Articles

Potential application of human neural crest-derived nasal turbinate stem cells for the treatment of neuropathology and impaired cognition in models of Alzheimer’s disease

Stem cell transplantation is a fascinating therapeutic approach for the treatment of many neurodegenerative disorders; however, clinical trials using stem cells have not been as effective as expected based on ...

Authors: Jung Yeon Lim, Sang In Park, Soon A. Park, Jung Ho Jeon, Ho Yong Jung, Jung-Min Yon, Sin-Soo Jeun, Hyun Kook Lim and Sung Won Kim

Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn’s disease: a retrospective observational study

Perianal fistula is one of the most common complications in Crohn’s disease, and various medical and surgical treatments are being tried. The aim of this study was to compare the perianal fistula closure rates...

Authors: Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang and Chang Sik Yu

A focus on allogeneic mesenchymal stromal cells as a versatile therapeutic tool for treating multiple sclerosis

Multiple sclerosis (MS) is a central nervous system (CNS) chronic illness with autoimmune, inflammatory, and neurodegenerative effects characterized by neurological disorder and axonal loss signs due to myelin...

Authors: Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi and Jafar Ai

Comparison of mesenchymal stromal cells from peritoneal dialysis effluent with those from umbilical cords: characteristics and therapeutic effects on chronic peritoneal dialysis in uremic rats

A long-term of peritoneal dialysis (PD) using a hypertonic PD solution (PDS) leads to patient’s peritoneal membrane (PM) injury, resulting in ultrafiltration failure (UFF) and PD drop-out. Our previous study s...

Authors: Yangchun Du, Ming Zong, Qiunong Guan, Zhongli Huang, Lan Zhou, Jing Cai, Gerald da Roza, Hao Wang, Hualin Qi, Yiping Lu and Caigan Du

Human umbilical cord mesenchymal stromal cells attenuate pulmonary fibrosis via regulatory T cell through interaction with macrophage

Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy is being investigated in clinical trials for the treatment...

Authors: Zan Tang, Junxiao Gao, Jie Wu, Guifang Zeng, Yan Liao, Zhenkun Song, Xiao Liang, Junyuan Hu, Yong Hu, Muyun Liu and Nan Li

Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling

Effective treatments for acute-on-chronic liver failure (ACLF) are lacking. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been applied in tissue regeneration and repair, acting through pa...

Authors: Yulin He, Xingrong Guo, Tingyu Lan, Jianbo Xia, Jinsong Wang, Bei Li, Chunyan Peng, Yue Chen, Xiang Hu and Zhongji Meng

CD90^low glioma-associated mesenchymal stromal/stem cells promote temozolomide resistance by activating FOXS1-mediated epithelial-mesenchymal transition in glioma cells

The tumour microenvironment contributes to chemotherapy resistance in gliomas, and glioma-associated mesenchymal stromal/stem cells (gaMSCs) are important stromal cell components that play multiple roles in tu...

Authors: Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu

Scintigraphic tracking of ^99mTechnetium-labelled equine peripheral blood-derived mesenchymal stem cells after intravenous, intramuscular, and subcutaneous injection in healthy dogs

Mesenchymal stem cell treatments in dogs have been investigated as a potential innovative alternative to current conventional therapies for a variety of conditions. So far, the precise mode of action of the MS...

Authors: Charlotte Beerts, Carlien Brondeel, Glenn Pauwelyn, Eva Depuydt, Liesa Tack, Luc Duchateau, Yangfeng Xu, Jimmy H. Saunders, Kathelijne Peremans and Jan H. Spaas

Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway

Diabetic foot ulceration is a serious chronic complication of diabetes mellitus characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has been widely used for diabetic wound he...

Authors: Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed M. Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed H. Khalil, Sami F. Abdalla, Mohamed El-Sherbiny…

Cell heterogeneity, rather than the cell storage solution, affects the behavior of mesenchymal stem cells in vitro and in vivo

Mesenchymal stem cells (MSCs) have to be expanded in vitro to reach a sufficient cell dose for the treatment of various diseases. During the process of expansion, some obstacles remain to be overcome. The purp...

Authors: Yong-Hong Wang, Ya-Chao Tao, Dong-Bo Wu, Meng-Lan Wang, Hong Tang and En-Qiang Chen

Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2/Smad1/5/9 signalling pathway

Nontraumatic osteonecrosis of the femoral head (NONFH) is a common, progressive, and refractory orthopaedic disease. Decreased osteogenesis and angiogenesis are considered the main factors in the pathogenesis ...

Authors: Wu Yang, Weiwen Zhu, Yunfei Yang, Minkang Guo, Husun Qian, Weiqian Jiang, Yu Chen, Chengjie Lian, Zijie Xu, Haobo Bai, Tingmei Chen and Jian Zhang

Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis

Aberrations in exosomal circular RNA (circRNA) expression have been identified in various human diseases. In this study, we investigated whether exosomal circRNAs could act as competing endogenous RNAs (ceRNAs...

Authors: Guping Mao, Yiyang Xu, Dianbo Long, Hong Sun, Hongyi Li, Ruobin Xin, Ziji Zhang, Zhiwen Li, Zhi Yang and Yan Kang

Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features...

Authors: Rishi Man Chugh, Hang-soo Park, Abdeljabar El Andaloussi, Amro Elsharoud, Sahar Esfandyari, Mara Ulin, Lale Bakir, Alshimaa Aboalsoud, Mohamed Ali, Dalia Ashour, Prosper Igboeli, Nahed Ismail, Jan McAllister and Ayman Al-Hendy

Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4

Neointimal hyperplasia remains a major obstacle in vascular regeneration. Sca-1-positive progenitor cells residing within the vascular adventitia play a crucial role in the assemblage of vascular smooth muscle...

Authors: Yan Wu, Yuan-jin Li, Liu-liu Shi, Yun Liu, Yan Wang, Xin Bao, Wei Xu, Lu-yuan Yao, Magdaleena Naemi Mbadhi, Long Chen, Shan Li, Xing-yuan Li, Zhi-feng Zhang, Sen Zhao, Ruo-nan Zhang, Shi-You Chen…

Stem cell therapies for autoimmune hepatitis

Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as ...

Authors: Ahmed Lotfy, Aya Elgamal, Anna Burdzinska, Ayman A. Swelum, Reham Soliman, Ayman A. Hassan and Gamal Shiha

The tissue origin of human mesenchymal stem cells dictates their therapeutic efficacy on glucose and lipid metabolic disorders in type II diabetic mice

The therapeutic efficacy of mesenchymal stem cells (MSCs) of different tissue origins on metabolic disorders can be varied in many ways but remains poorly defined. Here we report a comprehensive comparison of ...

Authors: Yinzhong Ma, Lisha Wang, Shilun Yang, Dongyu Liu, Yi Zeng, Lilong Lin, Linhui Qiu, Jiahao Lu, Junlei Chang and Zhihuan Li

Application of mesenchymal stem cell sheet to treatment of ischemic heart disease

In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation ...

Authors: Dehua Chang, Taibing Fan, Shuang Gao, Yongqiang Jin, Mingkui Zhang and Minoru Ono

Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor

As a promising way to repair bone defect, bone tissue engineering has attracted a lot of attentions from researchers in recent years. Searching for new molecular target to modify the seed cells and enhance the...

Authors: Xuenan Liu, Xiaomin Lian, Xuejiao Liu, Yangge Du, Yuan Zhu, Menglong Hu, Ping Zhang, Yunsong Liu and Yongsheng Zhou

Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells

Tissue-engineered bone grafts (TEBGs) that undergo vascularization and neurotization evolve into functioning bone tissue. Previously, we verified that implanting sensory nerve tracts into TEBGs promoted osteog...

Authors: Xinxin Zhang, Xiaorui Jiang, Shan Jiang, Xiyu Cai, Shengji Yu and Guoxian Pei

Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway

Radiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused on stem cell properties to obtain ideal therapeutic effects, and Sox9 ...

Authors: Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang, Xiaocheng Wang, Maosheng Cheng, Jie Chen, Zhi Chen, Jianwen Chen, Caihua Zhang, Gan Xiong, Xiuyun Xu, Demeng Chen, Heping Li and Liang Peng

Small blood stem cells for enhancing early osseointegration formation on dental implants: a human phase I safety study

Small blood stem cells (SB cells), isolated from human peripheral blood, demonstrated the ability to benefit bone regeneration and osseointegration. The primary goal of our study is to examine the safety and t...

Authors: Sheng-Wei Feng, Yi-Han Su, Yen-Kuang Lin, Yu-Chih Wu, Yen-Hua Huang, Fu-Hung Yang, Hsi-Jen Chiang, Yun Yen and Peter Da-Yen Wang

Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury

Embryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative of ES cells. Acute kidney injury (AKI) is a common acut...

Authors: Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu, Zhongchao Han, Xiangmei Chen, Zongjin Li and Na Liu

Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by modulating T cell function through CCR2-CCL2 axis

Idiopathic pneumonia syndrome (IPS) is a non-infectious fatal complication characterized by a massive infiltration of leukocytes in lungs and diffuse pulmonary injury after allogeneic hematopoietic stem cell t...

Authors: Min Cao, Huihui Liu, Yujun Dong, Wei Liu, Zhengyu Yu, Qingya Wang, Qingyun Wang, Zeying Liang, Yuan Li and Hanyun Ren

Systemic therapy of MSCs in bone regeneration: a systematic review and meta-analysis

Over the past decades, many studies focused on mesenchymal stem cells (MSCs) therapy for bone regeneration. Due to the efficiency of topical application has been widely dicussed and systemic application was al...

Authors: Jingfei Fu, Yanxue Wang, Yiyang Jiang, Juan Du, Junji Xu and Yi Liu

Hypoproliferative human neural progenitor cell xenografts survived extendedly in the brain of immunocompetent rats

There is a huge controversy about whether xenograft or allograft in the “immune-privileged” brain needs immunosuppression. In animal studies, the prevailing sophisticated use of immunosuppression or immunodefi...

Authors: Chunhua Liu, Xiaoyun Wang, Wenhao Huang, Wei Meng, Zhenghui Su, Qi Xing, Heng Shi, Di Zhang, Min Zhou, Yifan Zhao, Haitao Wang, Guangjin Pan, Xiaofen Zhong, Duanqing Pei and Yiping Guo

High-efficiency c-Myc-mediated induction of functional hepatoblasts from the human umbilical cord mesenchymal stem cells

Direct reprogramming of human fibroblasts to hepatocyte-like cells was proposed to generate large-scale functional hepatocytes demanded by liver tissue engineering. However, the difficulty in obtaining large q...

Authors: Jie Deng, Kai Luo, Pengchao Xu, Qingyuan Jiang, Yuan Wang, Yunqi Yao, Xiaolei Chen, Fuyi Cheng, Dan Xie and Hongxin Deng

CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies

Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered ...

Authors: Faroogh Marofi, Marwan Mahmood Saleh, Heshu Sulaiman Rahman, Wanich Suksatan, Moaed E. Al-Gazally, Walid Kamal Abdelbasset, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Ali Hassanzadeh, Mahboubeh Yazdanifar, Roza Motavalli, Yashwant Pathak, Adel Naimi, Behzad Baradaran, Marzieh Nikoo and Farhad Motavalli Khiavi

Inter-center comparison of good manufacturing practices-compliant stromal vascular fraction and proposal for release acceptance criteria: a review of 364 productions

Even though the manufacturing processes of the stromal vascular fraction for clinical use are performed in compliance with the good manufacturing practices applying to advanced therapy medicinal products, spec...

Authors: Pauline François, Giulio Rusconi, Laurent Arnaud, Luca Mariotta, Laurent Giraudo, Greta Minonzio, Julie Veran, Baptiste Bertrand, Chloé Dumoulin, Fanny Grimaud, Luc Lyonnet, Dominique Casanova, Camille Giverne, Audrey Cras, Guy Magalon, Françoise Dignat-George…

LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels

Manipulation of neural stem and progenitor cells (NSPCs) is critical for the successful treatment of spinal cord injury (SCI) by NSPC transplantation, since their differentiation into neurons and oligodendrocy...

Authors: Chen-Guang Zhao, Jie Qin, Jia Li, Shan Jiang, Fen Ju, Wei Sun, Zhen Ren, Yu-Qiang Ji, Rui Wang, Xiao-Long Sun, Xiang Mou and Hua Yuan

Double overexpression of miR-19a and miR-20a in induced pluripotent stem cell-derived mesenchymal stem cells effectively preserves the left ventricular function in dilated cardiomyopathic rat

This study tested the hypothesis that double overexpression of miR-19a and miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left vent...

Authors: Jiunn-Jye Sheu, Han-Tan Chai, Pei-Hsun Sung, John Y. Chiang, Tien-Hung Huang, Pei-Lin Shao, Shun-Cheng Wu and Hon-Kan Yip

Combined melatonin-adipose derived mesenchymal stem cells therapy effectively protected the testis from testicular torsion-induced ischemia-reperfusion injury

This study tested the hypothesis that combined melatonin (Mel) and adipose-derived mesenchymal stem cells (ADMSCs) treatment was superior to either one alone on protecting the testis against acute testicular t...

Authors: Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Chi-Ruei Huang, Kuan-Hui Huang and Hon-Kan Yip

Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo

The cerebellum is the sensitive region of the brain to developmental abnormalities related to the effects of oxidative stresses. Abnormal cerebellar lobe formation, found in Jun dimerization protein 2 (Jdp2)-knoc...

Authors: Chia-Chen Ku, Kenly Wuputra, Kohsuke Kato, Jia-Bin Pan, Chia-Pei Li, Ming-Ho Tsai, Michiya Noguchi, Yukio Nakamura, Chung-Jung Liu, Te-Fu Chan, Ming-Feng Hou, Shigeharu Wakana, Yang-Chang Wu, Chang-Shen Lin, Deng-Chyang Wu and Kazunari K. Yokoyama

hPMSCs inhibit the expression of PD-1 in CD4⁺IL-10⁺ T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway

The activation of T cells and imbalanced redox metabolism enhances the development of graft-versus-host disease (GVHD). Human placenta-derived mesenchymal stromal cells (hPMSCs) can improve GVHD through regula...

Authors: Aiping Zhang, Jiashen Zhang, Xiaohua Li, Hengchao Zhang, Yanlian Xiong, Zhuoya Wang, Nannan Zhao, Feifei Wang and Xiying Luan

Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy

Acute kidney injury (AKI) is an emerging global healthcare issue without effective therapy yet. Autophagy recycles damaged organelles and helps maintain tissue homeostasis in acute renal ischemia-reperfusion (...

Authors: Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung and Der-Cherng Tarng

Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual

Stem cells are the main choice for seed cells in tissue engineering, but using most traditional stem cells requires invasive and complicated procedures. Human urine-derived stem cells (hUSCs) are an alternativ...

Authors: Jiachen Sun, Fei Xing, Min Zou, Min Gong, Lang Li and Zhou Xiang

Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality

State-of-the-art advances have indicated the pivotal characteristics of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) in hematopoietic microenvironment as well as coordinate contribution to hema...

Authors: Leisheng Zhang, Ying Chi, Yimeng Wei, Wenxia Zhang, Fuxu Wang, Lei Zhang, Linglin Zou, Baoquan Song, Xing Zhao and Zhongchao Han

Human amniotic mesenchymal stem cells-conditioned medium protects mice from high-fat diet-induced obesity

Obesity is a metabolic disorder syndrome characterized by excessive fat accumulation that is related to many diseases. Human amniotic mesenchymal stem cells (hAMSCs) have a great potential for cell-based thera...

Authors: Hui-Lan Tan, Xiao-Hui Guan, Min Hu, Jie Wu, Rong-Zhen Li, Ling-Fang Wang, Hou-Da Huang, Zhen-Ping Yu, Xiao-Yu Wang, Yun-Fei Xiao, Ke-Yu Deng and Hong-Bo Xin

Percutaneous administration of allogeneic bone-forming cells for the treatment of delayed unions of fractures: a pilot study

Overall, 5–10% of fractures result in delayed unions or non-unions, causing major disabilities and a huge socioeconomic burden. Since rescue surgery with autologous bone grafts can cause additional challenges,...

Authors: Marc Jayankura, Arndt Peter Schulz, Olivier Delahaut, Richard Witvrouw, Lothar Seefried, Bruno Vande Berg, Guy Heynen and Wendy Sonnet

Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells

Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancrea...

Authors: Yumeng Zhang, Jiaqi Xu, Zhili Ren, Ya Meng, Weiwei Liu, Ligong Lu, Zhou Zhou and Guokai Chen

Surfing the clinical trials of mesenchymal stem cell therapy in ischemic cardiomyopathy

While existing remedies failed to fully address the consequences of heart failure, stem cell therapy has been introduced as a promising approach. The present review is a comprehensive appraisal of the impacts ...

Authors: Iman Razeghian-Jahromi, Anthony G. Matta, Ronan Canitrot, Mohammad Javad Zibaeenezhad, Mahboobeh Razmkhah, Anahid Safari, Vanessa Nader and Jerome Roncalli

Characterisation of mesenchymal stromal cells in clinical trial reports: analysis of published descriptors

Mesenchymal stem or stromal cells are the most widely used cell therapy to date. They are heterogeneous, with variations in growth potential, differentiation capacity and protein expression profile depending o...

Authors: Alison J. Wilson, Emma Rand, Andrew J. Webster and Paul G. Genever

Individual heterogeneity screened umbilical cord-derived mesenchymal stromal cells with high Treg promotion demonstrate improved recovery of mouse liver fibrosis

To investigate the heterogeneities of human umbilical cord mesenchymal stromal cells (HUCMSCs) derived from different donors and their therapeutic variations when applied to mouse liver fibrosis model.

Authors: Yuanyuan Xie, Shuo Liu, Liudi Wang, Hui Yang, Chenxu Tai, Li Ling, Libo Chen, Shanshan Liu and Bin Wang

Three-dimensional cultured mesenchymal stem cells enhance repair of ischemic stroke through inhibition of microglia

We show previously that three-dimensional (3D) spheroid cultured mesenchymal stem cells (MSCs) exhibit reduced cell size thus devoid of lung entrapment following intravenous (IV) infusion. In this study, we de...

Authors: Yuejiao Li, Yankai Dong, Ye Ran, Yanan Zhang, Boyao Wu, Jundong Xie, Yanpei Cao, Miaohua Mo, Sen Li, Hao Deng, Wenbo Hao, Shengyuan Yu and Yaojiong Wu

The effects and potential applications of concentrated growth factor in dentin–pulp complex regeneration

The dentin–pulp complex is essential for the long-term integrity and viability of teeth but it is susceptible to damage caused by external factors. Because traditional approaches for preserving the dentin–pulp...

Authors: Zixia Li, Liu Liu, Liu Wang and Dongzhe Song

Embryoid research calls for reassessment of legal regulations

It is known that in countries, in which basic research on human embryos is in fact prohibited by law, working with imported human embryonic stem cells (hESCs) can still be permitted. As long as hESCs are not c...

Authors: Markus Hengstschläger and Margit Rosner

Adipose-derived stem cells therapy effectively attenuates PM_2.5-induced lung injury

The adverse health effects of fine particulate matter (PM_2.5) exposure are associated with marked inflammatory responses. Adipose-derived stem cells (ADSCs) have immunosuppressive effects, and ADSC transplantatio...

Authors: Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji and Zhongbing Lu

Combining autologous bone marrow buffy coat and angioconductive bioceramic rod grafting with advanced core decompression improves short-term outcomes in early avascular necrosis of the femoral head: a prospective, randomized, comparative study

Treatment of avascular necrosis of the femoral head (ANFH) in young patients remains a clinical challenge. A current controversy is whether hip-preserving surgery results in better outcomes. The adverse effect...

Authors: Qingtian Li, Weihong Liao, Guangtao Fu, Junxing Liao, Ruiying Zhang, Mengyuan Li, Yuhui Yang, Yuanchen Ma, Minghao Zheng and Qiujian Zheng

Enhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells

Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor ...

Authors: Wei Shan, Qin Yu, Yan Long, Qian Luo, Honghu Li, Yingli Han, Yulin Xu, Shan Fu, Xiangjun Zeng, Cong Wei, Yang Gao, Xiaoqing Li, Xia Li, Lifei Zhang, Lizhen Liu, Ming Chen…

Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti

Hearing loss affects 25% of the population at ages 60–69 years. Loss of the hair cells of the inner ear commonly underlies deafness and once lost this cell type cannot spontaneously regenerate in higher verteb...

Authors: Hiroki Takeda, Anna Dondzillo, Jessica A. Randall and Samuel P. Gubbels

Correction to: Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension

Authors: Wenda Xi, Wendong Chen, Weihong Sun, Xiangxiao Li, Zhimin Suo, Gonghao Jiang, Pingjin Gao and Qun Li