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  1. This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they are added.

    Authors: Juan Fafián-Labora, Miriam Morente-López, María José Sánchez-Dopico, Onno J. Arntz, Fons A. J. van de Loo, Javier De Toro and María C. Arufe
    Citation: Stem Cell Research & Therapy 2020 11:13
    Content type: Research Published on:

  2. Extracellular vesicles (EVs), especially stem cell-derived EVs, have emerged as a potential novel therapy for acute kidney injury (AKI). However, their effects remain incompletely understood. Therefore, we per...

    Authors: Chao Liu, Jin Wang, Jie Hu, Bo Fu, Zhi Mao, Hengda Zhang, Guangyan Cai, Xiangmei Chen and Xuefeng Sun
    Citation: Stem Cell Research & Therapy 2020 11:11
    Content type: Research Published on:

  3. The functions of HULC have been demonstrated in several cancers. However, its mechanism has not been elucidated in human liver cancer stem cells.

    Authors: Chen Wang, Xiaoxue Jiang, Xiaonan Li, Shuting Song, Qiuyu Meng, Liyan Wang, Yanan Lu, Xiaoru Xin, Hu Pu, Xin Gui, Tianming Li and Dongdong Lu
    Citation: Stem Cell Research & Therapy 2020 11:8
    Content type: Research Published on:

  4. Adult human pancreatic beta cells are the “gold standard” for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently take...

    Authors: Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop and Decio L. Eizirik
    Citation: Stem Cell Research & Therapy 2020 11:7
    Content type: Research Published on:

  5. Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by ...

    Authors: Neety Sahu, Gaurav Budhiraja and Anuradha Subramanian
    Citation: Stem Cell Research & Therapy 2020 11:6
    Content type: Research Published on:

  6. Human placenta-derived mesenchymal stem cells (PD-MSCs) are powerful sources for cell therapy in regenerative medicine. However, a limited lifespan by senescence through mechanisms that are well unknown is the...

    Authors: Jin Seok, Hyun Sook Jung, Sohae Park, Jung Ok Lee, Chong Jai Kim and Gi Jin Kim
    Citation: Stem Cell Research & Therapy 2020 11:1
    Content type: Research Published on:

  7. Mesenchymal stem cells (MSCs) play a crucial role in maintaining the dynamic balance of bone metabolism. Melatonin may have a regulatory effect on bone metabolism by regulating the lineage commitment and diffe...

    Authors: Tianyuan Jiang, Chao Xia, Xiaoting Chen, Yan Hu, Yan Wang, Jin Wu, Shuyan Chen and Yanhong Gao
    Citation: Stem Cell Research & Therapy 2019 10:408
    Content type: Research Published on:

  8. Imbalance in bone formation and resorption is a crucial component of the pathological process leading to osteoporosis. Electromagnetic fields (EMFs) have been reported to be beneficial to osteogenesis, althoug...

    Authors: Yingchi Zhang, Wenkai Li, Chaoxu Liu, Jiyuan Yan, Xuefeng Yuan, Wei Wang, Huaixi Wang, Hua Wu and Yong Yang
    Citation: Stem Cell Research & Therapy 2019 10:407
    Content type: Research Published on:

  9. Menstrual blood-derived stem cells (MenSCs) have great potential in the treatment of various diseases. As a novel type of mesenchymal stem cells (MSCs), MenSCs have attracted more interest due to their therape...

    Authors: Lijun Chen, Jingjing Qu, Tianli Cheng, Xin Chen and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2019 10:406
    Content type: Review Published on:

  10. Myopathy and exercise intolerance are prominent clinical features in carriers of a point-mutation or large-scale deletion in the mitochondrial DNA (mtDNA). In the majority of patients, the mtDNA mutation is he...

    Authors: Florence van Tienen, Ruby Zelissen, Erika Timmer, Marike van Gisbergen, Patrick Lindsey, Mattia Quattrocelli, Maurilio Sampaolesi, Elvira Mulder-den Hartog, Irenaeus de Coo and Hubert Smeets
    Citation: Stem Cell Research & Therapy 2019 10:405
    Content type: Research Published on:

  11. After publication of our article [1] we became aware that there were errors in Fig. 5b and Fig. 6c, namely that the immunofluorescence of EDU-positive cells of the CABLES1 transfection group in Fig. 5b (panel ...

    Authors: Jingjin Liu, Yongshun Wang, Jinjin Cui, Meng Sun, Zhongyue Pu, Chao Wang, Wenjuan Du, Xinxin Liu, Jian Wu, Jingbo Hou, Shuo Zhang and Bo Yu
    Citation: Stem Cell Research & Therapy 2019 10:404
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2017 8:127

  12. Billions of dollars are invested annually by pharmaceutical companies in search of new options for treating hair loss conditions; nevertheless, the challenge remains. One major limitation to hair follicle rese...

    Authors: Yiqun Su, Jie Wen, Junrong Zhu, Zhiwei Xie, Chang Liu, Chuan Ma, Qun Zhang, Xin Xu and Xunwei Wu
    Citation: Stem Cell Research & Therapy 2019 10:403
    Content type: Research Published on:

  13. Mesenchymal stem cells (MSCs) are multipotent stem cells that are able to differentiate into several cell types, including cartilage, fat, and bone. As a common progenitor, MSC differentiation has to be tightl...

    Authors: Chanchao Lorthongpanich, Kanjana Thumanu, Kantpitchar Tangkiettrakul, Nittaya Jiamvoraphong, Chuti Laowtammathron, Nattaya Damkham, Yaowalak U-pratya and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2019 10:402
    Content type: Research Published on:

  14. Clinical applications have shown extracellular vesicles (EVs) to be a major paracrine effector in therapeutic responses produced by human mesenchymal stromal/stem cells (hMSCs). As the regenerative capacity of...

    Authors: Afnan Munshi, Jelica Mehic, Marybeth Creskey, Jonathan Gobin, Jun Gao, Emma Rigg, Gauri Muradia, Christian C. Luebbert, Carole Westwood, Andrew Stalker, David S. Allan, Michael J. W. Johnston, Terry Cyr, Michael Rosu-Myles and Jessie R. Lavoie
    Citation: Stem Cell Research & Therapy 2019 10:401
    Content type: Research Published on:

  15. Emerging evidence suggests that miR-124 performs important biological functions in neural stem cells (NSCs); it regulates NSC behavior and promotes the differentiation of NSCs into neurons, but the exact molec...

    Authors: Yi Cui, Yanyun Yin, Zhifeng Xiao, Yannan Zhao, Bing Chen, Bin Yang, Bai Xu, Hongwei Song, Yunlong Zou, Xu Ma and Jianwu Dai
    Citation: Stem Cell Research & Therapy 2019 10:400
    Content type: Research Published on:

  16. Spermatogonial stem cells (SSCs) are the cornerstone of sperm production and thus perpetual male fertility. In clinics, transplantation of patient’s own SSCs into testes is a promising technique to restore fer...

    Authors: Tianjiao Li, Qiwen Chen, Yi Zheng, Pengfei Zhang, Xiaoxu Chen, Junna Lu, Yinghua Lv, Shiguo Sun and Wenxian Zeng
    Citation: Stem Cell Research & Therapy 2019 10:399
    Content type: Research Published on:

  17. Aging is one of the dominant factors contributing to erectile dysfunction (ED), and effective treatments for age-associated ED are urgently demanded. In this study, the therapeutic efficiency of bone marrow-de...

    Authors: Qiwei Liu, Yubin Cui, Haojian Lin, Daoyuan Hu, Tao Qi, Bo Wang, Zhansen Huang, Jun Chen, Ke Li and Hengjun Xiao
    Citation: Stem Cell Research & Therapy 2019 10:398
    Content type: Research Published on:

  18. Emerging evidence suggests that neural crest-derived cells (NCCs) present important functions in peripheral nerve regeneration to correct the insufficiency of autogenous Schwann cells. Postmigratory NCCs have ...

    Authors: Haiyan Shi, Xiaoli Li, Junling Yang, Yahong Zhao, Chengbin Xue, Yaxian Wang, Qianru He, Mi Shen, Qi Zhang, Yumin Yang and Fei Ding
    Citation: Stem Cell Research & Therapy 2019 10:397
    Content type: Research Published on:

  19. Human periodontal ligament stem cells (hPDLSCs) are one of the most promising types of seed cells in periodontal tissue regeneration. Suitable biomaterials are additional essential components that must coopera...

    Authors: Xue Xiong, Xiao Yang, Hongwei Dai, Gang Feng, Yuanyuan Zhang, Jianping Zhou and Wenwen Zhou
    Citation: Stem Cell Research & Therapy 2019 10:396
    Content type: Research Published on:

  20. Mesenchymal stromal cells (MSCs), adult stromal cells most commonly isolated from bone marrow (BM), are being increasingly utilized in various therapeutic applications including tissue repair via immunomodulat...

    Authors: Fiorella Rossi, Hunter Noren, Leonor Sarria, Paul C. Schiller, Lubov Nathanson and Vladimir Beljanski
    Citation: Stem Cell Research & Therapy 2019 10:395
    Content type: Research Published on:

  21. In athlete horses, suspensory ligament (SL) injuries are the most common cause of lameness. Healing of SL injury is still problematic, and even proper rehabilitation and pharmacological therapy do not guarante...

    Authors: Katarzyna Kornicka-Garbowska, Rafał Pędziwiatr, Paulina Woźniak, Katarzyna Kucharczyk and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2019 10:394
    Content type: Short report Published on:

  22. Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. ...

    Authors: Qing Mao, Xiu-Lin Liang, Chuan-Long Zhang, Yi-Heng Pang and Yong-Xiang Lu
    Citation: Stem Cell Research & Therapy 2019 10:393
    Content type: Research Published on:

  23. Chondrogenesis represents a highly dynamic cellular process that leads to the establishment of various types of cartilage. However, when stress-related injuries occur, a rapid and efficient regeneration of the...

    Authors: Lynda Bourebaba, Izabela Michalak, Meriem Baouche, Katarzyna Kucharczyk and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2019 10:392
    Content type: Research Published on:

  24. Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or inducible variants of these recombinases are expressed u...

    Authors: Andrey A. Kuzmin, Veronika V. Ermakova, Sergey A. Sinenko, Sergey V. Ponomartsev, Tatiana Y. Starkova, Elena V. Skvortsova, Olga Cherepanova and Alexey N. Tomilin
    Citation: Stem Cell Research & Therapy 2019 10:391
    Content type: Short report Published on:

  25. Spinal cord injury (SCI) is a complex and severe neurological condition. Mesenchymal stem cells (MSCs) and their secreted factors show promising potential for regenerative medicine. Many studies have investiga...

    Authors: Ya-Tzu Chen, May-Jywan Tsai, Nini Hsieh, Ming-Jei Lo, Meng-Jen Lee, Henrich Cheng and Wen-Cheng Huang
    Citation: Stem Cell Research & Therapy 2019 10:390
    Content type: Research Published on:

  26. Neural tube defects (NTDs) are the most serious and common birth defects in the clinic. The SRY-related HMG box B1 (SoxB1) gene family has been implicated in different processes of early embryogenesis. Sox19b ...

    Authors: Xian Li, Wenjuan Zhou, Xinyue Li, Ming Gao, Shufang Ji, Wenyu Tian, Guangyu Ji, Jingyi Du and Aijun Hao
    Citation: Stem Cell Research & Therapy 2019 10:389
    Content type: Research Published on:

  27. Animal cell-based systems have been critical tools in understanding tissue development and physiology, but they are less successful in more practical tasks, such as predicting human toxicity to pharmacological...

    Authors: Alessandro Pirosa, Karen L. Clark, Jian Tan, Shuting Yu, Yuanheng Yang, Rocky S. Tuan and Peter G. Alexander
    Citation: Stem Cell Research & Therapy 2019 10:388
    Content type: Research Published on:

  30. Incomplete recovery from acute kidney injury (AKI) can result in long-term functional deficits and has been recognized as a major contributor to chronic kidney disease (CKD), which is termed the AKI-CKD transi...

    Authors: Lingfei Zhao, Fei Han, Junni Wang and Jianghua Chen
    Citation: Stem Cell Research & Therapy 2019 10:385
    Content type: Review Published on:

  31. MicroRNA (miR)-containing exosomes released by acute myeloid leukemia (AML) cells can be delivered into hematopoietic progenitor cells to suppress normal hematopoiesis. Herein, our study was performed to evalu...

    Authors: Chen Zhao, Feng Du, Yang Zhao, Shanshan Wang and Ling Qi
    Citation: Stem Cell Research & Therapy 2019 10:384
    Content type: Research Published on:

  32. Radiation dermatitis is a refractory skin injury caused by radiotherapy. Human fetal skin-derived stem cell (hFSSC) is a preferable source for cell therapy and skin tissue regeneration. In the present study, w...

    Authors: Xiaoli Rong, Jiannan Li, Yanyan Yang, Liyan Shi and Tiechao Jiang
    Citation: Stem Cell Research & Therapy 2019 10:383
    Content type: Research Published on:

  33. Spermatogonial stem cell (SSC) transplantation technology as a promising option for male fertility preservation has received increasing attention, along with efficient SSC purification technology as a necessar...

    Authors: Jia Tian, Ke Ma, Cheng-bin Pei, Shao-hua Zhang, Xue Li, Yue Zhou, Bei Yan, Hong-yan Wang and Liang-hong Ma
    Citation: Stem Cell Research & Therapy 2019 10:382
    Content type: Research Published on:

  34. Mesenchymal stem cells (MSCs) play a significant role in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication by delivering microRNAs (miRNAs). This study aimed to ...

    Authors: Haiyang Xu, Guifang Zhao, Yu Zhang, Hong Jiang, Weiyao Wang, Donghai Zhao, Jin Hong, Hongquan Yu and Ling Qi
    Citation: Stem Cell Research & Therapy 2019 10:381
    Content type: Research Published on:

  35. Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal loss, which finally leads to functional impairments and long-term disability. Our previous studies have demonstrated that the ...

    Authors: Masoumeh Zarei-Kheirabadi, Mahdi Hesaraki, Sahar Kiani and Hossein Baharvand
    Citation: Stem Cell Research & Therapy 2019 10:380
    Content type: Research Published on:

  36. Restoration of massive bone defects remains a huge challenge for orthopedic surgeons. Insufficient vascularization and slow bone regeneration limited the application of tissue engineering in bone defect. The e...

    Authors: Jingyuan Chen, Chang Tu, Xiangyu Tang, Hao Li, Jiyuan Yan, Yongzhuang Ma, Hua Wu and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2019 10:379
    Content type: Research Published on:

  37. Magnesium (Mg2+)-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells (DPSCs), but the regulatory mechanisms remain undefined. The aim of this work was to assess magnesiu...

    Authors: Yuanyuan Kong, Xiaoli Hu, Yingqun Zhong, Ke Xu, Buling Wu and Jianmao Zheng
    Citation: Stem Cell Research & Therapy 2019 10:378
    Content type: Research Published on:

  38. Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological processes such as prolifera...

    Authors: Lizhi Han, Bo Wang, Ruoyu Wang, Song Gong, Guo Chen and Weihua Xu
    Citation: Stem Cell Research & Therapy 2019 10:377
    Content type: Review Published on:

  39. The umbilical cord blood (UCB) has been widely accepted as an alternative source of hematopoietic stem/progenitor cells (HSPCs) for transplantation, and its use in adults is still restricted because of low abs...

    Authors: Qiuyang Li, Dewan Zhao, Qiang Chen, Maowen Luo, Jingcao Huang, Cao Yang, Fangfang Wang, Wenxian Li and Ting Liu
    Citation: Stem Cell Research & Therapy 2019 10:376
    Content type: Research Published on:

  40. Aspirin has been demonstrated to promote osteoblast-mediated bone formation and inhibit osteoclast (OC)-mediated bone resorption. However, it remains unclear whether aspirin influences other immune cells durin...

    Authors: Lili Wu, Zhenhua Luo, Yitong Liu, Lu Jia, Yiyang Jiang, Juan Du, Lijia Guo, Yuxing Bai and Yi Liu
    Citation: Stem Cell Research & Therapy 2019 10:375
    Content type: Research Published on:

  41. Limbal stem cells (LSC) sustain the corneal integrity and homeostasis. LSC deficiency (LSCD) leads to loss of corneal transparency and blindness. A clinical approach to treat unilateral LSCD comprises autologo...

    Authors: Nuria Nieto-Nicolau, Eva M. Martínez-Conesa, Alba M. Velasco-García, Caterina Aloy-Reverté, Anna Vilarrodona and Ricardo P. Casaroli-Marano
    Citation: Stem Cell Research & Therapy 2019 10:374
    Content type: Research Published on:

  42. Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap betwee...

    Authors: Jack F. Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M. Broughton, Esperanza Agullo-Pascual, Mark A. Sussman, Roger J. Hajjar, Kevin D. Costa and Irene C. Turnbull
    Citation: Stem Cell Research & Therapy 2019 10:373
    Content type: Research Published on:

  43. Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) via paracrine hepatocyte growth factor (HGF) and to induce the differentiation of dendritic cells (DCs) into tolerogenic dendr...

    Authors: Zhonghua Lu, Wei Chang, Shanshan Meng, Xiuping Xu, Jianfeng Xie, Fengmei Guo, Yi Yang, Haibo Qiu and Ling Liu
    Citation: Stem Cell Research & Therapy 2019 10:372
    Content type: Research Published on:

  44. Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As early gestational-phase embryonic tissues exhibit...

    Authors: Karl-Henrik Grinnemo, Marie Löfling, Lubov Nathanson, Roland Baumgartner, Daniel F. J. Ketelhuth, Vladimir Beljanski, Lindsay C. Davies and Cecilia Österholm
    Citation: Stem Cell Research & Therapy 2019 10:371
    Content type: Research Published on:

  45. We have recently demonstrated that amniotic fluid stem cells (AFSC) express renal progenitor markers and can be differentiated in vitro into renal lineage cell types, viz, juxtaglomerular and renal proximal tu...

    Authors: Ekta Minocha, Rohit Anthony Sinha, Manali Jain, Chandra Prakash Chaturvedi and Soniya Nityanand
    Citation: Stem Cell Research & Therapy 2019 10:370
    Content type: Research Published on:

  46. Cartilage tissue engineering is a promising technique for repairing cartilage defect. Due to the limitation of cell number and proliferation, mesenchymal stem cells (MSCs) have been developed as a substitute t...

    Authors: Imam Rosadi, Karina Karina, Iis Rosliana, Siti Sobariah, Irsyah Afini, Tias Widyastuti and Anggraini Barlian
    Citation: Stem Cell Research & Therapy 2019 10:369
    Content type: Research Published on:

  47. Gingiva-derived mesenchymal stem cells (GMSCs) obtained multipotent differentiation and immunomodulatory properties. However, collecting healthy gingival tissues may be challenging in the clinical situation. T...

    Authors: Tingting Yu, Boxi Yan, Jing Li, Ting Zhang, Ruili Yang, Xuedong Wang, Yan Liu and Dawei Liu
    Citation: Stem Cell Research & Therapy 2019 10:368
    Content type: Research Published on:

  48. The airways of mammalian lung are lined with highly specialized cell types that are the target of airborne toxicants and injury. Several epithelial cell types and bone marrow-derived mesenchymal stem cells hav...

    Authors: Suyun Fang, Suhong Zhang, Haiting Dai, Xiaoxiang Hu, Changgong Li and Yiming Xing
    Citation: Stem Cell Research & Therapy 2019 10:366
    Content type: Research Published on:

  49. Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies have shown that the regeneration ability of SCs decreases dramatically...

    Authors: Cheng Cheng, Yunfeng Wang, Luo Guo, Xiaoling Lu, Weijie Zhu, Waqas Muhammad, Liyan Zhang, Ling Lu, Junyan Gao, Mingliang Tang, Fangyi Chen, Xia Gao, Huawei Li and Renjie Chai
    Citation: Stem Cell Research & Therapy 2019 10:365
    Content type: Research Published on:

  50. The limited proliferative ability of hepatocytes is a major limitation to meet their demand for cell-based therapy, bio-artificial liver device, and drug tests. One strategy is to amplify cells at the hepatobl...

    Authors: Tingcai Pan, Yan Chen, Yuanqi Zhuang, Fan Yang, Yingying Xu, Jiawang Tao, Kai You, Ning Wang, Yuhang Wu, Xianhua Lin, Feima Wu, Yanli Liu, Yingrui Li, Guodong Wang and Yin-xiong Li
    Citation: Stem Cell Research & Therapy 2019 10:364
    Content type: Research Published on:
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Stem Cell Research & Therapy

ISSN: 1757-6512