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  1. Content type: Research

    Prior in vivo murine studies suggest circadian oscillations for hematopoietic stem cell release, which are maintained following administration of granulocyte colony-stimulating factor (G-CSF) or plerixafor. Furth...

    Authors: Patricia A Shi, Luis M Isola, Janice L Gabrilove, Erin L Moshier, James H Godbold, Lorraine K Miller and Paul S Frenette

    Citation: Stem Cell Research & Therapy 2013 4:30

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  2. Content type: Research

    Heme oxygenase (HO), a major cytoprotective enzyme, attenuates oxidative stress and obesity. The canonical Wnt signaling cascade plays a pivotal role in the regulation of adipogenesis. The present study examin...

    Authors: Luca Vanella, Komal Sodhi, Dong Hyun Kim, Nitin Puri, Mani Maheshwari, Terry D Hinds Jr, Lars Bellner, Dov Goldstein, Stephen J Peterson, Joseph I Shapiro and Nader G Abraham

    Citation: Stem Cell Research & Therapy 2013 4:28

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  3. Content type: Research

    Adipose tissue is an attractive and abundant source of multipotent stem cells. Human adipose stem cells (ASCs) have shown to have therapeutic relevancy in diverse clinical applications. Nevertheless, expansion...

    Authors: Mimmi Patrikoski, Miia Juntunen, Shayne Boucher, Andrew Campbell, Mohan C Vemuri, Bettina Mannerström and Susanna Miettinen

    Citation: Stem Cell Research & Therapy 2013 4:27

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  4. Content type: Research

    The acute respiratory distress syndrome (ARDS), affects up to 150,000 patients per year in the United States. We and other groups have demonstrated that bone marrow derived mesenchymal stromal stem cells preve...

    Authors: Mauricio Rojas, Richard E Parker, Natalie Thorn, Claudia Corredor, Smita S Iyer, Marta Bueno, Lyle Mroz, Nayra Cardenes, Ana L Mora, Arlene A Stecenko and Kenneth L Brigham

    Citation: Stem Cell Research & Therapy 2013 4:26

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  5. Content type: Research

    Endothelial progenitor cells (EPCs) play a critical role in restoration of ischemic diseases. However, the actual status of EPC development and the mechanisms of EPC dysfunctions in patients with various ische...

    Authors: Shizu Tsukada, Sang-Mo Kwon, Takenori Matsuda, Seok-Yun Jung, Jun-Hee Lee, Sang-Hun Lee, Haruchika Masuda and Takayuki Asahara

    Citation: Stem Cell Research & Therapy 2013 4:20

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  6. Content type: Review

    Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. Its invasive nature currently represents the most challenging hurdle to surgical resection. The mechanism adopted by GBM cells to car...

    Authors: Barbara Ortensi, Matteo Setti, Daniela Osti and Giuliana Pelicci

    Citation: Stem Cell Research & Therapy 2013 4:18

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  7. Content type: Commentary

    The work presented in this study focuses on evaluating health-related quality of life using the International Short Form 36-Item Health Survey in chronic liver disease patients in Cairo, Egypt, who received ei...

    Authors: Adeeb M AlZoubi and Farah Khalifeh

    Citation: Stem Cell Research & Therapy 2013 4:16

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  8. Content type: Research

    Currently, human adipose stem cells (hASCs) are differentiated towards osteogenic lineages using culture medium supplemented with L-ascorbic acid 2-phosphate (AsA2-P), dexamethasone (Dex) and beta-glycerophosp...

    Authors: Laura Kyllönen, Suvi Haimi, Bettina Mannerström, Heini Huhtala, Kristiina M Rajala, Heli Skottman, George K Sándor and Susanna Miettinen

    Citation: Stem Cell Research & Therapy 2013 4:17

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  9. Content type: Research

    The OCT4 transcription factor is involved in many cellular processes, including development, reprogramming, maintaining pluripotency and differentiation. Synthetic OCT4 mRNA was recently used (in conjunction with...

    Authors: Jason P Awe, Agustin Vega Crespo, You Li, Megerditch Kiledjian and James A Byrne

    Citation: Stem Cell Research & Therapy 2013 4:15

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  10. Content type: Review

    Bone is a load-bearing tissue and physical forces play key roles in the development and maintenance of its structure. Mechanical cues can stimulate the expression of an osteogenic phenotype, enhance matrix and...

    Authors: Ben P Hung, Daphne L Hutton and Warren L Grayson

    Citation: Stem Cell Research & Therapy 2013 4:10

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  11. Content type: Research

    Adipose-derived stem cells (ASCs) have emerged as important regulators of inflammatory/immune responses in vitro and in vivo and represent attractive candidates for cell-based therapies for diseases that involve ...

    Authors: Shijia Zhang, Svitlana D Danchuk, Kathleen MP Imhof, Julie A Semon, Brittni A Scruggs, Ryan W Bonvillain, Amy L Strong, Jeffrey M Gimble, Aline M Betancourt, Deborah E Sullivan and Bruce A Bunnell

    Citation: Stem Cell Research & Therapy 2013 4:13

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  12. Content type: Research

    Mesenchymal stem cells (MSCs) are immunosuppressive, but we lack an understanding of how these adult stem cells are in turn affected by immune cells and the surrounding tissue environment. As MSCs have stromal...

    Authors: Zul'atfi Rahmat, Shinsmon Jose, Rajesh Ramasamy and Sharmili Vidyadaran

    Citation: Stem Cell Research & Therapy 2013 4:12

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  13. Content type: Research

    Stem cell therapy can promote good recovery from stroke. Several studies have demonstrated that mesenchymal stem cells (MSC) are safe and effective. However, more information regarding appropriate cell type is...

    Authors: María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, M Teresa Vallejo-Cremades, Blanca Fuentes, Sebastián Cerdán and Exuperio Díez-Tejedor

    Citation: Stem Cell Research & Therapy 2013 4:11

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  14. Content type: Research

    Neural stem cell transplantation is a promising tool for the restoration of the enteric nervous system in a variety of motility disorders. However, limited cell viability after transplantation has restricted i...

    Authors: Wei Liu, Weiming Yue and Rongde Wu

    Citation: Stem Cell Research & Therapy 2013 4:7

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  15. Content type: Commentary

    Reprogramming strategies allow for the generation of virtually any cell type of the human body, which could be useful for cell-based therapy. Among the different reprogramming technologies available, direct li...

    Authors: Emmanuel Nivet, Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte

    Citation: Stem Cell Research & Therapy 2013 4:2

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  16. Content type: Research

    A feature which makes stem cells promising candidates for cell therapy is their ability to migrate effectively into damaged or diseased tissues. Recent reports demonstrated the increased motility of human mese...

    Authors: Grigory Vertelov, Ludmila Kharazi, M G Muralidhar, Givon Sanati, Timothy Tankovich and Alex Kharazi

    Citation: Stem Cell Research & Therapy 2013 4:5

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  17. Content type: Research

    Stimulating the commitment of implanted dystrophin+ muscle-derived stem cells (MDSCs) into myogenic, as opposed to lipofibrogenic lineages, is a promising therapeutic strategy for Duchenne muscular dystrophy (...

    Authors: James Tsao, Dolores A Vernet, Robert Gelfand, Istvan Kovanecz, Gaby Nolazco, Kevin W Bruhn and Nestor F Gonzalez-Cadavid

    Citation: Stem Cell Research & Therapy 2013 4:4

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  18. Content type: Research

    Nervous system injuries comprise a diverse group of disorders that include traumatic brain injury (TBI). The potential of mesenchymal stem cells (MSCs) to differentiate into neural cell types has aroused hope ...

    Authors: Joan E Nichols, Jean A Niles, Douglas DeWitt, Donald Prough, Margaret Parsley, Stephanie Vega, Andrea Cantu, Eric Lee and Joaquin Cortiella

    Citation: Stem Cell Research & Therapy 2013 4:3

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  19. Content type: Research

    This study investigated the promising effect of a new Platelet Glue obtained from Cryoprecipitation of Apheresis Platelet products (PGCAP) used in combination with Mesenchymal Stromal Cells (MSC) loaded on cer...

    Authors: Marina Trouillas, Marie Prat, Christelle Doucet, Isabelle Ernou, Corinne Laplace-Builhé, Patrick Saint Blancard, Xavier Holy and Jean-Jacques Lataillade

    Citation: Stem Cell Research & Therapy 2013 4:1

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  20. Content type: Research

    Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) are self-renewing multipotent progenitors with the potential to differentiate into multiple lineages of mesoderm, in addition to generating ecto...

    Authors: Mundackal S Divya, George E Roshin, Thulasi S Divya, Vazhanthodi Abdul Rasheed, Thankayyan R Santhoshkumar, Kandathil E Elizabeth, Jackson James and Radhakrishna M Pillai

    Citation: Stem Cell Research & Therapy 2012 3:57

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  21. Content type: Commentary

    Human embryonic stem cells (hESCs) have been reported to confer cytoprotection in the context of tissue injury. This is somewhat counterintuitive given that microenvironmental factors such as hypoxia and oxida...

    Authors: Eoin P Cummins

    Citation: Stem Cell Research & Therapy 2012 3:52

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  22. Content type: Research

    Transplantation of neural stem cells (NSCs) is increasingly suggested to become part of future therapeutic approaches to improve functional outcome of various central nervous system disorders. However, recentl...

    Authors: Kristien Reekmans, Nathalie De Vocht, Jelle Praet, Erik Fransen, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Annemie Van der Linden, Zwi Berneman and Peter Ponsaerts

    Citation: Stem Cell Research & Therapy 2012 3:56

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  23. Content type: Review

    Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure ...

    Authors: Anthony Conway and David V Schaffer

    Citation: Stem Cell Research & Therapy 2012 3:50

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  24. Content type: Research

    One of the most challenging safety issues in the manufacture of cell based medicinal products is the control of microbial risk as cell-based products cannot undergo terminal sterilization. Accordingly, sensiti...

    Authors: Mika Pietilä, Kaarina Lähteenmäki, Siri Lehtonen, Hannu-Ville Leskelä, Marko Närhi, Maarit Lönnroth, Jaana Mättö, Petri Lehenkari and Katrina Nordström

    Citation: Stem Cell Research & Therapy 2012 3:53

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  25. Content type: Research

    We previously found that mesenchymal stem cells (MSCs) injected intravenously could attenuate peritoneal adhesion by secreting tumor necrosis alpha-stimulating gene (TSG)-6, while MSCs injected intraperitoneal...

    Authors: Nan Wang, Yeqing Shao, Yan Mei, Li Zhang, Qinggang Li, Diangeng Li, Suozhu Shi, Quan Hong, Hongli Lin and Xiangmei Chen

    Citation: Stem Cell Research & Therapy 2012 3:51

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  26. Content type: Research

    This prospective cohort study aimed to assess the influence of stem cell therapy (SCT) on health-related quality of life (HRQOL) by using the SF-36 v2 and to elucidate the influence of objective clinical varia...

    Authors: Hosny Salama, Abdel-Rahamn N Zekri, Rasha Ahmed, Iman Medhat, El Sayed Abdallah, Tarneem Darwish, Ola S Ahmed and Abeer Bahnassy

    Citation: Stem Cell Research & Therapy 2012 3:49

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  27. Content type: Research

    Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent cells that can differentiate into different cell lineages and have emerged as a promising tool for cell-targeted therapies and tissue engineering. T...

    Authors: Serena Redaelli, Angela Bentivegna, Dana Foudah, Mariarosaria Miloso, Juliana Redondo, Gabriele Riva, Simona Baronchelli, Leda Dalprà and Giovanni Tredici

    Citation: Stem Cell Research & Therapy 2012 3:47

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  28. Content type: Review

    Controlled expansion and differentiation of pluripotent stem cells (PSCs) using reproducible, high-throughput methods could accelerate stem cell research for clinical therapies. Hydrodynamic culture systems fo...

    Authors: Krista M Fridley, Melissa A Kinney and Todd C McDevitt

    Citation: Stem Cell Research & Therapy 2012 3:45

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  29. Content type: Review

    The assembly of cells into tissues is a complex process controlled by numerous signaling pathways to ensure the fidelity of the final structure. Tissue assembly is also very dynamic, as exemplified by the form...

    Authors: Sriram Manivannan and Celeste M Nelson

    Citation: Stem Cell Research & Therapy 2012 3:42

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  30. Content type: Review

    Stem cells interact with biochemical and biophysical signals in their extracellular environment. The biophysical signals are transduced to the stem cells either through the underlying extracellular matrix or e...

    Authors: Evelyn KF Yim and Michael P Sheetz

    Citation: Stem Cell Research & Therapy 2012 3:41

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  31. Content type: Research

    Induced pluripotent stem cells (iPSCs) are a potent cell source for neurogenesis. Previously we have generated iPSCs from human dental stem cells carrying transgene vectors. These exogenous transgenes may affe...

    Authors: Xiao-Ying Zou, Hsiao-Ying Yang, Zongdong Yu, Xiao-Bing Tan, Xing Yan and George T-J Huang

    Citation: Stem Cell Research & Therapy 2012 3:43

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  32. Content type: Research

    Bone marrow mesenchymal stem cells (BMMSCs) are a heterogeneous population of postnatal precursor cells with the capacity of adhering to culture dishes generating colony-forming unit-fibroblasts (CFU-F). Here ...

    Authors: Kentaro Akiyama, Yong-Ouk You, Takayoshi Yamaza, Chider Chen, Liang Tang, Yan Jin, Xiao-Dong Chen, Stan Gronthos and Songtao Shi

    Citation: Stem Cell Research & Therapy 2012 3:40

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  33. Content type: Research

    X-linked adrenoleukodystrophy (X-ALD) is a complex disorder with variable expressivity that affects the nervous, adrenocortical and male reproductive systems. Although ABCD1 mutations are known to provide the gen...

    Authors: Xiao-Ming Wang, Wing Yan Yik, Peilin Zhang, Wange Lu, Patricia K Dranchak, Darryl Shibata, Steven J Steinberg and Joseph G Hacia

    Citation: Stem Cell Research & Therapy 2012 3:39

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  34. Content type: Review

    Cellular therapy products are an emerging medical product class undergoing rapid scientific and clinical innovation worldwide. These products pose unique regulatory challenges both for countries with existing ...

    Authors: Judith A Arcidiacono, Joan W Blair and Kimberly A Benton

    Citation: Stem Cell Research & Therapy 2012 3:38

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  35. Content type: Review

    Therapeutic strategies using stem cells for treating neurological diseases are receiving more attention as the scientific community appreciates cell-autonomous contributions to several diseases of the central ...

    Authors: Akshata A Almad and Nicholas J Maragakis

    Citation: Stem Cell Research & Therapy 2012 3:37

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  36. Content type: Research

    A number of questions remain unanswered in the field of cell therapy for acute myocardial infarction, including what is the optimal cell type, and can therapeutic efficacy be enhanced by conditioning regimens....

    Authors: Aidan Flynn, Xizhe Chen, Enda O'Connell and Timothy O'Brien

    Citation: Stem Cell Research & Therapy 2012 3:36

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  37. Content type: Review

    The recent derivation of disease-specific induced pluripotent stem cells (iPSCs) from somatic cells of patients with familial and sporadic forms of diseases and the demonstration of their ability to give rise ...

    Authors: Hsiang-Po Huang, Ching-Yu Chuang and Hung-Chih Kuo

    Citation: Stem Cell Research & Therapy 2012 3:34

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  38. Content type: Research

    Adipose stem cells (ASCs) secrete many trophic factors that can stimulate tissue repair, including angiogenic factors, but little is known about how ASCs and their secreted factors influence cartilage regenera...

    Authors: Christopher SD Lee, Olivia A Burnsed, Vineeth Raghuram, Jonathan Kalisvaart, Barbara D Boyan and Zvi Schwartz

    Citation: Stem Cell Research & Therapy 2012 3:35

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