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  1. Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs below the injured segment. SCI not only results in physical and psychological harm to patients but can also cause a hu...

    Authors: Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li and Xue-wen Kang
    Citation: Stem Cell Research & Therapy 2021 12:102
    Content type: Review Published on:

  2. Distraction osteogenesis (DO) is a highly efficacious form of reconstructive bone regeneration, but its clinical utility is limited by the prolonged period required for bone consolidation to occur. Understandi...

    Authors: Weidong Jiang, Peiqi Zhu, Tao Zhang, Fengchun Liao, Yangyang Yu, Yan Liu, Huijuan Shen, Zhenchen Zhao, Xuanping Huang and Nuo Zhou
    Citation: Stem Cell Research & Therapy 2021 12:101
    Content type: Research Published on:

  3. Human periodontal ligament stem cells (hPDLSCs) are ideal seed cells for periodontal regeneration. A greater understanding of the dynamic protein profiles during osteogenic differentiation contributed to the i...

    Authors: Jianjia Li, Zhifa Wang, Xiangyu Huang, Zhaodan Wang, Zehao Chen, Runting Wang, Zhao Chen, Wei Liu, Buling Wu, Fuchun Fang and Wei Qiu
    Citation: Stem Cell Research & Therapy 2021 12:98
    Content type: Research Published on:

  4. Protein tyrosine phosphatase 1B (PTP1B) is one of the major negative regulators of leptin and insulin signaling, and has been strongly implicated in insulin resistance development in the course of obesity and ...

    Authors: Lynda Bourebaba, Katarzyna Kornicka-Garbowska, Mohamad Al Naem, Michael Röcken, Jacek Łyczko and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2021 12:97
    Content type: Research Published on:

  5. Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generate...

    Authors: Jing Kong, Shiyuan Wen, Wenjing Cao, Peng Yue, Xin Xu, Yu Zhang, Lisha Luo, Taigui Chen, Lianbao Li, Feng Wang, Jian Tao, Guozhong Zhou, Suyi Luo, Aihua Liu and Fukai Bao
    Citation: Stem Cell Research & Therapy 2021 12:95
    Content type: Review Published on:

  6. The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) ca...

    Authors: Jingting Chen, Yinmin Wang, Haoyue Hu, Yao Xiong, Shoubao Wang and Jun Yang
    Citation: Stem Cell Research & Therapy 2021 12:94
    Content type: Research Published on:

  7. Cell therapies present an exciting potential but there is a long history of expensive translational failures in stroke research. Researchers engaged in cell therapy research would benefit from a practical fram...

    Authors: Anjali Nagpal, Austin G. Milton, Simon A. Koblar and M. Anne Hamilton-Bruce
    Citation: Stem Cell Research & Therapy 2021 12:93
    Content type: Method Published on:

  8. Dyskeratosis congenita (DC) is a rare telomere biology disorder, which results in different clinical manifestations, including severe bone marrow failure. To date, the only curative treatment for the bone marr...

    Authors: Carlos Carrascoso-Rubio, Hidde A. Zittersteijn, Laura Pintado-Berninches, Beatriz Fernández-Varas, M. Luz Lozano, Cristina Manguan-Garcia, Leandro Sastre, Juan A. Bueren, Rosario Perona and Guillermo Guenechea
    Citation: Stem Cell Research & Therapy 2021 12:92
    Content type: Short report Published on:

  9. Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human mesenchymal stem cells (MSCs) as a potential treatment for...

    Authors: Seyed-Mohammad Reza Hashemian, Rasoul Aliannejad, Morteza Zarrabi, Masoud Soleimani, Massoud Vosough, Seyedeh-Esmat Hosseini, Hamed Hossieni, Saeid Heidari Keshel, Zeinab Naderpour, Ensiyeh Hajizadeh-Saffar, Elham Shajareh, Hamidreza Jamaati, Mina Soufi-Zomorrod, Naghmeh Khavandgar, Hediyeh Alemi, Aliasghar Karimi…
    Citation: Stem Cell Research & Therapy 2021 12:91
    Content type: Research Published on:

  11. Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling ...

    Authors: Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye and Qiang Su
    Citation: Stem Cell Research & Therapy 2021 12:89
    Content type: Research Published on:

  12. Tissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members ...

    Authors: Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper and Nathan R. Schiele
    Citation: Stem Cell Research & Therapy 2021 12:88
    Content type: Research Published on:

  13. Erectile dysfunction (ED) has often been observed in patients with obstructive sleep apnea (OSA). Research on adipose-derived mesenchymal stem cell (ADSC)-derived exosomes has shown that they have significant ...

    Authors: Li Liang, Dachao Zheng, Chao Lu, Qinghong Xi, Hua Bao, Wengfeng Li, Yufei Gu, Yuanshen Mao, Bin Xu and Xin Gu
    Citation: Stem Cell Research & Therapy 2021 12:87
    Content type: Research Published on:

  14. Leukemia stem cells (LSCs) are responsible for the initiation, progression, and relapse of acute myeloid leukemia (AML). Therefore, a therapeutic strategy targeting LSCs is a potential approach to eradicate AM...

    Authors: Yongliang Liu, Guiqin Wang, Jiasi Zhang, Xue Chen, Huailong Xu, Gang Heng, Jun Chen, Yongchun Zhao, Jiatao Li, Yuanli Ni, Yingzi Zhang, Juanjuan Shan and Cheng Qian
    Citation: Stem Cell Research & Therapy 2021 12:86
    Content type: Research Published on:

  15. Sufficient vascular network plays an important role in the repair of bone defects. Bone morphogenetic protein 2 (BMP2) being a key regulator of angiogenesis has attracted the attention of researchers. In addit...

    Authors: Mingjiao Chen, Meng Zhou, Yao Fu, Jin Li and Zi Wang
    Citation: Stem Cell Research & Therapy 2021 12:85
    Content type: Research Published on:

  16. Drug-induced liver injury (DILI) is one of the leading causes of clinical trial failures and high drug attrition rates. Currently, the commonly used hepatocyte models include primary human hepatocytes (PHHs), ...

    Authors: Meixian Jin, Xiao Yi, Wei Liao, Qi Chen, Wanren Yang, Yang Li, Shao Li, Yi Gao, Qing Peng and Shuqin Zhou
    Citation: Stem Cell Research & Therapy 2021 12:84
    Content type: Review Published on:

  17. Adult mammalian retinal stem cells (RSCs) readily proliferate, self-renew, and generate progeny that differentiate into all retinal cell types in vitro. RSC-derived progeny can be induced to differentiate into...

    Authors: Kenneth N. Grisé, Nelson X. Bautista, Krystal Jacques, Brenda L. K. Coles and Derek van der Kooy
    Citation: Stem Cell Research & Therapy 2021 12:83
    Content type: Research Published on:

  18. Multipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unkn...

    Authors: Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz and Marc G. Jeschke
    Citation: Stem Cell Research & Therapy 2021 12:82
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:256

  19. CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (IT...

    Authors: Faroogh Marofi, Roza Motavalli, Vladimir A. Safonov, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Markov Alexander, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Mostafa Jarahian, Sepideh Izadi, Ali Hassanzadeh, Naghmeh Shirafkan, Safa Tahmasebi and Farhad Motavalli Khiavi
    Citation: Stem Cell Research & Therapy 2021 12:81
    Content type: Review Published on:

  20. Patients with peripheral nerve injury (PNI) often suffer from hypoxic ischemic impairments, in particular when combined with vascular damage, causing neuronal dysfunction and death. Increasing attention has be...

    Authors: Meng Cong, Mi Shen, Xia Wu, Yan Li, Liting Wang, Qianru He, Haiyan Shi and Fei Ding
    Citation: Stem Cell Research & Therapy 2021 12:80
    Content type: Research Published on:

  21. The liver is one of the vital organs involved in detoxification and metabolism. The sex-based differences between the functionality of male and female liver have been previously reported, i.e., male’s liver ar...

    Authors: Imran Ullah, Yurianna Shin, Yeongji Kim, Keon Bong Oh, Seongsoo Hwang, Young-Im Kim, Jeong Woong Lee, Tai-Young Hur, Seunghoon Lee and Sun A Ock
    Citation: Stem Cell Research & Therapy 2021 12:79
    Content type: Research Published on:

  22. Duchenne muscular dystrophy (DMD) is an inherited progressive disorder that causes skeletal and cardiac muscle deterioration with chronic inflammation. Dental pulp stem cells (DPSCs) are attractive candidates ...

    Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Posadas Herrera Guillermo, Hiromi Hayashita-Kinoh, Yasunobu Maruoka, Aki Nakamura-Takahasi, Koichi Kimura, Shin’ichi Takeda and Takashi Okada
    Citation: Stem Cell Research & Therapy 2021 12:78
    Content type: Research Published on:

  23. Chemotherapy is an effective anti-tumor treatment. Mesenchymal stem cells (MSCs), exerting therapy effect on injured tissues during chemotherapy, may be damaged in the process. The possibility of self-healing ...

    Authors: Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu, Jie Wu and Zongjin Li
    Citation: Stem Cell Research & Therapy 2021 12:77
    Content type: Research Published on:

  24. Reconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration is crucial in determining the therapeutic outcomes of craniofacial CSD. Stem ...

    Authors: Yao Liu, Xueying Zhuang, Si Yu, Ning Yang, Jianhong Zeng, Xuemei Liu and Xu Chen
    Citation: Stem Cell Research & Therapy 2021 12:76
    Content type: Research Published on:

  25. Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp...

    Authors: Jie Chen, Huaxing Xu, Kun Xia, Shuhua Cheng and Qi Zhang
    Citation: Stem Cell Research & Therapy 2021 12:75
    Content type: Research Published on:

  27. Life-long tissue homeostasis of adult tissues is supposedly maintained by the resident stem cells. These stem cells are quiescent in nature and rarely divide to self-renew and give rise to tissue-specific “pro...

    Authors: Deepa Bhartiya
    Citation: Stem Cell Research & Therapy 2021 12:73
    Content type: Commentary Published on:

  28. One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage an...

    Authors: Haggai Kaspi, Jonathan Semo, Nathalie Abramov, Chen Dekel, Stacy Lindborg, Ralph Kern, Chaim Lebovits and Revital Aricha
    Citation: Stem Cell Research & Therapy 2021 12:72
    Content type: Research Published on:

  29. Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected ...

    Authors: Yaya Tang, Yan Zhou and Hong-Jun Li
    Citation: Stem Cell Research & Therapy 2021 12:71
    Content type: Review Published on:

  30. Age-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis pigmentosa (RP), an inherited early-onset disease, results from premature loss ...

    Authors: Harshini Surendran, Swapna Nandakumar, Vijay Bhaskar Reddy K, Jonathan Stoddard, Varsha Mohan K, Pramod K. Upadhyay, Trevor J. McGill and Rajarshi Pal
    Citation: Stem Cell Research & Therapy 2021 12:70
    Content type: Research Published on:

  31. Optic-nerve injury results in impaired transmission of visual signals to central targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss. Therapies with mesenchymal stem ce...

    Authors: Almir Jordão da Silva-Junior, Louise Alessandra Mesentier-Louro, Gabriel Nascimento-dos-Santos, Leandro Coelho Teixeira-Pinheiro, Juliana F. Vasques, Luiza Chimeli-Ormonde, Victor Bodart-Santos, Luiza Rachel Pinheiro de Carvalho, Marcelo Felippe Santiago and Rosalia Mendez-Otero
    Citation: Stem Cell Research & Therapy 2021 12:69
    Content type: Research Published on:

  32. In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing.

    Authors: Frederik Penzien Mamsen, Lea Munthe-Fog, Mikela Karen Mungal Kring, Dominik Duscher, Mikkel Taudorf, Adam J. Katz and Stig-Frederik Trojahn Kølle
    Citation: Stem Cell Research & Therapy 2021 12:68
    Content type: Review Published on:

  33. As the most important component of the vascular wall, vascular smooth muscle cells (VSMCs) participate in the pathological process by phenotype transformation or differentiation from stem/progenitor cells. The...

    Authors: Qing Zhang, Ting Chen, Yun Zhang, Lingxia Lyu, Bohuan Zhang, Chengchen Huang, Xuhao Zhou, Yutao Wu and Zhoubin Li
    Citation: Stem Cell Research & Therapy 2021 12:67
    Content type: Research Published on:

  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnuolo, José David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. Laflamme
    Citation: Stem Cell Research & Therapy 2021 12:66
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:417

  35. Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The di...

    Authors: Boyan Wang, Yi Wang, Hainan Chen, Senyu Yao, Xiaofan Lai, Yuan Qiu, Jianye Cai, Yinong Huang, Xiaoyue Wei, Yuanjun Guan, Tao Wang, Jiancheng Wang and Andy Peng Xiang
    Citation: Stem Cell Research & Therapy 2021 12:65
    Content type: Research Published on:

  36. Human adipose-derived stem cells (hADSCs) are stem cells with the potential to differentiate in multiple directions. miR-204-5p is expressed at low levels during the osteogenic differentiation of hADSCs, and i...

    Authors: You Zhou, Siyu Liu, Wei Wang, Qiang Sun, Mengzhu Lv, Shude Yang, Shuang Tong and Shu Guo
    Citation: Stem Cell Research & Therapy 2021 12:64
    Content type: Research Published on:

  37. Radiation-induced rectal epithelial damage is a very common side effect of pelvic radiotherapy and often compromise the life quality and treatment outcome in patients with pelvic malignancies. Unlike small bow...

    Authors: Felipe Rodriguez Tirado, Payel Bhanja, Eduardo Castro-Nallar, Ximena Diaz Olea, Catalina Salamanca and Subhrajit Saha
    Citation: Stem Cell Research & Therapy 2021 12:63
    Content type: Research Published on:

  38. Hair follicle (HF) development and growth are dependent on epithelial-mesenchymal interactions (EMIs). Dermal papilla (DP) cells are recognized as the key inductive mesenchymal player, but the ideal source of ...

    Authors: Carla M. Abreu, Rogério P. Pirraco, Rui L. Reis, Mariana T. Cerqueira and Alexandra P. Marques
    Citation: Stem Cell Research & Therapy 2021 12:62
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:302

  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu
    Citation: Stem Cell Research & Therapy 2021 12:61
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:454

  40. Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types...

    Authors: Sara Galindo, Ana de la Mata, Marina López-Paniagua, Jose M. Herreras, Inmaculada Pérez, Margarita Calonge and Teresa Nieto-Miguel
    Citation: Stem Cell Research & Therapy 2021 12:60
    Content type: Review Published on:

  41. Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression whi...

    Authors: Nathalie Sumien, Matthew S. Wells, Akram Sidhu, Jessica M. Wong, Michael J. Forster, Qiao-Xi Zheng and Judith A. Kelleher-Andersson
    Citation: Stem Cell Research & Therapy 2021 12:59
    Content type: Short report Published on:

  42. Critical limb ischemia (CLI) is the most advanced form of peripheral arterial disease (PAD) characterized by ischemic rest pain and non-healing ulcers. Currently, the standard therapy for CLI is the surgical r...

    Authors: Pegah Nammian, Seyedeh-Leili Asadi-Yousefabad, Sajad Daneshi, Mohammad Hasan Sheikhha, Seyed Mohammad Bagher Tabei and Vahid Razban
    Citation: Stem Cell Research & Therapy 2021 12:58
    Content type: Research Published on:

  43. Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear....

    Authors: Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga and Tomoaki Taguchi
    Citation: Stem Cell Research & Therapy 2021 12:57
    Content type: Research Published on:

  44. In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients’ survival rate. Bone marrow mesenchymal stem cells...

    Authors: Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu and Shaoyi Zheng
    Citation: Stem Cell Research & Therapy 2021 12:56
    Content type: Research Published on:

  45. Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potent...

    Authors: Breanna S. Borys, Tiffany Dang, Tania So, Leili Rohani, Tamas Revay, Tylor Walsh, Madalynn Thompson, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee and Michael S. Kallos
    Citation: Stem Cell Research & Therapy 2021 12:55
    Content type: Research Published on:

  46. Chronic obstructive pulmonary disease (COPD) is an incurable and debilitating chronic disease characterized by progressive airflow limitation associated with abnormal levels of tissue inflammation. Therefore, ...

    Authors: Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi and Badrul Hisham Yahaya
    Citation: Stem Cell Research & Therapy 2021 12:54
    Content type: Research Published on:

  47. Retinitis pigmentosa (RP) is a progressive inherited retinal disease with great interest for finding effective treatment modalities. Stem cell-based therapy is one of the promising candidates. We aimed to inve...

    Authors: Aekkachai Tuekprakhon, Siripakorn Sangkitporn, Adisak Trinavarat, Aulia Rahmi Pawestri, Visit Vamvanij, Monchai Ruangchainikom, Panya Luksanapruksa, Phitchapa Pongpaksupasin, Areerat Khorchai, Acharaporn Dambua, Patcharaporn Boonchu, Chonlada Yodtup, Mongkol Uiprasertkul, Somchai Sangkitporn and La-ongsri Atchaneeyasakul
    Citation: Stem Cell Research & Therapy 2021 12:52
    Content type: Research Published on:

  48. In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capac...

    Authors: Wen Li, Shanshan Wang, Hui He, Jianbing Qin, Xiang Cheng, Heyan Zhao, Meiling Tian, Xinhua Zhang and Guohua Jin
    Citation: Stem Cell Research & Therapy 2021 12:51
    Content type: Research Published on:

  49. Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue stem cells, especially mesenchymal stem cel...

    Authors: Shengchao Zhang, Jiankai Fang, Zhanhong Liu, Pengbo Hou, Lijuan Cao, Yuyan Zhang, Rui Liu, Yanan Li, Qianwen Shang, Yongjing Chen, Chao Feng, Guan Wang, Gerry Melino, Ying Wang, Changshun Shao and Yufang Shi
    Citation: Stem Cell Research & Therapy 2021 12:50
    Content type: Research Published on:

  50. Diabetic wounds remain a challenging clinical problem, which requires further treatment development. Published data showed that dermis-derived stem/progenitor cells (DSPCs) display superior wound healing in vi...

    Authors: Yu Xin, Peng Xu, Xiangsheng Wang, Yunsheng Chen, Zheng Zhang and Yixin Zhang
    Citation: Stem Cell Research & Therapy 2021 12:49
    Content type: Research Published on:
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