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  1. Erectile dysfunction (ED) has often been observed in patients with obstructive sleep apnea (OSA). Research on adipose-derived mesenchymal stem cell (ADSC)-derived exosomes has shown that they have significant ...

    Authors: Li Liang, Dachao Zheng, Chao Lu, Qinghong Xi, Hua Bao, Wengfeng Li, Yufei Gu, Yuanshen Mao, Bin Xu and Xin Gu

    Citation: Stem Cell Research & Therapy 2021 12:87

    Content type: Research

    Published on:

  2. Leukemia stem cells (LSCs) are responsible for the initiation, progression, and relapse of acute myeloid leukemia (AML). Therefore, a therapeutic strategy targeting LSCs is a potential approach to eradicate AM...

    Authors: Yongliang Liu, Guiqin Wang, Jiasi Zhang, Xue Chen, Huailong Xu, Gang Heng, Jun Chen, Yongchun Zhao, Jiatao Li, Yuanli Ni, Yingzi Zhang, Juanjuan Shan and Cheng Qian

    Citation: Stem Cell Research & Therapy 2021 12:86

    Content type: Research

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  3. Sufficient vascular network plays an important role in the repair of bone defects. Bone morphogenetic protein 2 (BMP2) being a key regulator of angiogenesis has attracted the attention of researchers. In addit...

    Authors: Mingjiao Chen, Meng Zhou, Yao Fu, Jin Li and Zi Wang

    Citation: Stem Cell Research & Therapy 2021 12:85

    Content type: Research

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  4. Drug-induced liver injury (DILI) is one of the leading causes of clinical trial failures and high drug attrition rates. Currently, the commonly used hepatocyte models include primary human hepatocytes (PHHs), ...

    Authors: Meixian Jin, Xiao Yi, Wei Liao, Qi Chen, Wanren Yang, Yang Li, Shao Li, Yi Gao, Qing Peng and Shuqin Zhou

    Citation: Stem Cell Research & Therapy 2021 12:84

    Content type: Review

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  5. Adult mammalian retinal stem cells (RSCs) readily proliferate, self-renew, and generate progeny that differentiate into all retinal cell types in vitro. RSC-derived progeny can be induced to differentiate into...

    Authors: Kenneth N. Grisé, Nelson X. Bautista, Krystal Jacques, Brenda L. K. Coles and Derek van der Kooy

    Citation: Stem Cell Research & Therapy 2021 12:83

    Content type: Research

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  6. Multipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unkn...

    Authors: Gertraud Eylert, Reinhard Dolp, Alexandra Parousis, Richard Cheng, Christopher Auger, Magdalena Holter, Ingrid Lang-Olip, Viola Reiner, Lars-Peter Kamolz and Marc G. Jeschke

    Citation: Stem Cell Research & Therapy 2021 12:82

    Content type: Research

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  7. CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (IT...

    Authors: Faroogh Marofi, Roza Motavalli, Vladimir A. Safonov, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Markov Alexander, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Mostafa Jarahian, Sepideh Izadi, Ali Hassanzadeh, Naghmeh Shirafkan, Safa Tahmasebi and Farhad Motavalli Khiavi

    Citation: Stem Cell Research & Therapy 2021 12:81

    Content type: Review

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  8. The liver is one of the vital organs involved in detoxification and metabolism. The sex-based differences between the functionality of male and female liver have been previously reported, i.e., male’s liver ar...

    Authors: Imran Ullah, Yurianna Shin, Yeongji Kim, Keon Bong Oh, Seongsoo Hwang, Young-Im Kim, Jeong Woong Lee, Tai-Young Hur, Seunghoon Lee and Sun A Ock

    Citation: Stem Cell Research & Therapy 2021 12:79

    Content type: Research

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  9. Duchenne muscular dystrophy (DMD) is an inherited progressive disorder that causes skeletal and cardiac muscle deterioration with chronic inflammation. Dental pulp stem cells (DPSCs) are attractive candidates ...

    Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Posadas Herrera Guillermo, Hiromi Hayashita-Kinoh, Yasunobu Maruoka, Aki Nakamura-Takahasi, Koichi Kimura, Shin’ichi Takeda and Takashi Okada

    Citation: Stem Cell Research & Therapy 2021 12:78

    Content type: Research

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  10. Chemotherapy is an effective anti-tumor treatment. Mesenchymal stem cells (MSCs), exerting therapy effect on injured tissues during chemotherapy, may be damaged in the process. The possibility of self-healing ...

    Authors: Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu, Jie Wu and Zongjin Li

    Citation: Stem Cell Research & Therapy 2021 12:77

    Content type: Research

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  11. Reconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration is crucial in determining the therapeutic outcomes of craniofacial CSD. Stem ...

    Authors: Yao Liu, Xueying Zhuang, Si Yu, Ning Yang, Jianhong Zeng, Xuemei Liu and Xu Chen

    Citation: Stem Cell Research & Therapy 2021 12:76

    Content type: Research

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  12. Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp...

    Authors: Jie Chen, Huaxing Xu, Kun Xia, Shuhua Cheng and Qi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:75

    Content type: Research

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  14. Life-long tissue homeostasis of adult tissues is supposedly maintained by the resident stem cells. These stem cells are quiescent in nature and rarely divide to self-renew and give rise to tissue-specific “pro...

    Authors: Deepa Bhartiya

    Citation: Stem Cell Research & Therapy 2021 12:73

    Content type: Commentary

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  15. One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage an...

    Authors: Haggai Kaspi, Jonathan Semo, Nathalie Abramov, Chen Dekel, Stacy Lindborg, Ralph Kern, Chaim Lebovits and Revital Aricha

    Citation: Stem Cell Research & Therapy 2021 12:72

    Content type: Research

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  16. Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected ...

    Authors: Yaya Tang, Yan Zhou and Hong-Jun Li

    Citation: Stem Cell Research & Therapy 2021 12:71

    Content type: Review

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  17. Age-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis pigmentosa (RP), an inherited early-onset disease, results from premature loss ...

    Authors: Harshini Surendran, Swapna Nandakumar, Vijay Bhaskar Reddy K, Jonathan Stoddard, Varsha Mohan K, Pramod K. Upadhyay, Trevor J. McGill and Rajarshi Pal

    Citation: Stem Cell Research & Therapy 2021 12:70

    Content type: Research

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  18. Optic-nerve injury results in impaired transmission of visual signals to central targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss. Therapies with mesenchymal stem ce...

    Authors: Almir Jordão da Silva-Junior, Louise Alessandra Mesentier-Louro, Gabriel Nascimento-dos-Santos, Leandro Coelho Teixeira-Pinheiro, Juliana F. Vasques, Luiza Chimeli-Ormonde, Victor Bodart-Santos, Luiza Rachel Pinheiro de Carvalho, Marcelo Felippe Santiago and Rosalia Mendez-Otero

    Citation: Stem Cell Research & Therapy 2021 12:69

    Content type: Research

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  19. In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing.

    Authors: Frederik Penzien Mamsen, Lea Munthe-Fog, Mikela Karen Mungal Kring, Dominik Duscher, Mikkel Taudorf, Adam J. Katz and Stig-Frederik Trojahn Kølle

    Citation: Stem Cell Research & Therapy 2021 12:68

    Content type: Review

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  20. As the most important component of the vascular wall, vascular smooth muscle cells (VSMCs) participate in the pathological process by phenotype transformation or differentiation from stem/progenitor cells. The...

    Authors: Qing Zhang, Ting Chen, Yun Zhang, Lingxia Lyu, Bohuan Zhang, Chengchen Huang, Xuhao Zhou, Yutao Wu and Zhoubin Li

    Citation: Stem Cell Research & Therapy 2021 12:67

    Content type: Research

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  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnuolo, José David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. Laflamme

    Citation: Stem Cell Research & Therapy 2021 12:66

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:417

  22. Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The di...

    Authors: Boyan Wang, Yi Wang, Hainan Chen, Senyu Yao, Xiaofan Lai, Yuan Qiu, Jianye Cai, Yinong Huang, Xiaoyue Wei, Yuanjun Guan, Tao Wang, Jiancheng Wang and Andy Peng Xiang

    Citation: Stem Cell Research & Therapy 2021 12:65

    Content type: Research

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  23. Human adipose-derived stem cells (hADSCs) are stem cells with the potential to differentiate in multiple directions. miR-204-5p is expressed at low levels during the osteogenic differentiation of hADSCs, and i...

    Authors: You Zhou, Siyu Liu, Wei Wang, Qiang Sun, Mengzhu Lv, Shude Yang, Shuang Tong and Shu Guo

    Citation: Stem Cell Research & Therapy 2021 12:64

    Content type: Research

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  24. Radiation-induced rectal epithelial damage is a very common side effect of pelvic radiotherapy and often compromise the life quality and treatment outcome in patients with pelvic malignancies. Unlike small bow...

    Authors: Felipe Rodriguez Tirado, Payel Bhanja, Eduardo Castro-Nallar, Ximena Diaz Olea, Catalina Salamanca and Subhrajit Saha

    Citation: Stem Cell Research & Therapy 2021 12:63

    Content type: Research

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  25. Hair follicle (HF) development and growth are dependent on epithelial-mesenchymal interactions (EMIs). Dermal papilla (DP) cells are recognized as the key inductive mesenchymal player, but the ideal source of ...

    Authors: Carla M. Abreu, Rogério P. Pirraco, Rui L. Reis, Mariana T. Cerqueira and Alexandra P. Marques

    Citation: Stem Cell Research & Therapy 2021 12:62

    Content type: Research

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  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu

    Citation: Stem Cell Research & Therapy 2021 12:61

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:454

  27. Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types...

    Authors: Sara Galindo, Ana de la Mata, Marina López-Paniagua, Jose M. Herreras, Inmaculada Pérez, Margarita Calonge and Teresa Nieto-Miguel

    Citation: Stem Cell Research & Therapy 2021 12:60

    Content type: Review

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  28. Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression whi...

    Authors: Nathalie Sumien, Matthew S. Wells, Akram Sidhu, Jessica M. Wong, Michael J. Forster, Qiao-Xi Zheng and Judith A. Kelleher-Andersson

    Citation: Stem Cell Research & Therapy 2021 12:59

    Content type: Short report

    Published on:

  29. Critical limb ischemia (CLI) is the most advanced form of peripheral arterial disease (PAD) characterized by ischemic rest pain and non-healing ulcers. Currently, the standard therapy for CLI is the surgical r...

    Authors: Pegah Nammian, Seyedeh-Leili Asadi-Yousefabad, Sajad Daneshi, Mohammad Hasan Sheikhha, Seyed Mohammad Bagher Tabei and Vahid Razban

    Citation: Stem Cell Research & Therapy 2021 12:58

    Content type: Research

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  30. Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear....

    Authors: Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga and Tomoaki Taguchi

    Citation: Stem Cell Research & Therapy 2021 12:57

    Content type: Research

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  31. In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients’ survival rate. Bone marrow mesenchymal stem cells...

    Authors: Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu and Shaoyi Zheng

    Citation: Stem Cell Research & Therapy 2021 12:56

    Content type: Research

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  32. Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potent...

    Authors: Breanna S. Borys, Tiffany Dang, Tania So, Leili Rohani, Tamas Revay, Tylor Walsh, Madalynn Thompson, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee and Michael S. Kallos

    Citation: Stem Cell Research & Therapy 2021 12:55

    Content type: Research

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  33. Chronic obstructive pulmonary disease (COPD) is an incurable and debilitating chronic disease characterized by progressive airflow limitation associated with abnormal levels of tissue inflammation. Therefore, ...

    Authors: Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi and Badrul Hisham Yahaya

    Citation: Stem Cell Research & Therapy 2021 12:54

    Content type: Research

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  34. Mesenchymal stromal cell (MSC)-based therapies are being actively investigated in various inflammatory disorders. However, functional variability among MSCs cultured in vitro will lead to distinct therapeutic ...

    Authors: Changbin Sun, Kehua Zhang, Jianhui Yue, Shufang Meng and Xi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:53

    Content type: Research

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  35. Retinitis pigmentosa (RP) is a progressive inherited retinal disease with great interest for finding effective treatment modalities. Stem cell-based therapy is one of the promising candidates. We aimed to inve...

    Authors: Aekkachai Tuekprakhon, Siripakorn Sangkitporn, Adisak Trinavarat, Aulia Rahmi Pawestri, Visit Vamvanij, Monchai Ruangchainikom, Panya Luksanapruksa, Phitchapa Pongpaksupasin, Areerat Khorchai, Acharaporn Dambua, Patcharaporn Boonchu, Chonlada Yodtup, Mongkol Uiprasertkul, Somchai Sangkitporn and La-ongsri Atchaneeyasakul

    Citation: Stem Cell Research & Therapy 2021 12:52

    Content type: Research

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  36. In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capac...

    Authors: Wen Li, Shanshan Wang, Hui He, Jianbing Qin, Xiang Cheng, Heyan Zhao, Meiling Tian, Xinhua Zhang and Guohua Jin

    Citation: Stem Cell Research & Therapy 2021 12:51

    Content type: Research

    Published on:

  37. Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue stem cells, especially mesenchymal stem cel...

    Authors: Shengchao Zhang, Jiankai Fang, Zhanhong Liu, Pengbo Hou, Lijuan Cao, Yuyan Zhang, Rui Liu, Yanan Li, Qianwen Shang, Yongjing Chen, Chao Feng, Guan Wang, Gerry Melino, Ying Wang, Changshun Shao and Yufang Shi

    Citation: Stem Cell Research & Therapy 2021 12:50

    Content type: Research

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  38. Diabetic wounds remain a challenging clinical problem, which requires further treatment development. Published data showed that dermis-derived stem/progenitor cells (DSPCs) display superior wound healing in vi...

    Authors: Yu Xin, Peng Xu, Xiangsheng Wang, Yunsheng Chen, Zheng Zhang and Yixin Zhang

    Citation: Stem Cell Research & Therapy 2021 12:49

    Content type: Research

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  39. Spinal cord injury (SCI) is a neurological, medically incurable disorder. Human pluripotent stem cells (hPSCs) have the potential to generate neural stem/progenitor cells (NS/PCs), which hold promise in the tr...

    Authors: Rui Bai, Yun Chang, Amina Saleem, Fujian Wu, Lei Tian, Siyao Zhang, Ya’nan Li, Shuhong Ma, Tao Dong, Tianwei Guo, Youxu Jiang, Yi You, Wen-Jing Lu, Hong Feng Jiang and Feng Lan

    Citation: Stem Cell Research & Therapy 2021 12:48

    Content type: Research

    Published on:

  40. Paracrine signaling from endothelial progenitor cells (EPCs) is beneficial for angiogenesis and thus promotes tissue regeneration. Microgravity (MG) environment is found to facilitate the functional potentials...

    Authors: Lingchi Kong, Yan Wang, Haixing Wang, Qi Pan, Rongtai Zuo, Shanshan Bai, Xiaoting Zhang, Wayne Yukwai Lee, Qinglin Kang and Gang Li

    Citation: Stem Cell Research & Therapy 2021 12:47

    Content type: Research

    Published on:

  41. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are regarded as promising cell type for cardiac cell replacement therapy, but it is not known whether the developmental stage influences their per...

    Authors: Gabriel Peinkofer, Martina Maass, Kurt Pfannkuche, Agapios Sachinidis, Stephan Baldus, Jürgen Hescheler, Tomo Saric and Marcel Halbach

    Citation: Stem Cell Research & Therapy 2021 12:46

    Content type: Research

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  42. Epidermal stem cells (EpSCs) can self-renew, which are responsible for the long-term maintenance of the skin, and it also plays a critical role in wound re-epithelization, but the mechanism underlying EpSCs pr...

    Authors: Xiaohong Zhao, Ruyu Bian, Fan Wang, Ying Wang, Xue Li, Yicheng Guo, Xiaorong Zhang, Gaoxing Luo and Rixing Zhan

    Citation: Stem Cell Research & Therapy 2021 12:42

    Content type: Research

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  43. Precision or individualized medicine is increasingly pervasive across medical and surgical disciplines. However, the concept has not been introduced in regenerative medicine.

    Authors: Amy L. Lightner and Timothy Chan

    Citation: Stem Cell Research & Therapy 2021 12:39

    Content type: Viewpoint

    Published on:

  44. Inflammatory bowel disease is a chronic and excessive inflammation of the colon and small intestine. We previously reported that priming of mesenchymal stromal cells (MSCs) with poly(I:C) induced them to expre...

    Authors: Ji-Young Lim, Byung-Su Kim, Da-Bin Ryu, Tae Woo Kim, Gyeongsin Park and Chang-Ki Min

    Citation: Stem Cell Research & Therapy 2021 12:37

    Content type: Research

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  46. Umbilical cord mesenchymal stem cells (UC-MSCs) have certain advantages over other MSCs and about 300 clinical trials have been registered using UC-MSCs to treat diseases such as osteoarthritis, autoimmune dis...

    Authors: Shaoyang Zhang, Jing Yi Wang, Baojie Li, Feng Yin and Huijuan Liu

    Citation: Stem Cell Research & Therapy 2021 12:25

    Content type: Letter

    Published on:

  47. Mesenchymal stem cell-based acellular therapies have been widely exploited in managing hypertrophic scars. However, low maintenance dose and transitory therapeutic effects during topical medication remain a th...

    Authors: Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen and Xiaosong Chen

    Citation: Stem Cell Research & Therapy 2021 12:23

    Content type: Research

    Published on:

  48. Previous studies have suggested that promoting endogenous neurogenesis has great significance for the recovery of cognitive dysfunction caused by cerebral ischemia (CI). Pharmacological inhibition of GABAB recept...

    Authors: Dan Song, Yaohua Chen, Cheng Chen, Lili Chen and Oumei Cheng

    Citation: Stem Cell Research & Therapy 2021 12:22

    Content type: Research

    Published on:

  49. Steroid-induced osteonecrosis of the femoral head (SONFH) is a devastating orthopedic disease, which seriously affects the quality of life of patients. The study aims to investigate the effects of LncRNA NORAD...

    Authors: Dapeng Fu, Sheng Yang, Jianmin Lu, Haoyi Lian and Kairong Qin

    Citation: Stem Cell Research & Therapy 2021 12:18

    Content type: Research

    Published on:

  50. The creation of a bioengineered cardiac patch (BCP) is a potential novel strategy for myocardial repair. Nevertheless, the ideal scaffold for BCP is unknown.

    Authors: Yu Jiang, Si-Jia Sun, Zhe Zhen, Rui Wei, Nannan Zhang, Song-Yan Liao and Hung-Fat Tse

    Citation: Stem Cell Research & Therapy 2021 12:13

    Content type: Research

    Published on:

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