. Although much is known about their role in maintaining cardiac c-kit+ cell pluripotency, the m...

    Authors: Jingjin Liu, Yongshun Wang, Jinjin Cui, Meng Sun, Zhongyue Pu, Chao Wang, Wenjuan Du, Xinxin Liu, Jian Wu, Jingbo Hou, Shuo Zhang and Bo Yu
    Citation: Stem Cell Research & Therapy 2017 8:127
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:404

  25. Autoimmune dacryoadenitis, such as Sjögren syndrome, comprises multifactorial and complex diseases. Inflammation of the lacrimal gland plays a key role in the pathogenesis of diseases. Unfortunately, current t...

    Authors: Xiaoxiao Lu, Xilian Wang, Hong Nian, Dan Yang and Ruihua Wei
    Citation: Stem Cell Research & Therapy 2017 8:126
    Content type: Review Published on:

  27. Adipose-derived stem cells (ADSCs) are easily obtained and expanded, and have emerged as a novel source of adult stem cells for the treatment of cardiovascular diseases. These cells have been shown to have the...

    Authors: Teng Ma, Jiacheng Sun, Zhenao Zhao, Wei Lei, Yueqiu Chen, Xu Wang, Junjie Yang and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2017 8:124
    Content type: Review Published on:

  29. Mesenchymal stem cells (MSCs) can be differentiated into an osteoblastic lineage in the presence of growth factors (GFs). Platelet-rich plasma (PRP), which can be easily isolated from whole blood, contains a l...

    Authors: Zunpeng Liu, Xue Yuan, Gabriela Fernandes, Rosemary Dziak, Ciprian N. Ionita, Chunyi Li, Changdong Wang and Shuying Yang
    Citation: Stem Cell Research & Therapy 2017 8:122
    Content type: Research Published on:

  30. In this study we evaluated the interactions of human adipose tissue-derived stem cells (ADSCs) and different human breast cancer cell lines (BRCAs) with regard to the safety of cell-assisted lipotransfers for ...

    Authors: Eva Koellensperger, Lilly-Claire Bonnert, Inka Zoernig, Frederik Marmé, Stefanie Sandmann, Günter Germann, Felix Gramley and Uwe Leimer
    Citation: Stem Cell Research & Therapy 2017 8:121
    Content type: Research Published on:

  31. We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant (MSC-Sp) on the wound healing capacity of equine ...

    Authors: Amanda B. Sherman, Brian C. Gilger, Alix K. Berglund and Lauren V. Schnabel
    Citation: Stem Cell Research & Therapy 2017 8:120
    Content type: Research Published on:

  32. Malignant pleural mesothelioma is an aggressive cancer, characterized by rapid progression and high mortality. Persistence of tumor-initiating cells (TICs, or cancer stem cells) after cytotoxic drug treatment ...

    Authors: Alessandra Pattarozzi, Elisa Carra, Roberto E. Favoni, Roberto Würth, Daniela Marubbi, Rosa Angela Filiberti, Luciano Mutti, Tullio Florio, Federica Barbieri and Antonio Daga
    Citation: Stem Cell Research & Therapy 2017 8:119
    Content type: Research Published on:

  33. Cardiovascular diseases are the leading causes of death in the world. The limited regenerative capacity of adult cardiomyocytes is the major barrier for heart regeneration. After myocardial infarction, myofibr...

    Authors: Yueqiu Chen, Ziying Yang, Zhen-Ao Zhao and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2017 8:118
    Content type: Review Published on:

  35. Autosomal dominant polycystic kidney disease (ADPKD) is a genetic ciliopathy disease characterized by progressive formation and enlargement of cysts in multiple organs. The kidneys are particularly affected an...

    Authors: Atieh Makhlough, Soroosh Shekarchian, Reza Moghadasali, Behzad Einollahi, Seyedeh Esmat Hosseini, Neda Jaroughi, Tina Bolurieh, Hossein Baharvand and Nasser Aghdami
    Citation: Stem Cell Research & Therapy 2017 8:116
    Content type: Research Published on:

  36. Mesenchymal stem cells derived from the synovial membrane (synovial MSCs) are a candidate cell source for regenerative medicine of cartilage and menisci due to their high chondrogenic ability. Regenerative med...

    Authors: Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Shizuka Fujii, Koji Otabe, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2017 8:115
    Content type: Research Published on:

  37. Basic fibroblast growth factor (bFGF) plays an important role in promoting wound healing and reducing scar, but the possible molecular mechanisms are still unclear. Our previous studies have found that activat...

    Authors: Peng Wang, Bin Shu, Yingbin Xu, Jiayuan Zhu, Jian Liu, Ziheng Zhou, Lei Chen, Jingling Zhao, Xusheng Liu, Shaohai Qi, Kun Xiong and Julin Xie
    Citation: Stem Cell Research & Therapy 2017 8:114
    Content type: Research Published on:

  38. Cell-based therapy that can rejuvenate the endothelium with stimulated adipose-derived mesenchymal stem cells (AMSCs) is a promising therapeutic strategy for the re-endothelialization of denuded arteries at th...

    Authors: Sami G. Almalki and Devendra K. Agrawal
    Citation: Stem Cell Research & Therapy 2017 8:113
    Content type: Research Published on:

  39. Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is one of the new therapeutic strategies for treating ischemic stroke. However, the relatively poor migratory capacity of BMSCs toward infa...

    Authors: Lin Li, Lisheng Chu, Yan Fang, Yan Yang, Tiebing Qu, Jianping Zhang, Yuanjun Yin and Jingjing Gu
    Citation: Stem Cell Research & Therapy 2017 8:112
    Content type: Research Published on:

  40. Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a conditio...

    Authors: Thomas Duncan and Michael Valenzuela
    Citation: Stem Cell Research & Therapy 2017 8:111
    Content type: Review Published on:

  41. Stem cells are undifferentiated cells and have multi-lineage differentiation potential. Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cell...

    Authors: Na Li, Bo Long, Wei Han, Shumin Yuan and Kun Wang
    Citation: Stem Cell Research & Therapy 2017 8:110
    Content type: Review Published on:

  42. Long-term ventricular pacing has deleterious effects and becomes more significant when cumulative percent ventricular pacing (Cum%VP) exceeds 40% of time. However, cellular disturbances and pathways by which p...

    Authors: Chang Cui, Le Geng, Jiaojiao Shi, Yue Zhu, Gang Yang, Zidun Wang, Jiaxian Wang and Minglong Chen
    Citation: Stem Cell Research & Therapy 2017 8:109
    Content type: Research Published on:

  43. The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal stem cells interacting with intervertebral disc cells, such as nucleus pulpos...

    Authors: Kang Lu, Hai-yin Li, Kuang Yang, Jun-long Wu, Xiao-wei Cai, Yue Zhou and Chang-qing Li
    Citation: Stem Cell Research & Therapy 2017 8:108
    Content type: Research Published on:

  44. Interstitial cystitis (IC) is a chronic inflammation disorder mainly within the submucosal and muscular layers of the bladder. As the cause of IC remains unknown, no effective treatments are currently availabl...

    Authors: Jia Li, Hui Luo, Xingyou Dong, Qian Liu, Chao Wu, Teng Zhang, Xiaoyan Hu, Yuanyuan Zhang, Bo Song and Longkun Li
    Citation: Stem Cell Research & Therapy 2017 8:107
    Content type: Research Published on:

  45. Microcarrier cultures which are useful for producing large cell numbers can act as scaffolds to create stem cell-laden microcarrier constructs for cartilage tissue engineering. However, the critical attributes...

    Authors: Youshan Melissa Lin, Jialing Lee, Jessica Fang Yan Lim, Mahesh Choolani, Jerry Kok Yen Chan, Shaul Reuveny and Steve Kah Weng Oh
    Citation: Stem Cell Research & Therapy 2017 8:93
    Content type: Research Published on:

  46. Mesangiogenic progenitor cells (MPCs) have shown the ability to differentiate in-vitro toward mesenchymal stromal cells (MSCs) as well as angiogenic potential. MPCs have so far been described in detail as prog...

    Authors: Marina Montali, Francesca M. Panvini, Serena Barachini, Francesca Ronca, Vittoria Carnicelli, Stefano Mazzoni, Iacopo Petrini and Simone Pacini
    Citation: Stem Cell Research & Therapy 2017 8:106
    Content type: Research Published on:

  47. Radiation enteropathy is a common complication in patients with abdominopelvic cancer, but no treatment has yet been established. Stem cell therapy may be a viable therapeutic option because intestinal stem ce...

    Authors: Young-Min Han, Jong-Min Park, Yong Soo Choi, Hee Jin, Yun-Sil Lee, Na-Young Han, Hookeun Lee and Ki Baik Hahm
    Citation: Stem Cell Research & Therapy 2017 8:105
    Content type: Research Published on:

  48. Satellite cells are quiescent resident muscle stem cells that present an important potential to regenerate damaged tissue. However, this potential is diminished once they are removed from their niche environme...

    Authors: Claire Monge, Nicholas DiStasio, Thomas Rossi, Muriel Sébastien, Hiroshi Sakai, Benoit Kalman, Thomas Boudou, Shahragim Tajbakhsh, Isabelle Marty, Anne Bigot, Vincent Mouly and Catherine Picart
    Citation: Stem Cell Research & Therapy 2017 8:104
    Content type: Research Published on:

  49. Mesenchymal stem cells (MSCs) show promising characteristics for their use in advanced therapy medicinal products. However, there are some unresolved concerns, such as the use of animal components for their ex...

    Authors: Arantxa Blázquez-Prunera, José María Díez, Rodrigo Gajardo and Salvador Grancha
    Citation: Stem Cell Research & Therapy 2017 8:103
    Content type: Research Published on:

  50. Mesenchymal stem cells (MSCs) have entered the clinic as an Advanced Therapy Medicinal Product and are currently evaluated in a wide range of studies for tissue regeneration or in autoimmune disorders. Various...

    Authors: Madeleine C. Killer, Philipp Nold, Katharina Henkenius, Lea Fritz, Tabea Riedlinger, Christina Barckhausen, Miriam Frech, Holger Hackstein, Andreas Neubauer and Cornelia Brendel
    Citation: Stem Cell Research & Therapy 2017 8:100
    Content type: Research Published on:
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