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  1. The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effectiv...

    Authors: Ronghua Yang, Fengxia Liu, Jingru Wang, Xiaodong Chen, Julin Xie and Kun Xiong

    Citation: Stem Cell Research & Therapy 2019 10:229

    Content type: Review

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  2. Human-induced pluripotent stem cells (hiPSCs) show a great promise as a renewable source of cells with broad biomedical applications. Since insulin has been used in the maintenance of hiPSCs, in this study we ...

    Authors: Mohammad Shahbazi, Paige Cundiff, Wenyu Zhou, Philip Lee, Achchhe Patel, Sunita L. D’Souza, Fahim Abbasi, Thomas Quertermous and Joshua W. Knowles

    Citation: Stem Cell Research & Therapy 2019 10:228

    Content type: Research

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  3. High temperature has a very adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility through either apoptosis or DNA damage. However, the direct effects of heat stress on the dev...

    Authors: Jia Wang, Wei-Jun Gao, Shou-Long Deng, Xiang Liu, Hua Jia and Wen-Zhi Ma

    Citation: Stem Cell Research & Therapy 2019 10:227

    Content type: Research

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  4. Intrauterine adhesion (IUA) is one of the most serious complications in patients with endometrial repair disorder after injury. Currently, there is no effective treatment for IUA. Stem cell is the main candida...

    Authors: Yuan Yao, Ran Chen, Guowu Wang, Yu Zhang and Fang Liu

    Citation: Stem Cell Research & Therapy 2019 10:225

    Content type: Research

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  5. Interferon-β (IFN-β) is a cytokine with pleiotropic cellular functions, including antiviral, antiproliferative, and immunomodulatory activities. IFN-β inhibits multiple tumor cell growth in vitro. However, the...

    Authors: Lingqian Du, Qianyu Liang, Shaohua Ge, Chengzhe Yang and Pishan Yang

    Citation: Stem Cell Research & Therapy 2019 10:224

    Content type: Research

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  6. The diabetic foot ulcer (DFU) is one of the most prevalent complications of diabetes mellitus and often develops severe effects that can lead to amputation. A non-healing “minor” amputation often precedes a ma...

    Authors: Roberto Lonardi, Nicola Leone, Stefano Gennai, Giulia Trevisi Borsari, Tea Covic and Roberto Silingardi

    Citation: Stem Cell Research & Therapy 2019 10:223

    Content type: Research

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  7. iRoot BP Plus is a novel bioceramic endodontic material. Recently, it has been considered as an alternative to MTA which is the most popular scaffold cover during regenerative endodontic therapy. This study ai...

    Authors: Jiamin Lu, Zehan Li, Xiao Wu, Yan Chen, Ming Yan, Xingyun Ge and Jinhua Yu

    Citation: Stem Cell Research & Therapy 2019 10:222

    Content type: Research

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  8. Familial hypercholesterolemia type IIA (FH) is due to mutations in the low-density lipoprotein receptor (LDLR) resulting in elevated levels of low-density lipoprotein cholesterol (LDL-c) in plasma and in prema...

    Authors: Jérôme Caron, Véronique Pène, Laia Tolosa, Maxime Villaret, Eléanor Luce, Angélique Fourrier, Jean-Marie Heslan, Samir Saheb, Eric Bruckert, María José Gómez-Lechón, Tuan Huy Nguyen, Arielle R. Rosenberg, Anne Weber and Anne Dubart-Kupperschmitt

    Citation: Stem Cell Research & Therapy 2019 10:221

    Content type: Research

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  9. Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription f...

    Authors: Yingying Wang, Baosen Guo, Zengrong Xiao, Haijun Lin, Xi Zhang, Yueqiang Song, Yalei Li, Xuehu Gao, Jinjun Yu, Zhihua Shao, Xuekun Li, Yuping Luo and Siguang Li

    Citation: Stem Cell Research & Therapy 2019 10:220

    Content type: Research

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  10. Cancer remains one of the leading lethal diseases worldwide. Identifying biomarkers of cancers might provide insights into the strategies for the development of novel targeted anti-cancer therapies. Leucine-ri...

    Authors: Liangliang Xu, Weiping Lin, Longping Wen and Gang Li

    Citation: Stem Cell Research & Therapy 2019 10:219

    Content type: Review

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  11. Mesenchymal stem cells (MSCs) are attracting increasing interest for cell-based therapies, making use of both their immuno-modulating and regenerative potential. For such therapeutic applications, a massive in...

    Authors: Daniela Hladik, Ines Höfig, Ursula Oestreicher, Johannes Beckers, Martina Matjanovski, Xuanwen Bao, Harry Scherthan, Michael J. Atkinson and Michael Rosemann

    Citation: Stem Cell Research & Therapy 2019 10:218

    Content type: Research

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  12. Both genetic and environmental factors are implicated in the pathogenesis of cleft palate. However, the molecular and cellular mechanisms that regulate the development of palatal shelves, which are composed of...

    Authors: Lungang Shi, Binchen Li, Binna Zhang, Congyuan Zhen, Jianda Zhou and Shijie Tang

    Citation: Stem Cell Research & Therapy 2019 10:217

    Content type: Research

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  13. Temporomandibular joint osteoarthritis (TMJOA) is an inflammatory joint disease. This study investigated whether exosomes (Exos) of stem cells from human exfoliated deciduous teeth (SHEDs) have a therapeutic e...

    Authors: Ping Luo, Chao Jiang, Ping Ji, Menghong Wang and Jie Xu

    Citation: Stem Cell Research & Therapy 2019 10:216

    Content type: Research

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  14. The original article [1] contains errors in Fig. 1. The authors noticed a potentially misleading aspect of the original article Fig. 1 where representative flow cytometry data for different panels were from di...

    Authors: Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal and Sujata Mohanty

    Citation: Stem Cell Research & Therapy 2019 10:215

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2018 9:298

  15. To explore the mechanism of human umbilical cord-derived mesenchymal stem cell (hUMSC) transplantation to improve ovarian function and the endometrial receptivity in autoimmune premature ovarian failure (POF) ...

    Authors: Xueyan Lu, Jingjing Cui, Linlu Cui, Qianqian Luo, Qizhi Cao, Wendan Yuan and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2019 10:214

    Content type: Research

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  16. As the representative of fenamic acids, an important group of NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in the clinic. Recently, researches have focused on the role of som...

    Authors: Xuenan Liu, Zheng Li, Hao Liu, Yuan Zhu, Dandan Xia, Siyi Wang, Ranli Gu, Weiliang Wu, Ping Zhang, Yunsong Liu and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2019 10:213

    Content type: Research

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  17. Over 50% of acute stroke patients have hyperglycemia, which is associated with a poorer prognosis and outcome. Our aim was to investigate the impact of hyperglycemia on behavioral recovery and brain repair of ...

    Authors: Mari Carmen Gómez-de Frutos, Fernando Laso-García, Luke Diekhorst, Laura Otero-Ortega, Blanca Fuentes, Jukka Jolkkonen, Olivier Detante, Anaick Moisan, Arturo Martínez-Arroyo, Exuperio Díez-Tejedor and María Gutiérrez-Fernández

    Citation: Stem Cell Research & Therapy 2019 10:212

    Content type: Research

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  18. Autosomal recessive osteopetrosis is a genetically and phenotypically heterogeneous disease, caused by defects in osteoclast formation and function. The only available treatment is allogeneic stem cell transpl...

    Authors: Fatma Visal Okur, İnci Cevher, Cansu Özdemir, Çetin Kocaefe and Duygu Uçkan Çetinkaya

    Citation: Stem Cell Research & Therapy 2019 10:211

    Content type: Research

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  19. The paradigm of hematopoietic stem and progenitor cells (HSPCs) has become accepted ever since the discovery of adult mouse liver hematopoietic stem cells and their multipotent characteristics that give rise t...

    Authors: Yuhong Qin, Keke Fang, Nan Lu, Yuan Hu, Zhigang Tian and Cai Zhang

    Citation: Stem Cell Research & Therapy 2019 10:210

    Content type: Research

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  20. Definitive treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) have not been developed. Cell-based therapy is an attractive treatment method for intractable diseases in the medical...

    Authors: Shinichiro Kuroshima, Kazunori Nakajima, Muneteru Sasaki, Takashi I, Yoshinori Sumita, Takayuki Asahara, Izumi Asahina and Takashi Sawase

    Citation: Stem Cell Research & Therapy 2019 10:209

    Content type: Research

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  21. Stem cell therapy has revealed a promising future for treating erectile dysfunction (ED), but the fate and curative mechanism of intracavernosal transplanted stem cells are under further exploration. This stud...

    Authors: Hai-Bo Zhang, Feng-Zhi Chen, Shu-Hua He, Yan-Bing Liang, Zhi-Qiang Wang, Li Wang, Ze-Rong Chen, Wei Ding, Shan-Chao Zhao and An-Yang Wei

    Citation: Stem Cell Research & Therapy 2019 10:208

    Content type: Research

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  22. The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mesenchymal stromal cells (MSCs) involved in regulating t...

    Authors: Ming Li, Zhongyu Xie, Zhaopeng Cai, Fang Su, Guan Zheng, Jinteng Li, Shan Wang, Shuizhong Cen, Wenjie Liu, Su’an Tang, Guiwen Ye, Zhaofeng Li, Rujia Mi, Yiqian Pan, Peng Wang, Yanfeng Wu…

    Citation: Stem Cell Research & Therapy 2019 10:207

    Content type: Research

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  23. The original article [1] displayed a co-author, Junbo Ge who has since stated that he should not have been a co-author in the article; the article has now been amended to remove Junbo Ge accordingly. All autho...

    Authors: Mengkang Fan, Yin Huang, Zhangwei Chen, Yan Xia, Ao Chen, Danbo Lu, Yuan Wu, Ning Zhang and Juying Qian

    Citation: Stem Cell Research & Therapy 2019 10:206

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2019 10:150

  24. Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at i...

    Authors: María Elena Quintanilla, Fernando Ezquer, Paola Morales, Daniela Santapau, Pablo Berríos-Cárcamo, Marcelo Ezquer, Mario Herrera-Marschitz and Yedy Israel

    Citation: Stem Cell Research & Therapy 2019 10:205

    Content type: Research

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  25. Endometrial regenerative cells (ERCs) are a new type of mesenchymal-like stromal cells, and their therapeutic potential has been tested in a variety of disease models. SDF-1/CXCR4 axis plays a chemotaxis role ...

    Authors: Xiang Li, Xu Lan, Yiming Zhao, Grace Wang, Ganggang Shi, Hongyue Li, Yonghao Hu, Xiaoxi Xu, Baoren Zhang, Kui Ye, Xiangying Gu, Caigan Du and Hao Wang

    Citation: Stem Cell Research & Therapy 2019 10:204

    Content type: Research

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  26. Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy...

    Authors: Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, Wan Wai Tse, Bimal Gurung, Suet Yee Mak, Deborah K. Lieu, Kevin D. Costa, Camie W. Chan, Alain Martelli, Joseph F. Nabhan and Ronald A. Li

    Citation: Stem Cell Research & Therapy 2019 10:203

    Content type: Research

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  27. By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma cells (ECCs) are...

    Authors: Ildercílio Mota de Souza Lima, Josiane Lilian dos Santos Schiavinato, Sarah Blima Paulino Leite, Danuta Sastre, Hudson Lenormando de Oliveira Bezerra, Bruno Sangiorgi, Amanda Cristina Corveloni, Carolina Hassibe Thomé, Vitor Marcel Faça, Dimas Tadeu Covas, Marco Antônio Zago, Mauro Giacca, Miguel Mano and Rodrigo Alexandre Panepucci

    Citation: Stem Cell Research & Therapy 2019 10:202

    Content type: Research

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  28. The meniscus tear is one of the most common knee injuries particularly seen in athletes and aging populations. Subchondral bone sclerosis, irreparable joint damage, and the early onset of osteoarthritis make t...

    Authors: Feng Liu, Hongyao Xu and He Huang

    Citation: Stem Cell Research & Therapy 2019 10:201

    Content type: Research

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  29. Follicle depletion is one of the causes of premature ovarian failure (POF) and primary ovarian insufficiency (POI). Hence, maintenance of a certain number of female germline stem cells (FGSCs) is optimal to pr...

    Authors: Yu Jiang, Dantian Zhu, Wenfeng Liu, Qiushi Qin, Zhi Fang and Zezheng Pan

    Citation: Stem Cell Research & Therapy 2019 10:198

    Content type: Research

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  30. Adipose-derived stem cells (ASCs) are promising therapeutic cells for ischemic heart diseases, due to the ease and efficiency of acquisition, the potential of myocardial lineage differentiation, and the paracr...

    Authors: Xiaoting Li, Teng Ma, Jiacheng Sun, Mingjing Shen, Xiang Xue, Yongbing Chen and Zhiwei Zhang

    Citation: Stem Cell Research & Therapy 2019 10:196

    Content type: Review

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  31. Recent progress in the induced generation of dopaminergic (DA) neurons from different types of stem cells or reprogrammed somatic cells holds tremendous potential for the treatment of Parkinson’s disease (PD)....

    Authors: Hao Yang, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An and Jingjing Zhao

    Citation: Stem Cell Research & Therapy 2019 10:195

    Content type: Research

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  32. Exosomes are bilayer membrane vesicles with cargos that contain a variety of surface proteins, markers, lipids, nucleic acids, and noncoding RNAs. Exosomes from different cardiac cells participate in the proce...

    Authors: Ming-yue Xu, Zhi-shuai Ye, Xian-tao Song and Rong-chong Huang

    Citation: Stem Cell Research & Therapy 2019 10:194

    Content type: Review

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  33. Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. In addition, transplantation studies using pi...

    Authors: Junjun Xu, Leqian Yu, Jianxiong Guo, Jinzhu Xiang, Zheng Zheng, Dengfeng Gao, Bingbo Shi, Haiyang Hao, Deling Jiao, Liang Zhong, Yu Wang, Jun Wu, Hongjiang Wei and Jianyong Han

    Citation: Stem Cell Research & Therapy 2019 10:193

    Content type: Research

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  34. The use of mesenchymal stem cells (MSCs) is being extensively studied in clinical trials in the setting of various diseases including diabetes, stroke, and progressive multiple sclerosis. The unique immunomodu...

    Authors: Caroline Laroye, Amir Boufenzer, Lucie Jolly, Lisiane Cunat, Corentine Alauzet, Jean-Louis Merlin, Clémence Yguel, Danièle Bensoussan, Loïc Reppel and Sébastien Gibot

    Citation: Stem Cell Research & Therapy 2019 10:192

    Content type: Research

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  35. WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. ...

    Authors: Maryam Kay, Bahram Mohammad Soltani, Fahimeh Hosseini Aghdaei, Hassan Ansari and Hossein Baharvand

    Citation: Stem Cell Research & Therapy 2019 10:191

    Content type: Research

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  36. There is an urgent need for targeted biological therapies for prostate cancer with greater efficacy and less toxicity, particularly for metastatic disease, where current therapies are not curative. Therapeutic...

    Authors: Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Ling Ma, Ruth A. Gjerset and Yinghui Huang

    Citation: Stem Cell Research & Therapy 2019 10:190

    Content type: Research

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  37. Management of fracture healing with a large bone defect remains a tricky subject in orthopedic trauma. Enhancing osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the useful t...

    Authors: Kai Hang, Chenyi Ye, Jianxiang Xu, Erman Chen, Cong Wang, Wei Zhang, Lic Ni, Zhih Kuang, Li Ying, Deting Xue and Zhijun Pan

    Citation: Stem Cell Research & Therapy 2019 10:189

    Content type: Research

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  38. Feline adipose-derived mesenchymal stem cells (ASCs) have been successfully used in clinical trials for the treatment of immune-mediated diseases with T cell dysregulation. However, the immunomodulatory pathwa...

    Authors: Nopmanee Taechangam, Smita S. Iyer, Naomi J. Walker, Boaz Arzi and Dori L. Borjesson

    Citation: Stem Cell Research & Therapy 2019 10:188

    Content type: Research

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  39. Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissues. However, in order to evaluate the therapeutic activity of MSC, cell tracking techniques are r...

    Authors: Anna Andrzejewska, Anna Jablonska, Martyna Seta, Sylwia Dabrowska, Piotr Walczak, Miroslaw Janowski and Barbara Lukomska

    Citation: Stem Cell Research & Therapy 2019 10:187

    Content type: Research

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  40. Mesenchymal stem/stromal cells (MSCs) derived from human embryonic stem cells (hESCs) are attractive for their hematopoietic-supporting or potential therapeutic effects. However, procedures for high-effective ...

    Authors: Yimeng Wei, Huixing Hou, Leisheng Zhang, Nianhuan Zhao, Chengwen Li, Jiali Huo, Ying Liu, Wenxia Zhang, Zongjin Li, Dengke Liu, Zhibo Han, Lei Zhang, Baoquan Song, Ying Chi and Zhongchao Han

    Citation: Stem Cell Research & Therapy 2019 10:186

    Content type: Research

    Published on:

  41. Disease modeling with patient-derived induced pluripotent stem cells (iPSCs) is a powerful tool for elucidating the mechanisms underlying disease pathogenesis and developing safe and effective treatments. Pati...

    Authors: Takashi Okumura, Yumi Horie, Chen-Yi Lai, Huan-Ting Lin, Hirofumi Shoda, Bunki Natsumoto, Keishi Fujio, Eri Kumaki, Tsubasa Okano, Shintaro Ono, Kay Tanita, Tomohiro Morio, Hirokazu Kanegane, Hisanori Hasegawa, Fumitaka Mizoguchi, Kimito Kawahata…

    Citation: Stem Cell Research & Therapy 2019 10:185

    Content type: Research

    Published on:

  42. Our group has developed a novel method for spontaneous spheroid formation using a specific low-adherence culture plate with around 90° water contact angle. In this study, this method was applied for oral mucos...

    Authors: Ni Li, Xianqi Li, Kai Chen, Hongwei Dong and Hideaki Kagami

    Citation: Stem Cell Research & Therapy 2019 10:184

    Content type: Research

    Published on:

  43. Evidence has suggested that human adipose-derived stem cells (hADSCs) and low-level laser has neuroprotective effects on spinal cord injury (SCI). Therefore, the combined effect of the hADSCs and laser on neur...

    Authors: Arash Sarveazad, Atousa Janzadeh, Gholamreza Taheripak, Sima Dameni, Mahmoud Yousefifard and Farinaz Nasirinezhad

    Citation: Stem Cell Research & Therapy 2019 10:183

    Content type: Research

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  44. The use and effectiveness of hematopoietic stem cell transplantation (HSCT) are limited by lethal complications, i.e., acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively), in which immu...

    Authors: Lu Zhao, Shanquan Chen, Panxin Yang, Hongcui Cao and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2019 10:182

    Content type: Review

    Published on:

  45. Radiation exposure negatively affects the regenerative ability and makes reconstruction of bone defects after tumor section difficult. miR-34a is involved in radiation biology and bone metabolism. The aim of t...

    Authors: Huan Liu, Yan Dong, Xiaoke Feng, Liya Li, Yang Jiao, Shizhu Bai, Zhihong Feng, Hao Yu, Xuejian Li and Yimin Zhao

    Citation: Stem Cell Research & Therapy 2019 10:180

    Content type: Research

    Published on:

  46. Disruptions of angiogenesis can have a significant effect on the healing of uterine scars. Human endometrial perivascular cells (CD146+PDGFRβ+) function as stem cells in the endometrium. Cysteine-rich angiogen...

    Authors: Zhongxun Li, Guijun Yan, Qiang Diao, Fei Yu, Xin’an Li, Xiaoqiang Sheng, Yong Liu, Yimin Dai, Huaijun Zhou, Xin Zhen, Yali Hu, Bruno Péault, Lijun Ding, Haixiang Sun and Hairong Li

    Citation: Stem Cell Research & Therapy 2019 10:179

    Content type: Research

    Published on:

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