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  1. Repair of large bone defects remains a significant clinical challenge. Bone marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived mesenchymal stem cells, show therapeutic potential fo...

    Authors: Meadhbh Á Brennan, Audrey Renaud, Jérôme Amiaud, Markus T Rojewski, Hubert Schrezenmeier, Dominique Heymann, Valerie Trichet and Pierre Layrolle

    Citation: Stem Cell Research & Therapy 2014 5:114

    Content type: Research

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  2. Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cel...

    Authors: Angela Fülbier, Reinhild Schnabel, Stefanie Michael, Peter M Vogt, Sarah Strauß, Kerstin Reimers and Christine Radtke

    Citation: Stem Cell Research & Therapy 2014 5:113

    Content type: Research

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  3. Mesenchymal stem cells have been increasingly used for cell-based therapies. Adipose-derived stem/stromal cells (ASCs) from the stromal vascular fraction (SVF) of fat tissue are a particularly attractive optio...

    Authors: Hetal D Marble, Bryan A Sutermaster, Manisha Kanthilal, Vera C Fonseca and Eric M Darling

    Citation: Stem Cell Research & Therapy 2014 5:145

    Content type: Research

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  4. Mesenchymal stem cells (MSCs) have the ability to differentiate into osteoblasts, chondroblasts, adipocytes, and even myoblasts. Most studies have focused on finding MSCs in different parts of the body for med...

    Authors: Eduardo Branco de Sousa, Priscila Ladeira Casado, Vivaldo Moura Neto, Maria Eugenia Leite Duarte and Diego Pinheiro Aguiar

    Citation: Stem Cell Research & Therapy 2014 5:112

    Content type: Review

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  5. Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative...

    Authors: Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger

    Citation: Stem Cell Research & Therapy 2014 5:100

    Content type: Research

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  6. Poor cell survival and limited functional benefits have restricted the efficacy of bone marrow mesenchymal stem cells (BMSCs) in the treatment of myocardial infarction. We showed recently that hypoxia precondi...

    Authors: Xian-Bao Liu, Jian-An Wang, Xiao-Ya Ji, Shan Ping Yu and Ling Wei

    Citation: Stem Cell Research & Therapy 2014 5:111

    Content type: Research

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  7. Myocardial infarction is accompanied by a significant loss of cardiomyocytes (CMs). Functional CMs, differentiated from human embryonic stem cells (hESCs), offer a potentially unlimited cell source for cardiac...

    Authors: Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jian Li, William R Birch, Shaul Reuveny and Steve Kah-Weng Oh

    Citation: Stem Cell Research & Therapy 2014 5:110

    Content type: Research

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  8. Systemic administration of mesenchymal stem (stromal) cells (MSCs) has shown benefit in a range of experimental models of acute kidney injury, although the reported mechanisms of action and requirement for MSC...

    Authors: Michelle M Duffy and Matthew D Griffin

    Citation: Stem Cell Research & Therapy 2014 5:109

    Content type: Commentary

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  9. Asthma is characterized by a chronic inflammatory process which may lead to several changes in bone marrow cell composition. We hypothesized that bone marrow mononuclear cells (BMMCs) obtained from ovalbumin (...

    Authors: Soraia C Abreu, Mariana A Antunes, Lucas Mendonça, Vivian C Branco, Elga Bandeira de Melo, Priscilla C Olsen, Bruno L Diaz, Daniel J Weiss, Bruno D Paredes, Debora G Xisto, Marcelo M Morales and Patricia RM Rocco

    Citation: Stem Cell Research & Therapy 2014 5:108

    Content type: Research

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  10. Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lun...

    Authors: Courtney A McDonald, Jacqueline M Melville, Graeme R Polglase, Graham Jenkin and Timothy JM Moss

    Citation: Stem Cell Research & Therapy 2014 5:107

    Content type: Research

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  11. Despite numerous research efforts, mechanisms underlying regeneration of pancreas remains controversial. Views are divided whether stem cells are involved during pancreatic regeneration or it involves duplicat...

    Authors: Deepa Bhartiya, Akash Mundekar, Vaibhav Mahale and Hiren Patel

    Citation: Stem Cell Research & Therapy 2014 5:106

    Content type: Research

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  12. Osteoporosis is a disease characterized by low bone mineral density (BMD) and increased risk of fractures. Studies have demonstrated the use of phytoestrogens, or plant-derived estrogens, such as genistein and...

    Authors: Amy L Strong, Jason F Ohlstein, Quan Jiang, Qiang Zhang, Shilong Zheng, Stephen M Boue, Steven Elliott, Jeffrey M Gimble, Matthew E Burow, Guangdi Wang and Bruce A Bunnell

    Citation: Stem Cell Research & Therapy 2014 5:105

    Content type: Research

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  13. Mesenchymal stem cells (MSCs) have the ability to repair and regenerate tissue, home to sites of inflammation, and evade the host immune system. As such, they represent an attractive therapy for the treatment ...

    Authors: Catherine B Sullivan, Ryan M Porter, Chris H Evans, Thomas Ritter, Georgina Shaw, Frank Barry and Josephine Mary Murphy

    Citation: Stem Cell Research & Therapy 2014 5:104

    Content type: Research

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  14. The transplantation of genetically modified progenitor cells such as bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the natural healing of articular cartilage defects. I...

    Authors: Janina Frisch, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Henning Madry and Magali Cucchiarini

    Citation: Stem Cell Research & Therapy 2014 5:103

    Content type: Research

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  15. The objective of this work was to evaluate the efficacy of placenta-derived mesenchymal stem cell (MSC) therapy in a mouse model of myocardial infarction (MI). Since MSCs can be obtained from two different reg...

    Authors: Juliana A Passipieri, Tais H Kasai-Brunswick, Grazielle Suhett, Andreza B Martins, Guilherme V Brasil, Dilza B Campos, Nazareth N Rocha, Isalira P Ramos, Debora B Mello, Deivid C Rodrigues, Beatriz B Christie, Bernardo J Silva-Mendes, Alex Balduíno, Renato M Sá, Laudelino M Lopes, Regina C Goldenberg…

    Citation: Stem Cell Research & Therapy 2014 5:102

    Content type: Research

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  16. Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection o...

    Authors: Li Xing, Rui Cui, Lei Peng, Jing Ma, Xiao Chen, Ru-Juan Xie and Bing Li

    Citation: Stem Cell Research & Therapy 2014 5:101

    Content type: Research

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  17. Mesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs ...

    Authors: Paul Lohan, Cynthia M Coleman, J Mary Murphy, Matthew D Griffin, Thomas Ritter and Aideen E Ryan

    Citation: Stem Cell Research & Therapy 2014 5:99

    Content type: Review

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  18. It has long been established that germline stem cells (GSCs) are responsible for lifelong gametogenesis in males, and some female invertebrates (for example, Drosophila) and lower vertebrates (for example, teleos...

    Authors: Cheryl E Dunlop, Evelyn E Telfer and Richard A Anderson

    Citation: Stem Cell Research & Therapy 2014 5:98

    Content type: Review

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  19. Our previous works demonstrated that systemic orbital fat-derived stem cell (OFSC) transplantation was effective in ameliorating lipopolysaccharide (LPS)-induced extensive acute lung injury (ALI) in vivo mainly t...

    Authors: Gi-Shih Lien, Jen-Fang Liu, Ming-Hsien Chien, Wei-Tse Hsu, Tzu-Hao Chang, Chia-Chi Ku, Andrea Tung-Qian Ji, Peng Tan, Ting-Lieh Hsieh, Liang-Ming Lee and Jennifer H Ho

    Citation: Stem Cell Research & Therapy 2014 5:97

    Content type: Research

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  20. Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation of these ce...

    Authors: Benjamin A Kansy, Philip A Dißmann, Hatim Hemeda, Kirsten Bruderek, Anna M Westerkamp, Vivien Jagalski, Patrick Schuler, Katinka Kansy, Stephan Lang, Claudia A Dumitru and Sven Brandau

    Citation: Stem Cell Research & Therapy 2014 5:95

    Content type: Research

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  21. Autologous mesenchymal stem cell (MSC) injection into naturally-occurring equine tendon injuries has been shown to be safe and efficacious and protocols inform translation of the technique into humans. Efficie...

    Authors: Elaine R Garvican, Sandra Cree, Lydia Bull, Roger KW Smith and Jayesh Dudhia

    Citation: Stem Cell Research & Therapy 2014 5:1

    Content type: Research

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    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:161

  22. The optimal cell lineage for cardiac-regeneration approaches remains mysterious. Additionally, electrical stimulation promotes cardiomyogenic differentiation of stimulated cells. Therefore, we hypothesized tha...

    Authors: Aida Llucià-Valldeperas, Benjamin Sanchez, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Javier Rosell-Ferrer, Ramon Bragos and Antoni Bayes-Genis

    Citation: Stem Cell Research & Therapy 2014 5:93

    Content type: Short Report

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  23. Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal...

    Authors: Xiaoming Wang, Hui Zhang, Liangming Nie, Linhai Xu, Min Chen and Zhaoping Ding

    Citation: Stem Cell Research & Therapy 2014 5:92

    Content type: Research

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  24. The loss of neurons and degeneration of axons after spinal cord injury result in the loss of sensory and motor functions. A bridging biomaterial construct that allows the axons to grow through has been investi...

    Authors: Bikesh Shrestha, Katherine Coykendall, Yongchao Li, Alex Moon, Priyanka Priyadarshani and Li Yao

    Citation: Stem Cell Research & Therapy 2014 5:91

    Content type: Review

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  25. Autologous mesenchymal stem cells (MSCs) are an attractive concept in regenerative medicine, but their mechanism of action remains poorly defined. No immune response is reported after in vivo injection of allogen...

    Authors: Yasmin Z Paterson, Nicola Rash, Elaine R Garvican, Romain Paillot and Deborah J Guest

    Citation: Stem Cell Research & Therapy 2014 5:90

    Content type: Research

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  26. MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, diff...

    Authors: Manoj K Gupta and Tata Nageswara Rao

    Citation: Stem Cell Research & Therapy 2014 5:89

    Content type: Commentary

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  27. Mesenchymal stromal/stem cells (MSCs) for clinical use have largely been isolated from the bone marrow, although isolation of these cells from many different adult and fetal tissues has been reported as well. ...

    Authors: Priyanka Swamynathan, Parvathy Venugopal, Suresh Kannan, Charan Thej, Udaykumar Kolkundar, Swaroop Bhagwat, Malancha Ta, Anish Sen Majumdar and Sudha Balasubramanian

    Citation: Stem Cell Research & Therapy 2014 5:88

    Content type: Research

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  28. Motor neurons are cells located in specific areas of the central nervous system, such as brain cortex (upper motor neurons), brain stem, and spinal cord (lower motor neurons), which maintain control over volun...

    Authors: Irene Faravelli, Monica Bucchia, Paola Rinchetti, Monica Nizzardo, Chiara Simone, Emanuele Frattini and Stefania Corti

    Citation: Stem Cell Research & Therapy 2014 5:87

    Content type: Review

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  29. Rapid progress in biotechnology has introduced a host of pressing ethical and policy issues pertaining to stem cell research. In this review, we provide an overview of the most significant issues with which th...

    Authors: Nancy MP King and Jacob Perrin

    Citation: Stem Cell Research & Therapy 2014 5:85

    Content type: Review

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  30. Chronic renal failure is an important clinical problem with significant socioeconomic impact worldwide. Despite advances in renal replacement therapies and organ transplantation, poor quality of life for dialy...

    Authors: Alfonso Eirin and Lilach O Lerman

    Citation: Stem Cell Research & Therapy 2014 5:83

    Content type: Review

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  31. New therapeutic options are necessary for patients with chronic Chagas disease, a leading cause of heart failure in Latin American countries. Stem cell therapy focused on improving cardiac function is a promis...

    Authors: Daniela Nascimento Silva, Bruno Solano de Freitas Souza, Carine Machado Azevedo, Juliana Fraga Vasconcelos, Rejane Hughes Carvalho, Milena Botelho Pereira Soares and Ricardo Ribeiro dos Santos

    Citation: Stem Cell Research & Therapy 2014 5:81

    Content type: Research

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  32. The mortality of rhabdomyolysis-induced acute kidney injury (AKI) is still high, as there is no effective therapy. It has been shown that bone marrow-derived mesenchymal stem cells (MSCs) can induce M2 macroph...

    Authors: Yanqiu Geng, Li Zhang, Bo Fu, Jianrong Zhang, Quan Hong, Jie Hu, Diangeng Li, Congjuan Luo, Shaoyuan Cui, Fei Zhu and Xiangmei Chen

    Citation: Stem Cell Research & Therapy 2014 5:80

    Content type: Research

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  33. Pathophysiologic changes associated with diabetes impair new blood vessel formation and wound healing. Mesenchymal stem cells derived from adipose tissue (ASCs) have been used clinically to promote healing, al...

    Authors: Robert C Rennert, Michael Sorkin, Michael Januszyk, Dominik Duscher, Revanth Kosaraju, Michael T Chung, James Lennon, Anika Radiya-Dixit, Shubha Raghvendra, Zeshaan N Maan, Michael S Hu, Jayakumar Rajadas, Melanie Rodrigues and Geoffrey C Gurtner

    Citation: Stem Cell Research & Therapy 2014 5:79

    Content type: Research

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  34. The optimization of an organic scaffold for specific types of applications and cells is vital to successful tissue engineering. In this study, we investigated the effects of a new fibrin sealant derived from s...

    Authors: Vinícius P O Gasparotto, Fernanda C Landim-Alvarenga, Alexandre L R Oliveira, Gustavo Ferreira Simões, João F Lima-Neto, Benedito Barraviera and Rui S Ferreira Jr

    Citation: Stem Cell Research & Therapy 2014 5:78

    Content type: Research

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  35. In the present study, we established a novel in vitro coculture model to evaluate the influence of osteoarthritis (OA) cartilage explants on the composition of newly produced matrix and chondrogenic differentiati...

    Authors: Michaela Leyh, Andreas Seitz, Lutz Dürselen, Hans-Robert Springorum, Peter Angele, Anita Ignatius, Joachim Grifka and Susanne Grässel

    Citation: Stem Cell Research & Therapy 2014 5:77

    Content type: Research

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  36. Mesenchymal stem cell-conditioned medium (MSC-CM) has been shown to have protective effects against various cellular-injury models. This mechanism of protection, however, has yet to be elucidated. Recently, ex...

    Authors: Cheau Yih Tan, Ruenn Chai Lai, Winnie Wong, Yock Young Dan, Sai-Kiang Lim and Han Kiat Ho

    Citation: Stem Cell Research & Therapy 2014 5:76

    Content type: Research

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  37. Posttranscriptional control of mRNA by microRNA (miRNA) has been implicated in the regulation of diverse biologic processes from directed differentiation of stem cells through organism development. We describe...

    Authors: Vilas Wagh, Alexander Pomorski, Karlijn J Wilschut, Sebastian Piombo and Harold S Bernstein

    Citation: Stem Cell Research & Therapy 2014 5:75

    Content type: Research

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  38. Mesenchymal stem cells (MSCs) reside in a variety of tissues and provide a stromal role in regulating progenitor cell function. Current studies focus on identifying the specific factors in the niche that can a...

    Authors: Michael De Lisio, Tor Jensen, Richard A Sukiennik, Heather D Huntsman and Marni D Boppart

    Citation: Stem Cell Research & Therapy 2014 5:74

    Content type: Research

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  39. Insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs) and angiopoietin-like proteins (ANGPTLs) can enhance the ex vivo expansion of hematopoietic stem cells (HSCs) when used with a standard cytokine c...

    Authors: Xiubo Fan, Florence PH Gay, Francesca WI Lim, Justina ML Ang, Pat PY Chu, Sudipto Bari and William YK Hwang

    Citation: Stem Cell Research & Therapy 2014 5:71

    Content type: Research

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  40. We have assessed the utility of autologous mesenchymal stem cell (MSC) peripheral vein infusion as a possible therapeutic modality for patients with end-stage liver diseases.

    Authors: Hosny Salama, Abdel-Rahman N Zekri, Eman Medhat, Shereen A Al Alim, Ola S Ahmed, Abeer A Bahnassy, Mai M Lotfy, Rasha Ahmed and Sherief Musa

    Citation: Stem Cell Research & Therapy 2014 5:70

    Content type: Research

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  41. Engineered bladder tissues, created with autologous bladder cells seeded on biodegradable scaffolds, are being developed for use in patients who need cystoplasty. However, in individuals with organ damage from...

    Authors: Danian Qin, Ting Long, Junhong Deng and Yuanyuan Zhang

    Citation: Stem Cell Research & Therapy 2014 5:69

    Content type: Review

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  42. Male infertility management has made significant progress during the past three decades, especially after the introduction of intracytoplasmic sperm injection in 1992. However, many boys and men still suffer f...

    Authors: Hooman Sadri-Ardekani and Anthony Atala

    Citation: Stem Cell Research & Therapy 2014 5:68

    Content type: Review

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  43. Periodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis is still unknown. We hypothesized that bacterial components can affect the functions of stem cells...

    Authors: Chenghua Li, Bei Li, Zhiwei Dong, Li Gao, Xiaoning He, Li Liao, Chenghu Hu, Qintao Wang and Yan Jin

    Citation: Stem Cell Research & Therapy 2014 5:67

    Content type: Research

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  44. Bone marrow mesenchymal stem cells (BMSCs) possess low immunogenicity and immunosuppression as an allograft, can differentiate into insulin-producing cells (IPCs) by in vitro induction, and may be a valuable cell...

    Authors: Yihua Zhang and Zhongying Dou

    Citation: Stem Cell Research & Therapy 2014 5:66

    Content type: Research

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