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  1. Bladder cancer (BLCA) is the fifth most common type of cancer worldwide, with high recurrence and progression rates. Although considerable progress has been made in the treatment of BLCA through accurate typin...

    Authors: Chaozhi Tang, Jiakang Ma, Xiuli Liu and Zhengchun Liu

    Citation: Stem Cell Research & Therapy 2020 11:457

    Content type: Research

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  2. Efficient osteogenic differentiation of mesenchymal stem cells (MSCs) is a critical step in the treatment of bone defects and skeletal disorders, which present challenges for cell-based therapy and regenerativ...

    Authors: Mahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini and Mohamadreza Baghaban Eslaminejad

    Citation: Stem Cell Research & Therapy 2020 11:456

    Content type: Review

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  3. Cervical cancer is the most prevalent gynecological malignancies accompanied by high mortality, where finding a more effective therapeutic option for cervical cancer is necessary. The inhibitory role of microR...

    Authors: Feng Ding, Jinhua Liu and Xiaofei Zhang

    Citation: Stem Cell Research & Therapy 2020 11:455

    Content type: Research

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  4. Human hair follicle mesenchymal stem cells (hHFMSCs) isolated from hair follicles possess multilineage differentiation potential. OCT4 is a gene critically associated with pluripotency properties. The cell mor...

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu

    Citation: Stem Cell Research & Therapy 2020 11:454

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:61

  5. Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both. Some of these rare diseases are caused by aberration...

    Authors: C. Eguizabal, L. Herrera, M. Inglés-Ferrándiz and J. C. Izpisua Belmonte

    Citation: Stem Cell Research & Therapy 2020 11:453

    Content type: Review

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  6. We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ...

    Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl

    Citation: Stem Cell Research & Therapy 2020 11:330

    Content type: Research

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  7. Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in the clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve w...

    Authors: Mengna Duan, Yan Zhang, Haiyang Zhang, Yupeng Meng, Ming Qian and Guokun Zhang

    Citation: Stem Cell Research & Therapy 2020 11:452

    Content type: Research

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  8. Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic ...

    Authors: Angelo Trivisonno, Dania Nachira, Ivo Boškoski, Venanzio Porziella, Giuliana Di Rocco, Silvia Baldari and Gabriele Toietta

    Citation: Stem Cell Research & Therapy 2020 11:451

    Content type: Review

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  9. Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor o...

    Authors: Defu Kong, Huiming Xu, Mo Chen, Yeping Yu, Yongbing Qian, Tian Qin, Ying Tong, Qiang Xia and Hualian Hang

    Citation: Stem Cell Research & Therapy 2020 11:449

    Content type: Research

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  10. Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene deli...

    Authors: Helena Meyer-Berg, Lucia Zhou Yang, María Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde and Deborah R. Gill

    Citation: Stem Cell Research & Therapy 2020 11:448

    Content type: Short report

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  11. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2020 11:446

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2018 9:340

  12. Osteonecrosis of femoral head (ONFH) is a seriously degenerative disease with no effective therapies to slow its progression. Several studies have reported short-term efficacy of stem cells on early-stage ONFH...

    Authors: Lianghao Mao, Pan Jiang, Xuan Lei, Chenlie Ni, Yiming Zhang, Bing Zhang, Qiping Zheng and Dapeng Li

    Citation: Stem Cell Research & Therapy 2020 11:445

    Content type: Review

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  13. Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but t...

    Authors: Fangcao Jin, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang, Xiaojun Liu, Bingjie Cai and Guangwen Yin

    Citation: Stem Cell Research & Therapy 2020 11:444

    Content type: Research

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Daphne Hingert, Karin Ekström, Jonathan Aldridge, Rossella Crescitelli and Helena Brisby

    Citation: Stem Cell Research & Therapy 2020 11:443

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:323

  15. Bone marrow mesenchymal stem cells (BMSCs) have been used as important cell-based tools for clinical applications. Oxidative stress-induced apoptosis causes a low survival rate after transplantation, and the u...

    Authors: Chongxi Fan, Jianyu Feng, Chi Tang, Zhengbin Zhang, Yingtong Feng, Weixun Duan, Mingming Zhai, Zedong Yan, Liwen Zhu, Lele Feng, Hanzhao Zhu and Erping Luo

    Citation: Stem Cell Research & Therapy 2020 11:442

    Content type: Research

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  16. Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays...

    Authors: Yang Li, Kangkang Zhi, Shilong Han, Xue Li, Maoquan Li, Weishuai Lian, Haijun Zhang and Xiaoping Zhang

    Citation: Stem Cell Research & Therapy 2020 11:441

    Content type: Research

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  17. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca2+-activated K+ (BKCa channels) ch...

    Authors: Ahui Song, Jingjing Wang, Yan Tong, Junyan Fang, Yi Zhang, Huiping Zhang, Hongqiang Ruan, Kai Wang and Yingli Liu

    Citation: Stem Cell Research & Therapy 2020 11:440

    Content type: Research

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  18. Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing ...

    Authors: Yue Zhang, Fanhong Zeng, Xu Han, Jun Weng and Yi Gao

    Citation: Stem Cell Research & Therapy 2020 11:438

    Content type: Review

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  19. The COVID-19 pandemic has negatively impacted the global public health and the international economy; therefore, there is an urgent need for an effective therapy to treat COVID-19 patients. Mesenchymal stem ce...

    Authors: Sara Al-Khawaga and Essam M. Abdelalim

    Citation: Stem Cell Research & Therapy 2020 11:437

    Content type: Review

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  20. Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation...

    Authors: Shahrbanoo Jahangir, David Eglin, Naomi Pötter, Mojtaba Khozaei Ravari, Martin J. Stoddart, Ali Samadikuchaksaraei, Mauro Alini, Mohammadreza Baghaban Eslaminejad and Majid Safa

    Citation: Stem Cell Research & Therapy 2020 11:436

    Content type: Research

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  21. The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate of transplanted BMSCs in woun...

    Authors: Ling Guo, Juan Du, Dan-feng Yuan, Ya Zhang, Shu Zhang, Hua-cai Zhang, Jun-wei Mi, Ya-lei Ning, Min-jia Chen, Da-lin Wen, Jian-hui Sun, Di Liu, Ling Zeng, Anqiang Zhang, Jianxin Jiang and Hong Huang

    Citation: Stem Cell Research & Therapy 2020 11:434

    Content type: Research

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  22. Current strategies for craniofacial defect are faced with unmet outcome. Combining 3D-printing with safe, noninvasive magnetic therapy could be a promising breakthrough.

    Authors: Chang Tu, Jingyuan Chen, Chunwei Huang, Yifan Xiao, Xiangyu Tang, Hao Li, Yongzhuang Ma, Jiyuan Yan, Weigang Li, Hua Wu and Chaoxu Liu

    Citation: Stem Cell Research & Therapy 2020 11:433

    Content type: Research

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  23. The autologous nerve graft, despite its donor site morbidity and unpredictable functional recovery, continues to be the gold standard in peripheral nerve repair. Rodent research studies have shown promising re...

    Authors: Silvia Palombella, Martino Guiotto, Gillian C. Higgins, Laurent L. Applegate, Wassim Raffoul, Mario Cherubino, Andrew Hart, Mathis O. Riehle and Pietro G. di Summa

    Citation: Stem Cell Research & Therapy 2020 11:432

    Content type: Research

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  24. Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide suffic...

    Authors: Shumei Zhao, Kui Duan, Zongyong Ai, Baohua Niu, Yanying Chen, Ruize Kong and Tianqing Li

    Citation: Stem Cell Research & Therapy 2020 11:431

    Content type: Research

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  25. Bronchioalveolar stem cells (BASCs) located at the bronchioalveolar-duct junction (BADJ) are stem cells residing in alveoli and terminal bronchioles that can self-renew and differentiate into alveolar type (AT...

    Authors: Naoya Kawakita, Hiroaki Toba, Keiko Miyoshi, Shinichi Sakamoto, Daisuke Matsumoto, Mika Takashima, Mariko Aoyama, Seiya Inoue, Masami Morimoto, Takeshi Nishino, Hiromitsu Takizawa and Akira Tangoku

    Citation: Stem Cell Research & Therapy 2020 11:430

    Content type: Research

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  26. Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate...

    Authors: Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda and Toshihiro Akisue

    Citation: Stem Cell Research & Therapy 2020 11:429

    Content type: Research

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  27. Stem cell transplantation has been proposed as an alternative treatment for intractable optic nerve disorders characterized by irrecoverable loss of cells. Mesenchymal stem cells, with varying tissue regenerat...

    Authors: Kyungmin Koh, Mira Park, Eun Soo Bae, Van-An Duong, Jong-Moon Park, Hookeun Lee and Helen Lew

    Citation: Stem Cell Research & Therapy 2020 11:428

    Content type: Research

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  28. Periodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive compa...

    Authors: Qiang Li, Guangwen Yang, Jialing Li, Meng Ding, Na Zhou, Heng Dong and Yongbin Mou

    Citation: Stem Cell Research & Therapy 2020 11:427

    Content type: Research

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  29. Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated quality controls must confirm this activity in the context of clinical trials. This study p...

    Authors: Tess Nicotra, Aurélie Desnos, Justine Halimi, Hélène Antonot, Loïc Reppel, Thomas Belmas, Alice Freton, Floriane Stranieri, Miryam Mebarki, Jérôme Larghero, Audrey Cras and Lionel Faivre

    Citation: Stem Cell Research & Therapy 2020 11:426

    Content type: Research

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  30. As a critical cellular component in the hepatic stem cell niche, hepatic stellate cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver regeneration, and fibrogenesis. Howev...

    Authors: Jian-Yun Ge, Yun-Wen Zheng, Tomonori Tsuchida, Kinji Furuya, Hiroko Isoda, Hideki Taniguchi, Nobuhiro Ohkohchi and Tatsuya Oda

    Citation: Stem Cell Research & Therapy 2020 11:425

    Content type: Research

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  31. Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted growing attention during the...

    Authors: Jiangmei Wang, Jie Xia, Ruoqiong Huang, Yaoqin Hu, Jiajie Fan, Qiang Shu and Jianguo Xu

    Citation: Stem Cell Research & Therapy 2020 11:424

    Content type: Review

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  32. Currently, numerous animal studies have shown that exposure to commonly used general anesthetics during pregnancy may cause neurocognitive impairment in the offspring. Reportedly, exposure to sevoflurane durin...

    Authors: Yi Zhang, Ziyi Wu, Xingyue Li, Yuxiao Wan, Yinong Zhang and Ping Zhao

    Citation: Stem Cell Research & Therapy 2020 11:423

    Content type: Research

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  33. Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Re...

    Authors: Mirae Lee, Seok-hyung Kim, Jong Hyun Jhee, Tae Yeon Kim, Hoon Young Choi, Hyung Jong Kim and Hyeong Cheon Park

    Citation: Stem Cell Research & Therapy 2020 11:422

    Content type: Research

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  34. Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes...

    Authors: Golara Nasiri, Negar Azarpira, Aliakbar Alizadeh, Sanaz Goshtasbi and Lobat Tayebi

    Citation: Stem Cell Research & Therapy 2020 11:421

    Content type: Review

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  35. Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs)...

    Authors: Guodong Song, Jia Zhou, Ruimei Song, Dalu Liu, Weidi Yu, Wangcheng Xie, Zhilong Ma, Jian Gong, Hongbo Meng, Tingsong Yang and Zhenshun Song

    Citation: Stem Cell Research & Therapy 2020 11:420

    Content type: Research

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  36. Stem cell therapy is becoming an emerging therapeutic option for chronic liver disease (CLD). However, whether stem cell therapy is more effective than conventional treatment remains questionable. We performed...

    Authors: Guang-Peng Zhou, Yi-Zhou Jiang, Li-Ying Sun and Zhi-Jun Zhu

    Citation: Stem Cell Research & Therapy 2020 11:419

    Content type: Research

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  37. Immune system disorders play important roles in acute lung injury (ALI), and mesenchymal stem cell (MSC) treatment can reduce inflammation during ALI. In this study, we compared the changes in lung B cells dur...

    Authors: Bing Feng, Jiaqi Zhu, Yanping Xu, Wenyi Chen, Xinyu Sheng, Xudong Feng, Xiaowei Shi, Jingqi Liu, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao

    Citation: Stem Cell Research & Therapy 2020 11:418

    Content type: Research

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  38. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show tremendous promise for cardiac regeneration, but the successful development of hESC-CM-based therapies requires improved tools to investigate th...

    Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnuolo, José David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. Laflamme

    Citation: Stem Cell Research & Therapy 2020 11:417

    Content type: Research

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  39. Mesenchymal stem cells (MSCs) have been recognized for their regenerative and anti-inflammatory capacity which makes them very attractive to cell therapy, especially those ones to treat inflammatory and autoim...

    Authors: Mónica Kurte, Ana María Vega-Letter, Patricia Luz-Crawford, Farida Djouad, Danièle Noël, Maroun Khoury and Flavio Carrión

    Citation: Stem Cell Research & Therapy 2020 11:416

    Content type: Research

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  40. Millions suffer from skin diseases. Functional interfollicular epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional interfollicular epidermal stem cells with intac...

    Authors: Ling Leng, Jie Ma, Luye Lv, Wenjuan Wang, Dunqin Gao, Yunping Zhu and Zhihong Wu

    Citation: Stem Cell Research & Therapy 2020 11:415

    Content type: Short report

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  41. The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models of premature infant diseases. Micromolecule peptides have shown promise for the treatment of premature i...

    Authors: Yu Wang, Lin Zhang, Yun Wu, Rongping Zhu, Yan Wang, Yan Cao, Wei Long, Chenbo Ji, Huaiyan Wang and Lianghui You

    Citation: Stem Cell Research & Therapy 2020 11:414

    Content type: Research

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  42. Ischaemic stroke has become the main cause of death and severe neurological disorders, for which effective restorative treatments are currently limited. While stem cell transplantation offers therapeutic poten...

    Authors: Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang and Jin Fu

    Citation: Stem Cell Research & Therapy 2020 11:413

    Content type: Research

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  43. Acute kidney injury (AKI) is a common clinical disease with complex pathophysiology and limited therapeutic choices. This prompts the need for novel therapy targeting multiple aspects of this disease. Human am...

    Authors: Yifei Ren, Ying Chen, Xizi Zheng, Hui Wang, Xin Kang, Jiawei Tang, Lei Qu, Xiaoyan Shao, Suxia Wang, Shuangling Li, Gang Liu and Li Yang

    Citation: Stem Cell Research & Therapy 2020 11:410

    Content type: Research

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  44. Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists dependin...

    Authors: Kelly Mulfaul, Joseph C. Giacalone, Andrew P. Voigt, Megan J. Riker, Dalyz Ochoa, Ian C. Han, Edwin M. Stone, Robert F. Mullins and Budd A. Tucker

    Citation: Stem Cell Research & Therapy 2020 11:409

    Content type: Method

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  45. This study is designed to generate and propagate human spermatogonial stem cells (SSCs) derived from human pluripotent stem cells (hPSCs).

    Authors: Huiming Xu, Mengbo Yang, Ruhui Tian, Yonghui Wang, Linhong Liu, Zijue Zhu, Shi Yang, Qingqing Yuan, Minghui Niu, Chencheng Yao, Erlei Zhi, Peng Li, Chenhao Zhou, Zuping He, Zheng Li and Wei-Qiang Gao

    Citation: Stem Cell Research & Therapy 2020 11:408

    Content type: Research

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  46. Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement for the expansion of mesenchymal stromal cells (MSCs) for bone tissue engineering (BTE) applications. Due to a growing demand, the ...

    Authors: Siddharth Shanbhag, Samih Mohamed-Ahmed, Turid Helen Felli Lunde, Salwa Suliman, Anne Isine Bolstad, Tor Hervig and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2020 11:351

    Content type: Research

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