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  1. Although tissue-engineered cartilage has been broadly studied, complete integration of regenerated cartilage with residual cartilage is still difficult for the inferior mechanical and biochemical feature of ne...

    Authors: Baixiang Cheng, Teng Tu, Xiao Shi, Yanzheng Liu, Ying Zhao, Yinhua Zhao, Yijie Li, Hui Chen, Yongjin Chen and Min Zhang

    Citation: Stem Cell Research & Therapy 2019 10:298

    Content type: Research

    Published on:

  2. Odontoblasts are cells that contribute to the formation of the dental pulp complex. The differentiation of dental tissue-derived mesenchymal stem cells into odontoblasts comprises many factors and signaling pa...

    Authors: Fuchun Fang, Kaiying Zhang, Zhao Chen and Buling Wu

    Citation: Stem Cell Research & Therapy 2019 10:297

    Content type: Review

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  3. A dynamic interaction between tumor cells and its surrounding stroma promotes the initiation, progression, metastasis, and chemoresistance of solid tumors. Emerging evidences suggest that targeting the stromal...

    Authors: Tithi Ghosh, Partha Nandi, Nilanjan Ganguly, Ipsita Guha, Avishek Bhuniya, Sarbari Ghosh, Anirban Sarkar, Akata Saha, Shayani Dasgupta, Rathindranath Baral and Anamika Bose

    Citation: Stem Cell Research & Therapy 2019 10:296

    Content type: Research

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  4. Interleukin 33 is known to have an important influence in the process of myocardial infarction, and the immunoregulatory function of MSCs could be influenced by cell factors. In this study, we evaluated the th...

    Authors: Yueqiu Chen, Jianfeng Zuo, Weiqian Chen, Ziying Yang, Yanxia Zhang, Fei Hua, Lianbo Shao, Jingjing Li, Yihuan Chen, Yunsheng Yu and Zhenya Shen

    Citation: Stem Cell Research & Therapy 2019 10:295

    Content type: Research

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  5. Accumulation of vascular smooth muscle cells (VSMCs) within the neointimal region is a hallmark of atherosclerosis and vessel injury. Evidence has shown that Sca-1-positive (Sca-1+) progenitor cells residing i...

    Authors: Yan Wu, Xin Liu, Ling-Yun Guo, Lei Zhang, Fei Zheng, Shan Li, Xing-Yuan Li, Ye Yuan, Yu Liu, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jin-xuan Zhang and Jun-Ming Tang

    Citation: Stem Cell Research & Therapy 2019 10:294

    Content type: Research

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  6. The field of regenerative medicine provides enormous opportunities for generating beta cells from different stem cell sources for cellular therapy. Even though insulin-secreting cells can be generated from a v...

    Authors: Nimshitha Pavathuparambil Abdul Manaph, Kisha N. Sivanathan, Jodie Nitschke, Xin-Fu Zhou, Patrick T. Coates and Christopher John Drogemuller

    Citation: Stem Cell Research & Therapy 2019 10:293

    Content type: Review

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  7. In the field of regenerative medicine, delivery of human adipose-derived mesenchymal stem/stromal cells (hASCs) has shown great promise to promote wound healing. However, a hostile environment of the injured t...

    Authors: Jasmi Kiiskinen, Arto Merivaara, Tiina Hakkarainen, Minna Kääriäinen, Susanna Miettinen, Marjo Yliperttula and Raili Koivuniemi

    Citation: Stem Cell Research & Therapy 2019 10:292

    Content type: Research

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  8. The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Previous studies have found that perinatal...

    Authors: Yoon Jeong Choi, Jun Bon Koo, Hee Yeon Kim, Jin Won Seo, Eun Jeong Lee, Woo Ram Kim, Joo Young Cho, Ki Baik Hahm, Sung Pyo Hong, Duk Hwan Kim and Jun-Hwan Yoo

    Citation: Stem Cell Research & Therapy 2019 10:291

    Content type: Research

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  9. Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. Despite remarkable short-term recovery, long-term lung survival continues to fa...

    Authors: Mohammad Afzal Khan, Fatimah Alanazi, Hala Abdalrahman Ahmed, Talal Shamma, Kilian Kelly, Mohamed A. Hammad, Abdullah O. Alawad, Abdullah Mohammed Assiri and Dieter Clemens Broering

    Citation: Stem Cell Research & Therapy 2019 10:290

    Content type: Research

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  10. Stem cell-derived pancreatic β-like cells hold great promise for treating diabetes. Gallbladder belongs to the extrahepatic bile duct system and possesses stem-like cells. These stem cells could be expanded in...

    Authors: Fei Chen, Tuo Li, Yu Sun, Qinggui Liu, Tao Yang, Jiajia Chen, Haiying Zhu, Yongquan Shi, Yi-Ping Hu and Min-Jun Wang

    Citation: Stem Cell Research & Therapy 2019 10:289

    Content type: Research

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  11. Adult mesenchymal stem cells (MSCs) improve the host response during experimental sepsis in animals. MSCs from various sources express a procoagulant activity that has been linked to the expression of tissue f...

    Authors: Desirée Perlee, Alex F. de Vos, Brendon P. Scicluna, Anja Maag, Pablo Mancheño, Olga de la Rosa, Wilfried Dalemans, Sandrine Florquin, Cornelis van’t Veer, Eleuterio Lombardo and Tom van der Poll

    Citation: Stem Cell Research & Therapy 2019 10:286

    Content type: Research

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  12. Transient receptor potential vanilloid 1 (TRPV1), recognized as a hyperosmolarity sensor, is a crucial ion channel involved in the pathogenesis of neural and glial signaling. Recently, TRPV1 was determined to ...

    Authors: Chih-Chien Hsu, Ke-Hung Chien, Aliaksandr A. Yarmishyn, Waradee Buddhakosai, Wen-Ju Wu, Tai-Chi Lin, Shih-Hwa Chiou, Jiann-Torng Chen, Chi-Hsien Peng, De-Kuang Hwang, Shih-Jen Chen and Yuh-Lih Chang

    Citation: Stem Cell Research & Therapy 2019 10:284

    Content type: Research

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  13. Recent studies suggested that miR-17~106 family was involved in the regulation of neural stem/progenitor cells (NPCs). However, distinct function of each family member was reported in regulating stem cells within...

    Authors: Xiaohuan Xia, Hongfang Lu, Chunhong Li, Yunlong Huang, Yi Wang, Xiaoyu Yang and Jialin C. Zheng

    Citation: Stem Cell Research & Therapy 2019 10:282

    Content type: Research

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  14. Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confin...

    Authors: Peng Wang, Zhicheng Hu, Xiaoling Cao, Shaobin Huang, Yunxian Dong, Pu Cheng, Hailin Xu, Bin Shu, Julin Xie, Jun Wu, Bing Tang and Jiayuan Zhu

    Citation: Stem Cell Research & Therapy 2019 10:154

    Content type: Research

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  15. Stem cell therapy has been applied in many fields. Basic and clinical studies on stem cell therapy for acute kidney injury (AKI) have been conducted. Stem cells have been found to exert renal protection throug...

    Authors: Si-Yang Wang, Quan Hong, Chao-Yang Zhang, Yuan-Jun Yang, Guang-Yan Cai and Xiang-Mei Chen

    Citation: Stem Cell Research & Therapy 2019 10:281

    Content type: Review

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  16. The incidence of obesity and diabetes is increasing rapidly. Optimal management is still elusive. Obesity associated with type 2 diabetes is known to cause adipose tissue inflammation, increase oxidative stres...

    Authors: Cleyton C. Domingues, Nabanita Kundu, Yana Kropotova, Neeki Ahmadi and Sabyasachi Sen

    Citation: Stem Cell Research & Therapy 2019 10:280

    Content type: Research

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  17. Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascu...

    Authors: Yuansen Luo, Xiaoyou Yi, Tangzhao Liang, Shihai Jiang, Ronghan He, Ying Hu, Li Bai, Chunmei Wang, Kun Wang and Lei Zhu

    Citation: Stem Cell Research & Therapy 2019 10:279

    Content type: Research

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  18. Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communi...

    Authors: Na Li, Lu Zhao, Yankai Wei, Vicki L. Ea, Hong Nian and Ruihua Wei

    Citation: Stem Cell Research & Therapy 2019 10:278

    Content type: Review

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  19. Chrysosplenetin is an O-methylated flavonol compound isolated from the plant Chamomilla recutita and Laggera pterodonta. The aim of our research is to evaluate the function of Chrysosplenetin on osteogenesis of h...

    Authors: Guoju Hong, Xiaoming He, Yingshan Shen, Xiaojun Chen, Fang Yang, Peng Yang, Fengxiang Pang, Xiaorui Han, Wei He and Qiushi Wei

    Citation: Stem Cell Research & Therapy 2019 10:277

    Content type: Research

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  20. Tooth loss caused by caries or injuries has a negative effect on human health; thus, it is important to develop a reliable method of tooth regeneration. Research on tooth regeneration has mainly focused on mou...

    Authors: Qian Li, Siqi Zhang, Yi Sui, Xiaoming Fu, Yan Li and Shicheng Wei

    Citation: Stem Cell Research & Therapy 2019 10:276

    Content type: Research

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  21. Hypertrophic scars (HSs) are formed via an aberrant response to the wound healing process. HSs can be cosmetic or can result in functional problems. Prolonged proliferation and remodeling phases disrupt wound ...

    Authors: Ching-Hsuan Hu, Yi-Wen Tseng, Chih-Yung Chiou, Kuan-Chun Lan, Chih-Hung Chou, Chun-San Tai, Hsien-Da Huang, Chiung-Wen Hu, Ko-Hsun Liao, Shiow-Shuh Chuang, Jui-Yung Yang and Oscar K. Lee

    Citation: Stem Cell Research & Therapy 2019 10:275

    Content type: Research

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  22. Retrotransposition of protein-coding genes is thought to occur due to the existence of numerous processed pseudogenes in both animals and plants. Unlike retrotransposons including Alu and LINE-1, direct evidence ...

    Authors: Saki Aoto, Saki Katagiri, Yi Wang, Alistair T. Pagnamenta, Rie Sakamoto-Abutani, Masashi Toyoda, Akihiro Umezawa and Kohji Okamura

    Citation: Stem Cell Research & Therapy 2019 10:273

    Content type: Research

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  23. Oligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS. Oligodendrocyte death and defects are the leading causes of s...

    Authors: Poommaree Namchaiw, Han Wen, Florian Mayrhofer, Olga Chechneva, Sangita Biswas and Wenbin Deng

    Citation: Stem Cell Research & Therapy 2019 10:272

    Content type: Research

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  24. Male infertility is a serious social problem in modern society. Nonobstructive azoospermia (NOA) caused by germ cell gene defects is an important reason for male infertility, but effective clinical treatment f...

    Authors: Xiaoyu Li, Tiecheng Sun, Xiuxia Wang, Jixin Tang and Yixun Liu

    Citation: Stem Cell Research & Therapy 2019 10:271

    Content type: Research

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  25. Testicular torsion is an urological emergency that may lead to infertility due to ischemic injury. Promptly surgical correction by orchiopexy is the only way to avoid infertility and no effective treatment for...

    Authors: Chi-Hao Hsiao, Andrea Tung-Qian Ji, Chih-Cheng Chang, Ming-Hsien Chien, Liang-Ming Lee and Jennifer Hui-Chun Ho

    Citation: Stem Cell Research & Therapy 2019 10:270

    Content type: Research

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  26. Adult stem cells and progenitors are responsible for breast tissue regeneration. Human breast epithelial progenitors are organized in a lineage hierarchy consisting of bipotent progenitors (BPs), myoepithelial...

    Authors: Vasudeva Bhat, Victoria Lee-Wing, Pingzhao Hu and Afshin Raouf

    Citation: Stem Cell Research & Therapy 2019 10:269

    Content type: Research

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  27. PBX homeobox 1 (PBX1) is involved in the maintenance of the pluripotency of human embryonic and hematopoietic stem cells; however, the effects of PBX1 in the self-renewal and reprogramming of hair follicle mes...

    Authors: Yixu Jiang, Feilin Liu, Fei Zou, Yingyao Zhang, Bo Wang, Yuying Zhang, Aobo Lian, Xing Han, Zinan Liu, Xiaomei Liu, Minghua Jin, Dianliang Wang, Gang Li and Jinyu Liu

    Citation: Stem Cell Research & Therapy 2019 10:268

    Content type: Research

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  28. To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate sodium.

    Authors: Xin Li, Qian Wang, Li Ding, Yu-Xing Wang, Zhi-Dong Zhao, Ning Mao, Chu-Tse Wu, Hua Wang, Heng Zhu and Shou-Bin Ning

    Citation: Stem Cell Research & Therapy 2019 10:267

    Content type: Research

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  29. Mesenchymal stem cells (MSCs) have been recognized as a promising tool for the treatment of various inflammatory disorders and autoimmune diseases. Stress conditions affect immune-mediated treatment and activa...

    Authors: Shuizhong Cen, Peng Wang, Zhongyu Xie, Rui Yang, Jinteng Li, Zhenhua Liu, Shan Wang, Xiaohua Wu, Wenjie Liu, Ming Li, Su’an Tang, Huiyong Shen and Yanfeng Wu

    Citation: Stem Cell Research & Therapy 2019 10:265

    Content type: Research

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  30. Even though mesenchymal stromal cells (MSCs) mitigate lung and distal organ damage in experimental polymicrobial sepsis, mortality remains high. We investigated whether preconditioning with eicosapentaenoic ac...

    Authors: Johnatas D. Silva, Miquéias Lopes-Pacheco, Ligia L. de Castro, Jamil Z. Kitoko, Stefano A. Trivelin, Natália R. Amorim, Vera L. Capelozzi, Marcelo M. Morales, Bianca Gutfilen, Sergio A. L. de Souza, Daniel J. Weiss, Bruno L. Diaz and Patricia R. M. Rocco

    Citation: Stem Cell Research & Therapy 2019 10:264

    Content type: Research

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  31. Myocardial fibrosis is a common pathophysiological change in cardiovascular disease, which can cause cardiac dysfunction and even sudden death. Excessively activated fibroblasts proliferate and secret excessiv...

    Authors: Fengxia Lin, Zhicong Zeng, Yinzhi Song, Liang Li, Zijun Wu, Xiaoduo Zhang, Zhiwen Li, Xiao Ke and Xun Hu

    Citation: Stem Cell Research & Therapy 2019 10:263

    Content type: Research

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  32. The efficacy of mesenchymal stem cell (MSC)-based therapy for acute liver injury (ALI) involves coordination with the hepatic immune system, a complex and coordinated network of immune-cell interactions. Howev...

    Authors: Jingqi Liu, Bing Feng, Yanping Xu, Jiaqi Zhu, Xudong Feng, Wenyi Chen, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jiong Yu, Xun Zeng, Hongcui Cao and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2019 10:262

    Content type: Research

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  33. Recently published article by Pieri’s group suggested that follicle-stimulating hormone (FSH) activates canine testicular spermatogonial stem cells (SSCs) and results in increased expression of pluripotent mar...

    Authors: Hiren Patel and Deepa Bhartiya

    Citation: Stem Cell Research & Therapy 2019 10:261

    Content type: Letter

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  34. Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has l...

    Authors: Fangqi Li, Yiyong Tang, Bin Song, Menglei Yu, Qingyue Li, Congda Zhang, Jingyi Hou and Rui Yang

    Citation: Stem Cell Research & Therapy 2019 10:260

    Content type: Review

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  35. Mesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the anti-diabetic effect of MSCs is partially mediated by eliciting macropha...

    Authors: Jieqing Gao, Yu Cheng, Haojie Hao, Yaqi Yin, Jing Xue, Qi Zhang, Lin Li, Jiejie Liu, Zongyan Xie, Songyan Yu, Bing Li, Weidong Han and Yiming Mu

    Citation: Stem Cell Research & Therapy 2019 10:259

    Content type: Research

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  36. Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for gen...

    Authors: Ernesto Goulart, Luiz Carlos de Caires-Junior, Kayque Alves Telles-Silva, Bruno Henrique Silva Araujo, Gerson S. Kobayashi, Camila Manso Musso, Amanda Faria Assoni, Danyllo Oliveira, Elia Caldini, Jonathan A. Gerstenhaber, Silvano Raia, Peter I. Lelkes and Mayana Zatz

    Citation: Stem Cell Research & Therapy 2019 10:258

    Content type: Research

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  37. Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal ...

    Authors: Mirasbek Kuterbekov, Paul Machillot, Francis Baillet, Alain M. Jonas, Karine Glinel and Catherine Picart

    Citation: Stem Cell Research & Therapy 2019 10:256

    Content type: Short report

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  38. Obesity impairs a variety of cell types including adipose-derived mesenchymal stem cells (ASCs). ASCs are indispensable for tissue homeostasis/repair, immunomodulation, and cell renewal. It has been demonstrat...

    Authors: Andreas Ritter, Nina-Naomi Kreis, Susanne Roth, Alexandra Friemel, Lukas Jennewein, Christine Eichbaum, Christine Solbach, Frank Louwen and Juping Yuan

    Citation: Stem Cell Research & Therapy 2019 10:255

    Content type: Research

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  39. Stem cell-based bone tissue engineering shows promise for bone repair but faces some challenges, such as insufficient osteogenesis and limited architecture flexibility of the cell-delivery scaffold.

    Authors: Hang Lin, Ying Tang, Thomas P. Lozito, Nicholas Oyster, Bing Wang and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2019 10:254

    Content type: Research

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  40. For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro i...

    Authors: Carla Dessels, Melvin A. Ambele and Michael S. Pepper

    Citation: Stem Cell Research & Therapy 2019 10:253

    Content type: Research

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  41. Taking advantage of cellular paracrine mechanisms, the secretome of adipose-derived stem cells (ADSCs) and adipose tissue has been demonstrated to induce tissue repair and regeneration in various ischemic and ...

    Authors: Yunfan He, Jing Xia, Hsinkai Chen, Liangyue Wang, Chengliang Deng and Feng Lu

    Citation: Stem Cell Research & Therapy 2019 10:252

    Content type: Research

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  42. Autosomal dominant osteopetrosis type II (ADO2) is a rare human genetic disease that has been broadly studied as an important osteopetrosis model; however, there are no disease-specific induced pluripotent ste...

    Authors: Minglin Ou, Chunhong Li, Donge Tang, Wen Xue, Yong Xu, Peng Zhu, Bo Li, Jiansheng Xie, Jiejing Chen, Weiguo Sui, Lianghong Yin and Yong Dai

    Citation: Stem Cell Research & Therapy 2019 10:251

    Content type: Research

    Published on:

  43. Premature ovarian insufficiency (POI) is one of the leading causes of female infertility, which is caused by an abnormal ovarian reserve. Currently, there is no effective treatment to restore the fertility of ...

    Authors: Ziling Yang, Xin Du, Cunli Wang, Jin Zhang, Conghui Liu, Yu Li and Hong Jiang

    Citation: Stem Cell Research & Therapy 2019 10:250

    Content type: Research

    Published on:

  44. The generation of functional human epidermal melanocytes (HEM) from stem cells provides an unprecedented source for cell-based therapy in vitiligo. Despite the important efforts exerted to obtain melanin-produ...

    Authors: Gabriela Zavala, Carolina Sandoval, Daniel Meza, Rafael Contreras, Walter Gubelin and Maroun Khoury

    Citation: Stem Cell Research & Therapy 2019 10:249

    Content type: Research

    Published on:

  45. Mesenchymal stem/stromal cells (MSCs) are considered an important candidate in cell therapy and tissue engineering approaches. The culture of stem cells in a 3D environment is known to better resemble the in v...

    Authors: Dominik Egger, Ana Catarina Oliveira, Barbara Mallinger, Hatim Hemeda, Verena Charwat and Cornelia Kasper

    Citation: Stem Cell Research & Therapy 2019 10:248

    Content type: Research

    Published on:

  46. Increasing evidence has shown that mesenchymal stem cells (MSCs) yield a favorable therapeutic benefit for thermal burn skin wounds. Human amniotic MSCs (hAMSCs) derived from amniotic membrane have multilineag...

    Authors: Jing-Yuan Li, Kang-Kang Ren, Wen-Jie Zhang, Ling Xiao, Han-You Wu, Qian-Yu Liu, Ting Ding, Xiang-Cheng Zhang, Wen-Jia Nie, Yu Ke, Ke-Yu Deng, Quan-Wen Liu and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2019 10:247

    Content type: Research

    Published on:

  47. Graves’ ophthalmopathy (GO) is a complication of Graves’ disease (GD), in which orbital connective tissues become inflamed and increase in volume and orbital fibroblasts within the orbital fat and extraocular ...

    Authors: Mira Park, J. Paul Banga, Gi Jin Kim, MinYoung Kim and Helen Lew

    Citation: Stem Cell Research & Therapy 2019 10:246

    Content type: Research

    Published on:

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