Fridenshtein A, Piatetskii S II. Petrakova KV [Osteogenesis in transplants of bone marrow cells]. Arkh Anat Gistol Embriol. 1969;56:3–11.
PubMed
Google Scholar
Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–7.
Article
CAS
PubMed
Google Scholar
Abu-Rmeileh NM, Husseini A, Capewell S, et al. Preventing type 2 diabetes among Palestinians: comparing five future policy scenarios. BMJ Open. 2013;3:e003558.
Article
PubMed
PubMed Central
Google Scholar
Spees JL, Lee RH, Gregory CA. Mechanisms of mesenchymal stem/stromal cell function. Stem Cell Res Ther. 2016;7:125.
Article
PubMed
PubMed Central
CAS
Google Scholar
Squillaro T, Peluso G, Galderisi U. Clinical trials with mesenchymal stem cells: an update. Cell Transplant. 2016;25:829–48.
Article
PubMed
Google Scholar
Li T, Xia M, Gao Y, et al. Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy. Expert Opin Biol Ther. 2015;15:1293–306.
Article
PubMed
CAS
Google Scholar
Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7.
Article
CAS
PubMed
Google Scholar
Ferrand J, Noel D, Lehours P, et al. Human bone marrow-derived stem cells acquire epithelial characteristics through fusion with gastrointestinal epithelial cells. PLoS ONE. 2011;6:e19569.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee RH, Pulin AA, Seo MJ, et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell. 2009;5:54–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goolaerts A, Pellan-Randrianarison N, Larghero J, et al. Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Am J Physiol Lung Cell Mol Physiol. 2014;306:L975-985.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ogisu K, Fujio M, Tsuchiya S, et al. Conditioned media from mesenchymal stromal cells and periodontal ligament fibroblasts under cyclic stretch stimulation promote bone healing in mouse calvarial defects. Cytotherapy. 2020;22:543–51.
Article
CAS
PubMed
Google Scholar
Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell. 2011;9:11–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Morrison TJ, Jackson MV, Cunningham EK, et al. Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer. Am J Respir Crit Care Med. 2017;196:1275–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ren J, Jin P, Sabatino M, et al. Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency. Cytotherapy. 2011;13:661–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cruz-Barrera M, Florez-Zapata N, Lemus-Diaz N, et al. Integrated analysis of transcriptome and secretome from umbilical cord mesenchymal stromal cells reveal new mechanisms for the modulation of inflammation and immune activation. Front Immunol. 2020;11:575488.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mathivanan S, Fahner CJ, Reid GE, et al. ExoCarta 2012: database of exosomal proteins, RNA and lipids. Nucleic Acids Res. 2012;40:D1241–4.
Article
CAS
PubMed
Google Scholar
Vlassov AV, Magdaleno S, Setterquist R, et al. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 2012;1820:940–8.
Article
CAS
PubMed
Google Scholar
Skotland T, Hessvik NP, Sandvig K, et al. Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology. J Lipid Res. 2019;60:9–18.
Article
CAS
PubMed
Google Scholar
Wang J, Jia H, Zhang B, et al. HucMSC exosome-transported 14-3-3zeta prevents the injury of cisplatin to HK-2 cells by inducing autophagy in vitro. Cytotherapy. 2018;20:29–44.
Article
PubMed
CAS
Google Scholar
Tomasoni S, Longaretti L, Rota C, et al. Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells. Stem Cells Dev. 2013;22:772–80.
Article
CAS
PubMed
Google Scholar
Zhang W, Wang Y, Kong J, et al. Therapeutic efficacy of neural stem cells originating from umbilical cord-derived mesenchymal stem cells in diabetic retinopathy. Sci Rep. 2017;7:408.
Article
PubMed
PubMed Central
CAS
Google Scholar
Cao J, Wang B, Tang T, et al. Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury. Stem Cell Res Ther. 2020;11:206.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ebrahim N, Ahmed IA, Hussien NI, et al. Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway. Cells. 2018;7:226.
Article
CAS
PubMed Central
Google Scholar
Li L, Zhang Y, Mu J, et al. Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury. Nano Lett. 2020;20:4298–305.
Article
CAS
PubMed
Google Scholar
Chen Q, Liu Y, Ding X, et al. Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7. Mol Cell Biochem. 2020;465:103–14.
Article
CAS
PubMed
Google Scholar
Ma T, Fu B, Yang X, et al. Adipose mesenchymal stem cell-derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/beta-catenin signaling in cutaneous wound healing. J Cell Biochem. 2019;120:10847–54.
Article
CAS
PubMed
Google Scholar
Bucan V, Vaslaitis D, Peck CT, et al. Effect of exosomes from rat adipose-derived mesenchymal stem cells on neurite outgrowth and sciatic nerve regeneration after crush injury. Mol Neurobiol. 2019;56:1812–24.
Article
CAS
PubMed
Google Scholar
Sun L, Xu R, Sun X, et al. Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell. Cytotherapy. 2016;18:413–22.
Article
CAS
PubMed
Google Scholar
Jang SC, Kim OY, Yoon CM, et al. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano. 2013;7:7698–710.
Article
CAS
PubMed
Google Scholar
Oh K, Kim SR, Kim DK, et al. In vivo differentiation of therapeutic insulin-producing cells from bone marrow cells via extracellular vesicle-mimetic nanovesicles. ACS Nano. 2015;9:11718–27.
Article
CAS
PubMed
Google Scholar
Jo W, Kim J, Yoon J, et al. Large-scale generation of cell-derived nanovesicles. Nanoscale. 2014;6:12056–64.
Article
CAS
PubMed
Google Scholar
Kim HY, Bhang SH. Stem cell-engineered nanovesicles exert proangiogenic and neuroprotective effects. Materials (Basel). 2021;14:1078.
Article
CAS
Google Scholar
Ko KW, Yoo YI, Kim JY, et al. Attenuation of tumor necrosis factor-alpha induced inflammation by umbilical cord-mesenchymal stem cell derived exosome-mimetic nanovesicles in endothelial cells. Tissue Eng Regen Med. 2020;17:155–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim HY, Kumar H, Jo MJ, et al. Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from mesenchymal stem cells for spinal cord injury treatment. Nano Lett. 2018;18:4965–75.
Article
CAS
PubMed
Google Scholar
Toh WS, Lai RC, Zhang B, et al. MSC exosome works through a protein-based mechanism of action. Biochem Soc Trans. 2018;46:843–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lai RC, Tan SS, Teh BJ, et al. Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome. Int J Proteom. 2012;2012:971907.
Google Scholar
Katsuda T, Tsuchiya R, Kosaka N, et al. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep. 2013;3:1197.
Article
PubMed
PubMed Central
CAS
Google Scholar
Han D, Yang J, Zhang E, et al. Analysis of mesenchymal stem cell proteomes in situ in the ischemic heart. Theranostics. 2020;10:11324–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang ZG, He ZY, Liang S, et al. Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2020;11:511.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nasiri Kenari A, Kastaniegaard K, Greening DW, et al. Proteomic and post-translational modification profiling of exosome-mimetic nanovesicles compared to exosomes. Proteomics. 2019;19:e1800161.
Article
PubMed
CAS
Google Scholar
Liu J, Ren L, Li S, et al. The biology, function, and applications of exosomes in cancer. Acta Pharm Sin B. 2021;11:2783–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kalimuthu S, Gangadaran P, Rajendran RL, et al. A new approach for loading anticancer drugs into mesenchymal stem cell-derived exosome mimetics for cancer therapy. Front Pharmacol. 2018;9:1116.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu JY, Ji AL, Wang ZX, et al. Exosome-Mimetic Nanovesicles from Hepatocytes promote hepatocyte proliferation in vitro and liver regeneration in vivo. Sci Rep. 2018;8:2471.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sung BH, Parent CA, Weaver AM. Extracellular vesicles: critical players during cell migration. Dev Cell. 2021;56:1861–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dozio V, Sanchez JC. Characterisation of extracellular vesicle-subsets derived from brain endothelial cells and analysis of their protein cargo modulation after TNF exposure. J Extracell Vesicles. 2017;6:1302705.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ding XQ, Wang ZY, Xia D, et al. Proteomic profiling of serum exosomes from patients with metastatic gastric cancer. Front Oncol. 2020;10:1113.
Article
PubMed
PubMed Central
Google Scholar
Dalton HM, Curran SP. Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans. PLoS Genet. 2018;14:e1007520.
Article
PubMed
PubMed Central
CAS
Google Scholar
Awah CU, Chen L, Bansal M, et al. Ribosomal protein S11 influences glioma response to TOP2 poisons. Oncogene. 2020;39:5068–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Venugopal S, Mascarenhas J, Steensma DP. Loss of 5q in myeloid malignancies: a gain in understanding of biological and clinical consequences. Blood Rev. 2021;46:100735.
Article
CAS
PubMed
Google Scholar
Li X, Chen R, Kemper S, et al. Structural and functional characterization of fibronectin in extracellular vesicles from hepatocytes. Front Cell Dev Biol. 2021;9:640667.
Article
PubMed
PubMed Central
Google Scholar
Liu Y, Zhuang X, Yu S, et al. Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization. Stem Cell Res Ther. 2021;12:76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu J, Han L, Liu R, et al. Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study. J Transl Med. 2021;19:331.
Article
CAS
PubMed
PubMed Central
Google Scholar
Valle L, de Voer RM, Goldberg Y, et al. Update on genetic predisposition to colorectal cancer and polyposis. Mol Aspects Med. 2019;69:10–26.
Article
CAS
PubMed
Google Scholar
Bhar S, Zhou F, Reineke LC, et al. Expansion of germline RPS20 mutation phenotype to include Diamond-Blackfan anemia. Hum Mutat. 2020;41:1918–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Guillot A, Guerri L, Feng D, et al. Bile acid-activated macrophages promote biliary epithelial cell proliferation through integrin alphavbeta6 upregulation following liver injury. J Clin Invest. 2021. https://doi.org/10.1172/JCI132305.
Article
PubMed
PubMed Central
Google Scholar
Lin TY, Guo H, Chen X. Unraveling mechanisms of pentraxin 3 secretion in adipocytes during inflammation. J Mol Endocrinol. 2021;67:55–69.
Article
CAS
PubMed
Google Scholar
Kotani S, Yoda A, Kon A, et al. Molecular pathogenesis of disease progression in MLL-rearranged AML. Leukemia. 2019;33:612–24.
Article
CAS
PubMed
Google Scholar
Soong BW, Huang YH, Tsai PC, et al. Exome sequencing identifies GNB4 mutations as a cause of dominant intermediate Charcot–Marie–Tooth disease. Am J Hum Genet. 2013;92:422–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Campillo-Marcos I, Garcia-Gonzalez R, Navarro-Carrasco E, et al. The human VRK1 chromatin kinase in cancer biology. Cancer Lett. 2021;503:117–28.
Article
CAS
PubMed
Google Scholar
Zhu Y, Zhang G, Lin S, et al. Sec61beta facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules. Protein Cell. 2018;9:616–28.
Article
CAS
PubMed
Google Scholar
Roosen DA, Blauwendraat C, Cookson MR, et al. DNAJC proteins and pathways to parkinsonism. FEBS J. 2019;286:3080–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shrestha C, Zhao L, Chen K, et al. Enhanced healing of diabetic wounds by subcutaneous administration of human umbilical cord derived stem cells and their conditioned media. Int J Endocrinol. 2013;2013:592454.
PubMed
PubMed Central
Google Scholar
Rackov G, Garcia-Romero N, Esteban-Rubio S, et al. Vesicle-mediated control of cell function: the role of extracellular matrix and microenvironment. Front Physiol. 2018;9:651.
Article
PubMed
PubMed Central
Google Scholar
Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117:1219–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Davis FM, Kimball A, Boniakowski A, et al. Dysfunctional wound healing in diabetic foot ulcers: new crossroads. Curr Diab Rep. 2018;18:2.
Article
PubMed
Google Scholar
Zhang J, Chen C, Hu B, et al. Exosomes derived from human endothelial progenitor cells accelerate cutaneous wound healing by promoting angiogenesis through Erk1/2 signaling. Int J Biol Sci. 2016;12:1472–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang J, Chen Z, Pan D, et al. Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin regeneration. Int J Nanomed. 2020;15:5911–26.
Article
CAS
Google Scholar
Liu W, Yu M, Xie D, et al. Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway. Stem Cell Res Ther. 2020;11:259.
Article
PubMed
PubMed Central
CAS
Google Scholar
Hu Y, Rao SS, Wang ZX, et al. Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function. Theranostics. 2018;8:169–84.
Article
CAS
PubMed
PubMed Central
Google Scholar