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  1. This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1+/− heterozygote mouse using blastocyst complementation. Additionally, this approach corrected n...

    Authors: Aleta R. Steevens, Matthew W. Griesbach, Yun You, James R. Dutton, Walter C. Low and Peter A. Santi
    Citation: Stem Cell Research & Therapy 2021 12:122
    Content type: Short report Published on:

  2. Mesenchymal stem cells (MSCs) are favourable treatments for ischaemic diseases; however, MSCs from diabetic patients are not useful for this purpose. Recent studies have...

    Authors: Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu and Zhuoqi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:115
    Content type: Research Published on:

  3. Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are asso...

    Authors: Jun Sung Kim, Young Hyun Jung, Hyun Jik Lee, Chang Woo Chae, Gee Euhn Choi, Jae Ryong Lim, Seo Yihl Kim, Joo Eun Lee and Ho Jae Han
    Citation: Stem Cell Research & Therapy 2021 12:114
    Content type: Research Published on:

  4. Despite recent rapid progress in method development and biological understanding of induced pluripotent stem (iPS) cells, there has been a relative shortage of tools that monitor the early reprogramming proces...

    Authors: Sandhya Sriram, Nam-Young Kang, Subha Subramanian, Tannistha Nandi, Samydurai Sudhagar, Qiaorui Xing, Gerine Jin-Ling Tong, Allen Kuan-Liang Chen, Thekkeparambil Chandrabose Srijaya, Patrick Tan, Yuin-Han Loh, Young-Tae Chang and Shigeki Sugii
    Citation: Stem Cell Research & Therapy 2021 12:113
    Content type: Method Published on:

  5. Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD+)-dependent sirtuins (SIRTs). SIRTs regulate functi...

    Authors: Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima and Julia Skokowa
    Citation: Stem Cell Research & Therapy 2021 12:112
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:299

  6. Cerebral ischemia-reperfusion (I/R) injury, the most common form of stroke, has high mortality and often brings persistent and serious brain dysfunction among survivors. Administration of adipose-derived mesen...

    Authors: Yamei Zhang, Junying Liu, Mi Su, Xin Wang and Chenchen Xie
    Citation: Stem Cell Research & Therapy 2021 12:111
    Content type: Research Published on:

  7. Novel therapeutic strategies for the healing of nonunion, which has serious effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of local transplantation of human stromal...

    Authors: Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura…
    Citation: Stem Cell Research & Therapy 2021 12:110
    Content type: Research Published on:

  8. Effective stem cell therapy is dependent on the stem cell quality that is determined by their differentiation potential, impairment of which leads to poor engraftment and survival into the target cells. Howeve...

    Authors: Smarajit Chakraborty, Wee Kiat Ong, Winifred W. Y. Yau, Zhihong Zhou, K. N. Bhanu Prakash, Sue-Anne Toh, Weiping Han, Paul M. Yen and Shigeki Sugii
    Citation: Stem Cell Research & Therapy 2021 12:109
    Content type: Research Published on:

  9. Bone fracture repair has gained a lot of attention due to the high incidence of delayed union or even nonunion especially in osteoporotic patients, resulting in a dreadful impact on the quality of life. Howeve...

    Authors: Liang Chen, Ri-Yan Zhang, Jun Xie, Jia-Yi Yang, Kang-Hao Fang, Chen-Xuan Hong, Rong-Bo Yang, Najeeb Bsoul and Lei Yang
    Citation: Stem Cell Research & Therapy 2021 12:108
    Content type: Research Published on:

  10. A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There ar...

    Authors: Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang and Xueran Chen
    Citation: Stem Cell Research & Therapy 2021 12:107
    Content type: Research Published on:

  11. Mesenchymal stromal cells (MSCs) are an emerging prophylaxis option for graft-versus-host disease (GVHD) in haplo-identical hematopoietic stem cell transplantation (haplo-HSCT) recipients with severe aplastic ...

    Authors: Ruonan Li, Jingke Tu, Jingyu Zhao, Hong Pan, Liwei Fang and Jun Shi
    Citation: Stem Cell Research & Therapy 2021 12:106
    Content type: Research Published on:

  12. Multipotent mesenchymal stromal cells (MSCs) are potentially therapeutic for muscle disease because they can accumulate at the sites of injury and act as immunosuppressants. MSCs are attractive candidates for ...

    Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Yuki Oda, Hiromi Hayashita-Kinoh, Shin’ichi Takeda and Takashi Okada
    Citation: Stem Cell Research & Therapy 2021 12:105
    Content type: Research Published on:

  13. This study aimed to explore the effect of KAT6A on the decreased stemness of aging bone marrow-derived mesenchymal stem cells (BMSCs) and its potential mechanism.

    Authors: Dongdong Fei, Yazheng Wang, Qiming Zhai, Xige Zhang, Yang Zhang, Yang Wang, Bei Li and Qintao Wang
    Citation: Stem Cell Research & Therapy 2021 12:104
    Content type: Research Published on:

  14. The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still...

    Authors: Chao Yang, Mingjun Wu, Min You, Yu Chen, Maowen Luo and Qiang Chen
    Citation: Stem Cell Research & Therapy 2021 12:103
    Content type: Review Published on:

  15. Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs below the injured segment. SCI not only results in physical and psychological harm to patients but can also cause a hu...

    Authors: Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li and Xue-wen Kang
    Citation: Stem Cell Research & Therapy 2021 12:102
    Content type: Review Published on:

  16. Distraction osteogenesis (DO) is a highly efficacious form of reconstructive bone regeneration, but its clinical utility is limited by the prolonged period required for bone consolidation to occur. Understandi...

    Authors: Weidong Jiang, Peiqi Zhu, Tao Zhang, Fengchun Liao, Yangyang Yu, Yan Liu, Huijuan Shen, Zhenchen Zhao, Xuanping Huang and Nuo Zhou
    Citation: Stem Cell Research & Therapy 2021 12:101
    Content type: Research Published on:

  17. Secretome profiles of mesenchymal stem cells (MSCs) are reflective of their local microenvironments. These biologically active factors exert an impact on the surrounding cells, eliciting regenerative responses...

    Authors: Nurul Dinah Kadir, Zheng Yang, Afizah Hassan, Vinitha Denslin and Eng Hin Lee
    Citation: Stem Cell Research & Therapy 2021 12:100
    Content type: Research Published on:

  18. Reendothelialisation is the natural pathway that inhibits neointimal hyperplasia and in-stent restenosis. Circulating endothelial progenitor cells (EPCs) derived from bone marrow (BM) might contribute to endot...

    Authors: Wei Wang, Yingqian Zhang, Hui Hui, Wei Tong, Zechen Wei, Zhongxuan Li, Suhui Zhang, Xin Yang, Jie Tian and Yundai Chen
    Citation: Stem Cell Research & Therapy 2021 12:99
    Content type: Research Published on:

  19. Human periodontal ligament stem cells (hPDLSCs) are ideal seed cells for periodontal regeneration. A greater understanding of the dynamic protein profiles during osteogenic differentiation contributed to the i...

    Authors: Jianjia Li, Zhifa Wang, Xiangyu Huang, Zhaodan Wang, Zehao Chen, Runting Wang, Zhao Chen, Wei Liu, Buling Wu, Fuchun Fang and Wei Qiu
    Citation: Stem Cell Research & Therapy 2021 12:98
    Content type: Research Published on:

  20. Protein tyrosine phosphatase 1B (PTP1B) is one of the major negative regulators of leptin and insulin signaling, and has been strongly implicated in insulin resistance development in the course of obesity and ...

    Authors: Lynda Bourebaba, Katarzyna Kornicka-Garbowska, Mohamad Al Naem, Michael Röcken, Jacek Łyczko and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2021 12:97
    Content type: Research Published on:

  21. Previous reports have identified that human bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) with their cargo microRNAs (miRNAs) are a promising therapeutic approach for the treatmen...

    Authors: Jing Zhou, Yang Lin, Xiuhua Kang, Zhicheng Liu, Wei Zhang and Fei Xu
    Citation: Stem Cell Research & Therapy 2021 12:96
    Content type: Research Published on:

  22. Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generate...

    Authors: Jing Kong, Shiyuan Wen, Wenjing Cao, Peng Yue, Xin Xu, Yu Zhang, Lisha Luo, Taigui Chen, Lianbao Li, Feng Wang, Jian Tao, Guozhong Zhou, Suyi Luo, Aihua Liu and Fukai Bao
    Citation: Stem Cell Research & Therapy 2021 12:95
    Content type: Review Published on:

  23. The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) ca...

    Authors: Jingting Chen, Yinmin Wang, Haoyue Hu, Yao Xiong, Shoubao Wang and Jun Yang
    Citation: Stem Cell Research & Therapy 2021 12:94
    Content type: Research Published on:

  24. Cell therapies present an exciting potential but there is a long history of expensive translational failures in stroke research. Researchers engaged in cell therapy research would benefit from a practical fram...

    Authors: Anjali Nagpal, Austin G. Milton, Simon A. Koblar and M. Anne Hamilton-Bruce
    Citation: Stem Cell Research & Therapy 2021 12:93
    Content type: Method Published on:

  25. Dyskeratosis congenita (DC) is a rare telomere biology disorder, which results in different clinical manifestations, including severe bone marrow failure. To date, the only curative treatment for the bone marr...

    Authors: Carlos Carrascoso-Rubio, Hidde A. Zittersteijn, Laura Pintado-Berninches, Beatriz Fernández-Varas, M. Luz Lozano, Cristina Manguan-Garcia, Leandro Sastre, Juan A. Bueren, Rosario Perona and Guillermo Guenechea
    Citation: Stem Cell Research & Therapy 2021 12:92
    Content type: Short report Published on:

  26. Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human mesenchymal stem cells (MSCs) as a potential treatment for...

    Authors: Seyed-Mohammad Reza Hashemian, Rasoul Aliannejad, Morteza Zarrabi, Masoud Soleimani, Massoud Vosough, Seyedeh-Esmat Hosseini, Hamed Hossieni, Saeid Heidari Keshel, Zeinab Naderpour, Ensiyeh Hajizadeh-Saffar, Elham Shajareh, Hamidreza Jamaati, Mina Soufi-Zomorrod, Naghmeh Khavandgar, Hediyeh Alemi, Aliasghar Karimi…
    Citation: Stem Cell Research & Therapy 2021 12:91
    Content type: Research Published on:

  28. Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling ...

    Authors: Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye and Qiang Su
    Citation: Stem Cell Research & Therapy 2021 12:89
    Content type: Research Published on:

  29. Tissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members ...

    Authors: Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper and Nathan R. Schiele
    Citation: Stem Cell Research & Therapy 2021 12:88
    Content type: Research Published on:

  30. Erectile dysfunction (ED) has often been observed in patients with obstructive sleep apnea (OSA). Research on adipose-derived mesenchymal stem cell (ADSC)-derived exosomes has shown that they have significant ...

    Authors: Li Liang, Dachao Zheng, Chao Lu, Qinghong Xi, Hua Bao, Wengfeng Li, Yufei Gu, Yuanshen Mao, Bin Xu and Xin Gu
    Citation: Stem Cell Research & Therapy 2021 12:87
    Content type: Research Published on:

  31. Leukemia stem cells (LSCs) are responsible for the initiation, progression, and relapse of acute myeloid leukemia (AML). Therefore, a therapeutic strategy targeting LSCs is a potential approach to eradicate AM...

    Authors: Yongliang Liu, Guiqin Wang, Jiasi Zhang, Xue Chen, Huailong Xu, Gang Heng, Jun Chen, Yongchun Zhao, Jiatao Li, Yuanli Ni, Yingzi Zhang, Juanjuan Shan and Cheng Qian
    Citation: Stem Cell Research & Therapy 2021 12:86
    Content type: Research Published on:

  32. Sufficient vascular network plays an important role in the repair of bone defects. Bone morphogenetic protein 2 (BMP2) being a key regulator of angiogenesis has attracted the attention of researchers. In addit...

    Authors: Mingjiao Chen, Meng Zhou, Yao Fu, Jin Li and Zi Wang
    Citation: Stem Cell Research & Therapy 2021 12:85
    Content type: Research Published on:

  33. Drug-induced liver injury (DILI) is one of the leading causes of clinical trial failures and high drug attrition rates. Currently, the commonly used hepatocyte models include primary human hepatocytes (PHHs), ...

    Authors: Meixian Jin, Xiao Yi, Wei Liao, Qi Chen, Wanren Yang, Yang Li, Shao Li, Yi Gao, Qing Peng and Shuqin Zhou
    Citation: Stem Cell Research & Therapy 2021 12:84
    Content type: Review Published on:

  34. Adult mammalian retinal stem cells (RSCs) readily proliferate, self-renew, and generate progeny that differentiate into all retinal cell types in vitro. RSC-derived progeny can be induced to differentiate into...

    Authors: Kenneth N. Grisé, Nelson X. Bautista, Krystal Jacques, Brenda L. K. Coles and Derek van der Kooy
    Citation: Stem Cell Research & Therapy 2021 12:83
    Content type: Research Published on:

  35. Multipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unkn...

    Authors: Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz and Marc G. Jeschke
    Citation: Stem Cell Research & Therapy 2021 12:82
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:256

  36. CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (IT...

    Authors: Faroogh Marofi, Roza Motavalli, Vladimir A. Safonov, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Markov Alexander, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Mostafa Jarahian, Sepideh Izadi, Ali Hassanzadeh, Naghmeh Shirafkan, Safa Tahmasebi and Farhad Motavalli Khiavi
    Citation: Stem Cell Research & Therapy 2021 12:81
    Content type: Review Published on:

  37. Patients with peripheral nerve injury (PNI) often suffer from hypoxic ischemic impairments, in particular when combined with vascular damage, causing neuronal dysfunction and death. Increasing attention has be...

    Authors: Meng Cong, Mi Shen, Xia Wu, Yan Li, Liting Wang, Qianru He, Haiyan Shi and Fei Ding
    Citation: Stem Cell Research & Therapy 2021 12:80
    Content type: Research Published on:

  38. The liver is one of the vital organs involved in detoxification and metabolism. The sex-based differences between the functionality of male and female liver have been previously reported, i.e., male’s liver ar...

    Authors: Imran Ullah, Yurianna Shin, Yeongji Kim, Keon Bong Oh, Seongsoo Hwang, Young-Im Kim, Jeong Woong Lee, Tai-Young Hur, Seunghoon Lee and Sun A Ock
    Citation: Stem Cell Research & Therapy 2021 12:79
    Content type: Research Published on:

  39. Duchenne muscular dystrophy (DMD) is an inherited progressive disorder that causes skeletal and cardiac muscle deterioration with chronic inflammation. Dental pulp stem cells (DPSCs) are attractive candidates ...

    Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Posadas Herrera Guillermo, Hiromi Hayashita-Kinoh, Yasunobu Maruoka, Aki Nakamura-Takahasi, Koichi Kimura, Shin’ichi Takeda and Takashi Okada
    Citation: Stem Cell Research & Therapy 2021 12:78
    Content type: Research Published on:

  40. Chemotherapy is an effective anti-tumor treatment. Mesenchymal stem cells (MSCs), exerting therapy effect on injured tissues during chemotherapy, may be damaged in the process. The possibility of self-healing ...

    Authors: Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu, Jie Wu and Zongjin Li
    Citation: Stem Cell Research & Therapy 2021 12:77
    Content type: Research Published on:

  41. Reconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration is crucial in determining the therapeutic outcomes of craniofacial CSD. Stem ...

    Authors: Yao Liu, Xueying Zhuang, Si Yu, Ning Yang, Jianhong Zeng, Xuemei Liu and Xu Chen
    Citation: Stem Cell Research & Therapy 2021 12:76
    Content type: Research Published on:

  42. Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp...

    Authors: Jie Chen, Huaxing Xu, Kun Xia, Shuhua Cheng and Qi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:75
    Content type: Research Published on:

  44. Life-long tissue homeostasis of adult tissues is supposedly maintained by the resident stem cells. These stem cells are quiescent in nature and rarely divide to self-renew and give rise to tissue-specific “pro...

    Authors: Deepa Bhartiya
    Citation: Stem Cell Research & Therapy 2021 12:73
    Content type: Commentary Published on:

  45. One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage an...

    Authors: Haggai Kaspi, Jonathan Semo, Nathalie Abramov, Chen Dekel, Stacy Lindborg, Ralph Kern, Chaim Lebovits and Revital Aricha
    Citation: Stem Cell Research & Therapy 2021 12:72
    Content type: Research Published on:

  46. Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected ...

    Authors: Yaya Tang, Yan Zhou and Hong-Jun Li
    Citation: Stem Cell Research & Therapy 2021 12:71
    Content type: Review Published on:

  47. Age-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis pigmentosa (RP), an inherited early-onset disease, results from premature loss ...

    Authors: Harshini Surendran, Swapna Nandakumar, Vijay Bhaskar Reddy K, Jonathan Stoddard, Varsha Mohan K, Pramod K. Upadhyay, Trevor J. McGill and Rajarshi Pal
    Citation: Stem Cell Research & Therapy 2021 12:70
    Content type: Research Published on:

  48. Optic-nerve injury results in impaired transmission of visual signals to central targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss. Therapies with mesenchymal stem ce...

    Authors: Almir Jordão da Silva-Junior, Louise Alessandra Mesentier-Louro, Gabriel Nascimento-dos-Santos, Leandro Coelho Teixeira-Pinheiro, Juliana F. Vasques, Luiza Chimeli-Ormonde, Victor Bodart-Santos, Luiza Rachel Pinheiro de Carvalho, Marcelo Felippe Santiago and Rosalia Mendez-Otero
    Citation: Stem Cell Research & Therapy 2021 12:69
    Content type: Research Published on:

  49. In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing.

    Authors: Frederik Penzien Mamsen, Lea Munthe-Fog, Mikela Karen Mungal Kring, Dominik Duscher, Mikkel Taudorf, Adam J. Katz and Stig-Frederik Trojahn Kølle
    Citation: Stem Cell Research & Therapy 2021 12:68
    Content type: Review Published on:

  50. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnuolo, José David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. Laflamme
    Citation: Stem Cell Research & Therapy 2021 12:66
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:417

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