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  1. Adipose tissue-derived stromal vascular fraction (SVF) harbors multipotent cells with potential therapeutic relevance. We developed a method to form adipose spheroids (AS) from the SVF with complex organoid st...

    Authors: Fermín Robledo, Lila González-Hodar, Pablo Tapia, Ana-María Figueroa, Fernando Ezquer and Víctor Cortés
    Citation: Stem Cell Research & Therapy 2023 14:70
    Content type: Research Published on:

  2. Early weaning and shorter breastfeeding duration are applied by a proportion of young mothers, especially in the social spheres of poverty-stricken areas. Early childhood is a critical period for intestinal de...

    Authors: Junquan Tian, Yuying Li, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Yulong Yin and Kang Yao
    Citation: Stem Cell Research & Therapy 2023 14:65
    Content type: Research Published on:

  3. Detrusor underactivity is a disease that can cause chronic urinary tract infection, urinary tract infection, urinary retention and kidney failure and has no effective treatment in traditional medicine. The pre...

    Authors: Henrique Rodrigues Scherer Coelho, Silvia Cordeiro das Neves, Jovino Nogueira da Silva Menezes, Andréia Conceição Milan Brochado Antoniolli-Silva and Rodrigo Juliano Oliveira
    Citation: Stem Cell Research & Therapy 2023 14:64
    Content type: Research Published on:

  4. Post-translational modifications of proteins are crucial to the regulation of their activity and function. As a newly discovered acylation modification, crotonylation of non-histone proteins remains largely un...

    Authors: Jingran Zhang, Guang Shi, Junjie Pang, Xing Zhu, Qingcai Feng, Jie Na, Wenbin Ma, Dan Liu and Zhou Songyang
    Citation: Stem Cell Research & Therapy 2023 14:63
    Content type: Research Published on:

  5. Extracellular vesicles derived from stem cells (SC-EVs) have been proposed as a novel therapy for ischemic stroke. However, their effects remain incompletely understood. Therefore, we conducted this meta-analy...

    Authors: Jing Zhao, Huiyin Deng, Chengfeng Xun, Chunli Chen, Zhiping Hu, Lite Ge and Zheng Jiang
    Citation: Stem Cell Research & Therapy 2023 14:62
    Content type: Research Published on:

  6. Asherman syndrome (AS), or intrauterine adhesions, is a main cause of infertility in reproductive age women after endometrial injury. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) are pr...

    Authors: Nahid Mansouri-Kivaj, Abdoreza Nazari, Fereshteh Esfandiari, Faezeh Shekari, Marefat Ghaffari, Mohammad Pakzad and Hossein Baharvand
    Citation: Stem Cell Research & Therapy 2023 14:61
    Content type: Research Published on:

  7. Peripheral arterial disease (PAD) of lower extremities comprises a clinical spectrum that extends from asymptomatic patients to critical limb ischemia (CLI) patients. 10% to 40% of the patients are at the risk...

    Authors: Pawan Kumar Gupta, P. Shivashankar, M. Rajkumar, Subhendu S. Mahapatra, Sanjay C. Desai, Anita Dhar, Vinay Krishna, N. S. Raviraja, Samatha Bhat, Pachaiyappan Viswanathan, Suresh Kannan, Jijy Abraham, Hema Boggarapu, M. S. Manjuprasad and K. Udaykumar
    Citation: Stem Cell Research & Therapy 2023 14:60
    Content type: Research Published on:

  8. Human cerebral organoids (HCOs) offer unprecedented opportunities to study the human brain in vitro, but they also raise important ethical concerns. Here we report the first systematic analysis of scientists’ sta...

    Authors: Andrea Lavazza and Alice Andrea Chinaia
    Citation: Stem Cell Research & Therapy 2023 14:59
    Content type: Research Published on:

  9. Sorafenib is a first-line drug targeting the RTK-MAPK signalling pathway used to treat advanced hepatocellular carcinoma (HCC). However, tumour cells readily develop sorafenib resistance, limiting long-term th...

    Authors: Sining Zhou, Yiming Liu, Qi Zhang, Huikang Xu, Yangxin Fang, Xin Chen, Jiamin Fu, Yin Yuan, Yifei Li, Li Yuan and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2023 14:58
    Content type: Research Published on:

  10. Although the clinical application and transformation of exosomes are still in the exploration stage, the prospects are promising and have a profound impact on the future transformation medicine of exosomes. Ho...

    Authors: Li Han, Zhirong Zhao, Chuanshi He, Jiami Li, Xiangyu Li and Man Lu
    Citation: Stem Cell Research & Therapy 2023 14:57
    Content type: Review Published on:

  11. Recent studies have demonstrated that glioma-associated mesenchymal stem cells (GA-MSCs) are implicated in the regulation of glioma malignant progression. However, the prognostic value of GA-MSCs has not been ...

    Authors: Zesheng Peng, Yuxi Wu, Jiajing Wang, Sujie Gu, Yihao Wang, Bingzhou Xue, Peng Fu and Wei Xiang
    Citation: Stem Cell Research & Therapy 2023 14:56
    Content type: Research Published on:

  13. Progression of senile osteoporosis is associated with deteriorated regenerative potential of bone marrow-derived mesenchymal stem/stromal cells (BMSCs). According to the recent results, the senescent phenotype...

    Authors: Mateusz Sikora, Agnieszka Åšmieszek, Ariadna Pielok and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2023 14:54
    Content type: Research Published on:

  14. National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving stem cell lines is as an area with gaps and opportunities for ...

    Authors: Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig and Kapil Bharti
    Citation: Stem Cell Research & Therapy 2023 14:53
    Content type: Meeting report Published on:

  15. Endogenous neural stem cells (NSCs) are critical for the remyelination of axons following spinal cord injury (SCI). Cell–cell communication plays a key role in the regulation of the differentiation of NSCs. As...

    Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Cancan Wang, Yunlei Liu, Wang Ying, Kaixuan Li and Cailiang Shen
    Citation: Stem Cell Research & Therapy 2023 14:52
    Content type: Research Published on:

  16. The composite transplantation of a split-thickness skin graft (STSG) combined with an acellular dermal matrix (ADM) is a promising repair method for full-thickness skin defects. Due to delayed vascularization ...

    Authors: Zhiyong Wang, Hailin Xu, Hao Yang, Yi Zhang, Xiaoyan Wang, Peng Wang, Zhongye Xu, Dongming Lv, Yanchao Rong, Yunxian Dong, Bing Tang, Zhicheng Hu, Wuguo Deng and Jiayuan Zhu
    Citation: Stem Cell Research & Therapy 2023 14:51
    Content type: Research Published on:

  17. Three-dimensional (3D) human brain spheroids are instrumental to study central nervous system (CNS) development and (dys)function. Yet, in current brain spheroid models the limited variety of cell types hamper...

    Authors: Kim M. A. De Kleijn, Wieteke A. Zuure, Kirsten R. Straasheijm, Marijn B. Martens, M. Cristina Avramut, Roman I. Koning and Gerard J. M. Martens
    Citation: Stem Cell Research & Therapy 2023 14:50
    Content type: Research Published on:

  18. Therapeutic interventions that optimize angiogenic activities may reduce rates of end-stage kidney disease, critical limb ischemia, and lower extremity amputations in individuals with diabetic kidney disease (...

    Authors: Xiaohui Bian, Sabena M. Conley, Alfonso Eirin, Eric A. Zimmerman Zuckerman, Anastasia L. Smith, Cody C. Gowan, Zachary K. Snow, Tambi Jarmi, Houssam Farres, Young M. Erben, Albert G. Hakaim, Matthew A. Dietz, Abba C. Zubair, Saranya P. Wyles, Joy V. Wolfram, Lilach O. Lerman…
    Citation: Stem Cell Research & Therapy 2023 14:49
    Content type: Research Published on:

  19. Mesenchymal stem cells (MSCs) have demonstrated remarkable therapeutic promise for acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS). MSC secretomes contain various immuno...

    Authors: Kamal Hezam, Chen Wang, Enze Fu, Manqian Zhou, Yue Liu, Hui Wang, Lihong Zhu, Zhibo Han, Zhong-Chao Han, Ying Chang and Zongjin Li
    Citation: Stem Cell Research & Therapy 2023 14:48
    Content type: Research Published on:

  20. Because of the low regeneration efficiency and unclear underlying molecular mechanism, tooth regeneration applications are limited. In this study, we explored the influence of residual periodontal ligament on ...

    Authors: Bin Luo, Yu Luo, Lin He, Yangyang Cao and Qingsong Jiang
    Citation: Stem Cell Research & Therapy 2023 14:47
    Content type: Research Published on:

  21. The conditioned medium from human umbilical cord mesenchymal stem cells (UCMSCs-CM) provides a new cell-free therapy for tumors due to its unique secretome. However, there are many contradictory reports about ...

    Authors: Wenjing Wan, Yuyang Miao, Yuwei Niu, Kunyuan Zhu, Yingwan Ma, Menghao Pan, Baohua Ma and Qiang Wei
    Citation: Stem Cell Research & Therapy 2023 14:46
    Content type: Research Published on:

  22. Cholestatic liver fibrosis (CLF) is caused by inflammatory destruction of the intrahepatic bile duct and abnormal proliferation of the small bile duct after cholestasis. Activation of the Notch signaling pathw...

    Authors: Yan-nan Xu, Wen Xu, Xu Zhang, Dan-yang Wang, Xin-rui Zheng, Wei Liu, Jia-mei Chen, Gao-feng Chen, Cheng-hai Liu, Ping Liu and Yong-ping Mu
    Citation: Stem Cell Research & Therapy 2023 14:45
    Content type: Research Published on:

  23. A 24-year-old man with central nervous system (CNS) involvement of T-cell lineage acute lymphoblastic leukemia received sibling allogeneic stem cell transplantation (allo-SCT). He developed isolated CNS relaps...

    Authors: Jing Yuan, Fuxu Wang and Hanyun Ren
    Citation: Stem Cell Research & Therapy 2023 14:44
    Content type: Short report Published on:

  24. The capacity of self-renewal and multipotent differentiation makes mesenchymal stem cells (MSC) one of the most widely investigated cell lines in preclinical studies as cell-based therapies. However, the low s...

    Authors: Yaping Yan, Kaixiu Li, Jiang Jiang, Lihong Jiang, Xiang Ma, Fang Ai, Shuai Qiu and Wei Si
    Citation: Stem Cell Research & Therapy 2023 14:43
    Content type: Research Published on:

  25. The generation of induced pluripotent stem cells has opened the field of study for stem cell research, disease modeling and drug development. However, the epigenetic signatures present in somatic cells make ce...

    Authors: Alain Aguirre-Vázquez, Fabiola Castorena-Torres, Beatriz Silva-Ramírez, Katia Peñuelas-Urquides, María Elena Camacho-Moll, Luis A. Salazar-Olivo, Iván Velasco and Mario Bermúdez de León
    Citation: Stem Cell Research & Therapy 2023 14:42
    Content type: Research Published on:

  26. Extensive efforts have been made to achieve vascular regeneration accompanying tissue repair for treating vascular dysfunction-associated diseases. Recent advancements in stem cell biology and cell reprogrammi...

    Authors: Tae Min Kim, Ra Ham Lee, Min Seong Kim, Chloe A. Lewis and Changwon Park
    Citation: Stem Cell Research & Therapy 2023 14:41
    Content type: Review Published on:

  27. Mitochondrial dysfunction caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA, which codes for mitochondrial components, are known to be associated with various genetic and congenital disorders. Th...

    Authors: Jiahao Yang, Lu Liu, Yasuaki Oda, Keisuke Wada, Mako Ago, Shinichiro Matsuda, Miho Hattori, Tsukimi Goto, Yuki Kawashima, Yumi Matsuzaki and Takeshi Taketani
    Citation: Stem Cell Research & Therapy 2023 14:40
    Content type: Research Published on:

  28. Jaw-bone defects caused by various diseases lead to aesthetic and functional complications, which can seriously affect the life quality of patients. Current treatments cannot fully meet the needs of reconstruc...

    Authors: Jie Zhao, Ying-Hui Zhou, Ya-Qing Zhao, Zheng-Rong Gao, Ze-Yue Ouyang, Qin Ye, Qiong Liu, Yun Chen, Li Tan, Shao-Hui Zhang, Yao Feng, Jing Hu, Marie Aimee Dusenge, Yun-Zhi Feng and Yue Guo
    Citation: Stem Cell Research & Therapy 2023 14:39
    Content type: Review Published on:

  29. Deep understanding the differentiation process of human embryonic stem cells (hESCs) is essential for developing cell-based therapeutic strategy. Substantial efforts have been made to investigate protein-codin...

    Authors: Hai-Tao Luo, Qian He, Wei Yang, Fei He, Jun Dong, Chao-Feng Hu, Xiao-Fei Yang, Ning Li and Fu-Rong Li
    Citation: Stem Cell Research & Therapy 2023 14:38
    Content type: Research Published on:

  30. The vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications. Nevertheless, their role as molecular drivers of bone regeneration remains poo...

    Authors: Sara Reis Moura, Jaime Freitas, Cláudia Ribeiro-Machado, Jorge Lopes, Nuno Neves, Helena Canhão, Ana Maria Rodrigues, Mário Adolfo Barbosa and Maria Inês Almeida
    Citation: Stem Cell Research & Therapy 2023 14:37
    Content type: Research Published on:

  31. Bone marrow samples from discarded femoral heads are often used as healthy controls in studies investigating the in vitro characteristics of cells from patients with hematologic malignancies. Since patient sam...

    Authors: Jennifer Rivière, Jennifer Hock, Michèle C. Buck, Judith S. Hecker, Katharina S. Götze and Mark van der Garde
    Citation: Stem Cell Research & Therapy 2023 14:36
    Content type: Short report Published on:

  33. Cell sheet fabrication for articular cartilage regenerative medicine necessitates a large number of chondrocytes of consistent quality as a cell source. Previously, we have developed human-induced pluripotent ...

    Authors: Tomoka Takao, Masato Sato, Yuki Fujisawa, Eriko Toyoda, Daisuke Yamada, Yukio Hitsumoto, Eiji Nakata, Toshifumi Ozaki and Takeshi Takarada
    Citation: Stem Cell Research & Therapy 2023 14:34
    Content type: Short report Published on:

  34. CD34+ cells have been used to treat the patients with heart failure, but the outcome is variable. It is of great significance to scrutinize the fate and the mechanism of CD34+ cell differentiation in vivo during ...

    Authors: Luping Du, Xiaotong Sun, Hui Gong, Ting Wang, Liujun Jiang, Chengchen Huang, Xiaodong Xu, Zhoubin Li, Hongfei Xu, Liang Ma, Weidong Li, Ting Chen and Qingbo Xu
    Citation: Stem Cell Research & Therapy 2023 14:33
    Content type: Research Published on:

  35. Mesenchymal stem cells (MSCs) therapy for sepsis has been extensively studied in the past decade; however, the treatment regimen and mechanism of action of MSCs remain elusive. Here, we attempted to understand...

    Authors: Kui Li, Tao Wang, Rui Li, Fulai Xue, Guodan Zeng, Jingyao Zhang, Yuan Ma, Li Feng and Y. James Kang
    Citation: Stem Cell Research & Therapy 2023 14:32
    Content type: Research Published on:

  36. Human dental pulp stem cells represent a mesenchymal stem cell niche localized in the perivascular area of dental pulp and are characterized by low immunogenicity and immunomodulatory/anti-inflammatory propert...

    Authors: Giulia Bertani, Rosanna Di Tinco, Laura Bertoni, Giulia Orlandi, Alessandra Pisciotta, Roberto Rosa, Luca Rigamonti, Michele Signore, Jessika Bertacchini, Paola Sena, Sara De Biasi, Erica Villa and Gianluca Carnevale
    Citation: Stem Cell Research & Therapy 2023 14:31
    Content type: Research Published on:

  37. Authors: Xuemei Fan, Sheng He, Huifang Song, Wenjuan Yin, Jie Zhang, Zexu Peng, Kun Yang, Xiaoyan Zhai, Lingxia Zhao, Hui Gong, Yi Ping, Xiangying Jiao, Sanyuan Zhang, Changping Yan, Hongliang Wang, Ren-Ke Li…
    Citation: Stem Cell Research & Therapy 2023 14:30
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:344

  38. Fetal growth restriction (FGR) is associated with deficits in the developing brain, including neurovascular unit (NVU) dysfunction. Endothelial colony forming cells (ECFC) can mediate improved vascular stabili...

    Authors: Alexander Bell, Ashalyn P. Watt, Ingrid Dudink, Yen Pham, Amy E. Sutherland, Beth J. Allison, Courtney A. McDonald, Margie Castillo-Melendez, Graham Jenkin, Atul Malhotra, Suzanne L. Miller and Tamara Yawno
    Citation: Stem Cell Research & Therapy 2023 14:29
    Content type: Research Published on:

  39. Ovarian cancer (OC) is the most lethal gynecological malignancy due to tumor heterogeneity, the lack of reliable early diagnosis methods and the high incidence of chemoresistant recurrent disease. Although the...

    Authors: Huiying Ma, Tian Tian and Zhumei Cui
    Citation: Stem Cell Research & Therapy 2023 14:28
    Content type: Review Published on:

  40. Injury of alveolar epithelial cells and capillary endothelial cells is crucial in the pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Mesenchymal stem cells (MSCs) are a promi...

    Authors: Yuling Luo, Shanhui Ge, Qingui Chen, Shan Lin, Wanmei He and Mian Zeng
    Citation: Stem Cell Research & Therapy 2023 14:27
    Content type: Research Published on:

  41. Periodontitis is a high prevalence oral disease which damages both the hard and soft tissue of the periodontium, resulting in tooth mobility and even loss. Existing clinical treatment methods cannot fully achi...

    Authors: Liangrui Chen, Shasha Zhu, Shujuan Guo and Weidong Tian
    Citation: Stem Cell Research & Therapy 2023 14:26
    Content type: Review Published on:

  42. Hair follicle stem cells (HFSCs) are considered as a promising cell type in the stem cell transplantation treatment of neurological diseases because of their rich sources, easy access, and the same ectoderm so...

    Authors: Hao Tang, Xuemei Zhang, Xiaojun Hao, Haitong Dou, Chendan Zou, Yinglian Zhou, Bing Li, Hui Yue, Duo Wang, Yifei Wang, Chunxiao Yang and Jin Fu
    Citation: Stem Cell Research & Therapy 2023 14:25
    Content type: Research Published on:

  43. Hypoxia in ischemic disease impairs Ca2+ homeostasis and may promote angiogenesis. The therapeutic efficacy of mesenchymal stromal cells (MSCs) in peripheral arterial occlusive disease is well established, yet it...

    Authors: Kaixuan Yan, Jiaxing Zheng, Mark Andreas Kluth, Lin Li, Christoph Ganss, Benito Yard, Richard Magdeburg, Markus H. Frank, Prama Pallavi and Michael Keese
    Citation: Stem Cell Research & Therapy 2023 14:24
    Content type: Research Published on:

  44. Neural stem cells (NSCs) are believed to have the most therapeutic potential for neurological disorders because they can differentiate into various neurons and glial cells. This research evaluated the safety a...

    Authors: Zhongyue Lv, Ying Li, Yachen Wang, Fengyu Cong, Xiaoyan Li, Wanming Cui, Chao Han, Yushan Wei, Xiaojun Hong, Yong Liu, Luyi Ma, Yang Jiao, Chi Zhang, Huanjie Li, Mingyan Jin, Liang Wang…
    Citation: Stem Cell Research & Therapy 2023 14:23
    Content type: Research Published on:

  45. Adipose-derived stem cells (ASCs) have been reported to reduce fibrosis in various tissues. In this study, we investigated the inhibitory role of ASCs on capsule formation by analyzing the histologic, cellular...

    Authors: Bo-Yoon Park, Dirong Wu, Kyoo-Ri Kwon, Mi-Jin Kim, Tae-Gon Kim, Jun-Ho Lee, Do Young Park and Il-Kug Kim
    Citation: Stem Cell Research & Therapy 2023 14:22
    Content type: Research Published on:

  46. In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-lik...

    Authors: Ghaidaa Raheem Lateef Al-Awsi, Fahad Alsaikhan, Ria Margiana, Irfan Ahmad, Indrajit Patra, Mazin A. A. Najm, Ghulam Yasin, Iroda Rasulova, Ali Thaeer Hammid, Hamzah H. Kzar, Moaed E. Al-Gazally and Homayoon Siahmansouri
    Citation: Stem Cell Research & Therapy 2023 14:21
    Content type: Review Published on:

  47. Diabetes mellitus deteriorates the destruction and impairs the healing of periodontal wounds and craniofacial defects. This study is to evaluate the potential of self-assembled adipose-derived stem cell sphero...

    Authors: Che-Chang Tu, Nai-Chen Cheng, Jiashing Yu, Yi-Xuan Pan, Wei-Chiu Tai, Yin-Chuan Chen and Po-Chun Chang
    Citation: Stem Cell Research & Therapy 2023 14:20
    Content type: Research Published on:

  48. The generation of liver organoids recapitulating parenchymal and non-parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases. Although different types of multilineage liver ...

    Authors: Hyo Jin Kim, Gyeongmin Kim, Kyun Yoo Chi, Hyemin Kim, Yu Jin Jang, Seongyea Jo, Jihun Lee, Youngseok Lee, Dong-Hun Woo, Choongseong Han, Sang Kyum Kim, Han-Jin Park and Jong-Hoon Kim
    Citation: Stem Cell Research & Therapy 2023 14:19
    Content type: Research Published on:

  49. Neural stem cells (NSCs) have the potential to engraft and replace damaged brain tissue, repairing the damaged neonatal brain that causes cerebral palsy (CP). There are procedures that could increase engraftme...

    Authors: Madeleine J. Smith, Megan Finch-Edmondson, Suzanne L. Miller, Annabel Webb, Michael C. Fahey, Graham Jenkin, Madison Claire Badawy Paton and Courtney A. McDonald
    Citation: Stem Cell Research & Therapy 2023 14:18
    Content type: Research Published on:

  50. Many laboratories have described the in vitro isolation of multipotent cells with stem cell properties from the skin of various species termed skin-derived stem cells (SDSCs). However, the cellular origin of t...

    Authors: Wei Ge, Yuan-Chao Sun, Tian Qiao, Hai-Xia Liu, Tao-Ran He, Jun-Jie Wang, Chun-Lei Chen, Shun-Feng Cheng, Paul W. Dyce, Massimo De Felici and Wei Shen
    Citation: Stem Cell Research & Therapy 2023 14:17
    Content type: Research Published on:
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ISSN: 1757-6512