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  1. Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available.

    Authors: Cristian De Gregorio, David Contador, Diego Díaz, Constanza Cárcamo, Daniela Santapau, Lorena Lobos-Gonzalez, Cristian Acosta, Mario Campero, Daniel Carpio, Caterina Gabriele, Marco Gaspari, Victor Aliaga-Tobar, Vinicius Maracaja-Coutinho, Marcelo Ezquer and Fernando Ezquer
    Citation: Stem Cell Research & Therapy 2020 11:168
    Content type: Research Published on:

  2. Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and lon...

    Authors: Fabio S. Aguiar, André S. Melo, Ana Maria S. Araújo, Alexandre P. Cardoso, Sergio Augusto L. de Souza, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Debora G. Xisto, Karina D. Asensi, Lanuza Faccioli, Anna Beatriz S. Salgado, Maria Carolina P. P. Landesmann, Regina C. S. Goldenberg, Bianca Gutfilen, Marcelo M. Morales, Patricia R. M. Rocco…
    Citation: Stem Cell Research & Therapy 2020 11:167
    Content type: Research Published on:

  3. Fibroblasts are crucial for supporting normal wound healing. However, the functional state of these cells is impaired in diabetics because of a high-glucose (HG) microenvironment. Small extracellular vesicles ...

    Authors: Xiaowei Bian, Bingmin Li, Jie Yang, Kui Ma, Mengli Sun, Cuiping Zhang and Xiaobing Fu
    Citation: Stem Cell Research & Therapy 2020 11:166
    Content type: Research Published on:

  4. Mesenchymal stromal cell (MSC)-enriched products showed positive clinical outcomes in regenerative medicine, where tissue restoration and inflammation control are needed. GMP-expanded MSCs displayed an even hi...

    Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Carlotta Mondadori, Marco Viganò, Alessandra Colombini and Laura de Girolamo
    Citation: Stem Cell Research & Therapy 2020 11:165
    Content type: Research Published on:

  5. CD18 is the common beta subunit of β2 integrins, which are expressed on hematopoietic cells. β2 integrins are essential for cell adhesion and leukocyte trafficking.

    Authors: Cristina Mesa-Núñez, Diego Leon-Rico, Montserrat Aldea, Carlos Damián, Raquel Sanchez-Baltasar, Rebeca Sanchez, Omaira Alberquilla, José Carlos Segovia, Juan Antonio Bueren and Elena Almarza
    Citation: Stem Cell Research & Therapy 2020 11:164
    Content type: Research Published on:

  6. Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem ...

    Authors: Fei He, Ning Li, Hai-Bo Huang, Jing-Bo Wang, Xiao-Fei Yang, Hua-Dong Wang, Wei Huang and Fu-Rong Li
    Citation: Stem Cell Research & Therapy 2020 11:163
    Content type: Research Published on:

  7. M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. However, the possible synergistic effects between exogenous exosomes and endogenous M2 macrophages ...

    Authors: Dihan Zhu, Takerra K. Johnson, Yang Wang, Miracle Thomas, Ky Huynh, Qinglin Yang, Vincent C. Bond, Y. Eugene Chen and Dong Liu
    Citation: Stem Cell Research & Therapy 2020 11:162
    Content type: Research Published on:

  8. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to have therapeutic potential for ischemic diseases and are considered an alternative to cell therapy. However, the low retentio...

    Authors: Yue Liu, Jian Cui, Hongfen Wang, Kamal Hezam, Xiaotong Zhao, Haoyan Huang, Shang Chen, Zhibo Han, Zhong-Chao Han, Zhikun Guo and Zongjin Li
    Citation: Stem Cell Research & Therapy 2020 11:161
    Content type: Research Published on:

  9. Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of rad...

    Authors: Linqing Zou, Haoming Li, Xiao Han, Jianbing Qin and Guoqi Song
    Citation: Stem Cell Research & Therapy 2020 11:160
    Content type: Research Published on:

  10. Human amniotic epithelial cell (hAEC) transplantation holds great promise in treating premature ovarian insufficiency (POI). However, some deficient biological characteristics of hAECs restrict their application.

    Authors: Shunyu Hou, Chenyue Ding, Han Shen, Chunfeng Qian, Qinyan Zou, Jiafeng Lu, Boxian Huang, Jichun Tan and Hong Li
    Citation: Stem Cell Research & Therapy 2020 11:159
    Content type: Research Published on:

  11. Mesenchymal stromal cells (MSCs) represent an interesting tool to improve pancreatic islet transplantation. They have immunomodulatory properties and secrete supportive proteins. However, the functional proper...

    Authors: Orianne Villard, Mathieu Armanet, Guilhem Couderc, Claire Bony, Jerome Moreaux, Daniele Noël, John DeVos, Bernard Klein, Jean-Luc Veyrune and Anne Wojtusciszyn
    Citation: Stem Cell Research & Therapy 2020 11:158
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:190

  12. The development of somatic reprogramming, especially purely chemical reprogramming, has significantly advanced biological research. And chemical-induced extraembryonic endoderm-like (ciXEN) cells have been con...

    Authors: Xia He, Guangfan Chi, Meiying Li, Jinying Xu, Lihong Zhang, Yaolin Song, Lina Wang and Yulin Li
    Citation: Stem Cell Research & Therapy 2020 11:157
    Content type: Research Published on:

  13. Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of ...

    Authors: Amandda Évelin Silva-Carvalho, Leane Perim Rodrigues, Josiane Lilian Schiavinato, Marcos Rodrigo Alborghetti, Gustavo Bettarello, Belinda Pinto Simões, Francisco de Assis Rocha Neves, Rodrigo Alexandre Panepucci, Juliana Lott de Carvalho and Felipe Saldanha-Araujo
    Citation: Stem Cell Research & Therapy 2020 11:156
    Content type: Research Published on:

  14. The limited neuronal differentiation of the endogenous or grafted neural stem cells (NSCs) after brain injury hampers the clinic usage of NSCs. Panax notoginseng saponins (PNS) were extensively used for their cli...

    Authors: Liu-Lin Xiong, De-Lu Qiu, Guang-Hui Xiu, Mohammed Al-Hawwas, Ya Jiang, You-Cui Wang, Yue Hu, Li Chen, Qing-Jie Xia and Ting-Hua Wang
    Citation: Stem Cell Research & Therapy 2020 11:155
    Content type: Research Published on:

  15. Hepatocyte-like cells (iHEPs) generated by transcription factor-mediated direct reprogramming of somatic cells have been studied as potential cell sources for the development of novel therapies targeting liver...

    Authors: Iasmim Diniz Orge, Victoria L. Gadd, Judah Leão Barouh, Erik Aranha Rossi, Rejane Hughes Carvalho, Ian Smith, Kyan James Allahdadi, Bruno Diaz Paredes, Daniela Nascimento Silva, Patrícia Kauanna F. Damasceno, Gabriela Louise Sampaio, Stuart J. Forbes, Milena Botelho Pereira Soares and Bruno Solano de Freitas Souza
    Citation: Stem Cell Research & Therapy 2020 11:154
    Content type: Research Published on:

  16. To date, it has repeatedly been demonstrated that infusing bone marrow-derived stem cells (BMSCs) into acellular nerve scaffolds can promote and support axon regeneration through a peripheral nerve defect. How...

    Authors: Li Na Zhou, Jia Chuan Wang, Prince Last Mudenda Zilundu, Ya Qiong Wang, Wen Ping Guo, Sai Xia Zhang, Hui Luo, Jian Hong Zhou, Ru Dong Deng and Dong Feng Chen
    Citation: Stem Cell Research & Therapy 2020 11:153
    Content type: Research Published on:

  18. Chronic rhinosinusitis (CRS) is characterized by persistent symptomatic inflammation of the nasal passage and sinus mucosa. Various microRNAs (miRs) have been implicated in CRS. Hence, the current study was co...

    Authors: Jinzhang Cheng, Junjun Chen, Yin Zhao, Jingpu Yang, Kai Xue and Zonggui Wang
    Citation: Stem Cell Research & Therapy 2020 11:151
    Content type: Research Published on:

  19. Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue r...

    Authors: Xiu-Ru Zhang, Yi-Zhou Huang, Hong-Wei Gao, Yan-Lin Jiang, Jun-Gen Hu, Jin-Kui Pi, An-Jing Chen, Yi Zhang, Li Zhou and Hui-Qi Xie
    Citation: Stem Cell Research & Therapy 2020 11:150
    Content type: Research Published on:

  20. Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising application potential in regenerative medicine and immunomodulation. However, MSCs cultured in vitro exhibit functional heterogeneit...

    Authors: Changbin Sun, Lei Wang, Hailun Wang, Tingrun Huang, Wenwen Yao, Jing Li and Xi Zhang
    Citation: Stem Cell Research & Therapy 2020 11:149
    Content type: Research Published on:

  21. Adipose-derived stem cell (ADSC) transplantation is a promising strategy to promote wound healing because of the paracrine function of stem cells. However, glucose-associated effects on stem cell paracrine fun...

    Authors: Jin Xu, Xiaoyu Liu, Feng Zhao, Ying Zhang and Zhe Wang
    Citation: Stem Cell Research & Therapy 2020 11:148
    Content type: Research Published on:

  22. Strategies of generating functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful due to the lack of a comprehensive understanding of hematopoietic development. Endothelial-...

    Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:147
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:242

  23. Mesenchymal stem/stromal cells (MSCs) can replenish the aged cells of the musculoskeletal system in adult life. Stem cell exhaustion and decrease in their regenerative potential have been suggested to be hallm...

    Authors: Klemen Čamernik, Anže Mihelič, Rene Mihalič, Gregor Haring, Simon Herman, Darja Marolt Presen, Andrej Janež, Rihard Trebše, Janja Marc and Janja Zupan
    Citation: Stem Cell Research & Therapy 2020 11:146
    Content type: Research Published on:

  24. Bone marrow mesenchymal stem cells (BMSCs) have shown their therapeutic potential in cytotherapy for liver fibrosis. However, the insufficient homing of BMSCs and undefined proliferation of BMSCs represent a s...

    Authors: Ting Sun, Hualin Li, Yun Bai, Min Bai, Feng Gao, Jie Yu, Rong Wu, Lianfang Du and Fan Li
    Citation: Stem Cell Research & Therapy 2020 11:145
    Content type: Research Published on:

  25. Cultured epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) were capable of reconstituting functional hair follicles after implantation, while the signaling pathways that regulate neogenic hair ...

    Authors: Yu Chen, Zhimeng Fan, Xiaoxiao Wang, Miaohua Mo, Shu Bin Zeng, Ren-He Xu, Xusheng Wang and Yaojiong Wu
    Citation: Stem Cell Research & Therapy 2020 11:144
    Content type: Short report Published on:

  26. Factors such as poor engraftment, retention, and survival of the transplanted stem cells are deemed to limit their therapeutic efficacy for wound regeneration. Hence, it is necessary to explore these issues in...

    Authors: Qingzha Deng, Sunxing Huang, Jinkun Wen, Yiren Jiao, Xiaohu Su, Guang Shi and Junjiu Huang
    Citation: Stem Cell Research & Therapy 2020 11:143
    Content type: Research Published on:

  27. Retinal degeneration is a leading cause of blindness in the world; its etiology is complex and involves genetic defects and stress-associated aging. In addition to gene therapies for known genetically defectiv...

    Authors: Xiao Liu, Fenghua Chen, Yao Chen, Huayi Lu, Xiaoqin Lu, Xiaoyan Peng, Henry J. Kaplan, Douglas C. Dean, Ling Gao and Yongqing Liu
    Citation: Stem Cell Research & Therapy 2020 11:142
    Content type: Research Published on:

  28. Three-dimensional (3D) cultivation with biomaterials was proposed to facilitate stem cell epithelial differentiation for wound healing. However, whether human adipose-derived stem cells (hASCs) on collagen spo...

    Authors: Minxiong Li, Jun Ma, Yanbin Gao, Mengru Dong, Zijun Zheng, Yuchen Li, Rongwei Tan, Zhending She and Lei Yang
    Citation: Stem Cell Research & Therapy 2020 11:141
    Content type: Research Published on:

  29. Glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) is the most common in non-traumatic ONFH. Despite a strong relationship between GC and ONFH, the detailed mechanisms have remained elusiv...

    Authors: Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo and Yaping Ye
    Citation: Stem Cell Research & Therapy 2020 11:140
    Content type: Research Published on:

  30. To date, many attempts are employed to increase the regenerative potential of stem cells. In this study, we evaluated the hypothesis of whether an autophagy modulation could alter differentiation potency of CD146

    Authors: Mehdi Hassanpour, Jafar Rezaie, Masoud Darabi, Amirataollah Hiradfar, Reza Rahbarghazi and Mohammad Nouri
    Citation: Stem Cell Research & Therapy 2020 11:139
    Content type: Research Published on:

  32. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) plays a key role in bone formation, but its signaling pathway is not completely understood. Signal transducer and activator of transcription 3 (Stat3) tak...

    Authors: Lizhen Lei, Zhuwei Huang, Jingyi Feng, Zijing Huang, Yiwei Tao, Xiaoli Hu and Xiaolei Zhang
    Citation: Stem Cell Research & Therapy 2020 11:137
    Content type: Research Published on:

  33. Due to the low survival rate of cell transplantation, stem cell has not been widely used in clinical treatment of acute myocardial infarction (AMI). In this study, we immobilized the C domain peptide of insuli...

    Authors: Yong Yao, Liang Yang, Li-feng Feng, Zhi-wei Yue, Nian-huan Zhao, Zongjin Li and Zuo-xiang He
    Citation: Stem Cell Research & Therapy 2020 11:136
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:189

  34. Bone defects are a common clinical condition that has gained an increasing amount of attention in recent years. Causes of bone defect include tumors, inflammation, and fractures. Bone tissue engineering is a n...

    Authors: Yuan Zhu, Xiao Zhang, Ranli Gu, Xuenan Liu, Siyi Wang, Dandan Xia, Zheng Li, Xiaomin Lian, Ping Zhang, Yunsong Liu and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2020 11:135
    Content type: Research Published on:

  35. Human deciduous pulp stem cells (hDPSCs) have remarkable stem cell potency associated with cell proliferation, mesenchymal multipotency, and immunosuppressive function and have shown beneficial effects in a va...

    Authors: Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda and Tomoaki Taguchi
    Citation: Stem Cell Research & Therapy 2020 11:134
    Content type: Research Published on:

  36. In our previous research, we found that mesenchymal stem cell (MSC) transplantation therapy can inhibit intimal hyperplasia and enhance endothelial function in arterialized vein grafts in rats. However, whethe...

    Authors: Qingxi Qu, Yingxin Pang, Chunmei Zhang, Linghong Liu and Yanwen Bi
    Citation: Stem Cell Research & Therapy 2020 11:133
    Content type: Research Published on:

  37. Myelodysplastic syndrome (MDS) represents a heterogeneous group of clonal hematopoietic disorders, which is characterized by cytopenias in the peripheral blood and bone marrow dysplasia due to ineffective hema...

    Authors: Khaja Syed, Sara Naguib, Zhao-Jun Liu, Luisa Cimmino and Feng-Chun Yang
    Citation: Stem Cell Research & Therapy 2020 11:132
    Content type: Review Published on:

  38. Hypercholesterolemia increases the risk of tendon pain and tendon rupture. Tendon-derived stem cells (TDSCs) play a vital role in the development of tendinopathy. Our previous research found that high choleste...

    Authors: Kaiqun Li, Ye Deng, Ganming Deng, Pengyu Chen, Yutian Wang, Hangtian Wu, Zhiguo Ji, Zilong Yao, Xianrong Zhang, Bin Yu and Kairui Zhang
    Citation: Stem Cell Research & Therapy 2020 11:131
    Content type: Research Published on:

  39. Mesenchymal stem cells (MSCs) have been reported to promote the regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic preconditioning. In this study, we examined the thera...

    Authors: Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ken Yoshida, Satoshi Maeda, Ryo Kanai, Yumi Yamada, Takeshi Ike, Toshiki Doi, Yukio Kato and Takao Masaki
    Citation: Stem Cell Research & Therapy 2020 11:130
    Content type: Research Published on:

  40. Distraction osteogenesis (DO) is a surgical technique to promote bone regeneration which may require long duration for bone consolidation. Bone marrow-derived mesenchymal stem cells (MSCs) have been applied to...

    Authors: Yanhua Yang, Qi Pan, Kaijie Zou, Haixing Wang, Xiaoting Zhang, Zhengmeng Yang, Wayne Yuk Wai Lee, Bo Wei, Weidong Gu, Yunzhi Peter Yang, Sien Lin and Gang Li
    Citation: Stem Cell Research & Therapy 2020 11:129
    Content type: Research Published on:

  41. Vocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported pos...

    Authors: Stellan Hertegård, Srinivasa Rau Nagubothu, Emma Malmström and Katarina LeBlanc
    Citation: Stem Cell Research & Therapy 2020 11:128
    Content type: Research Published on:

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:173

  42. Organ replacement regenerative therapy based on human adult stem cells may be effective for salivary gland hypofunction. However, the generated tissues are immature because the signaling factors that induce th...

    Authors: Yi Sui, Siqi Zhang, Yongliang Li, Xin Zhang, Waner Hu, Yanrui Feng, Jingwei Xiong, Yuanyuan Zhang and Shicheng Wei
    Citation: Stem Cell Research & Therapy 2020 11:127
    Content type: Research Published on:

  43. The discovery of induced pluripotent stem cells (iPSCs) opened the possibilities for reprogramming cells back to a pluripotent state. Because of no apparent ethical issues connected with donation and derivatio...

    Authors: Marcin Orzechowski, Maximilian Schochow, Michael Kühl and Florian Steger
    Citation: Stem Cell Research & Therapy 2020 11:126
    Content type: Research Published on:

  44. Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been ...

    Authors: Jianyong Xu, Wei Lian, Jieting Chen, Wenlei Li, Lingyun Li and Zhong Huang
    Citation: Stem Cell Research & Therapy 2020 11:125
    Content type: Research Published on:

  45. Crohn’s fistula-in-ano is a refractory disease in colorectal and anal surgery. Although autologous adipose-derived stem cell (ADSC) has been used in the treatment of Crohn’s fistula-in-ano because of its conve...

    Authors: Chungen Zhou, Meng Li, Yang Zhang, Min Ni, Yehuang Wang, Dachao Xu, Yang Shi, Bo Zhang, Yanni Chen, Yan Huang, Sumin Zhang, Hongzhen Shi and Bin Jiang
    Citation: Stem Cell Research & Therapy 2020 11:124
    Content type: Research Published on:

  46. Autologous cellular immunotherapy or immune enhancement therapy has demonstrated some promising benefits for prostate cancer. T cell-based immunotherapy or sipuleucel-T therapy has yielded certain beneficial r...

    Authors: Zhu Wang, Youjia Li, Yuliang Wang, Dinglan Wu, Alaster Hang Yung Lau, Pan Zhao, Chang Zou, Yong Dai and Franky Leung Chan
    Citation: Stem Cell Research & Therapy 2020 11:123
    Content type: Research Published on:

  47. Diabetic cardiomyopathy (DCM) is a cardiac complication of long-term uncontrolled diabetes and is characterized by myocardial fibrosis and abnormal cardiac function. Mesenchymal stem cells (MSCs) are multipote...

    Authors: Liyuan Jin, Jinying Zhang, Zihui Deng, Jiejie Liu, Weidong Han, Guanghui Chen, Yiling Si and Ping Ye
    Citation: Stem Cell Research & Therapy 2020 11:122
    Content type: Research Published on:

  48. In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...

    Authors: María García-Bonilla, Betsaida Ojeda-Pérez, María L. García-Martín, M. Carmen Muñoz-Hernández, Javier Vitorica, Sebastián Jiménez, Manuel Cifuentes, Leonor Santos-Ruíz, Kirill Shumilov, Silvia Claros, Antonia Gutiérrez, Patricia Páez-González and Antonio J. Jiménez
    Citation: Stem Cell Research & Therapy 2020 11:121
    Content type: Research Published on:

  49. Adipose-derived mesenchymal stem cells (ASCs) therapy is emerging as a novel therapeutic option for the treatment of a variety of diseases including diabetes and diabetic wound healing. Multiple studies indica...

    Authors: Ran An, Yong Zhang, Yu Qiao, Lili Song, Hongjun Wang and Xiao Dong
    Citation: Stem Cell Research & Therapy 2020 11:120
    Content type: Research Published on:

  50. Though accumulated evidence has demonstrated visceral organ involvement in acute graft-versus-host disease (aGVHD), how aGVHD influences the bone marrow (BM) niche and the reconstitution of hematopoiesis post-...

    Authors: Li Ding, Hong-Mei Ning, Pei-Lin Li, Hong-Min Yan, Dong-Mei Han, Xiao-Li Zheng, Jing Liu, Ling Zhu, Mei Xue, Ning Mao, Zi-Kuan Guo, Heng Zhu and Heng-Xiang Wang
    Citation: Stem Cell Research & Therapy 2020 11:119
    Content type: Research Published on:
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Stem Cell Research & Therapy

ISSN: 1757-6512