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  1. Stem cell transplantation is a fascinating therapeutic approach for the treatment of many neurodegenerative disorders; however, clinical trials using stem cells have not been as effective as expected based on ...

    Authors: Jung Yeon Lim, Sang In Park, Soon A. Park, Jung Ho Jeon, Ho Yong Jung, Jung-Min Yon, Sin-Soo Jeun, Hyun Kook Lim and Sung Won Kim

    Citation: Stem Cell Research & Therapy 2021 12:402

    Content type: Research

    Published on:

  2. Perianal fistula is one of the most common complications in Crohn’s disease, and various medical and surgical treatments are being tried. The aim of this study was to compare the perianal fistula closure rates...

    Authors: Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang and Chang Sik Yu

    Citation: Stem Cell Research & Therapy 2021 12:401

    Content type: Research

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  3. Multiple sclerosis (MS) is a central nervous system (CNS) chronic illness with autoimmune, inflammatory, and neurodegenerative effects characterized by neurological disorder and axonal loss signs due to myelin...

    Authors: Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi and Jafar Ai

    Citation: Stem Cell Research & Therapy 2021 12:400

    Content type: Review

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  4. A long-term of peritoneal dialysis (PD) using a hypertonic PD solution (PDS) leads to patient’s peritoneal membrane (PM) injury, resulting in ultrafiltration failure (UFF) and PD drop-out. Our previous study s...

    Authors: Yangchun Du, Ming Zong, Qiunong Guan, Zhongli Huang, Lan Zhou, Jing Cai, Gerald da Roza, Hao Wang, Hualin Qi, Yiping Lu and Caigan Du

    Citation: Stem Cell Research & Therapy 2021 12:398

    Content type: Research

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  5. Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy is being investigated in clinical trials for the treatment...

    Authors: Zan Tang, Junxiao Gao, Jie Wu, Guifang Zeng, Yan Liao, Zhenkun Song, Xiao Liang, Junyuan Hu, Yong Hu, Muyun Liu and Nan Li

    Citation: Stem Cell Research & Therapy 2021 12:397

    Content type: Research

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  6. Effective treatments for acute-on-chronic liver failure (ACLF) are lacking. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been applied in tissue regeneration and repair, acting through pa...

    Authors: Yulin He, Xingrong Guo, Tingyu Lan, Jianbo Xia, Jinsong Wang, Bei Li, Chunyan Peng, Yue Chen, Xiang Hu and Zhongji Meng

    Citation: Stem Cell Research & Therapy 2021 12:396

    Content type: Research

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  7. The tumour microenvironment contributes to chemotherapy resistance in gliomas, and glioma-associated mesenchymal stromal/stem cells (gaMSCs) are important stromal cell components that play multiple roles in tu...

    Authors: Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu

    Citation: Stem Cell Research & Therapy 2021 12:394

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:493

  8. Mesenchymal stem cell treatments in dogs have been investigated as a potential innovative alternative to current conventional therapies for a variety of conditions. So far, the precise mode of action of the MS...

    Authors: Charlotte Beerts, Carlien Brondeel, Glenn Pauwelyn, Eva Depuydt, Liesa Tack, Luc Duchateau, Yangfeng Xu, Jimmy H. Saunders, Kathelijne Peremans and Jan H. Spaas

    Citation: Stem Cell Research & Therapy 2021 12:393

    Content type: Research

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  9. Diabetic foot ulceration is a serious chronic complication of diabetes mellitus characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has been widely used for diabetic wound he...

    Authors: Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed M. Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed H. Khalil, Sami F. Abdalla, Mohamed El-Sherbiny…

    Citation: Stem Cell Research & Therapy 2021 12:392

    Content type: Research

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  10. Mesenchymal stem cells (MSCs) have to be expanded in vitro to reach a sufficient cell dose for the treatment of various diseases. During the process of expansion, some obstacles remain to be overcome. The purp...

    Authors: Yong-Hong Wang, Ya-Chao Tao, Dong-Bo Wu, Meng-Lan Wang, Hong Tang and En-Qiang Chen

    Citation: Stem Cell Research & Therapy 2021 12:391

    Content type: Research

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  11. Nontraumatic osteonecrosis of the femoral head (NONFH) is a common, progressive, and refractory orthopaedic disease. Decreased osteogenesis and angiogenesis are considered the main factors in the pathogenesis ...

    Authors: Wu Yang, Weiwen Zhu, Yunfei Yang, Minkang Guo, Husun Qian, Weiqian Jiang, Yu Chen, Chengjie Lian, Zijie Xu, Haobo Bai, Tingmei Chen and Jian Zhang

    Citation: Stem Cell Research & Therapy 2021 12:390

    Content type: Research

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  12. Aberrations in exosomal circular RNA (circRNA) expression have been identified in various human diseases. In this study, we investigated whether exosomal circRNAs could act as competing endogenous RNAs (ceRNAs...

    Authors: Guping Mao, Yiyang Xu, Dianbo Long, Hong Sun, Hongyi Li, Ruobin Xin, Ziji Zhang, Zhiwen Li, Zhi Yang and Yan Kang

    Citation: Stem Cell Research & Therapy 2021 12:389

    Content type: Research

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  13. Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features...

    Authors: Rishi Man Chugh, Hang-soo Park, Abdeljabar El Andaloussi, Amro Elsharoud, Sahar Esfandyari, Mara Ulin, Lale Bakir, Alshimaa Aboalsoud, Mohamed Ali, Dalia Ashour, Prosper Igboeli, Nahed Ismail, Jan McAllister and Ayman Al-Hendy

    Citation: Stem Cell Research & Therapy 2021 12:388

    Content type: Research

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  14. Neointimal hyperplasia remains a major obstacle in vascular regeneration. Sca-1-positive progenitor cells residing within the vascular adventitia play a crucial role in the assemblage of vascular smooth muscle...

    Authors: Yan Wu, Yuan-jin Li, Liu-liu Shi, Yun Liu, Yan Wang, Xin Bao, Wei Xu, Lu-yuan Yao, Magdaleena Naemi Mbadhi, Long Chen, Shan Li, Xing-yuan Li, Zhi-feng Zhang, Sen Zhao, Ruo-nan Zhang, Shi-You Chen…

    Citation: Stem Cell Research & Therapy 2021 12:387

    Content type: Research

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  15. Autoimmune hepatitis is a chronic inflammatory hepatic disorder which may cause liver fibrosis. Appropriate treatment of autoimmune hepatitis is therefore important. Adult stem cells have been investigated as ...

    Authors: Ahmed Lotfy, Aya Elgamal, Anna Burdzinska, Ayman A. Swelum, Reham Soliman, Ayman A. Hassan and Gamal Shiha

    Citation: Stem Cell Research & Therapy 2021 12:386

    Content type: Review

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  16. The therapeutic efficacy of mesenchymal stem cells (MSCs) of different tissue origins on metabolic disorders can be varied in many ways but remains poorly defined. Here we report a comprehensive comparison of ...

    Authors: Yinzhong Ma, Lisha Wang, Shilun Yang, Dongyu Liu, Yi Zeng, Lilong Lin, Linhui Qiu, Jiahao Lu, Junlei Chang and Zhihuan Li

    Citation: Stem Cell Research & Therapy 2021 12:385

    Content type: Research

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  17. In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation ...

    Authors: Dehua Chang, Taibing Fan, Shuang Gao, Yongqiang Jin, Mingkui Zhang and Minoru Ono

    Citation: Stem Cell Research & Therapy 2021 12:384

    Content type: Review

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  18. As a promising way to repair bone defect, bone tissue engineering has attracted a lot of attentions from researchers in recent years. Searching for new molecular target to modify the seed cells and enhance the...

    Authors: Xuenan Liu, Xiaomin Lian, Xuejiao Liu, Yangge Du, Yuan Zhu, Menglong Hu, Ping Zhang, Yunsong Liu and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2021 12:383

    Content type: Research

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  19. Tissue-engineered bone grafts (TEBGs) that undergo vascularization and neurotization evolve into functioning bone tissue. Previously, we verified that implanting sensory nerve tracts into TEBGs promoted osteog...

    Authors: Xinxin Zhang, Xiaorui Jiang, Shan Jiang, Xiyu Cai, Shengji Yu and Guoxian Pei

    Citation: Stem Cell Research & Therapy 2021 12:382

    Content type: Research

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  20. Radiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused on stem cell properties to obtain ideal therapeutic effects, and Sox9 ...

    Authors: Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang, Xiaocheng Wang, Maosheng Cheng, Jie Chen, Zhi Chen, Jianwen Chen, Caihua Zhang, Gan Xiong, Xiuyun Xu, Demeng Chen, Heping Li and Liang Peng

    Citation: Stem Cell Research & Therapy 2021 12:381

    Content type: Research

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  21. Small blood stem cells (SB cells), isolated from human peripheral blood, demonstrated the ability to benefit bone regeneration and osseointegration. The primary goal of our study is to examine the safety and t...

    Authors: Sheng-Wei Feng, Yi-Han Su, Yen-Kuang Lin, Yu-Chih Wu, Yen-Hua Huang, Fu-Hung Yang, Hsi-Jen Chiang, Yun Yen and Peter Da-Yen Wang

    Citation: Stem Cell Research & Therapy 2021 12:380

    Content type: Research

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  22. Embryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative of ES cells. Acute kidney injury (AKI) is a common acut...

    Authors: Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu, Zhongchao Han, Xiangmei Chen, Zongjin Li and Na Liu

    Citation: Stem Cell Research & Therapy 2021 12:379

    Content type: Research

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  23. Idiopathic pneumonia syndrome (IPS) is a non-infectious fatal complication characterized by a massive infiltration of leukocytes in lungs and diffuse pulmonary injury after allogeneic hematopoietic stem cell t...

    Authors: Min Cao, Huihui Liu, Yujun Dong, Wei Liu, Zhengyu Yu, Qingya Wang, Qingyun Wang, Zeying Liang, Yuan Li and Hanyun Ren

    Citation: Stem Cell Research & Therapy 2021 12:378

    Content type: Research

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  24. There is a huge controversy about whether xenograft or allograft in the “immune-privileged” brain needs immunosuppression. In animal studies, the prevailing sophisticated use of immunosuppression or immunodefi...

    Authors: Chunhua Liu, Xiaoyun Wang, Wenhao Huang, Wei Meng, Zhenghui Su, Qi Xing, Heng Shi, Di Zhang, Min Zhou, Yifan Zhao, Haitao Wang, Guangjin Pan, Xiaofen Zhong, Duanqing Pei and Yiping Guo

    Citation: Stem Cell Research & Therapy 2021 12:376

    Content type: Research

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  25. Direct reprogramming of human fibroblasts to hepatocyte-like cells was proposed to generate large-scale functional hepatocytes demanded by liver tissue engineering. However, the difficulty in obtaining large q...

    Authors: Jie Deng, Kai Luo, Pengchao Xu, Qingyuan Jiang, Yuan Wang, Yunqi Yao, Xiaolei Chen, Fuyi Cheng, Dan Xie and Hongxin Deng

    Citation: Stem Cell Research & Therapy 2021 12:375

    Content type: Research

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  26. Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered ...

    Authors: Faroogh Marofi, Marwan Mahmood Saleh, Heshu Sulaiman Rahman, Wanich Suksatan, Moaed E. Al-Gazally, Walid Kamal Abdelbasset, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Ali Hassanzadeh, Mahboubeh Yazdanifar, Roza Motavalli, Yashwant Pathak, Adel Naimi, Behzad Baradaran, Marzieh Nikoo and Farhad Motavalli Khiavi

    Citation: Stem Cell Research & Therapy 2021 12:374

    Content type: Review

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  27. Even though the manufacturing processes of the stromal vascular fraction for clinical use are performed in compliance with the good manufacturing practices applying to advanced therapy medicinal products, spec...

    Authors: Pauline François, Giulio Rusconi, Laurent Arnaud, Luca Mariotta, Laurent Giraudo, Greta Minonzio, Julie Veran, Baptiste Bertrand, Chloé Dumoulin, Fanny Grimaud, Luc Lyonnet, Dominique Casanova, Camille Giverne, Audrey Cras, Guy Magalon, Françoise Dignat-George…

    Citation: Stem Cell Research & Therapy 2021 12:373

    Content type: Research

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  28. Manipulation of neural stem and progenitor cells (NSPCs) is critical for the successful treatment of spinal cord injury (SCI) by NSPC transplantation, since their differentiation into neurons and oligodendrocy...

    Authors: Chen-Guang Zhao, Jie Qin, Jia Li, Shan Jiang, Fen Ju, Wei Sun, Zhen Ren, Yu-Qiang Ji, Rui Wang, Xiao-Long Sun, Xiang Mou and Hua Yuan

    Citation: Stem Cell Research & Therapy 2021 12:372

    Content type: Research

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  29. This study tested the hypothesis that double overexpression of miR-19a and miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left vent...

    Authors: Jiunn-Jye Sheu, Han-Tan Chai, Pei-Hsun Sung, John Y. Chiang, Tien-Hung Huang, Pei-Lin Shao, Shun-Cheng Wu and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2021 12:371

    Content type: Research

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  30. This study tested the hypothesis that combined melatonin (Mel) and adipose-derived mesenchymal stem cells (ADMSCs) treatment was superior to either one alone on protecting the testis against acute testicular t...

    Authors: Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Chi-Ruei Huang, Kuan-Hui Huang and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2021 12:370

    Content type: Research

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  31. The cerebellum is the sensitive region of the brain to developmental abnormalities related to the effects of oxidative stresses. Abnormal cerebellar lobe formation, found in Jun dimerization protein 2 (Jdp2)-knoc...

    Authors: Chia-Chen Ku, Kenly Wuputra, Kohsuke Kato, Jia-Bin Pan, Chia-Pei Li, Ming-Ho Tsai, Michiya Noguchi, Yukio Nakamura, Chung-Jung Liu, Te-Fu Chan, Ming-Feng Hou, Shigeharu Wakana, Yang-Chang Wu, Chang-Shen Lin, Deng-Chyang Wu and Kazunari K. Yokoyama

    Citation: Stem Cell Research & Therapy 2021 12:369

    Content type: Research

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  32. The activation of T cells and imbalanced redox metabolism enhances the development of graft-versus-host disease (GVHD). Human placenta-derived mesenchymal stromal cells (hPMSCs) can improve GVHD through regula...

    Authors: Aiping Zhang, Jiashen Zhang, Xiaohua Li, Hengchao Zhang, Yanlian Xiong, Zhuoya Wang, Nannan Zhao, Feifei Wang and Xiying Luan

    Citation: Stem Cell Research & Therapy 2021 12:368

    Content type: Research

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  33. Acute kidney injury (AKI) is an emerging global healthcare issue without effective therapy yet. Autophagy recycles damaged organelles and helps maintain tissue homeostasis in acute renal ischemia-reperfusion (...

    Authors: Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung and Der-Cherng Tarng

    Citation: Stem Cell Research & Therapy 2021 12:367

    Content type: Research

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  34. Stem cells are the main choice for seed cells in tissue engineering, but using most traditional stem cells requires invasive and complicated procedures. Human urine-derived stem cells (hUSCs) are an alternativ...

    Authors: Jiachen Sun, Fei Xing, Min Zou, Min Gong, Lang Li and Zhou Xiang

    Citation: Stem Cell Research & Therapy 2021 12:366

    Content type: Research

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  35. State-of-the-art advances have indicated the pivotal characteristics of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) in hematopoietic microenvironment as well as coordinate contribution to hema...

    Authors: Leisheng Zhang, Ying Chi, Yimeng Wei, Wenxia Zhang, Fuxu Wang, Lei Zhang, Linglin Zou, Baoquan Song, Xing Zhao and Zhongchao Han

    Citation: Stem Cell Research & Therapy 2021 12:365

    Content type: Research

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  36. Obesity is a metabolic disorder syndrome characterized by excessive fat accumulation that is related to many diseases. Human amniotic mesenchymal stem cells (hAMSCs) have a great potential for cell-based thera...

    Authors: Hui-Lan Tan, Xiao-Hui Guan, Min Hu, Jie Wu, Rong-Zhen Li, Ling-Fang Wang, Hou-Da Huang, Zhen-Ping Yu, Xiao-Yu Wang, Yun-Fei Xiao, Ke-Yu Deng and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2021 12:364

    Content type: Research

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  37. Overall, 5–10% of fractures result in delayed unions or non-unions, causing major disabilities and a huge socioeconomic burden. Since rescue surgery with autologous bone grafts can cause additional challenges,...

    Authors: Marc Jayankura, Arndt Peter Schulz, Olivier Delahaut, Richard Witvrouw, Lothar Seefried, Bruno Vande Berg, Guy Heynen and Wendy Sonnet

    Citation: Stem Cell Research & Therapy 2021 12:363

    Content type: Research

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  38. Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancrea...

    Authors: Yumeng Zhang, Jiaqi Xu, Zhili Ren, Ya Meng, Weiwei Liu, Ligong Lu, Zhou Zhou and Guokai Chen

    Citation: Stem Cell Research & Therapy 2021 12:362

    Content type: Short report

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  39. While existing remedies failed to fully address the consequences of heart failure, stem cell therapy has been introduced as a promising approach. The present review is a comprehensive appraisal of the impacts ...

    Authors: Iman Razeghian-Jahromi, Anthony G. Matta, Ronan Canitrot, Mohammad Javad Zibaeenezhad, Mahboobeh Razmkhah, Anahid Safari, Vanessa Nader and Jerome Roncalli

    Citation: Stem Cell Research & Therapy 2021 12:361

    Content type: Review

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  40. Mesenchymal stem or stromal cells are the most widely used cell therapy to date. They are heterogeneous, with variations in growth potential, differentiation capacity and protein expression profile depending o...

    Authors: Alison J. Wilson, Emma Rand, Andrew J. Webster and Paul G. Genever

    Citation: Stem Cell Research & Therapy 2021 12:360

    Content type: Research

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  41. To investigate the heterogeneities of human umbilical cord mesenchymal stromal cells (HUCMSCs) derived from different donors and their therapeutic variations when applied to mouse liver fibrosis model.

    Authors: Yuanyuan Xie, Shuo Liu, Liudi Wang, Hui Yang, Chenxu Tai, Li Ling, Libo Chen, Shanshan Liu and Bin Wang

    Citation: Stem Cell Research & Therapy 2021 12:359

    Content type: Research

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  42. We show previously that three-dimensional (3D) spheroid cultured mesenchymal stem cells (MSCs) exhibit reduced cell size thus devoid of lung entrapment following intravenous (IV) infusion. In this study, we de...

    Authors: Yuejiao Li, Yankai Dong, Ye Ran, Yanan Zhang, Boyao Wu, Jundong Xie, Yanpei Cao, Miaohua Mo, Sen Li, Hao Deng, Wenbo Hao, Shengyuan Yu and Yaojiong Wu

    Citation: Stem Cell Research & Therapy 2021 12:358

    Content type: Research

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  43. The dentin–pulp complex is essential for the long-term integrity and viability of teeth but it is susceptible to damage caused by external factors. Because traditional approaches for preserving the dentin–pulp...

    Authors: Zixia Li, Liu Liu, Liu Wang and Dongzhe Song

    Citation: Stem Cell Research & Therapy 2021 12:357

    Content type: Review

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  44. It is known that in countries, in which basic research on human embryos is in fact prohibited by law, working with imported human embryonic stem cells (hESCs) can still be permitted. As long as hESCs are not c...

    Authors: Markus Hengstschläger and Margit Rosner

    Citation: Stem Cell Research & Therapy 2021 12:356

    Content type: Commentary

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  45. The adverse health effects of fine particulate matter (PM2.5) exposure are associated with marked inflammatory responses. Adipose-derived stem cells (ADSCs) have immunosuppressive effects, and ADSC transplantatio...

    Authors: Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji and Zhongbing Lu

    Citation: Stem Cell Research & Therapy 2021 12:355

    Content type: Research

    Published on:

  46. Treatment of avascular necrosis of the femoral head (ANFH) in young patients remains a clinical challenge. A current controversy is whether hip-preserving surgery results in better outcomes. The adverse effect...

    Authors: Qingtian Li, Weihong Liao, Guangtao Fu, Junxing Liao, Ruiying Zhang, Mengyuan Li, Yuhui Yang, Yuanchen Ma, Minghao Zheng and Qiujian Zheng

    Citation: Stem Cell Research & Therapy 2021 12:354

    Content type: Research

    Published on:

  47. Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor ...

    Authors: Wei Shan, Qin Yu, Yan Long, Qian Luo, Honghu Li, Yingli Han, Yulin Xu, Shan Fu, Xiangjun Zeng, Cong Wei, Yang Gao, Xiaoqing Li, Xia Li, Lifei Zhang, Lizhen Liu, Ming Chen…

    Citation: Stem Cell Research & Therapy 2021 12:353

    Content type: Research

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  48. Hearing loss affects 25% of the population at ages 60–69 years. Loss of the hair cells of the inner ear commonly underlies deafness and once lost this cell type cannot spontaneously regenerate in higher verteb...

    Authors: Hiroki Takeda, Anna Dondzillo, Jessica A. Randall and Samuel P. Gubbels

    Citation: Stem Cell Research & Therapy 2021 12:352

    Content type: Research

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