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  1. Crohn’s fistula-in-ano is a refractory disease in colorectal and anal surgery. Although autologous adipose-derived stem cell (ADSC) has been used in the treatment of Crohn’s fistula-in-ano because of its conve...

    Authors: Chungen Zhou, Meng Li, Yang Zhang, Min Ni, Yehuang Wang, Dachao Xu, Yang Shi, Bo Zhang, Yanni Chen, Yan Huang, Sumin Zhang, Hongzhen Shi and Bin Jiang

    Citation: Stem Cell Research & Therapy 2020 11:124

    Content type: Research

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  2. Autologous cellular immunotherapy or immune enhancement therapy has demonstrated some promising benefits for prostate cancer. T cell-based immunotherapy or sipuleucel-T therapy has yielded certain beneficial r...

    Authors: Zhu Wang, Youjia Li, Yuliang Wang, Dinglan Wu, Alaster Hang Yung Lau, Pan Zhao, Chang Zou, Yong Dai and Franky Leung Chan

    Citation: Stem Cell Research & Therapy 2020 11:123

    Content type: Research

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  3. Diabetic cardiomyopathy (DCM) is a cardiac complication of long-term uncontrolled diabetes and is characterized by myocardial fibrosis and abnormal cardiac function. Mesenchymal stem cells (MSCs) are multipote...

    Authors: Liyuan Jin, Jinying Zhang, Zihui Deng, Jiejie Liu, Weidong Han, Guanghui Chen, Yiling Si and Ping Ye

    Citation: Stem Cell Research & Therapy 2020 11:122

    Content type: Research

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  4. In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...

    Authors: María García-Bonilla, Betsaida Ojeda-Pérez, María L. García-Martín, M. Carmen Muñoz-Hernández, Javier Vitorica, Sebastián Jiménez, Manuel Cifuentes, Leonor Santos-Ruíz, Kirill Shumilov, Silvia Claros, Antonia Gutiérrez, Patricia Páez-González and Antonio J. Jiménez

    Citation: Stem Cell Research & Therapy 2020 11:121

    Content type: Research

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  5. Adipose-derived mesenchymal stem cells (ASCs) therapy is emerging as a novel therapeutic option for the treatment of a variety of diseases including diabetes and diabetic wound healing. Multiple studies indica...

    Authors: Ran An, Yong Zhang, Yu Qiao, Lili Song, Hongjun Wang and Xiao Dong

    Citation: Stem Cell Research & Therapy 2020 11:120

    Content type: Research

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  6. Though accumulated evidence has demonstrated visceral organ involvement in acute graft-versus-host disease (aGVHD), how aGVHD influences the bone marrow (BM) niche and the reconstitution of hematopoiesis post-...

    Authors: Li Ding, Hong-Mei Ning, Pei-Lin Li, Hong-Min Yan, Dong-Mei Han, Xiao-Li Zheng, Jing Liu, Ling Zhu, Mei Xue, Ning Mao, Zi-Kuan Guo, Heng Zhu and Heng-Xiang Wang

    Citation: Stem Cell Research & Therapy 2020 11:119

    Content type: Research

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  7. Oral squamous cell carcinoma (OSCC) is associated with high morbidity and ranks sixth among malignancies worldwide. Increasing evidence suggests that microRNAs (miRNAs or miRs) play a critical role in regulati...

    Authors: Xiaolong You, Zhengyu Zhou, Wen Chen, Xiaoyong Wei, Heqiang Zhou and Wenzheng Luo

    Citation: Stem Cell Research & Therapy 2020 11:117

    Content type: Research

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  8. The production of large quantities of cardiomyocyte is essential for the needs of cellular therapies. This study describes the selection of a human-induced pluripotent cell (hiPSC) line suitable for production...

    Authors: Filip Laco, Alan Tin-Lun Lam, Tsung-Liang Woo, Gerine Tong, Valerie Ho, Poh-Loong Soong, Elina Grishina, Kun-Han Lin, Shaul Reuveny and Steve Kah-Weng Oh

    Citation: Stem Cell Research & Therapy 2020 11:118

    Content type: Research

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  9. Mesenchymal stromal cells (MSCs) demonstrate considerable promise for acute respiratory distress syndrome (ARDS) and sepsis. However, standard approaches to MSC isolation generate highly heterogeneous cell pop...

    Authors: Shahd Horie, Claire Masterson, Jack Brady, Paul Loftus, Emma Horan, Lisa O’Flynn, Steve Elliman, Frank Barry, Timothy O’Brien, John G. Laffey and Daniel O’Toole

    Citation: Stem Cell Research & Therapy 2020 11:116

    Content type: Research

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  10. The ability of mesenchymal stem cells (MSCs) to modulate immune responses inspired a series of clinical trials addressing oral mucosal inflammation. We previously reported on the safety and efficacy of fresh, ...

    Authors: Boaz Arzi, Santiago Peralta, Nadine Fiani, Natalia Vapniarsky, Nopmanee Taechangam, Ubaldo Delatorre, Kaitlin C. Clark, Naomi J. Walker, Megan R. Loscar, Milinda J. Lommer, Amy Fulton, Jean Battig and Dori L. Borjesson

    Citation: Stem Cell Research & Therapy 2020 11:115

    Content type: Research

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  11. Long noncoding RNAs (lncRNAs) play an important role in the multiple differentiations of mesenchymal stem cells (MSCs). However, few studies have focused on the regulatory mechanism of lncRNAs in the odontogen...

    Authors: Zhao Chen, Kaiying Zhang, Wei Qiu, Yifei Luo, Yuhua Pan, Jianjia Li, Yeqing Yang, Buling Wu and Fuchun Fang

    Citation: Stem Cell Research & Therapy 2020 11:114

    Content type: Research

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  12. Microvesicles (MVs) derived from human Wharton’s jelly mesenchymal stem cells (MSC-MVs) were demonstrated to ameliorate acute lung injury (ALI). We have previously found that MSC-MV-transferred hepatocyte grow...

    Authors: Wen-xia Chen, Jun Zhou, Sha-sha Zhou, Yu-dan Zhang, Tong-yu Ji, Xiao-li Zhang, Shu-min Wang, Tao Du and De-gang Ding

    Citation: Stem Cell Research & Therapy 2020 11:113

    Content type: Research

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  13. Tooth movement is a unique bone remodeling process induced by mechanical stimulation. Macrophages are important in mediating inflammatory processes during mechanical load-induced tooth movement. However, how m...

    Authors: Danqing He, Fuliang Liu, Shengjie Cui, Nan Jiang, Huajie Yu, Yanheng Zhou, Yan Liu and Xiaoxing Kou

    Citation: Stem Cell Research & Therapy 2020 11:112

    Content type: Research

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  14. Although dental pulp stem cells (DPSCs) isolated from periodontally compromised teeth (P-DPSCs) have been demonstrated to retain pluripotency and regenerative potential, their use as therapeutics remains large...

    Authors: Huan Zhou, Xuan Li, Yuan Yin, Xiao-Tao He, Ying An, Bei-Min Tian, Yong-Long Hong, Li-An Wu and Fa-Ming Chen

    Citation: Stem Cell Research & Therapy 2020 11:110

    Content type: Research

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  15. Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public health problem. Osteogenic differentiation is a complex process associated with the differentiation of different cells...

    Authors: Liyuan Yu, Kai Xia, Xiao Cen, Xinqi Huang, Wentian Sun, Zhihe Zhao and Jun Liu

    Citation: Stem Cell Research & Therapy 2020 11:109

    Content type: Review

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  16. Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly dim...

    Authors: Lucia Beltran-Camacho, Margarita Jimenez-Palomares, Marta Rojas-Torres, Ismael Sanchez-Gomar, Antonio Rosal-Vela, Sara Eslava-Alcon, Mª Carmen Perez-Segura, Ana Serrano, Borja Antequera-González, Jose Angel Alonso-Piñero, Almudena González-Rovira, Mª Jesús Extremera-García, Manuel Rodriguez-Piñero, Rafael Moreno-Luna, Martin Røssel Larsen and Mª Carmen Durán-Ruiz

    Citation: Stem Cell Research & Therapy 2020 11:106

    Content type: Research

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  17. The use of mesenchymal stromal cells (MSCs) for research and clinical application is hampered by cellular heterogeneity and replicative senescence. Generation of MSC-like cells from induced pluripotent stem ce...

    Authors: Jonathan Hollmann, Johanna Brecht, Roman Goetzke, Julia Franzen, Anton Selich, Marco Schmidt, Monika Eipel, Alina Ostrowska, Jan Hapala, Eduardo Fernandez-Rebollo, Gerhard Müller-Newen, Michael Rothe, Thomas Eggermann, Martin Zenke and Wolfgang Wagner

    Citation: Stem Cell Research & Therapy 2020 11:105

    Content type: Research

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  18. Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been perfor...

    Authors: Ani Sun, Wenni Gao and Ting Xiao

    Citation: Stem Cell Research & Therapy 2020 11:104

    Content type: Research

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  19. In mammals, specification of primordial germ cells (PGCs) is established in the early post­implantation embryo. The bone morphogenetic protein (BMP)-SMAD and WNT3-β-catenin signaling initiate the gene regulato...

    Authors: Fang Fang, Zili Li, Qian Zhao, Chengliang Xiong and Ke Ni

    Citation: Stem Cell Research & Therapy 2020 11:100

    Content type: Research

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  20. Equine amniotic mesenchymal stromal cells (AMSCs) and their conditioned medium (CM) were evaluated for their ability to inhibit in vitro proliferation of peripheral blood mononuclear cells (PBMCs) with and withou...

    Authors: Anna Lange-Consiglio, Pietro Romele, Marta Magatti, Antonietta Silini, Antonella Idda, Nicola Antonio Martino, Fausto Cremonesi and Ornella Parolini

    Citation: Stem Cell Research & Therapy 2020 11:99

    Content type: Research

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  21. Retinitis pigmentosa (RP) is an inherited retinal disease characterized by progressive loss of photoreceptor cells. This study aim at exploring the effect of retinal pigment epithelium (RPE) derived from human...

    Authors: Deliang Zhu, Mengyuan Xie, Fabian Gademann, Jixing Cao, Peiyuan Wang, Yonglong Guo, Lan Zhang, Ting Su, Jun Zhang and Jiansu Chen

    Citation: Stem Cell Research & Therapy 2020 11:98

    Content type: Research

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  22. Hypoxia is a major cause of beta cell death and dysfunction after transplantation. The aim of this study was to investigate the effect of exosomes derived from mesenchymal stem cells (MSCs) on beta cells under...

    Authors: Jin Chen, Junqiu Chen, Yuanhang Cheng, Yunfeng Fu, Hongzhou Zhao, Minying Tang, Hu Zhao, Na Lin, Xiaohua Shi, Yan Lei, Shuiliang Wang, Lianghu Huang, Weizhen Wu and Jianming Tan

    Citation: Stem Cell Research & Therapy 2020 11:97

    Content type: Research

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  23. Organoids are three-dimensional in vitro-grown cell clusters that recapitulate key features of native organs. In regenerative medicine, organoid technology represents a promising approach for the replacement o...

    Authors: Marta Dossena, Roberta Piras, Alessandro Cherubini, Mario Barilani, Erica Dugnani, Francesca Salanitro, Till Moreth, Francesco Pampaloni, Lorenzo Piemonti and Lorenza Lazzari

    Citation: Stem Cell Research & Therapy 2020 11:94

    Content type: Research

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  24. The capacity of organoids to generate complex 3D structures resembling organs is revolutionizing the fields of developmental and stem cell biology. We are currently establishing the foundations for translation...

    Authors: Joaquim Vives and Laura Batlle-Morera

    Citation: Stem Cell Research & Therapy 2020 11:72

    Content type: Commentary

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  25. Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of unknown etiology, but is closely associated with damage to dopaminergic neurons. MSA progression is rapid. Hence, long-term drug treatm...

    Authors: Kyung-Ran Park, Chul Ju Hwang, Hyung-Mun Yun, In Jun Yeo, Dong-Young Choi, Pil-Hoon Park, Hyung Sook Kim, Jung Tae Lee, Young Suk Jung, Sang-Bae Han and Jin Tae Hong

    Citation: Stem Cell Research & Therapy 2020 11:63

    Content type: Research

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  26. The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development ev...

    Authors: Xiaowei Zhu, Suling Ding, Hui Li, Zhiwei Zhang, Lili Xu, Jian Wu, Xiangfei Wang, Yunzeng Zou, Xiangdong Yang and Junbo Ge

    Citation: Stem Cell Research & Therapy 2020 11:27

    Content type: Research

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  27. To determine the impact of donor age on the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSCs) in treating adverse remodeling as the result of right ventricle (RV) pressure overload.

    Authors: Rong Liufu, Guocheng Shi, Xiaomin He, Jingjing Lv, Wei Liu, Fang Zhu, Chen Wen, Zhongqun Zhu and Huiwen Chen

    Citation: Stem Cell Research & Therapy 2020 11:96

    Content type: Research

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  28. Chondrogenic progenitor cells (CPCs) have high self-renewal capacity and chondrogenic potential. Intra-articular delivery of purified mesenchymal stem cells (MSCs) from MRL/MpJ “superhealer” mice increased bon...

    Authors: Rikang Wang, Wei Jiang, Lang Zhang, Saisai Xie, Shuai Zhang, Shun Yuan, Yi Jin and Guangqian Zhou

    Citation: Stem Cell Research & Therapy 2020 11:93

    Content type: Research

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  29. As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status ...

    Authors: Yun Xie, Bin Fang, Wenhui Liu, Guangshuai Li, Ru-Lin Huang, Lu Zhang, Jiahao He, Shuangbai Zhou, Kai Liu and Qingfeng Li

    Citation: Stem Cell Research & Therapy 2020 11:92

    Content type: Research

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  30. Mesenchymal stem cells (MSCs) exert immunomodulatory functions by inducing the development and differentiation of naive T cells into T cells with an anti-inflammatory regulatory T cell (Treg) phenotype. Our pr...

    Authors: Qi-Hong Chen, Fei Wu, Lei Liu, Han-bing Chen, Rui-Qiang Zheng, Hua-Ling Wang and Li-Na Yu

    Citation: Stem Cell Research & Therapy 2020 11:91

    Content type: Research

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  31. Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only occurs in a dose-dependent manner but also occurs in some idiosyncratic individuals in a dose-independent manner. APAP overdose...

    Authors: Chenxia Hu, Lingfei Zhao, Zhongwen Wu and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2020 11:88

    Content type: Review

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  32. Mesenchymal stem cells (MSCs) are pluripotent mesenchymal cells present in various adult tissues. MSCs secrete exosomes as regulators of the tumor niche, with involvement in tumorigenesis and metastasis. The r...

    Authors: Yuan Liang, Dalin Zhang, Linlin Li, Tian Xin, Yuwei Zhao, Rui Ma and Jiang Du

    Citation: Stem Cell Research & Therapy 2020 11:87

    Content type: Research

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  33. Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome. Insulin-like growth factor-II (IGF-II), a paternally...

    Authors: Yi Sui, Wei Zhang, Tao Tang, Lili Gao, Ting Cao, Hongbo Zhu, Qinghua You, Bo Yu and Tao Yang

    Citation: Stem Cell Research & Therapy 2020 11:86

    Content type: Research

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  34. Embryonic Sertoli cells (eSCs) have been known for playing important roles in male reproductive development system. In current studies, eSCs were mainly generated from induced intermediate mesoderm. The derivi...

    Authors: Chenze Xu, Yichen Dai, Ali Mohsin, Haifeng Hang, Yingping Zhuang and Meijin Guo

    Citation: Stem Cell Research & Therapy 2020 11:85

    Content type: Research

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  35. The cancer stem cell hypothesis is an old idea which has been revived in recent years for many cancers, including gliomas. However, this concept has become controversial due to a series of studies with conflic...

    Authors: Lei Zhang, Hongwei Yu, Yuhui Yuan, John S. Yu, Zhenkun Lou, Yixue Xue and Yunhui Liu

    Citation: Stem Cell Research & Therapy 2020 11:84

    Content type: Review

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  36. Autologous peripheral blood stem cell (auto-PBSC) transplantation is an effective therapeutic for the osteonecrosis of the femoral head (ONFH) but without prognosis estimation. This study mainly aimed to (1) d...

    Authors: Jiafei Pan, Quanwei Ding, Shuaijie Lv, Bingjiang Xia, Hongting Jin, Di Chen, Luwei Xiao and Peijian Tong

    Citation: Stem Cell Research & Therapy 2020 11:83

    Content type: Research

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  37. Many studies have elegantly shown that murine and rat bone marrow-derived mesenchymal stromal cells (bmMSCs) contribute to muscle regeneration and improve muscle function. Yet, the ability of transplanted huma...

    Authors: Dominik Barisic, Marita Erb, Marie Follo, Dahlia Al-Mudaris, Bernd Rolauffs and Melanie L. Hart

    Citation: Stem Cell Research & Therapy 2020 11:79

    Content type: Research

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  38. Keloid formation occurs in Caucasian, African, and Asian populations and is a severe psychosocial burden on patients. There is no permanent treatment for this problem as its pathogenesis is not properly unders...

    Authors: Subramanian Arjunan, Shu Uin Gan, Mahesh Choolani, Vaishnevi Raj, Jane Lim, Arijit Biswas, Ariff Bongso and Chui Yee Fong

    Citation: Stem Cell Research & Therapy 2020 11:78

    Content type: Research

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  39. Induced pluripotent stem cells (iPSCs) exhibit limitless pluripotent plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a s...

    Authors: Yaqian Hu, Lei Chen, Yi Gao, Pengzhen Cheng, Liu Yang, Chengtie Wu and Qiang Jie

    Citation: Stem Cell Research & Therapy 2020 11:77

    Content type: Research

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  40. The unmet medical needs in repairing large muscle defects promote the development of tissue regeneration strategy. The use of bioactive molecules in combination with biomaterial scaffold has become an area of ...

    Authors: Yuanqiang Dong, Yuan Li, Chuan Zhang, Haibin Chen, Lijia Liu and Simeng Chen

    Citation: Stem Cell Research & Therapy 2020 11:76

    Content type: Research

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  41. Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have shed great light on cardiac regenerative medicine and specifically myocardial repair in heart failure patients. However, the treatment...

    Authors: Xumin Guan, Wanzi Xu, He Zhang, Qian Wang, Jiuyang Yu, Ruyi Zhang, Yamin Chen, Yunlong Xia, Jiaxian Wang and Dongjin Wang

    Citation: Stem Cell Research & Therapy 2020 11:73

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:201

  42. Generation of red blood cells (RBCs) from hematopoietic stem cells (HSCs) in vitro takes about 21 days, making it unaffordable for clinical applications. Acceleration of the in vitro erythropoiesis process by ...

    Authors: Rutuja Kuhikar, Nikhat Khan, Joseph Philip, Sameer Melinkeri, Vaijayanti Kale and Lalita Limaye

    Citation: Stem Cell Research & Therapy 2020 11:71

    Content type: Research

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  43. Mesenchymal stem cell-derived extracellular vesicles (EVs) are one of the most promising therapeutics in protective and/or regenerative therapy in animal models of stroke using a dose of 100 μg. However, wheth...

    Authors: Laura Otero-Ortega, Fernando Laso-García, Mari Carmen Gómez-de Frutos, Luke Diekhorst, Arturo Martínez-Arroyo, Elisa Alonso-López, María Laura García-Bermejo, Macarena Rodríguez-Serrano, Mercedes Arrúe-Gonzalo, Exuperio Díez-Tejedor, Blanca Fuentes and María Gutiérrez-Fernández

    Citation: Stem Cell Research & Therapy 2020 11:70

    Content type: Research

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  44. Transplantation of skeletal myoblast sheets is a promising strategy for the treatment of heart failure, and its therapeutic effects have already been proven in both animal disease models and clinical trials. M...

    Authors: Hiroko Iseoka, Shigeru Miyagawa, Atsuhiro Saito, Akima Harada and Yoshiki Sawa

    Citation: Stem Cell Research & Therapy 2020 11:69

    Content type: Research

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  45. Angiogenesis plays an important role in tissue repair and regeneration, and conditioned medium (CM) derived from mesenchymal stem cells (MSC-CM) possesses pro-angiogenesis. Nevertheless, the profile and concen...

    Authors: Shanshan Jin, Chengzhe Yang, Jiahui Huang, Lianlian Liu, Yu Zhang, Shutong Li, Liguo Zhang, Qinfeng Sun and Pishan Yang

    Citation: Stem Cell Research & Therapy 2020 11:68

    Content type: Research

    Published on:

  46. Articular cartilage shows little or no capacity for intrinsic repair, generating a critical need of regenerative therapies for joint injuries and diseases such as osteoarthritis. Human-induced pluripotent stem...

    Authors: Amanda Dicks, Chia-Lung Wu, Nancy Steward, Shaunak S. Adkar, Charles A. Gersbach and Farshid Guilak

    Citation: Stem Cell Research & Therapy 2020 11:66

    Content type: Research

    Published on:

  47. Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains ver...

    Authors: Pengxiang Qu, Yongsheng Wang, Chengsheng Zhang and Enqi Liu

    Citation: Stem Cell Research & Therapy 2020 11:65

    Content type: Review

    Published on:

  48. Graft-versus-host disease (GvHD) is the main life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Thirty to 80% of GvHD patients do not respond to first-line treatment an...

    Authors: Cynthia Morata-Tarifa, María del Mar Macías-Sánchez, Antonio Gutiérrez-Pizarraya and Rosario Sanchez-Pernaute

    Citation: Stem Cell Research & Therapy 2020 11:64

    Content type: Research

    Published on:

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