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  1. Content type: Research

    Stem cells from apical papilla (SCAP) are a subpopulation of mesenchymal stem cells (MSCs) isolated from the apical papilla of the developing tooth root apex of human teeth. Because of their osteogenic/dentino...

    Authors: Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Shion Hama, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2018 9:334

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  2. Content type: Research

    Cell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and a...

    Authors: Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams…

    Citation: Stem Cell Research & Therapy 2018 9:332

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  3. Content type: Research

    Bone tissue engineering is not widely used in clinical treatment. Two main reasons hide behind this: (1) the seed cells are difficult to obtain and (2) the process of tissue engineering bone construction is to...

    Authors: Dingyu Wu, Zhenxing Wang, Jinbing Wang, Yingnan Geng, Zhanzhao Zhang, Yu Li, Qiannan Li, Zhiwei Zheng, Yilin Cao and Zhi-Yong Zhang

    Citation: Stem Cell Research & Therapy 2018 9:331

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  4. Content type: Research

    Menstrual blood-derived endometrial stem cells (MenSCs) emerge as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. However, the major obstacle is the low survival rate in ti...

    Authors: Jiang Du, Xinxing Zhu, Rui Guo, Zhihao Xu, Fang Fang Cheng, Qing Liu, Fen Yang, Lihong Guan, Yanli Liu and Juntang Lin

    Citation: Stem Cell Research & Therapy 2018 9:330

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  5. Content type: Research

    Mesenchymal stem cells (MSCs) are found in synovial fluid (SF) and can easily be harvested during arthrocentesis or arthroscopy. However, SF-MSC characterization and chondrogenicity in collagen sponges have be...

    Authors: Paul Neybecker, Christel Henrionnet, Elise Pape, Didier Mainard, Laurent Galois, Damien Loeuille, Pierre Gillet and Astrid Pinzano

    Citation: Stem Cell Research & Therapy 2018 9:329

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  6. Content type: Research

    The tissue engineering of urinary bladder advances rapidly reflecting clinical need for a new kind of therapeutic solution for patients requiring urinary bladder replacement. Majority of the bladder augmentati...

    Authors: Marta Pokrywczynska, Arkadiusz Jundzill, Marta Rasmus, Jan Adamowicz, Daria Balcerczyk, Monika Buhl, Karolina Warda, Lukasz Buchholz, Maciej Gagat, Dariusz Grzanka and Tomasz Drewa

    Citation: Stem Cell Research & Therapy 2018 9:328

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  7. Content type: Research

    Lung cancer stem cells have the ability to self-renew and are resistant to conventional chemotherapy. MicroRNAs (miRNAs) regulate and control the expression and function of many target genes; therefore, miRNA ...

    Authors: Xiaoyuan Wang, Qingwei Meng, Wenbo Qiao, Ruishuang Ma, Weiwei Ju, Jing Hu, Hailing Lu, Jianqi Cui, Zhao Jin, Yanbin Zhao and Yan Wang

    Citation: Stem Cell Research & Therapy 2018 9:327

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  8. Content type: Research

    Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have been shown to prevent brain damage and improve neurocognition following intraventricular hemorrhage (IVH). However, the molecular mech...

    Authors: Hyo Rim Ko, So Yoon Ahn, Yun Sil Chang, Inwoo Hwang, Taegwan Yun, Dong Kyung Sung, Se In Sung, Won Soon Park and Jee-Yin Ahn

    Citation: Stem Cell Research & Therapy 2018 9:326

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  9. Content type: Research

    Regenerative medicine potentially offers the opportunity for curing male infertility. Native extracellular matrix (ECM) creates a reconstruction platform to replace the organs. In this study, we aimed to evalu...

    Authors: Elias Kargar-Abarghouei, Zahra Vojdani, Ashraf Hassanpour, Sanaz Alaee and Tahereh Talaei-Khozani

    Citation: Stem Cell Research & Therapy 2018 9:324

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  10. Content type: Short report

    The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therape...

    Authors: Luciana Lamarão Damous, Ana Elisa Teófilo Saturi de Carvalho, Juliana Sanajotti Nakamuta, Marcos Eiji Shiroma, Andressa Cristina Sposato Louzada, José Maria Soares-Jr, José Eduardo Krieger and Edmund C. Baracat

    Citation: Stem Cell Research & Therapy 2018 9:323

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  11. Content type: Research

    Early-stage diabetic retinopathy (DR) is characterized by neurovascular defects. In this study, we hypothesized that human adipose-derived stem cells (ASCs) positive for the pericyte marker CD140b, or their se...

    Authors: Sally L. Elshaer, William Evans, Mickey Pentecost, Raji Lenin, Ramesh Periasamy, Kumar Abhiram Jha, Shanta Alli, Jordy Gentry, Samuel M. Thomas, Nicolas Sohl and Rajashekhar Gangaraju

    Citation: Stem Cell Research & Therapy 2018 9:322

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  12. Content type: Research

    Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem c...

    Authors: Quan-Wen Liu, Qian-Yu Liu, Jing-Yuan Li, Li Wei, Kang-Kang Ren, Xiang-Cheng Zhang, Ting Ding, Ling Xiao, Wen-Jie Zhang, Han-You Wu and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2018 9:321

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  13. Content type: Review

    Mesenchymal stem cells (MSCs) are adult stromal cells with the capacity to differentiate into multiple types of cells. MSCs represent an attractive option in regenerative medicine due to their multifaceted abi...

    Authors: Guanguan Qiu, Guoping Zheng, Menghua Ge, Jiangmei Wang, Ruoqiong Huang, Qiang Shu and Jianguo Xu

    Citation: Stem Cell Research & Therapy 2018 9:320

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  14. Content type: Research article

    Better understanding of the signaling pathways that regulate human bone marrow stromal stem cell (hBMSC) differentiation into bone-forming osteoblasts is crucial for their clinical use in regenerative medicine...

    Authors: Nihal AlMuraikhi, Dalia Ali, Aliah Alshanwani, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem and Nehad M. Alajez

    Citation: Stem Cell Research & Therapy 2018 9:319

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  15. Content type: Research

    Developing cartilage constructed with the appropriate matrix composition and persistent chondrogenesis remains an enduring challenge in cartilage defects. Cartilage progenitor cell (CPC)-based tissue engineeri...

    Authors: Yahong Chen, Ke Xue, Xiaodie Zhang, Zhiwei Zheng and Kai Liu

    Citation: Stem Cell Research & Therapy 2018 9:318

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  16. Content type: Research

    Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem...

    Authors: Prashant Kadam, Elissavet Ntemou, Yoni Baert, Sven Van Laere, Dorien Van Saen and Ellen Goossens

    Citation: Stem Cell Research & Therapy 2018 9:317

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  17. Content type: Research

    Human muscle-derived stem cells (hMDSCs) have been shown to regenerate bone efficiently when they were transduced with Lenti-viral bone morphogenetic protein 2 (LBMP2). However, whether the age of hMDSCs and t...

    Authors: Xueqin Gao, Aiping Lu, Ying Tang, Johannes Schneppendahl, Andrea B. Liebowitz, Alex C. Scibetta, Elizabeth R. Morris, Haizi Cheng, Charles Huard, Sarah Amra, Bing Wang, Mary A. Hall, Walter R. Lowe and Johnny Huard

    Citation: Stem Cell Research & Therapy 2018 9:316

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  18. Content type: Research

    Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with tran...

    Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian

    Citation: Stem Cell Research & Therapy 2018 9:315

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    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:97

  19. Content type: Research

    Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exhibit strong and powerful potential in repairing different diseases. The expression profile of circular RNA (circRNA) provides valuable insight for re...

    Authors: Baolan Sun, Lei Shi, Qin Shi, Yao Jiang, Zhangyao Su, Xiaoqing Yang and Yuquan Zhang

    Citation: Stem Cell Research & Therapy 2018 9:314

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  20. Content type: Research

    We have shown that the differentiation of human-induced pluripotent stem cells (hiPSCs) into endothelial cells (ECs) is more efficient when performed with a 3-dimensional (3D) scaffold of biomaterial than in m...

    Authors: Liping Su, Xiaocen Kong, Szeyun Lim, Szejie Loo, Shihua Tan, Kiankeong Poh, James Dutton, Colin Stewart, Stuart Cook, Xiaofei Su, Jianhua Ma, Jianyi Zhang and Lei Ye

    Citation: Stem Cell Research & Therapy 2018 9:313

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  21. Content type: Research

    The aim of this study was to evaluate the safety of mesenchymal stem cell infusion in patients with autoimmune diseases.

    Authors: Jun Liang, Huayong Zhang, Wei Kong, Wei Deng, Dandan Wang, Xuebing Feng, Cheng Zhao, Bingzhu Hua, Hong Wang and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2018 9:312

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  22. Content type: Research

    Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous studies have shown that early intervention with bone ...

    Authors: Enguo Zhang, Ye Yang, Shangya Chen, Cheng Peng, Martin F. Lavin, Abrey J. Yeo, Chao Li, Xiaoshan Liu, Yingjun Guan, Xinjing Du, Zhongjun Du and Hua Shao

    Citation: Stem Cell Research & Therapy 2018 9:311

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  23. Content type: Research

    Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of therapeutic agents to disseminated gliobl...

    Authors: Lorena Favaro Pavon, Tatiana Tais Sibov, Andrea Vieira de Souza, Edgar Ferreira da Cruz, Suzana M. F. Malheiros, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Daniela Mara de Oliveira, Silvia Regina Caminada de Toledo, Luciana C. Marti, Jackeline Moraes Malheiros, Fernando F. Paiva, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Ana Marisa Chudzinski-Tavassi…

    Citation: Stem Cell Research & Therapy 2018 9:310

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  24. Content type: Research

    The positive effects of human bone marrow–derived mesenchymal stem cells (hBM-MSCs) and minocycline on ischemic stroke models have been well described through numerous studies. The aim of this study was to eva...

    Authors: Dong Young Cho and Sin-Soo Jeun

    Citation: Stem Cell Research & Therapy 2018 9:309

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  25. Content type: Research

    Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren’s syndrome (SS). We aim to compare the effects of MSC transplantation (MSCT) and the role ...

    Authors: Bingyu Shi, Jingjing Qi, Genhong Yao, Ruihai Feng, Zhuoya Zhang, Dandan Wang, Chen Chen, Xiaojun Tang, Liwei Lu, Wanjun Chen and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2018 9:308

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  26. Content type: Review

    In the context of regenerative medicine and cellular therapies, the treatment under study often targets a less common disease or condition for which recruitment of a large number of research participants at an...

    Authors: Erika Kleiderman, Audrey Boily, Craig Hasilo and Bartha Maria Knoppers

    Citation: Stem Cell Research & Therapy 2018 9:307

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  27. Content type: Research

    Cardiovascular complications, especially myocardial infarctions (MIs), are the leading mortality cause in diabetic patients. The transplantation of stem cells into damaged hearts has had considerable success a...

    Authors: Xiao He, Meng-Wei Yao, Ming Zhu, Dong-Lan Liang, Wei Guo, Yi Yang, Rong-Seng Zhao, Ting-Ting Ren, Xiang Ao, Wei Wang, Chun-Yu Zeng, Hua-Ping Liang, Dong-po Jiang, Jian Yu and Xiang Xu

    Citation: Stem Cell Research & Therapy 2018 9:306

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  28. Content type: Review

    Autophagy plays a critical role in the dynamic growth of each cell through different conditions. It seems that this intracellular mechanism acts as a two-edged sword against the numerous cell insults. Previous...

    Authors: Mehdi Hassanpour, Aysa Rezabakhsh, Masoud Pezeshkian, Reza Rahbarghazi and Mohammad Nouri

    Citation: Stem Cell Research & Therapy 2018 9:305

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  29. Content type: Research

    Autologous urothelial cells are often obtained via bladder biopsy to generate the bio-engineered urethra or bladder, while urine-derived stem cells (USC) can be obtained by a non-invasive approach. The objecti...

    Authors: Qian Wan, Geng Xiong, Guihua Liu, Thomas D. Shupe, Guanghui Wei, Deying Zhang, Dan Liang, Xiongbing Lu, Anthony Atala and Yuanyuan Zhang

    Citation: Stem Cell Research & Therapy 2018 9:304

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  30. Content type: Research

    Hyperbilirubinemia that occurs in pediatric liver diseases such as biliary atresia can result in the development of not only jaundice in the brain, eyes, and skin, but also tooth abnormalities including green ...

    Authors: Haruyoshi Yamaza, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2018 9:303

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  31. Content type: Research

    The generation of hematopoietic stem cells (HSCs) and blood cells from human embryonic stem cells (hESCs) is a major goal for regenerative medicine; however, the differentiation mechanisms are largely undefine...

    Authors: Pengfei Li, Mengyao Wu, Qiwang Lin, Shu Wang, Tong Chen and Hua Jiang

    Citation: Stem Cell Research & Therapy 2018 9:301

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  32. Content type: Research

    Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal...

    Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda and Roberta Tasso

    Citation: Stem Cell Research & Therapy 2018 9:300

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  33. Content type: Research

    Medical management of the severe musculocutaneous radiation syndrome involves surgical intervention with debridement of necrotic tissue. Even when skin excision is replaced by specific plastic surgery, treatme...

    Authors: Christine Linard, Michel Brachet, Bruno L’homme, Carine Strup-Perrot, Elodie Busson, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey and Marc Benderitter

    Citation: Stem Cell Research & Therapy 2018 9:299

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  34. Content type: Research

    Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue s...

    Authors: Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal and Sujata Mohanty

    Citation: Stem Cell Research & Therapy 2018 9:298

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  35. Content type: Research

    A single administration of mesenchymal stromal cells (MSCs) has been shown to reduce lung inflammation in experimental elastase-induced emphysema; however, effects were limited in terms of lung-tissue repair a...

    Authors: Hananda A. Poggio, Mariana A. Antunes, Nazareth N. Rocha, Jamil Z. Kitoko, Marcelo M. Morales, Priscilla C. Olsen, Miquéias Lopes-Pacheco, Fernanda F. Cruz and Patricia R. M. Rocco

    Citation: Stem Cell Research & Therapy 2018 9:296

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  36. Content type: Research

    We recently demonstrated that intracellular xenogen-contaminated autologous MSCs (FBS) and non-xenogen-contaminated allogeneic (ALLO) MSCs caused an adverse clinical response after repeated intra-articular inj...

    Authors: Aileen L. Rowland, Jiajie Jessica Xu, Amanda Jo Joswig, Carl A. Gregory, Douglas F. Antczak, Kevin J. Cummings and Ashlee E. Watts

    Citation: Stem Cell Research & Therapy 2018 9:295

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  37. Content type: Research

    The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the re...

    Authors: Ziyou Yu, Yizuo Cai, Mingwu Deng, Dong Li, Xiangsheng Wang, Hongjie Zheng, Yuda Xu, Wei Li and Wenjie Zhang

    Citation: Stem Cell Research & Therapy 2018 9:294

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  38. Content type: Research

    Mesenchymal stem cell-derived conditioned medium (MSC-CM) has emerged as a promising cell-free tool for restoring degenerative diseases and treating traumatic injuries. The present study describes the effect o...

    Authors: Junghyun Park, Jung Han Lee, Byung Sun Yoon, Eun Kyoung Jun, Gilju Lee, In Yong Kim and Seungkwon You

    Citation: Stem Cell Research & Therapy 2018 9:293

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  39. Content type: Research

    Deer antlers are bony structures that re-grow at very high rates, making them an attractive model for studying rapid bone regeneration.

    Authors: Dai Fei Elmer Ker, Dan Wang, Rashmi Sharma, Bin Zhang, Ben Passarelli, Norma Neff, Chunyi Li, William Maloney, Stephen Quake and Yunzhi Peter Yang

    Citation: Stem Cell Research & Therapy 2018 9:292

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  40. Content type: Short report

    Transplantation of allogeneic human cardiac/stem progenitor cells (hCSCs) is currently being tested in several phase I/II clinical trials as a novel and promising therapy for restoration of myocardial tissue f...

    Authors: Maria J Sebastião, Ramón Menta, Margarida Serra, Itziar Palacios, Paula M Alves, Belén Sanchez, Olga DelaRosa, Wilfried Dalemans, Eleuterio Lombardo and Patrícia Gomes-Alves

    Citation: Stem Cell Research & Therapy 2018 9:290

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  41. Content type: Research

    During the last decade, mesenchymal stem cells (MSCs) have gained much attention in the field of regenerative medicine due to their capacity to differentiate into different cell types and to promote immunosupp...

    Authors: Denise Philipp, Laura Suhr, Thorsten Wahlers, Yeong-Hoon Choi and Adnana Paunel-Görgülü

    Citation: Stem Cell Research & Therapy 2018 9:286

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  42. Content type: Research

    Human decidua basalis mesenchymal stem/multipotent stromal cells (DBMSCs) inhibit endothelial cell activation by inflammation induced by monocytes. This property makes them a promising candidate for cell-based th...

    Authors: M. A. Alshabibi, T. Khatlani, F. M. Abomaray, A. S. AlAskar, B. Kalionis, S. A. Messaoudi, R. Khanabdali, A. O. Alawad and M. H. Abumaree

    Citation: Stem Cell Research & Therapy 2018 9:275

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  43. Content type: Research

    To date, several trials have reported the use of mesenchymal stem cell (MSC) implantation for osteonecrosis of the femoral head (ONFH). However, the clinical outcomes have not been conclusive. This study compa...

    Authors: Joon Soon Kang, Young Ju Suh, Kyoung Ho Moon, Jun Sung Park, Tae Hoon Roh, Myung Hoon Park and Dong Jin Ryu

    Citation: Stem Cell Research & Therapy 2018 9:274

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  44. Content type: Research

    Mesenchymal stem cells (MSCs) are known for their ability to induce the conversion of conventional T cells (Tconvs) into induced regulatory T cells (iTregs) in specific inflammatory contexts. Stable Foxp3 expr...

    Authors: Maryam Khosravi, Ali Bidmeshkipour, José L. Cohen, Ali Moravej, Suzzan Hojjat-Assari, Sina Naserian and Mohammad Hossein Karimi

    Citation: Stem Cell Research & Therapy 2018 9:273

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  45. Content type: Correction

    The original article [1] contains an error in Fig. 5e whereby the immunofluorescence of ΔNp63α in the ME group is incorrectly presented; thus, the corrected figure is shown ahead.

    Authors: X. Y. Zhao, H. T. Xie, C. Y. Duan, J. Li and M. C. Zhang

    Citation: Stem Cell Research & Therapy 2018 9:270

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    The original article was published in Stem Cell Research & Therapy 2018 9:256

  46. Content type: Correction

    The original article [1] contains an error regarding the erroneous inclusion of 3 μl as a parameter in the x-axis of Fig. 2c; the correct version of Fig. 2c can instead be seen below.

    Authors: Siyuan Zha, Zhen Li, Qing Cao, Fei Wang and Fang Liu

    Citation: Stem Cell Research & Therapy 2018 9:269

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    The original article was published in Stem Cell Research & Therapy 2018 9:224

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