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  1. Type 1 long QT syndrome (LQT1) is a common type of cardiac channelopathy associated with loss-of-function mutations of KCNQ1. Currently there is a lack of drugs that target the defected slowly activating delayed ...

    Authors: Dongrui Ma, Heming Wei, Jun Lu, Dou Huang, Zhenfeng Liu, Li Jun Loh, Omedul Islam, Reginald Liew, Winston Shim and Stuart A Cook
    Citation: Stem Cell Research & Therapy 2015 6:39
    Content type: Research Published on:

  2. Unstable atherosclerotic plaques are prone to rupture, which leads to atherothrombosis. Endothelial progenitor cells (EPCs) are bone marrow-derived precursor cells that may repair vascular injury in atheroscle...

    Authors: Zhongwen Zhang, Jianjun Dong, Corrinne G Lobe, Peiyun Gong, Ju Liu and Lin Liao
    Citation: Stem Cell Research & Therapy 2015 6:36
    Content type: Research Published on:

  4. Local delivery of mesenchymal stem cells (MSCs) to the acutely injured or osteoarthritic joint retards cartilage destruction. However, in the absence of assistive materials the efficiency of engraftment of MSC...

    Authors: Sarah E Bulman, Cynthia M Coleman, J Mary Murphy, Nicholas Medcalf, Aideen E Ryan and Frank Barry
    Citation: Stem Cell Research & Therapy 2015 6:34
    Content type: Research Published on:

  5. Stem cells isolated from menstrual fluid (MenSCs) exhibit mesenchymal stem cell (MSCs)-like properties including multi-lineage differentiation capacity. Besides, menstrual fluid has important advantages over o...

    Authors: Francisca Alcayaga-Miranda, Jimena Cuenca, Patricia Luz-Crawford, Carolina Aguila-Díaz, Ainoa Fernandez, Fernando E Figueroa and Maroun Khoury
    Citation: Stem Cell Research & Therapy 2015 6:32
    Content type: Research Published on:

  6. Mesenchymal stromal/stem cells (MSCs) are multipotent cells that have the ability to express and secrete a wide range of immunomodulatory molecules, cytokines, growth factors and antiapoptotic proteins. MSCs m...

    Authors: Juliana Navarro Ueda Yaochite, Carolina Caliari-Oliveira, Lucas Eduardo Botelho de Souza, Lourenço Sbragia Neto, Patrícia Vianna Bonini Palma, Dimas Tadeu Covas, Kelen Cristina Ribeiro Malmegrim, Julio César Voltarelli and Eduardo Antônio Donadi
    Citation: Stem Cell Research & Therapy 2015 6:31
    Content type: Research Published on:

  7. Globoid cell leukodystrophy (GLD) is a severe disorder of the central and peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity. Cell-based therapies are highly promising stra...

    Authors: Xiao Ling Kuai, Run Zhou Ni, Guo Xiong Zhou, Zheng Biao Mao, Jian Feng Zhang, Nan Yi, Zhao Xiu Liu, Nan Shao, Wen Kai Ni and Zhi Wei Wang
    Citation: Stem Cell Research & Therapy 2015 6:30
    Content type: Research Published on:

  8. Retinitis pigmentosa (RP) is a severe neurodegenerative disease of the retina that can lead to blindness. Even without treatment, a clinical study with the use of stem cells is currently underway and the resul...

    Authors: Rubens C Siqueira, Andre Messias, Katharina Messias, Rafael S Arcieri, Milton A Ruiz, Neiglene F Souza, Lia C Martins and Rodrigo Jorge
    Citation: Stem Cell Research & Therapy 2015 6:29
    Content type: Research Published on:

  9. Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FB...

    Authors: José M Díez, Ewa Bauman, Rodrigo Gajardo and Juan I Jorquera
    Citation: Stem Cell Research & Therapy 2015 6:28
    Content type: Research Published on:

  10. Although there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best c...

    Authors: Leopoldo P Nucci, Helio R Silva, Viviana Giampaoli, Javier B Mamani, Mariana P Nucci and Lionel F Gamarra
    Citation: Stem Cell Research & Therapy 2015 6:27
    Content type: Research Published on:

  12. Bone marrow derived cellular therapies are an emerging approach to promoting therapeutic angiogenesis in ischemic cardiovascular disease. However, the percentage of regenerative cells in bone marrow mononuclea...

    Authors: Kelly J Ledford, Nikki Murphy, Frank Zeigler, Ronnda L Bartel and Ross Tubo
    Citation: Stem Cell Research & Therapy 2015 6:25
    Content type: Research Published on:

  13. Recent evidence has shown that bone marrow cells play critical roles during the inflammatory, proliferative and remodeling phases of cutaneous wound healing. Among the bone marrow cells delivered to wounds are...

    Authors: Luis Rodriguez-Menocal, Shahjahan Shareef, Marcela Salgado, Arsalan Shabbir and Evangelos Van Badiavas
    Citation: Stem Cell Research & Therapy 2015 6:24
    Content type: Research Published on:

  14. Depletion of limbal stem cells leads to a debilitating condition known as limbal stem cell deficiency, characterised by impaired corneal wound healing and poor vision. The aim of this study was to determine wh...

    Authors: Samantha Bobba, Sharron Chow, Stephanie Watson and Nick Di Girolamo
    Citation: Stem Cell Research & Therapy 2015 6:23
    Content type: Research Published on:

  15. The objective of the present study was to evaluate the capacity of a tissue-engineered complex of human osteoprotegerin (hOPG)-transfected periodontal ligament stem cells (PDLSCs) seeding on beta-tricalcium ph...

    Authors: Fang Su, Shi-Sen Liu, Jun-Li Ma, Dong-Sheng Wang, Ling-Ling E and Hong-Chen Liu
    Citation: Stem Cell Research & Therapy 2015 6:22
    Content type: Research Published on:

  16. Bone marrow-derived mesenchymal stem cells (BMSCs, also known as bone marrow-derived mesenchymal stromal cells) are known to be a component of the tumor microenvironment. BMSCs are multipotent stromal cells th...

    Authors: Chen Jiang, Jun Sun, Yafei Dai, Pengfei Cao, Liyang Zhang, Shuping Peng, Yanhong Zhou, Guiyuan Li, Jingqun Tang and Juanjuan Xiang
    Citation: Stem Cell Research & Therapy 2015 6:21
    Content type: Research Published on:

  17. Tumor necrosis factor-inducible gene 6 protein (TSG-6), one of the cytokines released by human mesenchymal stem/stromal cells (hMSC), has an anti-inflammatory effect and alleviates several pathological conditi...

    Authors: Sihyung Wang, Ji-Seon Lee, Jeongeun Hyun, Jieun Kim, Seung U Kim, Hyuk-Jin Cha and Youngmi Jung
    Citation: Stem Cell Research & Therapy 2015 6:20
    Content type: Research Published on:

  18. Mesenchymal stromal cells (MSC) have well defined immunomodulatory properties including the suppression of lymphocyte proliferation and inhibition of dendritic cell (DC) maturation involving both cell contact ...

    Authors: Emer F Cahill, Laura M Tobin, Fiona Carty, Bernard P Mahon and Karen English
    Citation: Stem Cell Research & Therapy 2015 6:19
    Content type: Research Published on:

  19. Microparticles (MPs) derived from kidney-derived mesenchymal stem cells (KMSCs) have recently been reported to ameliorate rarefaction of peritubular capillaries (PTC) in ischemic kidneys via delivery of proang...

    Authors: Hoon Young Choi, Hyun Gyu Lee, Beom Seok Kim, Sun Hee Ahn, Ara Jung, Mirae Lee, Jung Eun Lee, Hyung Jong Kim, Sung Kyu Ha and Hyeong Cheon Park
    Citation: Stem Cell Research & Therapy 2015 6:18
    Content type: Research Published on:

  20. Bone marrow mesenchymal stem cells (BMSCs), which have the ability to self-renew and to differentiate into multiple cell types, have recently become a novel strategy for cell-based therapies. The differentiati...

    Authors: Zhenzhen Li, Shichao Han, Xingqin Wang, Fu Han, Xiongxiang Zhu, Zhao Zheng, Hongtao Wang, Qin Zhou, Yunchuan Wang, Linlin Su, Jihong Shi, Chaowu Tang and Dahai Hu
    Citation: Stem Cell Research & Therapy 2015 6:17
    Content type: Research Published on:

  21. Developing cartilage constructs with injectability, appropriate matrix composition and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Bone marrow derived mesenchymal stem...

    Authors: Ruikai Ba, Jianhua Wei, Man Li, Xiaobing Cheng, Yimin Zhao and Wei Wu
    Citation: Stem Cell Research & Therapy 2015 6:16
    Content type: Research Published on:

  22. In recent years, mesenchymal stem cells (MSCs) have been demonstrated to play an important role in carcinogenesis. However, the effect of MSCs on tumor and metastasis development and the mechanisms underlying ...

    Authors: Aleksandra V Meleshina, Elena I Cherkasova, Marina V Shirmanova, Natalia V Klementieva, Ekaterina V Kiseleva, Ludmila Ð’ Snopova, Natalia N Prodanets and Elena V Zagaynova
    Citation: Stem Cell Research & Therapy 2015 6:15
    Content type: Research Published on:

  23. Human induced pluripotent stem cells (hiPSCs) have been derived from various somatic cell types. Granulosa cells, a group of cells which surround oocytes and are obtained from the (normally discarded) retrieve...

    Authors: Ching-Yu Chuang, Mei-Chi Huang, Hsin-Fu Chen, Li-Hui Tseng, Chun-Ying Yu, Lee Stone, Hsiang-Po Huang, Hong-Nerng Ho and Hung-Chih Kuo
    Citation: Stem Cell Research & Therapy 2015 6:14
    Content type: Research Published on:

  24. High-risk neuroblastoma (HR-NB) presenting with hematogenous metastasis is one of the most difficult cancers to cure. Patient survival is poor. Aggressive tumors contain populations of rapidly proliferating cl...

    Authors: Vijayabaskar Pandian, Satishkumar Ramraj, Faizan H Khan, Tasfia Azim and Natarajan Aravindan
    Citation: Stem Cell Research & Therapy 2015 6:400
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:32

  25. Follicular fluid is important for follicular development and oocyte maturation. Evidence suggests that follicular fluid is not only rich in proteins but cells. Besides oocytes, the follicular fluid contains gr...

    Authors: Dongmei Lai, Minhua Xu, Qiuwan Zhang, Yifei Chen, Ting Li, Qian Wang, Yimeng Gao and Chunsheng Wei
    Citation: Stem Cell Research & Therapy 2015 6:13
    Content type: Research Published on:

  26. Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum ...

    Authors: Julien Rossignol, Kyle D Fink, Andrew T Crane, Kendra K Davis, Matthew C Bombard, Steven Clerc, Angela M Bavar, Steven A Lowrance, Cheng Song, Steven Witte, Laurent Lescaudron and Gary L Dunbar
    Citation: Stem Cell Research & Therapy 2015 6:9
    Content type: Research Published on:

  27. An increasing number of private clinics in Australia are marketing and providing autologous stem cell therapies to patients. Although advocates point to the importance of medical innovation and the primacy of ...

    Authors: Alison K McLean, Cameron Stewart and Ian Kerridge
    Citation: Stem Cell Research & Therapy 2015 6:33
    Content type: Review Published on:

  28. The immunomodulatory properties of human amnion epithelial cells (hAECs) have been previously described in several disease models. We previously reported on the ability of hAECs to influence macrophage phenoty...

    Authors: Jean L Tan, Siow T Chan, Camden Y Lo, James A Deane, Courtney A McDonald, Claude CA Bernard, Euan M Wallace and Rebecca Lim
    Citation: Stem Cell Research & Therapy 2015 6:8
    Content type: Research Published on:

  29. Intra-arterial cell infusion is an efficient delivery route with which to target organs such as the ischemic brain. However, adverse events including microembolisms and decreased cerebral blood flow were recen...

    Authors: Li-li Cui, Erja Kerkelä, Abdulhameed Bakreen, Franziska Nitzsche, Anna Andrzejewska, Adam Nowakowski, Miroslaw Janowski, Piotr Walczak, Johannes Boltze, Barbara Lukomska and Jukka Jolkkonen
    Citation: Stem Cell Research & Therapy 2015 6:11
    Content type: Research Published on:

  30. Percutaneous transluminal renal angioplasty (PTRA) fails to fully improve cardiac injury and dysfunction in patients with renovascular hypertension (RVH). Mesenchymal stem cells (MSCs) restore renal function, ...

    Authors: Alfonso Eirin, Xiang-Yang Zhu, Christopher M Ferguson, Scott M Riester, Andre J van Wijnen, Amir Lerman and Lilach O Lerman
    Citation: Stem Cell Research & Therapy 2015 6:7
    Content type: Research Published on:

  31. Mesenchymal stem cells (MSCs) are a promising source of cells for regenerative therapies. Although they can be isolated easily from several tissues, cell expansion is limited since their properties are lost wi...

    Authors: Carlos Luzzani, Gabriel Neiman, Ximena Garate, María Questa, Claudia Solari, Darío Fernandez Espinosa, Marcela García, Ana Lía Errecalde, Alejandra Guberman, María Elida Scassa, Gustavo Emilio Sevlever, Leonardo Romorini and Santiago Gabriel Miriuka
    Citation: Stem Cell Research & Therapy 2015 6:6
    Content type: Research Published on:

  32. Urine-derived stem cells (USCs) have the ability to differentiate into osteogenic lineage. Previous studies have raised the possibility that USCs could be used for bone repair. To harness the power of USCs in ...

    Authors: Junjie Guan, Jieyuan Zhang, Zhenzhong Zhu, Xin Niu, Shangchun Guo, Yang Wang and Changqing Zhang
    Citation: Stem Cell Research & Therapy 2015 6:5
    Content type: Research Published on:

  33. Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly...

    Authors: Izuagie Attairu Ikhapoh, Christopher J Pelham and Devendra K Agrawal
    Citation: Stem Cell Research & Therapy 2015 6:4
    Content type: Research Published on:

  34. The different distribution of T cells among activation/differentiation stages in immune disorders may condition the outcome of mesenchymal stromal cell (MSC)-based therapies. Indeed, the effect of MSCs in the ...

    Authors: Paula Laranjeira, Monia Pedrosa, Susana Pedreiro, Joana Gomes, Antonio Martinho, Brigida Antunes, Tania Ribeiro, Francisco Santos, Helder Trindade and Artur Paiva
    Citation: Stem Cell Research & Therapy 2015 6:3
    Content type: Research Published on:

  35. Autologous fat grafting is commonly used to correct soft-tissue contour deformities. However, results are impaired by a variable and unpredictable resorption rate. Autologous adipose-derived stromal cells in c...

    Authors: Rossana Domenis, Lara Lazzaro, Sarah Calabrese, Damiano Mangoni, Annarita Gallelli, Evgenia Bourkoula, Ivana Manini, Natascha Bergamin, Barbara Toffoletto, Carlo A Beltrami, Antonio P Beltrami, Daniela Cesselli and Pier Camillo Parodi
    Citation: Stem Cell Research & Therapy 2015 6:2
    Content type: Research Published on:

  36. Pluripotent stem cells are increasingly used to build therapeutic models, including the transplantation of neural progenitors derived from human embryonic stem cells (hESCs). Recently, long non-coding RNAs (ln...

    Authors: Chu-Fan Mo, Fang-Chun Wu, Kang-Yu Tai, Wei-Chun Chang, Kai-Wei Chang, Hung-Chih Kuo, Hong-Nerng Ho, Hsin-Fu Chen and Shau-Ping Lin
    Citation: Stem Cell Research & Therapy 2015 6:1
    Content type: Research Published on:

  37. Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothel...

    Authors: Sushma Bartaula-Brevik, Torbjorn O Pedersen, Anna L Blois, Panagiota Papadakou, Anna Finne-Wistrand, Ying Xue, Anne Isine Bolstad and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2014 5:143
    Content type: Research Published on:

  38. Mesenchymal cells are emerging as a promising cell platform for regenerative therapies. However, the fate of cells after transplantation in many different disease settings and tissue beds remains unclear.

    Authors: Hitesh Agrawal, Hulan Shang, Anna Parker Sattah, Ning Yang, Shayn M Peirce and Adam J Katz
    Citation: Stem Cell Research & Therapy 2014 5:142
    Content type: Research Published on:

  39. Bone marrow mesenchymal stem cells/multipotent stromal cells (MSCs) are recruited to sites of injury and subsequently support regeneration through differentiation or paracrine activity. During periods of stres...

    Authors: Austin Nuschke, Melanie Rodrigues, Donna B Stolz, Charleen T Chu, Linda Griffith and Alan Wells
    Citation: Stem Cell Research & Therapy 2014 5:140
    Content type: Research Published on:

  40. Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstra...

    Authors: Orly Ravid, Ofer Shoshani, Meirav Sela, Ada Weinstock, Tommy Weiss Sadan, Eyal Gur, Dov Zipori and Nir Shani
    Citation: Stem Cell Research & Therapy 2014 5:139
    Content type: Research Published on:

  41. Scleroderma is characterized by cutaneous manifestations that mainly affect the hands, arms and face. As of today, there is no treatment for fibrotic skin lesions of scleroderma. Previously we generated and va...

    Authors: Nicolas Serratrice, Laurie Bruzzese, Jérémy Magalon, Julie Véran, Laurent Giraudo, Houssein Aboudou, Djaffar Ould-Ali, Pierre Sébastien Nguyen, Olivier Bausset, Aurélie Daumas, Dominique Casanova, Brigitte Granel, Lucile Andrac-Meyer, Florence Sabatier and Guy Magalon
    Citation: Stem Cell Research & Therapy 2014 5:138
    Content type: Research Published on:

  42. Mesenchymal stem cells (MSCs) are considered to play important roles in wound repair and tissue remodeling. Hypertrophic scar (HTS) is a cutaneous condition characterized by deposits of excessive amount of col...

    Authors: Yi-Lun Liu, Wei-Hua Liu, Jin Sun, Tuan-Jie Hou, Yue-Ming Liu, Hai-Rong Liu, Yong-Hui Luo, Ning-Ning Zhao, Ying Tang and Feng-Mei Deng
    Citation: Stem Cell Research & Therapy 2014 5:136
    Content type: Research Published on:

  43. Dental follicle gives rise to one or several tissues of the periodontium including the periodontal ligament, cementum and/or alveolar bone. Whether Wnt5a is expressed in the postnatal periodontium or regulates...

    Authors: Lusai Xiang, Mo Chen, Ling He, Bin Cai, Yu Du, Xinchun Zhang, Chen Zhou, Chenglin Wang, Jeremy J Mao and Junqi Ling
    Citation: Stem Cell Research & Therapy 2014 5:135
    Content type: Research Published on:

  44. Mesenchymal stem cells (MSCs) are a multipotent population of adult stem cells, which may represent a promising therapeutic approach for neurological autoimmune diseases such as multiple sclerosis. The mouse i...

    Authors: Carmen Marin-Bañasco, Margarita Suardíaz García, Issac Hurtado Guerrero, Rafael Maldonado Sánchez, Guillermo Estivill-Torrús, Laura Leyva Fernández and Oscar Fernández Fernández
    Citation: Stem Cell Research & Therapy 2014 5:134
    Content type: Research Published on:

  45. Rhinosinusitis is characterized by inflammation extending from the mucosa of the nasal cavity into the paranasal sinuses. There are some aggravating features, such as immunosuppression, that can cause the nasa...

    Authors: Erica Ortiz, Albina Altemani, Afonso Celso Vigorito, Eulalia Sakano and Ester Maria Danielli Nicola
    Citation: Stem Cell Research & Therapy 2014 5:133
    Content type: Research Published on:

  46. Mesenchymal stem cells (MSCs) are widely investigated in clinical researches to treat various diseases. Classic culture medium for MSCs, even for clinical use, contains fetal bovine serum. The serum-containing...

    Authors: Youwei Wang, Hehe Wu, Zhouxin Yang, Ying Chi, Lei Meng, Aibin Mao, Shulin Yan, Shanshan Hu, Jianzhong Zhang, Yun Zhang, Wenbo Yu, Yue Ma, Tao Li, Yan Cheng, Yongjuan Wang, Shanshan Wang…
    Citation: Stem Cell Research & Therapy 2014 5:132
    Content type: Research Published on:

  47. The present study aimed to elucidate the therapeutic effects of mesenchymal stem cells (MSCs) derived from the bone marrow of rats (BM) against toxic effects of lead (Pb) on the male gonads of experimental rats.

    Authors: Amal I Hassan and Sally S Alam
    Citation: Stem Cell Research & Therapy 2014 5:131
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:32

  48. Mesenchymal stem cells (MSCs) transplantation has been demonstrated to be an effective strategy for the treatment of cardiovascular disease. However, the low survival rate of MSCs at local diseased tissue redu...

    Authors: Yue Xing, Jingying Hou, Tianzhu Guo, Shaoxin Zheng, Changqing Zhou, Hui Huang, Yuyang Chen, Kan Sun, Tingting Zhong, Jingfeng Wang, Honghao Li and Tong Wang
    Citation: Stem Cell Research & Therapy 2014 5:130
    Content type: Research Published on:

  49. Clinically, a good deal of injury from stroke results from ischemic-reperfusion. There is a loss of cerebral parenchyma and its associated cells, disruption of neuronal connections, compromise of the blood-bra...

    Authors: Lei Huang, Sunnie Wong, Evan Y Snyder, Milton H Hamblin and Jean-Pyo Lee
    Citation: Stem Cell Research & Therapy 2014 5:129
    Content type: Research Published on:

  50. Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, t...

    Authors: Yao Li, Ming Yan, Zilu Wang, Yangyu Zheng, Junjun Li, Shu Ma, Genxia Liu and Jinhua Yu
    Citation: Stem Cell Research & Therapy 2014 5:125
    Content type: Research Published on:
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