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  1. The ability to self-renew, be easily expanded in vitro and differentiate into different mesenchymal tissues, render mesenchymal stem cells (MSCs) an attractive therapeutic method for degenerative diseases. The su...

    Authors: Andreia Ribeiro, Paula Laranjeira, Sandrine Mendes, Isabel Velada, Cristiana Leite, Pedro Andrade, Francisco Santos, Ana Henriques, Mário Grãos, Carla M P Cardoso, António Martinho, M Luísa Pais, Cláudia Lobato da Silva, Joaquim Cabral, Hélder Trindade and Artur Paiva

    Citation: Stem Cell Research & Therapy 2013 4:125

    Content type: Research

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  2. Ovarian dysfunction frequently occurs in female cancer patients after chemotherapy, but human amniotic epithelial cells (hAECs) that can differentiate into cell types that arise from all three germ layers may ...

    Authors: Fangyuan Wang, Li Wang, Xiaofen Yao, Dongmei Lai and Lihe Guo

    Citation: Stem Cell Research & Therapy 2013 4:124

    Content type: Research

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  3. Administration of bone marrow-derived cells produces beneficial effects in experimental extrapulmonary acute respiratory distress syndrome (ARDS). However, there are controversies regarding the effects of timi...

    Authors: Tatiana Maron-Gutierrez, Johnatas Dutra Silva, Fernanda Ferreira Cruz, Samantha Alegria, Debora Gonçalves Xisto, Edson Fernandes Assis, Hugo Caire Castro-Faria-Neto, Claudia Chimisso Dos Santos, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco

    Citation: Stem Cell Research & Therapy 2013 4:123

    Content type: Research

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  4. On 23 May 2013, the Italian health minister decided to endorse a law regarding controversial stem cell-based therapies in 32 young terminally ill patients, shocking many scientists. According to the internatio...

    Authors: Paola Frati, Giacomo Frati, Matteo Gulino, Gianluca Montanari Vergallo, Alessandro Di Luca and Vittorio Fineschi

    Citation: Stem Cell Research & Therapy 2013 4:122

    Content type: Review

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  5. Tissue factor (TF) is expressed in various types of cells. TF expression is essential for many biological processes, such as blood coagulation and embryonic development, while its high expression in stem cells...

    Authors: Yan-Hui Yu, Deng-Shu Wu, Fang-Fang Huang, Zheng Zhang, Lin-Xin Liu, Jian Zhang, Hui-En Zhan, Min-Yuan Peng, Hui Zeng and Fang-Ping Chen

    Citation: Stem Cell Research & Therapy 2013 4:121

    Content type: Research

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  6. Cell supplementation to the herniated or degenerated intervertebral disc (IVD) is a potential strategy to promote tissue regeneration and slow disc pathology. Human umbilical cord mesenchymal stromal cells (HU...

    Authors: Brian H Chon, Esther J Lee, Liufang Jing, Lori A Setton and Jun Chen

    Citation: Stem Cell Research & Therapy 2013 4:120

    Content type: Research

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  7. The standard procedure for the osteogenic differentiation of multipotent stem cells is treatment of a confluent monolayer with a cocktail of dexamethasone (Dex), ascorbic acid (Asc) and β-glycerophosphate (β-G...

    Authors: Fabian Langenbach and Jörg Handschel

    Citation: Stem Cell Research & Therapy 2013 4:117

    Content type: Review

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  8. Rat middle cerebral artery occlusion (MCAO) model is the most commonly used animal model in ischemic stroke studies. In the model, to increase the amount of stem cells or drugs to enter the brain after deliver...

    Authors: Ling Guo, Jianfeng Ge, Shan Wang, Ying Zhou, Xiaoxiao Wang and Yaojiong Wu

    Citation: Stem Cell Research & Therapy 2013 4:116

    Content type: Research

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  9. Studying cancer tumors’ microenvironment may reveal a novel role in driving cancer progression and metastasis. The biological interaction between stromal (mesenchymal) stem cells (MSCs) and cancer cells remain...

    Authors: Mashael Al-toub, Abdulaziz Almusa, Mohammed Almajed, May Al-Nbaheen, Moustapha Kassem, Abdullah Aldahmash and Nehad M Alajez

    Citation: Stem Cell Research & Therapy 2013 4:114

    Content type: Research

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  10. Treatment of chronic skin wounds is difficult and largely ineffective. Little improvement has been shown in promoting the healing of these wounds in the past few decades. Innovative treatments to enhance chron...

    Authors: Yunling Li, Lei Zheng, Xia Xu, Lili Song, Yin Li, Wei Li, Suhan Zhang, Feng Zhang and Haiyan Jin

    Citation: Stem Cell Research & Therapy 2013 4:113

    Content type: Research

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  11. Knowing the repertoire of cell signaling receptors would provide pivotal insight into the developmental and regenerative capabilities of bone marrow cell (BMC)-derived hematopoietic stem/progenitor cells (HSPC...

    Authors: Khairul Anam and Thomas A Davis

    Citation: Stem Cell Research & Therapy 2013 4:112

    Content type: Research

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  12. Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue ...

    Authors: Ikiru Atsuta, Shiyu Liu, Yasuo Miura, Kentaro Akiyama, Chider Chen, Ying An, Songtao Shi and Fa-Ming Chen

    Citation: Stem Cell Research & Therapy 2013 4:111

    Content type: Research

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  13. MicroRNA-21 (miR-21) functions have been linked to cancer progression and chemo- or radiotherapy resistance. While an increasing number of studies have reported a potential role of miR-21 expression in promoti...

    Authors: Hong-Yo Kang

    Citation: Stem Cell Research & Therapy 2013 4:110

    Content type: Commentary

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  14. Microspheres fabricated from natural materials serve as a promising biodegradable and biocompatible carrier in a small volume for efficient cell delivery to the lesion of the injured neural tissue to generate ...

    Authors: Li Yao, Francis Phan and Yongchao Li

    Citation: Stem Cell Research & Therapy 2013 4:109

    Content type: Research

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  15. Bones adapt to accommodate the physical forces they experience through changes in architecture and mass. Stem cells differentiate into bone-forming osteoblasts, and mechanical stimulation is involved in this p...

    Authors: Julia C Chen and Christopher R Jacobs

    Citation: Stem Cell Research & Therapy 2013 4:107

    Content type: Review

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  16. Advances in the fields of stem cell biology, biomaterials, and tissue engineering over the last decades have brought the possibility of constructing tissue substitutes with a broad range of applications in reg...

    Authors: Giuseppe Maria de Peppo and Darja Marolt

    Citation: Stem Cell Research & Therapy 2013 4:106

    Content type: Review

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  17. To stimulate healing of large bone defects research has concentrated on the application of mesenchymal stem cells (MSCs).

    Authors: Johannes C Reichert, Jonas Schmalzl, Patrick Prager, Fabian Gilbert, Verena MC Quent, Andre F Steinert, Maximilian Rudert and Ulrich Nöth

    Citation: Stem Cell Research & Therapy 2013 4:105

    Content type: Research

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  18. Potential stem cell niches (SNs) were recently reported in intervertebral discs (IVDs) and knee joints (KJs) in different mammals (located adjacent to the epiphyseal plate; EP). The aim here was to examine fur...

    Authors: Helena Barreto Henriksson, Anders Lindahl, Eva Skioldebrand, Katarina Junevik, Carolina Tängemo, Johan Mattsson and Helena Brisby

    Citation: Stem Cell Research & Therapy 2013 4:104

    Content type: Research

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  19. The apoptosis and subsequent injury of podocytes plays a pathogenic role in diabetic nephropathy (DN). Mesenchymal stem cells (MSCs) are promising therapeutic cells for preventing apoptosis and reducing cellul...

    Authors: Diangeng Li, Nan Wang, Li Zhang, Zhu Hanyu, Bai Xueyuan, Bo Fu, Cui Shaoyuan, Weiguang Zhang, Sun Xuefeng, Rongshan Li and Xiangmei Chen

    Citation: Stem Cell Research & Therapy 2013 4:103

    Content type: Research

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  20. Human neural stem cell transplants have potential as therapeutic candidates to treat a vast number of disorders of the central nervous system (CNS). StemCells, Inc. has purified human neural stem cells and dev...

    Authors: Ann Tsukamoto, Nobuko Uchida, Alexandra Capela, Thorsten Gorba and Stephen Huhn

    Citation: Stem Cell Research & Therapy 2013 4:102

    Content type: Review

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  21. Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in d...

    Authors: Nathalie De Vocht, Jelle Praet, Kristien Reekmans, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Zwi Berneman, Annemie Van der Linden and Peter Ponsaerts

    Citation: Stem Cell Research & Therapy 2013 4:101

    Content type: Review

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  22. Twenty years ago glial cells were shown to contribute to neuronal information processing, instead of merely supporting neuronal function, thus challenging the century old neuron doctrine. Due to the lack of ap...

    Authors: Sonia Spitzer, Sylvia Agathou and Ragnhildur Thora Karadottir

    Citation: Stem Cell Research & Therapy 2013 4:100

    Content type: Commentary

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  23. Guided migration of chondrogenically differentiated cells has not been well studied, even though it may be critical for growth, repair, and regenerative processes. The chemokine CCL25 is believed to play a cri...

    Authors: Mujib Ullah, Jan Eucker, Michael Sittinger and Jochen Ringe

    Citation: Stem Cell Research & Therapy 2013 4:99

    Content type: Research

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  24. Heart diseases remain a major cause of mortality and morbidity worldwide. However, terminally differentiated human adult cardiomyocytes (CMs) possess a very limited innate ability to regenerate. Directed diffe...

    Authors: Maggie Zi Chow, Kenneth R Boheler and Ronald A Li

    Citation: Stem Cell Research & Therapy 2013 4:97

    Content type: Review

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  25. Vascularization remains one of the primary obstacles in the repair of bone defects. In the previous issue of Stem Cell Research & Therapy, Pedersen and colleagues show that co-immobilization of endothelial cells ...

    Authors: Meadhbh Aín Brennan, Jean-Michel Davaine and Pierre Layrolle

    Citation: Stem Cell Research & Therapy 2013 4:96

    Content type: Commentary

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  26. Retinal Müller cells exhibit the characteristics of retinal progenitor cells, and differentiate into ganglion cells under certain conditions. However, the number of ganglion cells differentiated from retinal M...

    Authors: Wei-tao Song, Xue-yong Zhang and Xiao-bo Xia

    Citation: Stem Cell Research & Therapy 2013 4:94

    Content type: Research

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  27. Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous hea...

    Authors: Danielle Drury-Stewart, Mingke Song, Osama Mohamad, Ying Guo, Xiaohuan Gu, Dongdong Chen and Ling Wei

    Citation: Stem Cell Research & Therapy 2013 4:93

    Content type: Research

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  28. Multipotent mesenchymal stromal cells (MSCs) have gained considerable interest because of their potential use in the treatment of a variety of diseases and injuries. Although remarkable advancements have been ...

    Authors: Carolina Soares Barros Melo, Jerusa Araújo Quintão Arantes Faria, Natássia Caroline Resende Corrêa, Carolina de Andrade, Juliana Lott Carvalho, Alfredo M Goes, Michele A Rodrigues and Dawidson Assis Gomes

    Citation: Stem Cell Research & Therapy 2013 4:92

    Content type: Research

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  29. Adipose-derived stem cells (ADSCs) have been isolated, expanded, and applied in the treatment of many diseases. ADSCs have also been used to treat injured articular cartilage. However, there is controversy reg...

    Authors: Phuc Van Pham, Khanh Hong-Thien Bui, Dat Quoc Ngo, Ngoc Bich Vu, Nhung Hai Truong, Nhan Lu-Chinh Phan, Dung Minh Le, Triet Dinh Duong, Thanh Duc Nguyen, Vien Tuong Le and Ngoc Kim Phan

    Citation: Stem Cell Research & Therapy 2013 4:91

    Content type: Research

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  30. Experimental evidence has indicated a role of adult renal progenitor cells in kidney regeneration and a protective role of the kidney by erythropoietin (EPO) and suramin in animal models and in humans after ac...

    Authors: Pei-Rong Wang

    Citation: Stem Cell Research & Therapy 2013 4:89

    Content type: Commentary

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  31. Resistance of cancer stem/progenitor cells (CSPCs) to chemotherapy can lead to cancer relapse. Ovarian teratocarcinoma (OVTC) arises from germ cells and comprises pluripotent cells that can be used to study ca...

    Authors: Wei-Min Chung, Wei-Chun Chang, Lumin Chen, Ying-Yi Chang, Chih-Rong Shyr, Yao-Ching Hung and Wen-Lung Ma

    Citation: Stem Cell Research & Therapy 2013 4:88

    Content type: Research

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  32. The reprogramming of a patient’s somatic cells back into induced pluripotent stem cells (iPSCs) holds significant promise for future autologous cellular therapeutics. The continued presence of potentially onco...

    Authors: Jason P Awe, Patrick C Lee, Cyril Ramathal, Agustin Vega-Crespo, Jens Durruthy-Durruthy, Aaron Cooper, Saravanan Karumbayaram, William E Lowry, Amander T Clark, Jerome A Zack, Vittorio Sebastiano, Donald B Kohn, April D Pyle, Martin G Martin, Gerald S Lipshutz, Patricia E Phelps…

    Citation: Stem Cell Research & Therapy 2013 4:87

    Content type: Research

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  33. BALB/c mice and C57/BL6 mice have different abilities to recover from ischemia. C57/BL6 mice display increased vessel collateralization and vascular endothelial growth factor expression with a consequent rapid...

    Authors: Flavia Franco Cunha, Leonardo Martins, Priscila Keiko Matsumoto Martin, Roberta Sessa Stilhano and Sang Won Han

    Citation: Stem Cell Research & Therapy 2013 4:86

    Content type: Research

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  34. Tendon injury is a major cause of lameness and decreased performance in athletic equines. Various therapies for tendonitis have been described; however, none of these therapies results in complete tissue regen...

    Authors: Armandode Mattos Carvalho, Peres Ramos Badial, Luis Emiliano Cisneros Álvarez, Ana Lucia Miluzzi Yamada, Alexandre Secorun Borges, Elenice Deffune, Carlos Alberto Hussni and Ana Liz Garcia Alves

    Citation: Stem Cell Research & Therapy 2013 4:85

    Content type: Research

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  35. Epidermal neural crest stem cells (EPI-NCSCs) in the bulge of hair follicles are a promising source for cell-replacement therapies in neurodegenerative diseases. A prominent factor in cell-based therapy is the...

    Authors: Sareh Pandamooz, Mohammad Naji, Farid Alinezhad, Amin Zarghami and Mohsen Pourghasem

    Citation: Stem Cell Research & Therapy 2013 4:84

    Content type: Research

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  36. Bone marrow mesenchymal stem cells (BMMSCs) have been reported to facilitate liver regeneration after toxic injuries. However, the effect of BMMSCs on liver regeneration after massive hepatectomy is barely stu...

    Authors: Jun Yu, Shengyong Yin, Wu Zhang, Feng Gao, Yuanxing Liu, Zhiyun Chen, Min Zhang, Jiangjuan He and Shusen Zheng

    Citation: Stem Cell Research & Therapy 2013 4:83

    Content type: Research

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  37. Although blinding is a methodologic safeguard to ensure obtaining comparability of groups in a clinical trial, it is very difficult to maintain blinding from the beginning to the end of a study. The aim of the...

    Authors: Hyunsuk Jeong, Hyeon Woo Yim, Youngseung Cho, Hun Jun Park, Sona Jeong, Hyun-bin Kim, Wonhee Hong and Heejung Kim

    Citation: Stem Cell Research & Therapy 2013 4:82

    Content type: Research

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  38. Human Wharton’s jelly (WJ) has become a preferred source of mesenchymal stem cells (MSCs) whose clinical applications are limited by the use of adequate xeno-free (XF), in vitro manipulation conditions. Therefore...

    Authors: Maria Cristina Corotchi, Mirel Adrian Popa, Anca Remes, Livia Elena Sima, Ilinca Gussi and Marilena Lupu Plesu

    Citation: Stem Cell Research & Therapy 2013 4:81

    Content type: Research

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  39. Young patients receiving chemotherapy occasionally face infertility and premature ovarian failure (POF). Numerous investigations reported that adipose-derived stem cells (ADSCs) transplantation could ameliorat...

    Authors: Min Sun, Shufang Wang, Yi Li, Ling Yu, Fang Gu, Changyong Wang and Yuanqing Yao

    Citation: Stem Cell Research & Therapy 2013 4:80

    Content type: Research

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  40. Obesity, which is excessive expansion of white adipose tissue, is a major risk factor for several serious health issues, including diabetes, cardiovascular disease and cancer. Efforts to combat obesity and rel...

    Authors: Zachary A Schiller, Nathan R Schiele, James K Sims, Kyongbum Lee and Catherine K Kuo

    Citation: Stem Cell Research & Therapy 2013 4:79

    Content type: Research

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  41. Nestin-expressing cells isolated from different human tissues reveal self-renewal capacity and a multilineage differentiation potential. In particular, adult stem/progenitor cell populations from exocrine glan...

    Authors: Anja Richter, Nicole Nissen, Peter Mailänder, Felix Stang, Frank Siemers, Charli Kruse and Sandra Danner

    Citation: Stem Cell Research & Therapy 2013 4:78

    Content type: Research

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  42. Multiple sclerosis (MS) is the most common inflammatory demyelinating disorder of the central nervous system (CNS). Minocycline ameliorates the clinical severity of MS and exhibits antiinflammatory, neuroprote...

    Authors: Yun Hou, Chung Heon Ryu, Kwang Ywel Park, Seong Muk Kim, Chang Hyun Jeong and Sin-Soo Jeun

    Citation: Stem Cell Research & Therapy 2013 4:77

    Content type: Research

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  43. Cell therapy is a potential therapeutic approach for neurodegenerative disorders, such as Alzheimer disease (AD). Neuronal differentiation of stem cells before transplantation is a promising procedure for cell...

    Authors: Hui Yang, Zhao Hong Xie, Li Fei Wei, Hong Na Yang, Shao Nan Yang, Zheng Yu Zhu, Ping Wang, Cui Ping Zhao and Jian Zhong Bi

    Citation: Stem Cell Research & Therapy 2013 4:76

    Content type: Research

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