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  1. Older companion dogs naturally develop a dementia-like syndrome with biological, clinical and therapeutic similarities to Alzheimer disease (AD). Given there has been no new safe, clinically effective and wide...

    Authors: Michael Valenzuela, T. Duncan, A. Abey, A. Johnson, C. Boulamatsis, M. A. Dalton, E. Jacobson, L. Brunel, G. Child, D. Simpson, M. Buckland, A. Lowe, J. Siette, F. Westbrook and P. McGreevy
    Citation: Stem Cell Research & Therapy 2022 13:261
  2. Mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage in the retinal pigment epithelium (RPE) have been implicated in the pathogenesis of age-related macular degeneration (AMD). However, a deeper unde...

    Authors: Sujoy Bhattacharya, Jinggang Yin, Weihong Huo and Edward Chaum
    Citation: Stem Cell Research & Therapy 2022 13:260
  3. Obesity is a chronic process and could activate various inflammatory responses, which in turn aggravates obesity and related metabolic syndrome. Here we explored whether long-term inhibition of inflammation co...

    Authors: Liudi Wang, Tianyun Gao, Yu Li, Yuanyuan Xie, Sheng Zeng, Chenxu Tai, Yirui Feng, Pingping Shen and Bin Wang
    Citation: Stem Cell Research & Therapy 2022 13:259
  4. The SARS-COV-2 virus has infected the world at a very high rate by causing COVID-19 disease. Nearly 507 million individuals have been infected with this virus, with approximately 1.2% of these patients being d...

    Authors: Saman Yasamineh, Hesam Ghafouri Kalajahi, Pooneh Yasamineh, Omid Gholizadeh, Hamed Rahmani Youshanlouei, Saeed Karimi Matloub, Masoud Mozafari, Elham Jokar, Yalda Yazdani and Mehdi Dadashpour
    Citation: Stem Cell Research & Therapy 2022 13:257
  5. There is a lack of effective therapies for enteric nervous system (ENS) injury. Our previous study showed that transplanted bone marrow-derived mesenchymal stem cells (BMSCs) play a “glia-like cells” role in i...

    Authors: Mengke Fan, Huiying Shi, Hailing Yao, Weijun Wang, Yurui Zhang, Chen Jiang and Rong Lin
    Citation: Stem Cell Research & Therapy 2022 13:255
  6. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been widely used due to their multipotency, a broad range of sources, painless collection, and compliance with standard amplification. Cell sheet tec...

    Authors: Shuang Gao, Yongqiang Jin, Jianlin Ma, Juan Wang, Jing Wang, Zehua Shao, Taibing Fan, Mingkui Zhang and Dehua Chang
    Citation: Stem Cell Research & Therapy 2022 13:252
  7. Endothelial cells (ECs) form the inner lining of all blood vessels of the body play important roles in vascular tone regulation, hormone secretion, anticoagulation, regulation of blood cell adhesion and immune...

    Authors: Sarkawt Hamad, Daniel Derichsweiler, John Antonydas Gaspar, Konrad Brockmeier, Jürgen Hescheler, Agapios Sachinidis and Kurt Paul Pfannkuche
    Citation: Stem Cell Research & Therapy 2022 13:251
  8. Adipose-derived stromal cells (ASCs) possess a multitude of regenerative capabilities, which include immunomodulation, angiogenesis, and stimulation of extracellular matrix (ECM) remodeling. However, the under...

    Authors: Rebekka Harary Søndergaard, Lisbeth Drozd Højgaard, Alexander Lynge Reese-Petersen, Cecilie Hoeeg, Anders Bruun Mathiasen, Mandana Haack-Sørensen, Bjarke Follin, Federica Genovese, Jens Kastrup, Morten Juhl and Annette Ekblond
    Citation: Stem Cell Research & Therapy 2022 13:250
  9. In pre-clinical studies, human adipose-derived stem cells (hASCs) have shown great promise as a treatment modality for healing of cutaneous wounds. The advantages of hASCs are that they are relatively easy to ...

    Authors: Guoqiang Ren, Qiuyue Peng, Trine Fink, Vladimir Zachar and Simone Riis Porsborg
    Citation: Stem Cell Research & Therapy 2022 13:249
  10. In our previous study, activin B in combination with ADSCs enhances skin wound healing. However, the underlying molecular mechanisms are not well studied. Cdc42 is recognized to play a critical role in the reg...

    Authors: Simin Huang, Xueer Wang, Min Zhang, Mianbo Huang, Yuan Yan, Yinghua Chen, Yijia Zhang, Jinfu Xu, Lingwei Bu, Ruyi Fan, Huiyi Tang, Canjun Zeng, Lu Zhang and Lin Zhang
    Citation: Stem Cell Research & Therapy 2022 13:248
  11. Human umbilical cord-derived mesenchymal stem cells (HucMSCs) have been recognized as a promising cell for treating myocardial infarction (MI). Inflammatory response post MI is critical in determining the card...

    Authors: Jing Liu, Xiaoting Liang, Mimi Li, Fang Lin, Xiaoxue Ma, Yuanfeng Xin, Qingshu Meng, Rulin Zhuang, Qingliu Zhang, Wei Han, Ling Gao, Zhiying He, Xiaohui Zhou and Zhongmin Liu
    Citation: Stem Cell Research & Therapy 2022 13:247
  12. Cord blood plays a very important role in stem cell transplantation and therapy with an emerging implication also in regenerative medicine. The number of cells available in a single cord blood unit (CBU), in p...

    Authors: Stefania Fumarola, Alessandra Lucarini, Giovanna Lucchetti, Luana Piroli and Luca Pierelli
    Citation: Stem Cell Research & Therapy 2022 13:246
  13. The ubiquitin–proteasome system plays important roles in maintaining the self-renewal and differentiation of stem and progenitor cells through highly ordered degradation of cellular proteins. Fbxw11, an E3 lig...

    Authors: Lina Wang, Yongjun Piao, Dongyue Zhang, Wenli Feng, Chenchen Wang, Xiaoxi Cui, Qian Ren, Xiaofan Zhu and Guoguang Zheng
    Citation: Stem Cell Research & Therapy 2022 13:245
  14. It is generally accepted that colorectal cancer (CRC) originates from cancer stem cells (CSCs), which are responsible for CRC progression, metastasis and therapy resistance. The high heterogeneity of CSCs has ...

    Authors: Hang Zheng, Heshu Liu, Huayu Li, Weidong Dou, Jingui Wang, Junling Zhang, Tao Liu, Yingchao Wu, Yucun Liu and Xin Wang
    Citation: Stem Cell Research & Therapy 2022 13:244
  15. Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by intra-hepatocyte triglyceride accumulation and concomitant involvement of the immune system with subsequent histological changes, tissue damage, an...

    Authors: Zahra Moayedfard, Farnaz Sani, Aliakbar Alizadeh, Kamran Bagheri Lankarani, Mohammad Zarei and Negar Azarpira
    Citation: Stem Cell Research & Therapy 2022 13:242
  16. Repairing radiation-induced bone injuries remains a significant challenge in the clinic, and few effective medicines are currently available. Psoralen is a principal bioactive component of Cullen corylifolium (L....

    Authors: Bo-Feng Yin, Zhi-Ling Li, Zi-Qiao Yan, Zheng Guo, Jia-Wu Liang, Qian Wang, Zhi-Dong Zhao, Pei-Lin Li, Rui-Cong Hao, Meng-Yue Han, Xiao-Tong Li, Ning Mao, Li Ding, Da-Fu Chen, Yue Gao and Heng Zhu
    Citation: Stem Cell Research & Therapy 2022 13:241

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:361

  17. Primary membranous nephropathy (MN) is a kidney-specific autoimmune disease. Human embryonic stem cells-derived immunity-and-matrix regulatory cells (hESC-IMRCs) have immunoregulatory functions. We hypothesize...

    Authors: Hui-song Zhou, Zhao Cui, Hui Wang, Ting-ting Gao, Liu Wang, Jun Wu, Zu-ying Xiong, Jie Hao and Ming-hui Zhao
    Citation: Stem Cell Research & Therapy 2022 13:240
  18. Endothelial cells are located in the inner lumen of blood and lymphatic vessels and exhibit the capacity to form new vessel branches from existing vessels through a process called angiogenesis. This process is...

    Authors: Zhuangzhuang Yang, Miao Yu, Xuechun Li, Yuanyuan Tu, Chunyan Wang, Wei Lei, Min Song, Yong Wang, Ying Huang, Fengyue Ding, Kaili Hao, Xinglong Han, Xuan Ni, Lina Qu, Zhenya Shen and Shijun Hu
    Citation: Stem Cell Research & Therapy 2022 13:239
  19. Endothelial progenitor cells (EPCs), which are a type of stem cell, have been found to have strong angiogenic and tissue repair capabilities. Extracellular vesicles (EVs) contain many effective components, suc...

    Authors: Ke Chen, Yang Li, Luwei Xu, Yiguan Qian, Ning Liu, Changcheng Zhou, Jingyu Liu, Liuhua Zhou, Zheng Xu, Ruipeng Jia and Yu-Zheng Ge
    Citation: Stem Cell Research & Therapy 2022 13:238
  20. Stem cell transplantation may improve visual acuity in patients with dry age-related macular degeneration. Herein, we aimed to summarise the evidence on the risks and benefits of stem cell transplantation for ...

    Authors: Licheng Li, Yang Yu, Shu Lin and Jianmin Hu
    Citation: Stem Cell Research & Therapy 2022 13:237
  21. Human placenta-derived multipotent cells (hPDMCs) are isolated from a source uncomplicated by ethical issues and are ideal for therapeutic applications because of their capacity for multilineage differentiatio...

    Authors: Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling and Chun-Han Hou
    Citation: Stem Cell Research & Therapy 2022 13:236
  22. Pancreatic ductal adenocarcinoma (PDAC) is a malignant cancer and chemotherapy ineffectively treats PDAC, leading to the requirement for alternative tumor-targeted treatment. Human amniotic fluid mesenchymal s...

    Authors: Ying-Cheng Chen, Ying-Wei Lan, Shiaw-Min Huang, Chih-Ching Yen, Wei Chen, Wan-Ju Wu, Theresa Staniczek, Kowit-Yu Chong and Chuan-Mu Chen
    Citation: Stem Cell Research & Therapy 2022 13:235
  23. Bio-root regeneration is a promising treatment for tooth loss. It has been reported that dental-derived stem cells are effective seed cells for bio-root construction, but further applications are limited by th...

    Authors: Yu Yuan, Xiaonan Zhang, Yuzhen Zhan, Song Tang, Pingmeng Deng, Zhenxiang Wang and Jie Li
    Citation: Stem Cell Research & Therapy 2022 13:234
  24. Distinct regions harboring cancer stem cells (CSCs) have been identified within the microenvironment of various tumors, and as in the case of their healthy counterparts, these anatomical regions are termed “ni...

    Authors: Feng Ju, Manar M. Atyah, Nellie Horstmann, Sheraz Gul, Razi Vago, Christiane J. Bruns, Yue Zhao, Qiong-Zhu Dong and Ning Ren
    Citation: Stem Cell Research & Therapy 2022 13:233
  25. Mesenchymal stem cells (MSCs) derived from different tissues have variant biological characteristics, which may induce different performances in the treatment of diseases. At present, it is difficult to know w...

    Authors: Shanshan Li, Junfeng Wang, Bin Jiang, Jiang Jiang, Lilin Luo, Bingrong Zheng and Wei Si
    Citation: Stem Cell Research & Therapy 2022 13:231
  26. Primary Sjögren’s syndrome (pSS) is a diffuse connective tissue disease characterized by the invasion of exocrine glands such as lacrimal and salivary glands, abnormal proliferation of T and B lymphocytes, and...

    Authors: Jingwen Zhao, Qi An, Xueqing Zhu, Baoqi Yang, Xinnan Gao, Yuhu Niu, Liyun Zhang, Ke Xu and Dan Ma
    Citation: Stem Cell Research & Therapy 2022 13:230
  27. A series of biochemical responses, including hypoxia and aseptic inflammation, occur in periodontal ligament cells (PDLCs) during periodontal tissue remodeling of orthodontic tooth movement (OTM). However, the...

    Authors: Chenxin Wang, Qiaolin Yang, Yineng Han, Hao Liu, Yue Wang, Yiping Huang, Yunfei Zheng and Weiran Li
    Citation: Stem Cell Research & Therapy 2022 13:229
  28. Corneal transplantation is the only way to treat serious corneal diseases caused by corneal endothelial dysfunction. However, the shortage of donor corneal tissues and human corneal endothelial cells (HCECs) r...

    Authors: Peng Sun, Lin Shen, Yuan-Bin Li, Li-Qun Du and Xin-Yi Wu
    Citation: Stem Cell Research & Therapy 2022 13:228
  29. Intervertebral disc degeneration (IVDD) can cause low back pain, a major public health concern. IVDD is characterized with loss of cells especially those in nucleus pulposus (NP), due to the limited proliferat...

    Authors: Meng Xu, Junlan Huang, Min Jin, Wanling Jiang, Fengtao Luo, Qiaoyan Tan, Ruobin Zhang, Xiaoqing Luo, Liang Kuang, Dali Zhang, Sen Liang, Huabing Qi, Hangang Chen, Zhenhong Ni, Nan Su, Jing Yang…
    Citation: Stem Cell Research & Therapy 2022 13:227
  30. Skeletal muscle mass and function losses in aging individuals are associated with quality of life deterioration and disability. Mesenchymal stromal cells exert immunomodulatory and anti-inflammatory effects an...

    Authors: Limei Piao, Zhe Huang, Aiko Inoue, Masafumi Kuzuya and Xian Wu Cheng
    Citation: Stem Cell Research & Therapy 2022 13:226
  31. Distinct subsets of cancer stem cells (CSCs) drive the initiation and progression of malignant tumors via enhanced self-renewal and development of treatment/apoptosis resistance. Endometrial CSC-selective drug...

    Authors: Tomoka Takao, Hirotaka Masuda, Takashi Kajitani, Fumie Miki, Kaoru Miyazaki, Yushi Yoshimasa, Satomi Katakura, Shoko Tomisato, Sayaka Uchida, Hiroshi Uchida, Mamoru Tanaka and Tetsuo Maruyama
    Citation: Stem Cell Research & Therapy 2022 13:225
  32. Liver fibrosis is an outcome of restoring process in chronic liver injury. Human amniotic mesenchymal stem cells (hAMSCs) derived from amniotic membrane have multilineage differentiation, immunosuppressive, an...

    Authors: Quan-Wen Liu, Yan-Min Ying, Jia-Xin Zhou, Wen-Jie Zhang, Zhao-xiao Liu, Bing-Bing Jia, Hao-Cheng Gu, Chu-Yu Zhao, Xiao-Hui Guan, Ke-Yu Deng and Hong-Bo Xin
    Citation: Stem Cell Research & Therapy 2022 13:224
  33. Human-induced pluripotent stem cells (hiPSCs) are considered an ideal resource for regenerative medicine because of their ease of access and infinite expansion ability. To satisfy the sizable requirement for c...

    Authors: Ying Hua, Kenji Yoshimochi, Junjun Li, Kazuhiro Takekita, Motoshi Shimotsuma, Lingjun Li, Xiang Qu, Jingbo Zhang, Yoshiki Sawa, Li Liu and Shigeru Miyagawa
    Citation: Stem Cell Research & Therapy 2022 13:223
  34. Osteoarthritis (OA) is an age-related joint disease characterized by progressive cartilage loss. Synovial mesenchymal stem cells (MSCs) are anticipated as a cell source for OA treatment; however, synovial MSC ...

    Authors: Yugo Miura, Kentaro Endo, Keiichiro Komori and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2022 13:222
  35. The therapeutic and protective effects of human umbilical cord mesenchymal stem cells-exosomes (hucMSC-Exs) on traumatic pancreatitis (TP) remain unknown. Here, we established a rat model of TP and evaluated a...

    Authors: Li Han, Zhirong Zhao, Xingyun Chen, Ke Yang, Zhen Tan, Zhu Huang, Lichen Zhou and Ruiwu Dai
    Citation: Stem Cell Research & Therapy 2022 13:221
  36. Existing clinical studies supported the potential efficacy of mesenchymal stromal cells as well as derived exosomes in the treatment of COVID-19. We aimed to explore the safety and efficiency of aerosol inhala...

    Authors: Ying-Gang Zhu, Meng-meng Shi, Antoine Monsel, Cheng-xiang Dai, Xuan Dong, Hong Shen, Su-ke Li, Jing Chang, Cui-li Xu, Ping Li, Jing Wang, Mei-ping Shen, Cheng-jie Ren, De-chang Chen and Jie-Ming Qu
    Citation: Stem Cell Research & Therapy 2022 13:220
  37. Organoids are three-dimensional structures that closely recapitulate tissue architecture and cellular composition, thereby holding great promise for organoid-based drug screening. Although growing in three-dim...

    Authors: Xiaomeng Li, Guoxiang Fu, Long Zhang, Ruoyu Guan, Peiyuan Tang, Jialing Zhang, Xinxin Rao, Shengzhi Chen, Xiaoya Xu, Yi Zhou, Yun Deng, Tao Lv, Xingfeng He, Shaobo Mo, Peiyuan Mu, Jianjun Gao…
    Citation: Stem Cell Research & Therapy 2022 13:219
  38. Human pluripotent stem cells (hPSCs) have great potential in applications for regenerative medicine and drug development. However, 3D suspension culture systems for clinical-grade hPSC large-scale production h...

    Authors: Haibin Wu, Xianglian Tang, Yiyu Wang, Ning Wang, Qicong Chen, Jinghe Xie, Shoupei Liu, Zhiyong Zhong, Yaqi Qiu, Ping Situ, Mark A. Zern, Jue Wang, Honglin Chen and Yuyou Duan
    Citation: Stem Cell Research & Therapy 2022 13:218
  39. Retinal pigment epithelium (RPE) degeneration is the hallmark of age-related macular degeneration (AMD). AMD, as one of the most common causes of irreversible visual impairment worldwide, remains in need of an...

    Authors: Samaneh Dehghan, Reza Mirshahi, Alireza Shoae-Hassani and Masood Naseripour
    Citation: Stem Cell Research & Therapy 2022 13:217
  40. Intestinal ischemia–reperfusion injury (IRI) causes localized and distant tissue lesions. Multiple organ failure is a common complication of severe intestinal IRI, leading to its high rates of morbidity and mo...

    Authors: Yajing Shi, Xiaolan Zhang, Zhanhai Wan, Xin Liu, Feng Chen, Jianmin Zhang and Yufang Leng
    Citation: Stem Cell Research & Therapy 2022 13:216
  41. Human adipose-derived stem cells (hADSCs) have been widely used for regenerative medicine because of their therapeutic efficacy and differentiation capacity. However, there are still limitations to use them in...

    Authors: Sang Ho Lee, Yu-Jin Kim, Yeong Hwan Kim, Han Young Kim and Suk Ho Bhang
    Citation: Stem Cell Research & Therapy 2022 13:215
  42. Mesenchymal stromal cells (MSCs) have opened a new window to treat inflammatory and non-inflammatory diseases. Nonetheless, their clinical applications require rigorous control and monitoring procedures to ens...

    Authors: Behnoosh Tayebi, Mahnaz Babaahmadi, Mohammad Pakzad, Mostafa Hajinasrollah, Farhad Mostafaei, Shahrbanoo Jahangiri, Amir Kamali, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad, Seyedeh-Nafiseh Hassani and Ensiyeh Hajizadeh-Saffar
    Citation: Stem Cell Research & Therapy 2022 13:213
  43. Endometrial carcinoma is the most common gynecological cancer in Europe. Musashi-1 is known to be a key regulator of endometrial cancer stem cells and a negative prognostic marker. In the present study, we aim...

    Authors: Isabel Falke, Fabian M. Troschel, Heike Palenta, Maria T. Löblein, Kathrin Brüggemann, Katrin Borrmann, Hans Theodor Eich, Martin Götte and Burkhard Greve
    Citation: Stem Cell Research & Therapy 2022 13:212
  44. Hair follicle stem cells (HFSC) play an essential role in the maintenance of hair homeostasis; during the hair cycle, HFSC remain quiescent for most of its duration. The hairpoor mouse (+ /HrHp), an animal model ...

    Authors: Keonwoo Choi, Sang-Hee Park, Seo-Yeon Park and Sungjoo Kim Yoon
    Citation: Stem Cell Research & Therapy 2022 13:211
  45. Etiopathogenesis of fluoroquinolone-associated disability (FQAD) syndrome is not fully understood, yet research could progress by utilizing induced pluripotent stem cells (iPSc) from people with this syndrome....

    Authors: Dagmara Grot, Katarzyna Wasiak, Jerzy Tyszkowski, Ewelina Stoczynska-Fidelus, Tomasz P. Ochedalski and Piotr Rieske
    Citation: Stem Cell Research & Therapy 2022 13:210
  46. The metabolic phenotype of stem cells is increasingly recognized as a hallmark of their pluripotency with mitochondrial and oxygen-related metabolism playing a not completely defined role in this context. In a...

    Authors: Rosella Scrima, Francesca Agriesti, Consiglia Pacelli, Claudia Piccoli, Pietro Pucci, Angela Amoresano, Olga Cela, Luigi Nappi, Tiziana Tataranni, Giorgio Mori, Pietro Formisano and Nazzareno Capitanio
    Citation: Stem Cell Research & Therapy 2022 13:209
  47. Mesenchymal stem cells (MSCs) therapy is showing potential therapeutic effects on liver function improvement in patients with chronic liver disease; however, the consensus on efficacy and safety of MSCs has no...

    Authors: Yuwei Liu, Yutong Dong, Xiaojing Wu, Xiaotong Xu and Junqi Niu
    Citation: Stem Cell Research & Therapy 2022 13:204

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